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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for LHX8

Z-value: 0.51

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Transcription factors associated with LHX8

Gene Symbol Gene ID Gene Info
LHX8
ENSG00000162624.10 LIM homeobox 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX8hg19_v2_chr1_+_75594119_75594119,
hg19_v2_chr1_+_75600567_75600567		0.471.8e-02Click!

Activity profile of LHX8 motif

Sorted Z-values of LHX8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_17354617 2.08 ENST00000470360.1
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr9_-_123676827 1.91 ENST00000546084.1
TRAF1
TNF receptor-associated factor 1
chr8_+_17354587 1.77 ENST00000494857.1
ENST00000522656.1
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr7_-_22234381 1.68 ENST00000458533.1
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr7_-_92777606 1.65 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr2_+_201994042 1.11 ENST00000417748.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr11_-_72504681 0.86 ENST00000538536.1
ENST00000543304.1
ENST00000540587.1
ENST00000334805.6
STARD10
StAR-related lipid transfer (START) domain containing 10
chr12_-_39734783 0.85 ENST00000552961.1
KIF21A
kinesin family member 21A
chr2_+_201994208 0.81 ENST00000440180.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr3_+_119187785 0.77 ENST00000295588.4
ENST00000476573.1
POGLUT1
protein O-glucosyltransferase 1
chr12_+_9822331 0.75 ENST00000545918.1
ENST00000543300.1
ENST00000261339.6
ENST00000466035.2
CLEC2D
C-type lectin domain family 2, member D
chr1_-_247242048 0.66 ENST00000366503.2
ZNF670
zinc finger protein 670
chr3_+_147795932 0.56 ENST00000490465.1
RP11-639B1.1
RP11-639B1.1
chr3_-_112693865 0.55 ENST00000471858.1
ENST00000295863.4
ENST00000308611.3
CD200R1
CD200 receptor 1
chr17_-_76719807 0.54 ENST00000589297.1
CYTH1
cytohesin 1
chr1_+_165864821 0.52 ENST00000470820.1
UCK2
uridine-cytidine kinase 2
chr17_-_3301704 0.48 ENST00000322608.2
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr2_-_136678123 0.47 ENST00000422708.1
DARS
aspartyl-tRNA synthetase
chrX_+_108779870 0.46 ENST00000372107.1
NXT2
nuclear transport factor 2-like export factor 2
chr19_-_40228657 0.42 ENST00000221804.4
CLC
Charcot-Leyden crystal galectin
chr15_+_90611465 0.41 ENST00000559360.1
ZNF710
zinc finger protein 710
chr12_+_26205496 0.40 ENST00000537946.1
ENST00000541218.1
ENST00000282884.9
ENST00000545413.1
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr12_-_88974236 0.40 ENST00000228280.5
ENST00000552044.1
ENST00000357116.4
KITLG
KIT ligand
chr3_-_191000172 0.40 ENST00000427544.2
UTS2B
urotensin 2B
chr8_+_18248786 0.40 ENST00000520116.1
NAT2
N-acetyltransferase 2 (arylamine N-acetyltransferase)
chr1_+_145293371 0.39 ENST00000342960.5
NBPF10
neuroblastoma breakpoint family, member 10
chr13_+_38923959 0.38 ENST00000379649.1
ENST00000239878.4
ENST00000437952.1
ENST00000379641.1
UFM1
ubiquitin-fold modifier 1
chr19_-_4535233 0.37 ENST00000381848.3
ENST00000588887.1
ENST00000586133.1
PLIN5
perilipin 5
chr11_-_104817919 0.37 ENST00000533252.1
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr6_+_29364416 0.37 ENST00000383555.2
OR12D2
olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
chr14_-_101295407 0.37 ENST00000596284.1
AL117190.2
AL117190.2
chr12_+_97306295 0.37 ENST00000457368.2
NEDD1
neural precursor cell expressed, developmentally down-regulated 1
chr11_+_125757556 0.36 ENST00000526028.1
HYLS1
hydrolethalus syndrome 1
chr5_-_24645078 0.36 ENST00000264463.4
