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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for LHX6

Z-value: 0.59

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Transcription factors associated with LHX6

Gene Symbol Gene ID Gene Info
ENSG00000106852.11 LIM homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX6hg19_v2_chr9_-_124989804_124989865,
hg19_v2_chr9_-_124991124_124991246
-0.386.4e-02Click!

Activity profile of LHX6 motif

Sorted Z-values of LHX6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_102668879 1.41 ENST00000315274.6
matrix metallopeptidase 1 (interstitial collagenase)
chr11_-_102651343 1.36 ENST00000279441.4
ENST00000539681.1
matrix metallopeptidase 10 (stromelysin 2)
chr14_-_52535712 0.85 ENST00000216286.5
ENST00000541773.1
nidogen 2 (osteonidogen)
chr11_+_5710919 0.84 ENST00000379965.3
ENST00000425490.1
tripartite motif containing 22
chr13_+_37006421 0.78 ENST00000255465.4
cyclin A1
chr13_+_37005967 0.77 ENST00000440264.1
ENST00000449823.1
cyclin A1
chr13_+_37006398 0.77 ENST00000418263.1
cyclin A1
chr1_+_15986364 0.67 ENST00000345034.1
regulatory solute carrier protein, family 1, member 1
chr19_-_10491234 0.67 ENST00000524462.1
ENST00000531836.1
ENST00000525621.1
tyrosine kinase 2
chr18_+_60190682 0.67 ENST00000588676.1
zinc finger, CCHC domain containing 2
chr1_+_145438469 0.61 ENST00000369317.4
thioredoxin interacting protein
chr8_-_42623747 0.55 ENST00000534622.1
cholinergic receptor, nicotinic, alpha 6 (neuronal)
chr22_-_42017021 0.52 ENST00000263256.6
desumoylating isopeptidase 1
chr17_+_72772621 0.50 ENST00000335464.5
ENST00000417024.2
ENST00000578764.1
ENST00000582773.1
ENST00000582330.1
transmembrane protein 104
chr5_-_20575959 0.50 ENST00000507958.1
cadherin 18, type 2
chr10_+_13141441 0.50 ENST00000263036.5
optineurin
chr6_+_26402465 0.50 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
butyrophilin, subfamily 3, member A1
chr1_-_36906474 0.45 ENST00000433045.2
organic solute carrier partner 1
chr12_+_21654714 0.43 ENST00000542038.1
ENST00000540141.1
ENST00000229314.5
golgi transport 1B
chr10_+_13141585 0.43 ENST00000378764.2
optineurin
chr5_-_35938674 0.42 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
calcyphosine-like
chr6_+_29691198 0.40 ENST00000440587.2
ENST00000434407.2
major histocompatibility complex, class I, F
chr2_-_136678123 0.40 ENST00000422708.1
aspartyl-tRNA synthetase
chr11_+_33061543 0.39 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
t-complex 11, testis-specific-like 1
chr22_+_17956618 0.37 ENST00000262608.8
cat eye syndrome chromosome region, candidate 2
chr12_-_2113583 0.36 ENST00000397173.4
ENST00000280665.6
decapping mRNA 1B
chr10_+_13142225 0.35 ENST00000378747.3
optineurin
chr17_+_73452695 0.34 ENST00000582186.1
ENST00000582455.1
ENST00000581252.1
ENST00000579208.1
KIAA0195
chr6_+_29691056 0.34 ENST00000414333.1
ENST00000334668.4
ENST00000259951.7
major histocompatibility complex, class I, F
chr14_-_53258314 0.34 ENST00000216410.3
ENST00000557604.1
glucosamine-phosphate N-acetyltransferase 1
chr8_+_42010464 0.33 ENST00000518421.1
ENST00000174653.3
ENST00000396926.3
ENST00000521280.1
ENST00000522288.1
adaptor-related protein complex 3, mu 2 subunit
chr9_-_95640218 0.33 ENST00000395506.3
ENST00000375495.3
ENST00000332591.6
zinc finger protein 484
chrX_-_47509887 0.33 ENST00000247161.3
ENST00000592066.1
ENST00000376983.3
ELK1, member of ETS oncogene family
chr10_-_104001231 0.32 ENST00000370002.3
paired-like homeodomain 3
chr17_-_79623597 0.32 ENST00000574024.1
ENST00000331056.5
phosphodiesterase 6G, cGMP-specific, rod, gamma
chr9_+_80912059 0.31 ENST00000347159.2
ENST00000376588.3
phosphoserine aminotransferase 1
chr19_-_12833164 0.31 ENST00000356861.5
transportin 2
chr7_+_21582638 0.30 ENST00000409508.3
ENST00000328843.6
dynein, axonemal, heavy chain 11
chr1_+_28261492 0.30 ENST00000373894.3
sphingomyelin phosphodiesterase, acid-like 3B
chr1_+_28261621 0.29 ENST00000549094.1
sphingomyelin phosphodiesterase, acid-like 3B
chr1_-_152386732 0.29 ENST00000271835.3
cornulin
chr7_+_70597109 0.28 ENST00000333538.5
Williams-Beuren syndrome chromosome region 17
chr17_-_1532106 0.28 ENST00000301335.5
ENST00000382147.4
solute carrier family 43 (amino acid system L transporter), member 2
chr19_+_12902289 0.27 ENST00000302754.4
jun B proto-oncogene
chr20_+_18488137 0.26 ENST00000450074.1
ENST00000262544.2
ENST00000336714.3
ENST00000377475.3
Sec23 homolog B (S. cerevisiae)
chr14_+_32798462 0.25 ENST00000280979.4
A kinase (PRKA) anchor protein 6
chr6_+_34204642 0.25 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
high mobility group AT-hook 1
chr12_-_11244912 0.24 ENST00000531678.1
taste receptor, type 2, member 43
chr17_-_40337470 0.24 ENST00000293330.1
hypocretin (orexin) neuropeptide precursor
chr8_-_13134045 0.23 ENST00000512044.2
deleted in liver cancer 1
chr10_-_123274693 0.23 ENST00000429361.1
fibroblast growth factor receptor 2
chr17_-_72772462 0.23 ENST00000582870.1
ENST00000581136.1
ENST00000357814.3
ENST00000579218.1
ENST00000583476.1
ENST00000580301.1
ENST00000583757.1
ENST00000582524.1
N-acetyltransferase 9 (GCN5-related, putative)
chr17_+_18086392 0.23 ENST00000541285.1
alkB, alkylation repair homolog 5 (E. coli)
chr6_-_62996066 0.23 ENST00000281156.4
KH domain containing, RNA binding, signal transduction associated 2
chrX_-_119077695 0.23 ENST00000371410.3
NFKB activating protein
chr3_+_85008089 0.23 ENST00000383699.3
cell adhesion molecule 2
chr12_-_77459306 0.22 ENST00000547316.1
ENST00000416496.2
ENST00000550669.1
ENST00000322886.7
E2F transcription factor 7
chr15_+_90118685 0.22 ENST00000268138.7
TOPBP1-interacting checkpoint and replication regulator
chr1_+_62439037 0.22 ENST00000545929.1
InaD-like (Drosophila)
chr16_-_55866997 0.22 ENST00000360526.3
ENST00000361503.4
carboxylesterase 1
chr6_-_167040731 0.22 ENST00000265678.4
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr2_+_220143989 0.22 ENST00000336576.5
DnaJ (Hsp40) homolog, subfamily B, member 2
chr5_+_142149932 0.22 ENST00000274498.4
Rho GTPase activating protein 26
chr19_-_19302931 0.22 ENST00000444486.3
ENST00000514819.3
ENST00000585679.1
ENST00000162023.5
MEF2BNB-MEF2B readthrough
MEF2B neighbor
myocyte enhancer factor 2B
chr11_-_35287243 0.22 ENST00000464522.2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr14_+_74034310 0.22 ENST00000538782.1
acyl-CoA thioesterase 2
chr4_+_165675269 0.21 ENST00000507311.1
RP11-294O2.2
chr22_-_39190116 0.21 ENST00000406622.1
ENST00000216068.4
ENST00000406199.3
Sad1 and UNC84 domain containing 2
dynein, axonemal, light chain 4
chr10_+_24755416 0.21 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
chr1_-_13390765 0.21 ENST00000357367.2
PRAME family member 8
chr6_+_26402517 0.21 ENST00000414912.2
butyrophilin, subfamily 3, member A1
chr11_-_89653576 0.21 ENST00000420869.1
tripartite motif containing 49D1
chr3_-_53164423 0.21 ENST00000467048.1
ENST00000394738.3
ENST00000296292.3
RFT1 homolog (S. cerevisiae)
chr4_+_110736659 0.20 ENST00000394631.3
ENST00000226796.6
GAR1 ribonucleoprotein
chr15_+_90118723 0.20 ENST00000560985.1
TOPBP1-interacting checkpoint and replication regulator
chr19_+_56459198 0.20 ENST00000291971.3
ENST00000590542.1
NLR family, pyrin domain containing 8
chr2_+_220144052 0.20 ENST00000425450.1
ENST00000392086.4
ENST00000421532.1
DnaJ (Hsp40) homolog, subfamily B, member 2
chr18_+_616672 0.19 ENST00000338387.7
clusterin-like 1 (retinal)
chr9_+_130565147 0.19 ENST00000373247.2
ENST00000373245.1
ENST00000393706.2
ENST00000373228.1
folylpolyglutamate synthase
chr8_+_50822344 0.19 ENST00000518864.1
syntrophin, gamma 1
chr5_+_66300446 0.19 ENST00000261569.7
microtubule associated serine/threonine kinase family member 4
chr16_-_838329 0.19 ENST00000563560.1
ENST00000569601.1
ENST00000565809.1
ENST00000565377.1
ENST00000007264.2
ENST00000567114.1
RNA pseudouridylate synthase domain containing 1
chr6_+_36165133 0.19 ENST00000446974.1
ENST00000454960.1
bromodomain and PHD finger containing, 3
chr17_-_77770830 0.19 ENST00000269385.4
chromobox homolog 8
chr20_-_50418947 0.19 ENST00000371539.3
spalt-like transcription factor 4
chr12_-_5352315 0.19 ENST00000536518.1
RP11-319E16.1
chr18_+_5238549 0.18 ENST00000580684.1
long intergenic non-protein coding RNA 667
chr11_+_57435219 0.18 ENST00000527985.1
ENST00000287169.3
zinc finger, DHHC-type containing 5
chr5_-_171881362 0.18 ENST00000519643.1
SH3 and PX domains 2B
chr16_+_31724552 0.18 ENST00000539915.1