CDH10
cadherin 10, type 2 (T2-cadherin)
chr8_+_22424551 0.36 ENST00000523348.1
SORBS3
sorbin and SH3 domain containing 3
chr11_-_84634217 0.34 ENST00000524982.1
DLG2
discs, large homolog 2 (Drosophila)
chr5_-_150473127 0.34 ENST00000521001.1
TNIP1
TNFAIP3 interacting protein 1
chr10_+_90424196 0.34 ENST00000394375.3
ENST00000608620.1
ENST00000238983.4
ENST00000355843.2
LIPF
lipase, gastric
chr18_-_74839891 0.33 ENST00000581878.1
MBP
myelin basic protein
chr12_+_113354341 0.33 ENST00000553152.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr11_-_84634447 0.32 ENST00000532653.1
DLG2
discs, large homolog 2 (Drosophila)
chr1_+_144989309 0.31 ENST00000596396.1
AL590452.1
Uncharacterized protein
chr11_-_59612969 0.30 ENST00000541311.1
ENST00000257248.2
GIF
gastric intrinsic factor (vitamin B synthesis)
chr12_+_45686457 0.30 ENST00000441606.2
ANO6
anoctamin 6
chr22_-_50219548 0.29 ENST00000404034.1
BRD1
bromodomain containing 1
chr3_+_173116225 0.29 ENST00000457714.1
NLGN1
neuroligin 1
chr17_+_45000483 0.29 ENST00000576910.2
ENST00000439730.2
ENST00000393456.2
ENST00000415811.2
ENST00000575949.1
ENST00000225567.4
ENST00000572403.1
ENST00000570879.1
GOSR2
golgi SNAP receptor complex member 2
chr3_-_164913777 0.28 ENST00000475390.1
SLITRK3
SLIT and NTRK-like family, member 3
chr10_-_47151341 0.27 ENST00000422732.2
LINC00842
long intergenic non-protein coding RNA 842
chr3_-_57199397 0.27 ENST00000296318.7
IL17RD
interleukin 17 receptor D
chr15_-_43785274 0.26 ENST00000413546.1
TP53BP1
tumor protein p53 binding protein 1
chr19_-_48547294 0.26 ENST00000293255.2
CABP5
calcium binding protein 5
chr8_-_25902876 0.26 ENST00000520164.1
EBF2
early B-cell factor 2
chr5_-_147162263 0.25 ENST00000333010.6
ENST00000265272.5
JAKMIP2
janus kinase and microtubule interacting protein 2
chr2_-_158345462 0.25 ENST00000439355.1
ENST00000540637.1
CYTIP
cytohesin 1 interacting protein
chr1_-_168464875 0.25 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr10_-_29923893 0.24 ENST00000355867.4
SVIL
supervillin
chr5_+_157158205 0.24 ENST00000231198.7
THG1L
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr8_-_19102999 0.24 ENST00000517949.1
RP11-1080G15.1
RP11-1080G15.1
chr6_+_43543942 0.23 ENST00000372226.1
ENST00000443535.1
POLH
polymerase (DNA directed), eta
chr4_-_153332886 0.23 ENST00000603841.1
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr4_+_166300084 0.23 ENST00000402744.4
CPE
carboxypeptidase E
chr1_-_204135450 0.23 ENST00000272190.8
ENST00000367195.2
REN
renin
chr13_-_24895566 0.23 ENST00000422229.2
AL359736.1
protein PCOTH isoform 1
chr3_-_119182523 0.22 ENST00000319172.5
TMEM39A
transmembrane protein 39A
chr2_-_152830479 0.22 ENST00000360283.6
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr12_-_54982300 0.22 ENST00000547431.1
PPP1R1A
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr4_+_155484155 0.21 ENST00000509493.1
FGB
fibrinogen beta chain
chr17_+_58018269 0.21 ENST00000591035.1
RP11-178C3.1
Uncharacterized protein
chrX_+_103031421 0.21 ENST00000433491.1
ENST00000418604.1
ENST00000443502.1
PLP1
proteolipid protein 1
chr8_+_9009296 0.21 ENST00000521718.1
RP11-10A14.4
Uncharacterized protein
chr7_-_137028534 0.21 ENST00000348225.2
PTN
pleiotrophin
chr7_+_2394445 0.21 ENST00000360876.4
ENST00000413917.1
ENST00000397011.2
EIF3B
eukaryotic translation initiation factor 3, subunit B
chr7_-_137028498 0.21 ENST00000393083.2
PTN
pleiotrophin
chr1_+_160370344 0.21 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr19_+_44716678 0.20 ENST00000586228.1
ENST00000588219.1
ENST00000313040.7
ENST00000589707.1