ENST00000316491.9
ENST00000399681.3
ENST00000398696.3
ENST00000534369.1
zinc finger protein 720
chr20_-_50418972 0.18 ENST00000395997.3
spalt-like transcription factor 4
chr17_-_1531635 0.18 ENST00000571650.1
solute carrier family 43 (amino acid system L transporter), member 2
chr5_+_162864575 0.18 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
cyclin G1
chr2_-_55276320 0.17 ENST00000357376.3
reticulon 4
chr3_+_179280668 0.17 ENST00000429709.2
ENST00000450518.2
ENST00000392662.1
ENST00000490364.1
actin-like 6A
chr14_+_52456327 0.17 ENST00000556760.1
chromosome 14 open reading frame 166
chr16_+_2479390 0.17 ENST00000397066.4
cyclin F
chr3_-_112693865 0.17 ENST00000471858.1
ENST00000295863.4
ENST00000308611.3
CD200 receptor 1
chr12_-_21654479 0.16 ENST00000421138.2
ENST00000444129.2
ENST00000539672.1
ENST00000542432.1
ENST00000536964.1
ENST00000536240.1
ENST00000396093.3
ENST00000314748.6
RecQ protein-like (DNA helicase Q1-like)
chr15_-_64673665 0.16 ENST00000300035.4
KIAA0101
chr20_+_54967409 0.16 ENST00000415828.1
ENST00000217109.4
ENST00000428552.1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr12_-_45269430 0.16 ENST00000395487.2
NEL-like 2 (chicken)
chr10_-_99447024 0.16 ENST00000370626.3
arginine vasopressin-induced 1
chrX_+_19362011 0.16 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
pyruvate dehydrogenase (lipoamide) alpha 1
chr17_+_42786051 0.16 ENST00000315005.3
DBF4 homolog B (S. cerevisiae)
chr7_-_88425025 0.16 ENST00000297203.2
chromosome 7 open reading frame 62
chr16_+_6533729 0.16 ENST00000551752.1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr17_-_40829026 0.16 ENST00000412503.1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr9_+_34646624 0.16 ENST00000450095.2
ENST00000556278.1
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr5_-_54830871 0.16 ENST00000307259.8
phosphatidic acid phosphatase type 2A
chr2_-_227050079 0.16 ENST00000423838.1
AC068138.1
chr12_+_15125954 0.16 ENST00000266395.2
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr12_-_45270077 0.15 ENST00000551601.1
ENST00000549027.1
ENST00000452445.2
NEL-like 2 (chicken)
chr7_-_44613494 0.15 ENST00000431640.1
ENST00000258772.5
DEAD (Asp-Glu-Ala-Asp) box helicase 56
chr3_+_156009623 0.15 ENST00000389634.5
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr12_-_45270151 0.15 ENST00000429094.2
NEL-like 2 (chicken)
chr7_+_120628731 0.15 ENST00000310396.5
cadherin-like and PC-esterase domain containing 1
chr6_+_30687978 0.15 ENST00000327892.8
ENST00000435534.1
tubulin, beta class I
chr11_-_133826852 0.15 ENST00000533871.2
ENST00000321016.8
immunoglobulin superfamily, member 9B
chr18_-_5238525 0.15 ENST00000581170.1
ENST00000579933.1
ENST00000581067.1
RP11-835E18.5
long intergenic non-protein coding RNA 526
chrX_+_30261847 0.15 ENST00000378981.3
ENST00000397550.1
melanoma antigen family B, 1
chr18_-_67624160 0.14 ENST00000581982.1
ENST00000280200.4
CD226 molecule
chr6_-_139613269 0.14 ENST00000358430.3
taxilin beta
chr17_-_40828969 0.14 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr20_-_50722183 0.14 ENST00000371523.4
ZFP64 zinc finger protein
chr6_-_24358264 0.14 ENST00000378454.3
doublecortin domain containing 2
chr6_-_82957433 0.14 ENST00000306270.7
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr10_+_71561649 0.14 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
collagen, type XIII, alpha 1
chr19_-_42916499 0.14 ENST00000601189.1
ENST00000599211.1
lipase, hormone-sensitive
chr4_+_113558612 0.14 ENST00000505034.1
ENST00000324052.6
La ribonucleoprotein domain family, member 7
chr9_+_34646651 0.14 ENST00000378842.3
galactose-1-phosphate uridylyltransferase
chr19_-_10121144 0.14 ENST00000264828.3
collagen, type V, alpha 3
chr13_+_33590553 0.13 ENST00000380099.3
klotho
chr10_+_71561630 0.13 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
collagen, type XIII, alpha 1
chr4_-_113558014 0.13 ENST00000503172.1
ENST00000505019.1
ENST00000309071.5
chromosome 4 open reading frame 21
chr5_-_54830784 0.13 ENST00000264775.5
phosphatidic acid phosphatase type 2A
chr6_-_49681235 0.13 ENST00000339139.4
cysteine-rich secretory protein 2
chr10_+_99205894 0.13 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