ENST00000588394.1
ENST00000589005.1
ZNF227
zinc finger protein 227
chr8_+_7801144 0.20 ENST00000443676.1
ZNF705B
zinc finger protein 705B
chr8_-_27168737 0.20 ENST00000521253.1
ENST00000305364.4
TRIM35
tripartite motif containing 35
chr1_-_95391315 0.20 ENST00000545882.1
ENST00000415017.1
CNN3
calponin 3, acidic
chr9_+_96846740 0.20 ENST00000288976.3
PTPDC1
protein tyrosine phosphatase domain containing 1
chr1_+_119957554 0.20 ENST00000543831.1
ENST00000433745.1
ENST00000369416.3
HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr12_-_11548496 0.18 ENST00000389362.4
ENST00000565533.1
ENST00000546254.1
PRB2
PRB1
proline-rich protein BstNI subfamily 2
proline-rich protein BstNI subfamily 1
chr17_-_42144949 0.18 ENST00000591247.1
LSM12
LSM12 homolog (S. cerevisiae)
chr1_+_240177627 0.18 ENST00000447095.1
FMN2
formin 2
chr8_+_99076509 0.17 ENST00000318528.3
C8orf47
chromosome 8 open reading frame 47
chr16_-_11922665 0.17 ENST00000573319.1
ENST00000577041.1
ENST00000574028.1
ENST00000571259.1
ENST00000573037.1
ENST00000571158.1
BCAR4
breast cancer anti-estrogen resistance 4 (non-protein coding)
chr1_+_146373546 0.17 ENST00000446760.2
NBPF12
neuroblastoma breakpoint family, member 12
chr11_+_72975578 0.17 ENST00000393592.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr22_+_23054174 0.17 ENST00000390308.2
IGLV3-21
immunoglobulin lambda variable 3-21
chr2_+_185463093 0.17 ENST00000302277.6
ZNF804A
zinc finger protein 804A
chr4_-_48082192 0.17 ENST00000507351.1
TXK
TXK tyrosine kinase
chr11_+_72975524 0.16 ENST00000540342.1
ENST00000542092.1
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr9_-_21974820 0.16 ENST00000579122.1
ENST00000498124.1
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr7_-_20256965 0.16 ENST00000400331.5
ENST00000332878.4
MACC1
metastasis associated in colon cancer 1
chr16_-_20339123 0.16 ENST00000381360.5
GP2
glycoprotein 2 (zymogen granule membrane)
chr11_+_72975559 0.16 ENST00000349767.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr12_-_54982420 0.16 ENST00000257905.8
PPP1R1A
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr20_+_34824355 0.16 ENST00000397286.3
ENST00000320849.4
ENST00000373932.3
AAR2
AAR2 splicing factor homolog (S. cerevisiae)
chr3_+_39371191 0.16 ENST00000326306.4
CCR8
chemokine (C-C motif) receptor 8
chr3_-_112693759 0.16 ENST00000440122.2
ENST00000490004.1
CD200R1
CD200 receptor 1
chrX_+_108779004 0.15 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr7_-_140482926 0.15 ENST00000496384.2
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr6_-_128222103 0.15 ENST00000434358.1
ENST00000543064.1
ENST00000368248.2
THEMIS
thymocyte selection associated
chr4_+_74718906 0.14 ENST00000226524.3
PF4V1
platelet factor 4 variant 1
chr10_+_81892347 0.14 ENST00000372267.2
PLAC9
placenta-specific 9
chr19_+_21203426 0.14 ENST00000261560.5
ENST00000599548.1
ENST00000594110.1
ZNF430
zinc finger protein 430
chr4_-_83812248 0.14 ENST00000514326.1
ENST00000505434.1
ENST00000503058.1
ENST00000348405.4
ENST00000505984.1
ENST00000513858.1
ENST00000508479.1
ENST00000443462.2
ENST00000508502.1
ENST00000509142.1
ENST00000432794.1
ENST00000448323.1
ENST00000326950.5
ENST00000311785.7
SEC31A
SEC31 homolog A (S. cerevisiae)
chr7_-_14026063 0.14 ENST00000443608.1
ENST00000438956.1
ETV1
ets variant 1
chr15_-_35047166 0.14 ENST00000290374.4
GJD2
gap junction protein, delta 2, 36kDa
chr9_-_36276966 0.14 ENST00000543356.2
ENST00000396594.3
GNE
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr15_-_44116873 0.14 ENST00000267812.3
MFAP1
microfibrillar-associated protein 1