zinc finger, DHHC-type containing 16
chr1_+_40713573 0.13 ENST00000372766.3
transmembrane and coiled-coil domains 2
chr14_+_32798547 0.13 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
A kinase (PRKA) anchor protein 6
chr7_+_150929550 0.13 ENST00000482173.1
ENST00000495645.1
ENST00000035307.2
chondroitin polymerizing factor 2
chr11_+_55594695 0.13 ENST00000378397.1
olfactory receptor, family 5, subfamily L, member 2
chr14_+_21249200 0.13 ENST00000304677.2
ribonuclease, RNase A family, k6
chr6_+_30585486 0.12 ENST00000259873.4
ENST00000506373.2
mitochondrial ribosomal protein S18B
chr7_+_142458507 0.12 ENST00000492062.1
protease, serine, 1 (trypsin 1)
chr21_-_43916296 0.12 ENST00000398352.3
radial spoke head 1 homolog (Chlamydomonas)
chr14_+_99947715 0.12 ENST00000389879.5
ENST00000557441.1
ENST00000555049.1
ENST00000555842.1
cyclin K
chr12_-_22063787 0.12 ENST00000544039.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr10_+_99205959 0.12 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
zinc finger, DHHC-type containing 16
chr19_-_14889349 0.12 ENST00000315576.3
ENST00000392967.2
ENST00000346057.1
ENST00000353876.1
ENST00000353005.1
egf-like module containing, mucin-like, hormone receptor-like 2
chr7_-_99277610 0.12 ENST00000343703.5
ENST00000222982.4
ENST00000439761.1
ENST00000339843.2
cytochrome P450, family 3, subfamily A, polypeptide 5
chr1_+_28261533 0.11 ENST00000411604.1
ENST00000373888.4
sphingomyelin phosphodiesterase, acid-like 3B
chr4_-_113558079 0.11 ENST00000445203.2
chromosome 4 open reading frame 21
chr9_+_1050331 0.11 ENST00000382255.3
ENST00000382251.3
ENST00000412350.2
doublesex and mab-3 related transcription factor 2
chr16_-_55867146 0.11 ENST00000422046.2
carboxylesterase 1
chr10_+_71561704 0.11 ENST00000520267.1
collagen, type XIII, alpha 1
chr3_-_42003479 0.11 ENST00000420927.1
unc-51 like kinase 4
chr4_-_89951028 0.11 ENST00000506913.1
family with sequence similarity 13, member A
chr4_-_66536196 0.11 ENST00000511294.1
EPH receptor A5
chr16_+_15744078 0.11 ENST00000396354.1
ENST00000570727.1
nudE neurodevelopment protein 1
chr21_+_35014706 0.11 ENST00000399353.1
ENST00000444491.1
ENST00000381318.3
intersectin 1 (SH3 domain protein)
chr2_+_166095898 0.11 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
sodium channel, voltage-gated, type II, alpha subunit
chr5_+_142149955 0.11 ENST00000378004.3
Rho GTPase activating protein 26
chr20_+_49126881 0.11 ENST00000371621.3
ENST00000541713.1
protein tyrosine phosphatase, non-receptor type 1
chr20_-_54967187 0.10 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
aurora kinase A
chr4_-_46126093 0.10 ENST00000295452.4
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr6_-_27880174 0.10 ENST00000303324.2
olfactory receptor, family 2, subfamily B, member 2
chr16_+_6533380 0.10 ENST00000552089.1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr13_-_19755975 0.10 ENST00000400113.3
tubulin, alpha 3c
chr18_-_21017817 0.10 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
transmembrane protein 241
chr4_+_113558272 0.10 ENST00000509061.1
ENST00000508577.1
ENST00000513553.1
La ribonucleoprotein domain family, member 7
chr8_-_7243080 0.10 ENST00000400156.4
zinc finger protein 705G
chr10_+_124913930 0.10 ENST00000368858.5
BUB3 mitotic checkpoint protein
chr14_-_99947168 0.10 ENST00000331768.5
SET domain containing 3
chrX_+_49020882 0.10 ENST00000454342.1
MAGI family member, X-linked
chr6_+_52051171 0.10 ENST00000340057.1
interleukin 17A
chr5_-_147286065 0.10 ENST00000318315.4
ENST00000515291.1
chromosome 5 open reading frame 46
chr19_-_40931891 0.09 ENST00000357949.4
SERTA domain containing 1
chr12_+_21525818 0.09 ENST00000240652.3
ENST00000542023.1
ENST00000537593.1
islet amyloid polypeptide
chr9_-_127905736 0.09 ENST00000336505.6
ENST00000373549.4
suppressor of cancer cell invasion
chr17_-_44657017 0.09 ENST00000573185.1
ENST00000570550.1
ENST00000445552.2
ENST00000336125.5
ENST00000329240.4
ENST00000337845.7
ADP-ribosylation factor-like 17A
chr4_-_103749105 0.09 ENST00000394801.4
ENST00000394804.2
ubiquitin-conjugating enzyme E2D 3
chr11_-_102714534 0.09 ENST00000299855.5
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr12_-_53045948 0.09 ENST00000309680.3
keratin 2
chr20_+_32782375 0.09 ENST00000568305.1
agouti signaling protein
chr4_-_103749313 0.09 ENST00000394803.5
ubiquitin-conjugating enzyme E2D 3
chr12_-_95611149 0.09 ENST00000549499.1
ENST00000343958.4
ENST00000546711.1
FYVE, RhoGEF and PH domain containing 6
chr6_+_29624758 0.09 ENST00000376917.3
ENST00000376902.3
ENST00000533330.2
ENST00000376888.2
myelin oligodendrocyte glycoprotein
chr1_+_152943122 0.09 ENST00000328051.2
small proline-rich protein 4
chr3_+_108541608 0.09 ENST00000426646.1
T cell receptor associated transmembrane adaptor 1
chr17_+_80416050 0.09 ENST00000579198.1
ENST00000390006.4
ENST00000580296.1
nuclear prelamin A recognition factor
chr11_+_67798090 0.09 ENST00000313468.5
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr18_-_65184217 0.09 ENST00000310045.7
dermatan sulfate epimerase-like
chr16_+_838614 0.09 ENST00000262315.9
ENST00000455171.2
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
chr4_+_71296204 0.09 ENST00000413702.1
mucin 7, secreted
chr22_-_42343117 0.09 ENST00000407253.3
ENST00000215980.5
centromere protein M
chr4_-_103748880 0.09 ENST00000453744.2
ENST00000349311.8
ubiquitin-conjugating enzyme E2D 3
chr6_-_31125850 0.09 ENST00000507751.1
ENST00000448162.2
ENST00000502557.1
ENST00000503420.1
ENST00000507892.1
ENST00000507226.1
ENST00000513222.1
ENST00000503934.1
ENST00000396263.2
ENST00000508683.1
ENST00000428174.1
ENST00000448141.2
ENST00000507829.1
ENST00000455279.2
ENST00000376266.5
coiled-coil alpha-helical rod protein 1
chr17_+_80416482 0.09 ENST00000309794.11
ENST00000345415.7
ENST00000457415.3
ENST00000584411.1
ENST00000412079.2
ENST00000577432.1
nuclear prelamin A recognition factor
chr2_+_65454926 0.09 ENST00000542850.1
ENST00000377982.4
ARP2 actin-related protein 2 homolog (yeast)

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 0.4 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.1 0.3 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.1 0.4 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.1 0.3 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.1 0.3 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.1 0.8 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1 0.2 GO:0035602 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604)
0.1 0.2 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877) negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.1 2.3 GO:0007141 male meiosis I(GO:0007141)
0.1 0.2 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.1 0.2 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 0.4 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.2 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.3 GO:0006041 glucosamine metabolic process(GO:0006041)
0.1 0.7 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.1 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.1 0.3 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.0 0.2 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.0 0.1 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.0 0.4 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 1.5 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.0 0.3 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.4 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.2 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.1 GO:1900195 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.0 0.5 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.1 GO:0009822 alkaloid catabolic process(GO:0009822)
0.0 0.7 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 0.6 GO:0002347 response to tumor cell(GO:0002347)
0.0 0.1 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.2 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.2 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.0 0.2 GO:0046836 glycolipid transport(GO:0046836)
0.0 0.1 GO:0036079 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.0 0.3 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.0 0.2 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.1 GO:1900222 regulation of cell growth by extracellular stimulus(GO:0001560) negative regulation of beta-amyloid clearance(GO:1900222)
0.0 0.3 GO:0003356 regulation of cilium beat frequency(GO:0003356)