chr16_-_20338748 0.13 ENST00000575582.1
ENST00000341642.5
ENST00000381362.4
ENST00000572347.1
ENST00000572478.1
ENST00000302555.5
GP2
glycoprotein 2 (zymogen granule membrane)
chr1_-_217262969 0.13 ENST00000361525.3
ESRRG
estrogen-related receptor gamma
chr1_+_92632542 0.13 ENST00000409154.4
ENST00000370378.4
KIAA1107
KIAA1107
chr2_+_168043793 0.13 ENST00000409273.1
ENST00000409605.1
XIRP2
xin actin-binding repeat containing 2
chr4_-_83812402 0.13 ENST00000395310.2
SEC31A
SEC31 homolog A (S. cerevisiae)
chrX_+_13707235 0.13 ENST00000464506.1
RAB9A
RAB9A, member RAS oncogene family
chr7_-_28220354 0.13 ENST00000283928.5
JAZF1
JAZF zinc finger 1
chr4_-_95264008 0.13 ENST00000295256.5
HPGDS
hematopoietic prostaglandin D synthase
chr3_-_47934234 0.13 ENST00000420772.2
MAP4
microtubule-associated protein 4
chr16_-_2314222 0.13 ENST00000566397.1
RNPS1
RNA binding protein S1, serine-rich domain
chr7_-_14880892 0.12 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
DGKB
diacylglycerol kinase, beta 90kDa
chr15_+_36338242 0.12 ENST00000560056.1
RP11-684B21.1
RP11-684B21.1
chr11_-_3400442 0.12 ENST00000429541.2
ENST00000532539.1
ZNF195
zinc finger protein 195
chr19_+_42300548 0.12 ENST00000344550.4
CEACAM3
carcinoembryonic antigen-related cell adhesion molecule 3
chr5_+_140235469 0.12 ENST00000506939.2
ENST00000307360.5
PCDHA10
protocadherin alpha 10
chr11_-_118966167 0.12 ENST00000530167.1
H2AFX
H2A histone family, member X
chr21_-_34863998 0.12 ENST00000402202.1
ENST00000381947.3
DNAJC28
DnaJ (Hsp40) homolog, subfamily C, member 28
chr12_+_48866448 0.12 ENST00000266594.1
ANP32D
acidic (leucine-rich) nuclear phosphoprotein 32 family, member D
chr8_+_99076750 0.12 ENST00000545282.1
C8orf47
chromosome 8 open reading frame 47
chrX_+_56258844 0.12 ENST00000374928.3
KLF8
Kruppel-like factor 8
chr10_+_24738355 0.12 ENST00000307544.6
KIAA1217
KIAA1217
chr11_+_60048129 0.11 ENST00000355131.3
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4A
chr12_-_92536433 0.11 ENST00000551563.2
ENST00000546975.1
ENST00000549802.1
C12orf79
chromosome 12 open reading frame 79
chr10_+_94352956 0.11 ENST00000260731.3
KIF11
kinesin family member 11
chr14_-_57272366 0.11 ENST00000554788.1
ENST00000554845.1
ENST00000408990.3
OTX2
orthodenticle homeobox 2
chr1_-_33502528 0.11 ENST00000354858.6
AK2
adenylate kinase 2
chr9_+_108424738 0.11 ENST00000334077.3
TAL2
T-cell acute lymphocytic leukemia 2
chr1_-_217262933 0.11 ENST00000359162.2
ESRRG
estrogen-related receptor gamma
chr15_-_34610962 0.11 ENST00000290209.5
SLC12A6
solute carrier family 12 (potassium/chloride transporter), member 6
chr5_-_39270725 0.11 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB
FYN binding protein
chr1_+_145413268 0.10 ENST00000421822.2
ENST00000336751.5
ENST00000497365.1
ENST00000475797.1
HFE2
hemochromatosis type 2 (juvenile)
chr8_+_143915663 0.10 ENST00000522728.1
GML
glycosylphosphatidylinositol anchored molecule like
chr22_-_50970919 0.10 ENST00000329363.4
ENST00000437588.1
ODF3B
outer dense fiber of sperm tails 3B
chr3_+_186915274 0.10 ENST00000312295.4
RTP1
receptor (chemosensory) transporter protein 1
chr12_-_71551652 0.10 ENST00000546561.1
TSPAN8
tetraspanin 8
chr10_-_101825151 0.10 ENST00000441382.1
CPN1
carboxypeptidase N, polypeptide 1
chr12_+_26348246 0.10 ENST00000422622.2
SSPN
sarcospan
chr22_+_23487513 0.10 ENST00000263116.2
ENST00000341989.4
RAB36
RAB36, member RAS oncogene family
chr2_-_88285309 0.10 ENST00000420840.2
RGPD2
RANBP2-like and GRIP domain containing 2
chr12_-_21487829 0.10 ENST00000445053.1
ENST00000452078.1
ENST00000458504.1
ENST00000422327.1
ENST00000421294.1
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr3_+_35683651 0.10 ENST00000187397.4
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr15_-_43785303 0.09 ENST00000382039.3
ENST00000450115.2
ENST00000382044.4
TP53BP1
tumor protein p53 binding protein 1
chr21_-_28820892 0.09 ENST00000420186.2
AP001604.3
AP001604.3
chr4_+_71248795 0.09 ENST00000304915.3
SMR3B
submaxillary gland androgen regulated protein 3B
chr1_-_146040968 0.09 ENST00000401010.3
NBPF11
neuroblastoma breakpoint family, member 11
chr7_+_114055052 0.09 ENST00000462331.1
ENST00000408937.3
ENST00000403559.4
ENST00000350908.4
ENST00000393498.2
ENST00000393495.3
ENST00000378237.3
ENST00000393489.3
FOXP2
forkhead box P2
chr8_-_87242589 0.09 ENST00000419776.2
ENST00000297524.3
SLC7A13
solute carrier family 7 (anionic amino acid transporter), member 13
chr11_-_40315640 0.09 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr19_+_47852538 0.09 ENST00000328771.4
DHX34
DEAH (Asp-Glu-Ala-His) box polypeptide 34
chr15_+_33022885 0.08 ENST00000322805.4
GREM1
gremlin 1, DAN family BMP antagonist
chr12_-_11508520 0.08 ENST00000545626.1
ENST00000500254.2
PRB1
proline-rich protein BstNI subfamily 1
chr2_+_87144738 0.08 ENST00000559485.1
RGPD1
RANBP2-like and GRIP domain containing 1
chr4_+_155484103 0.08 ENST00000302068.4
FGB
fibrinogen beta chain
chr14_+_50291993 0.08 ENST00000595378.1
AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chr11_+_60048053 0.08 ENST00000337908.4
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4A
chr2_+_200775971 0.08 ENST00000319974.5
C2orf69
chromosome 2 open reading frame 69
chr13_+_24883703 0.07 ENST00000332018.4
C1QTNF9
C1q and tumor necrosis factor related protein 9
chr19_+_9361606 0.07 ENST00000456448.1
OR7E24
olfactory receptor, family 7, subfamily E, member 24
chr18_-_19994830 0.07 ENST00000525417.1
CTAGE1
cutaneous T-cell lymphoma-associated antigen 1
chr9_-_139372141 0.07 ENST00000313050.7
SEC16A
SEC16 homolog A (S. cerevisiae)
chr8_+_75262612 0.06 ENST00000220822.7
GDAP1
ganglioside induced differentiation associated protein 1
chr2_-_145275228 0.06 ENST00000427902.1
ENST00000409487.3
ENST00000470879.1
ENST00000435831.1
ZEB2
zinc finger E-box binding homeobox 2
chrX_-_23926004 0.06 ENST00000379226.4
ENST00000379220.3
APOO
apolipoprotein O
chr12_-_71551868 0.06 ENST00000247829.3
TSPAN8
tetraspanin 8
chr4_-_100242549 0.06 ENST00000305046.8
ENST00000394887.3
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide
chr2_+_108145913 0.06 ENST00000443205.1
AC096669.3
AC096669.3
chr11_+_60048004 0.06 ENST00000532114.1
MS4A4A
membrane-spanning 4-domains, subfamily A, member 4A
chr19_-_10697895 0.06 ENST00000591240.1
ENST00000589684.1
ENST00000591676.1
ENST00000250244.6
ENST00000590923.1
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr11_-_117800080 0.05 ENST00000524993.1
ENST00000528626.1
ENST00000445164.2
ENST00000430170.2
ENST00000526090.1
TMPRSS13
transmembrane protease, serine 13
chr4_+_68424434 0.05 ENST00000265404.2
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr22_+_29876197 0.05 ENST00000310624.6
NEFH
neurofilament, heavy polypeptide
chr4_+_88754113 0.05 ENST00000560249.1
ENST00000540395.1
ENST00000511670.1
ENST00000361056.3
MEPE
matrix extracellular phosphoglycoprotein
chr3_+_42977846 0.05 ENST00000383748.4
KRBOX1
KRAB box domain containing 1
chr22_-_29457832 0.05 ENST00000216071.4
C22orf31
chromosome 22 open reading frame 31
chr9_-_21368075 0.05 ENST00000449498.1
IFNA13
interferon, alpha 13
chr14_+_22433675 0.04 ENST00000390442.3
TRAV12-3