0.0 0.2 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.0 1.7 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.2 GO:1904179 positive regulation of adipose tissue development(GO:1904179)
0.0 0.1 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.0 0.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.1 GO:0061055 myotome development(GO:0061055)
0.0 0.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.2 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.1 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0 0.1 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 0.2 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.2 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.0 GO:0043396 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
0.0 0.5 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.2 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.1 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.6 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.3 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.1 GO:0001555 oocyte growth(GO:0001555)
0.0 0.0 GO:0051795 positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427)
0.0 0.1 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.1 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.5 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.0 0.1 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:0097123 cyclin A1-CDK2 complex(GO:0097123)
0.1 0.4 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.1 0.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.2 GO:0033597 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.2 GO:0072589 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.3 GO:0035976 AP1 complex(GO:0035976)
0.0 0.4 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0097679 other organism cytoplasm(GO:0097679)
0.0 0.2 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.4 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.2 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 1.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.0 GO:0034657 GID complex(GO:0034657)
0.0 0.9 GO:0015030 Cajal body(GO:0015030)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.2 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0060091 kinocilium(GO:0060091)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.3 GO:0097381 photoreceptor disc membrane(GO:0097381)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0046979 TAP2 binding(GO:0046979)
0.1 0.4 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.1 0.3 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.1 0.2 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.1 0.7 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 1.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.2 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.3 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.0 0.3 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.6 GO:0043495 protein anchor(GO:0043495)
0.0 0.6 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 2.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.2 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.2 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.7 GO:0008200 ion channel inhibitor activity(GO:0008200)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.1 GO:0031781 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.2 GO:0005549 odorant binding(GO:0005549)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.3 GO:0008483 transaminase activity(GO:0008483)
0.0 0.1 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.3 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 1.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.2 PID FGF PATHWAY FGF signaling pathway
0.0 0.5 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 0.7 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.6 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.6 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.2 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.5 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.2 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 0.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)