T cell receptor alpha variable 12-3
chr2_+_87135076 0.04 ENST00000409776.2
RGPD1
RANBP2-like and GRIP domain containing 1
chr2_+_158114051 0.04 ENST00000259056.4
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr10_+_135207623 0.04 ENST00000317502.6
ENST00000432508.3
MTG1
mitochondrial ribosome-associated GTPase 1
chr2_-_50201327 0.04 ENST00000412315.1
NRXN1
neurexin 1
chr9_-_21166659 0.04 ENST00000380225.1
IFNA21
interferon, alpha 21
chr12_-_10766184 0.04 ENST00000539554.1
ENST00000381881.2
ENST00000320756.2
MAGOHB
mago-nashi homolog B (Drosophila)
chr5_-_41213607 0.04 ENST00000337836.5
ENST00000433294.1
C6
complement component 6
chr20_+_30458431 0.04 ENST00000375938.4
ENST00000535842.1
ENST00000310998.4
ENST00000375921.2
TTLL9
tubulin tyrosine ligase-like family, member 9
chr4_-_68749745 0.04 ENST00000283916.6
TMPRSS11D
transmembrane protease, serine 11D
chr2_+_128377550 0.03 ENST00000437387.1
ENST00000409090.1
MYO7B
myosin VIIB
chr1_-_160492994 0.03 ENST00000368055.1
ENST00000368057.3
ENST00000368059.3
SLAMF6
SLAM family member 6
chr14_+_72399833 0.03 ENST00000553530.1
ENST00000556437.1
RGS6
regulator of G-protein signaling 6
chr11_+_101918153 0.03 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
C11orf70
chromosome 11 open reading frame 70

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0061461 lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410)
0.2 0.8 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.2 1.9 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.2 0.5 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.1 0.4 GO:1904397 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.1 1.6 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 0.4 GO:0070666 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.1 0.5 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.1 0.4 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.1 0.3 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.1 0.3 GO:0052250 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.1 0.4 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 0.3 GO:0097045 phosphatidylserine exposure on blood platelet(GO:0097045)
0.1 0.2 GO:0060490 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 0.3 GO:0030070 insulin processing(GO:0030070)
0.1 0.8 GO:0032782 bile acid secretion(GO:0032782)
0.1 0.2 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.1 0.3 GO:1904209 maintenance of blood-brain barrier(GO:0035633) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 0.4 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.1 GO:1903973 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.0 0.4 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.0 0.2 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.2 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.0 0.1 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.0 0.5 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.4 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.2 GO:0071494 cellular response to UV-C(GO:0071494)
0.0 0.3 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.3 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.1 GO:0090291 negative regulation of osteoclast proliferation(GO:0090291) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.2 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 0.4 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.1 GO:0006172 ADP biosynthetic process(GO:0006172)
0.0 0.2 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.1 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.0 0.3 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.5 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 1.9 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 0.1 GO:0044359 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.0 0.1 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.7 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.1 GO:0048936 neurofilament bundle assembly(GO:0033693) peripheral nervous system neuron axonogenesis(GO:0048936)
0.0 0.0 GO:0019242 methylglyoxal biosynthetic process(GO:0019242)
0.0 0.2 GO:2000111 senescence-associated heterochromatin focus assembly(GO:0035986) positive regulation of macrophage apoptotic process(GO:2000111)
0.0 0.1 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.4 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.2 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 0.3 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.2 GO:0006702 androgen biosynthetic process(GO:0006702)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 GO:0097342 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.1 0.8 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.4 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.3 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.5 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.2 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.7 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.3 GO:0032433 filopodium tip(GO:0032433)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.4 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)
0.0 0.5 GO:0035861 site of double-strand break(GO:0035861)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 GO:0005292 high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292)
0.3 0.8 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.1 0.4 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 1.7 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 1.9 GO:0031996 thioesterase binding(GO:0031996)
0.1 0.4 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 0.4 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.1 0.5 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.1 0.5 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.1 0.2 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.1 2.7 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.1 0.2 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 0.4 GO:0035473 lipase binding(GO:0035473)
0.1 0.4 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.5 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.5 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.0 0.3 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.2 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.3 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.3 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.0 0.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.3 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.0 GO:0004347 glucose-6-phosphate isomerase activity(GO:0004347)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.9 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME SIGNALING BY FGFR Genes involved in Signaling by FGFR
0.1 3.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.5 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.8 REACTOME PRE NOTCH EXPRESSION AND PROCESSING Genes involved in Pre-NOTCH Expression and Processing
0.0 0.4 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.5 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.2 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions