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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for MAFA

Z-value: 0.29

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Transcription factors associated with MAFA

Gene Symbol Gene ID Gene Info
ENSG00000182759.3 MAF bZIP transcription factor A

Activity profile of MAFA motif

Sorted Z-values of MAFA motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_74606223 0.57 ENST00000307407.3
ENST00000401931.1
interleukin 8
chr7_-_22234381 0.47 ENST00000458533.1
Rap guanine nucleotide exchange factor (GEF) 5
chrX_-_107975917 0.44 ENST00000563887.1
Uncharacterized protein
chr7_-_150754935 0.34 ENST00000297518.4
cyclin-dependent kinase 5
chr1_-_57045228 0.28 ENST00000371250.3
phosphatidic acid phosphatase type 2B
chr9_+_33629119 0.27 ENST00000331828.4
T cell receptor beta variable 21/OR9-2 (pseudogene)
chr22_+_23161491 0.27 ENST00000390316.2
immunoglobulin lambda variable 3-9 (gene/pseudogene)
chr16_+_56598961 0.21 ENST00000219162.3
metallothionein 4
chr16_-_46865286 0.20 ENST00000285697.4
chromosome 16 open reading frame 87
chr21_+_44589118 0.16 ENST00000291554.2
crystallin, alpha A
chr12_+_79258547 0.15 ENST00000457153.2
synaptotagmin I
chr12_+_79258444 0.15 ENST00000261205.4
synaptotagmin I
chr10_-_49701686 0.14 ENST00000417247.2
Rho GTPase activating protein 22
chr10_-_79397391 0.14 ENST00000286628.8
ENST00000406533.3
ENST00000354353.5
ENST00000404857.1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr16_-_46865047 0.13 ENST00000394806.2
chromosome 16 open reading frame 87
chr1_+_221054584 0.13 ENST00000549319.1
H2.0-like homeobox
chr15_-_90456156 0.12 ENST00000357484.5
chromosome 15 open reading frame 38
chr9_-_28670283 0.11 ENST00000379992.2
leucine rich repeat and Ig domain containing 2
chr12_+_53817633 0.11 ENST00000257863.4
ENST00000550311.1
ENST00000379791.3
anti-Mullerian hormone receptor, type II
chr22_+_22730353 0.10 ENST00000390296.2
immunoglobulin lambda variable 5-45
chr9_+_2622085 0.10 ENST00000382099.2
very low density lipoprotein receptor
chr11_-_57177586 0.09 ENST00000529411.1
Uncharacterized protein
chr11_-_2182388 0.09 ENST00000421783.1
ENST00000397262.1
ENST00000250971.3
ENST00000381330.4
ENST00000397270.1
insulin
INS-IGF2 readthrough
chr19_+_54641444 0.09 ENST00000221232.5
ENST00000358389.3
CCR4-NOT transcription complex, subunit 3
chr1_-_45956800 0.09 ENST00000538496.1
testis-specific kinase 2
chr8_-_63998590 0.08 ENST00000260116.4
tocopherol (alpha) transfer protein
chr6_+_7727030 0.07 ENST00000283147.6
bone morphogenetic protein 6
chr22_+_23222886 0.07 ENST00000390319.2
immunoglobulin lambda variable 3-1
chr12_+_54943134 0.07 ENST00000243052.3
phosphodiesterase 1B, calmodulin-dependent
chr8_-_89339705 0.07 ENST00000286614.6
matrix metallopeptidase 16 (membrane-inserted)
chr3_-_49823941 0.07 ENST00000321599.4
ENST00000395238.1
ENST00000468463.1
ENST00000460540.1
inositol hexakisphosphate kinase 1
chr7_-_135412925 0.07 ENST00000354042.4
solute carrier family 13 (sodium/sulfate symporter), member 4
chr6_+_116692102 0.07 ENST00000359564.2
dermatan sulfate epimerase
chr4_+_6784401 0.06 ENST00000425103.1
ENST00000307659.5
KIAA0232
chr13_+_28194873 0.06 ENST00000302979.3
polymerase (RNA) I polypeptide D, 16kDa
chr12_+_108525517 0.06 ENST00000332082.4
WSC domain containing 2
chr19_+_21541732 0.06 ENST00000311015.3
zinc finger protein 738
chr4_-_151936416 0.06 ENST00000510413.1
ENST00000507224.1
LPS-responsive vesicle trafficking, beach and anchor containing
chr4_-_151936865 0.06 ENST00000535741.1
LPS-responsive vesicle trafficking, beach and anchor containing
chr16_-_87525651 0.06 ENST00000268616.4
zinc finger, CCHC domain containing 14
chr9_+_2621798 0.06 ENST00000382100.3
very low density lipoprotein receptor
chr15_+_90744533 0.06 ENST00000411539.2
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr11_-_66103932 0.05 ENST00000311320.4
Ras and Rab interactor 1
chr17_-_39316983 0.05 ENST00000390661.3
keratin associated protein 4-4
chr6_+_89791507 0.05 ENST00000354922.3
proline-rich nuclear receptor coactivator 1
chr11_-_70507901 0.05 ENST00000449833.2
ENST00000357171.3
ENST00000449116.2
SH3 and multiple ankyrin repeat domains 2
chr8_+_145438870 0.05 ENST00000527931.1
family with sequence similarity 203, member B
chr7_-_73133959 0.05 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
syntaxin 1A (brain)
chr10_-_102289611 0.05 ENST00000299166.4
ENST00000370320.4
ENST00000531258.1
ENST00000370322.1
ENST00000535773.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
SEC31 homolog B (S. cerevisiae)
chr16_-_29415350 0.05 ENST00000524087.1
nuclear pore complex interacting protein family, member B11
chr19_-_4124079 0.05 ENST00000394867.4
ENST00000262948.5
mitogen-activated protein kinase kinase 2
chr19_+_21541777 0.05 ENST00000380870.4
ENST00000597810.1
ENST00000594245.1
zinc finger protein 738
chr16_+_22524844 0.05 ENST00000538606.1
ENST00000424340.1
ENST00000517539.1
ENST00000528249.1
nuclear pore complex interacting protein family, member B5
chr16_-_21436459 0.05 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
nuclear pore complex interacting protein family, member B3
chr15_+_80696666 0.05 ENST00000303329.4
aryl-hydrocarbon receptor nuclear translocator 2
chr22_+_22599075 0.05 ENST00000403807.3
pre-B lymphocyte 1
chr17_-_10325261 0.05 ENST00000403437.2
myosin, heavy chain 8, skeletal muscle, perinatal
chr3_+_140770183 0.05 ENST00000310546.2
splA/ryanodine receptor domain and SOCS box containing 4
chr5_-_114505624 0.05 ENST00000513154.1
tripartite motif containing 36
chr22_-_27014043 0.05 ENST00000215939.2
crystallin, beta B1
chr2_+_115199876 0.05 ENST00000436732.1
ENST00000410059.1
dipeptidyl-peptidase 10 (non-functional)
chr2_+_26915584 0.05 ENST00000302909.3
potassium channel, subfamily K, member 3
chr22_+_22599189 0.04 ENST00000302273.2
pre-B lymphocyte 1
chr1_-_54872059 0.04 ENST00000371320.3
single stranded DNA binding protein 3
chr16_-_21868739 0.04 ENST00000415645.2
nuclear pore complex interacting protein family, member B4
chr1_+_110754094 0.04 ENST00000369787.3
ENST00000413138.3
ENST00000438661.2
potassium voltage-gated channel, Shaw-related subfamily, member 4
chr10_-_79397479 0.04 ENST00000404771.3
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr8_-_114389353 0.04 ENST00000343508.3
CUB and Sushi multiple domains 3
chr20_-_43743790 0.04 ENST00000307971.4
ENST00000372789.4
WAP four-disulfide core domain 5
chr14_+_50779029 0.04 ENST00000245448.6
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
chr8_+_85095553 0.04 ENST00000521268.1
RALY RNA binding protein-like
chr14_-_36983034 0.04 ENST00000518529.2
surfactant associated 3
chr1_-_153517473 0.04 ENST00000368715.1
S100 calcium binding protein A4
chr3_+_42190714 0.04 ENST00000449246.1
trafficking protein, kinesin binding 1
chr5_+_176853702 0.04 ENST00000507633.1
ENST00000393576.3
ENST00000355958.5
ENST00000528793.1
ENST00000512684.1
G protein-coupled receptor kinase 6
chr20_-_30795511 0.04 ENST00000246229.4
pleiomorphic adenoma gene-like 2
chr15_+_98503922 0.03 ENST00000268042.6
arrestin domain containing 4
chrX_-_1511617 0.03 ENST00000381401.5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr1_+_206858328 0.03 ENST00000367103.3
mitogen-activated protein kinase-activated protein kinase 2
chr15_-_23086394 0.03 ENST00000337435.4
non imprinted in Prader-Willi/Angelman syndrome 1
chr12_-_22487618 0.03 ENST00000404299.3
ENST00000396037.4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr6_+_42896865 0.03 ENST00000372836.4
ENST00000394142.3
canopy FGF signaling regulator 3
chr11_+_107461948 0.03 ENST00000265840.7
ENST00000443271.2
ELMO/CED-12 domain containing 1
chrY_-_1461617 0.03 ENSTR0000381401.5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr6_-_24489842 0.03 ENST00000230036.1
glycosylphosphatidylinositol specific phospholipase D1
chr3_-_48754599 0.03 ENST00000413654.1
ENST00000454335.1
ENST00000440424.1
ENST00000449610.1
ENST00000443964.1
ENST00000417896.1
ENST00000413298.1
ENST00000449563.1
ENST00000443853.1
ENST00000437427.1
ENST00000446860.1
ENST00000412850.1
ENST00000424035.1
ENST00000340879.4
ENST00000431721.2
ENST00000434860.1
ENST00000328631.5
ENST00000432678.2
inositol hexakisphosphate kinase 2
chr11_-_104817919 0.03 ENST00000533252.1
caspase 4, apoptosis-related cysteine peptidase
chr2_+_103236004 0.03 ENST00000233969.2
solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
chr2_+_85811525 0.03 ENST00000306384.4
vesicle-associated membrane protein 5
chr17_-_41623009 0.03 ENST00000393664.2
ets variant 4
chr3_+_185304059 0.02 ENST00000427465.2
SUMO1/sentrin/SMT3 specific peptidase 2
chr16_-_67514982 0.02 ENST00000565835.1
ENST00000540149.1
ENST00000290949.3
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr3_+_107241882 0.02 ENST00000416476.2
bobby sox homolog (Drosophila)
chr2_+_102624977 0.02 ENST00000441002.1
interleukin 1 receptor, type II
chr16_-_29517141 0.02 ENST00000550665.1
Uncharacterized protein
chr1_-_32403370 0.02 ENST00000534796.1
protein tyrosine phosphatase type IVA, member 2
chr3_+_75955817 0.02 ENST00000487694.3
ENST00000602589.1
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr1_+_156124162 0.02 ENST00000368282.1
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr11_+_72929319 0.02 ENST00000393597.2
ENST00000311131.2
purinergic receptor P2Y, G-protein coupled, 2
chr11_+_33563821 0.02 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549-like
chr4_+_72053017 0.02 ENST00000351898.6
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr15_-_23086259 0.02 ENST00000538684.1
non imprinted in Prader-Willi/Angelman syndrome 1
chr9_+_97488939 0.02 ENST00000277198.2
ENST00000297979.5
chromosome 9 open reading frame 3
chr15_-_90456114 0.02 ENST00000398333.3
C15orf38-AP3S2 readthrough
chr6_-_139613269 0.02 ENST00000358430.3
taxilin beta
chr11_+_72929402 0.02 ENST00000393596.2
purinergic receptor P2Y, G-protein coupled, 2
chr19_+_33182823 0.01 ENST00000397061.3
nudix (nucleoside diphosphate linked moiety X)-type motif 19
chr17_+_41363854 0.01 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
transmembrane protein 106A
chr9_+_131549610 0.01 ENST00000223865.8
TBC1 domain family, member 13
chr5_+_138629337 0.01 ENST00000394805.3
ENST00000512876.1
ENST00000513678.1
matrin 3
chr15_-_66858298 0.01 ENST00000537670.1
lactase-like
chr6_+_22221010 0.01 ENST00000567753.1
RP11-524C21.2
chr6_+_147525541 0.01 ENST00000367481.3
ENST00000546097.1
syntaxin binding protein 5 (tomosyn)
chr11_-_777467 0.01 ENST00000397472.2
ENST00000524550.1
ENST00000319863.8
ENST00000526325.1
ENST00000442059.2
Parkinson disease 7 domain containing 1
chr11_-_66103867 0.01 ENST00000424433.2
Ras and Rab interactor 1
chr1_+_66458072 0.01 ENST00000423207.2
phosphodiesterase 4B, cAMP-specific
chr14_+_24605389 0.01 ENST00000382708.3
ENST00000561435.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr12_-_105478339 0.01 ENST00000424857.2
ENST00000258494.9
aldehyde dehydrogenase 1 family, member L2
chr12_+_56546363 0.01 ENST00000551834.1
ENST00000552568.1
myosin, light chain 6B, alkali, smooth muscle and non-muscle
chr10_-_81708854 0.01 ENST00000372292.3
surfactant protein D
chr17_-_39254391 0.01 ENST00000333822.4
keratin associated protein 4-8
chr15_-_41047421 0.01 ENST00000560460.1
ENST00000338376.3
ENST00000560905.1
regulator of microtubule dynamics 3
chrX_-_153141302 0.01 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
L1 cell adhesion molecule
chr22_+_48972118 0.01 ENST00000358295.5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr5_+_138629389 0.01 ENST00000504045.1
ENST00000504311.1
ENST00000502499.1
matrin 3
chr14_+_50779071 0.01 ENST00000426751.2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
chrX_-_65859096 0.01 ENST00000456230.2
ectodysplasin A2 receptor
chr17_-_76128488 0.01 ENST00000322914.3
transmembrane channel-like 6
chr17_-_47925379 0.01 ENST00000352793.2
ENST00000334568.4
ENST00000398154.1
ENST00000436235.1
ENST00000326219.5
tachykinin 4 (hemokinin)
chr5_-_179285785 0.01 ENST00000520698.1
ENST00000518235.1
ENST00000376931.2
ENST00000518219.1
ENST00000521333.1
ENST00000523084.1
chromosome 5 open reading frame 45
chr10_-_29811456 0.01 ENST00000535393.1
supervillin
chr3_+_131100515 0.01 ENST00000537561.1
ENST00000359850.3
ENST00000521288.1
ENST00000502852.1
nudix (nucleoside diphosphate linked moiety X)-type motif 16
chr7_-_30029367 0.00 ENST00000242059.5
secernin 1
chr7_+_100860949 0.00 ENST00000305105.2
zinc finger, HIT-type containing 1
chr7_-_30029574 0.00 ENST00000426154.1
ENST00000421434.1
ENST00000434476.2
secernin 1
chr5_+_138629628 0.00 ENST00000508689.1
ENST00000514528.1
matrin 3
chr5_-_179285848 0.00 ENST00000403396.2
ENST00000292586.6
chromosome 5 open reading frame 45
chrX_-_65858865 0.00 ENST00000374719.3
ENST00000450752.1
ENST00000451436.2
ectodysplasin A2 receptor
chr9_-_130712995 0.00 ENST00000373084.4
family with sequence similarity 102, member A
chr7_-_100860851 0.00 ENST00000223127.3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr1_-_38325256 0.00 ENST00000373036.4
metal-regulatory transcription factor 1
chr6_-_99797522 0.00 ENST00000389677.5
failed axon connections homolog (Drosophila)
chr20_-_31592113 0.00 ENST00000420875.1
ENST00000375519.2
ENST00000375523.3
ENST00000356173.3
Sad1 and UNC84 domain containing 5
chr6_-_74161977 0.00 ENST00000370318.1
ENST00000370315.3
Mab-21 domain containing 1
chr3_-_196439065 0.00 ENST00000399942.4
ENST00000409690.3
centrosomal protein 19kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of MAFA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.1 0.4 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.1 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.0 0.1 GO:1990262 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.0 0.2 GO:0034436 glycoprotein transport(GO:0034436)
0.0 0.1 GO:0052553 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
0.0 0.1 GO:0042360 vitamin E metabolic process(GO:0042360) regulation of establishment of blood-brain barrier(GO:0090210) negative regulation of establishment of blood-brain barrier(GO:0090212)
0.0 0.2 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.1 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.1 GO:0090031 positive regulation of steroid hormone biosynthetic process(GO:0090031)
0.0 0.1 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701) regulation of synaptic vesicle priming(GO:0010807)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.3 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.1 GO:0048787 presynaptic active zone membrane(GO:0048787) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.1 0.3 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.5 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.3 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.0 0.1 GO:0052839 inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.0 0.2 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.1 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.1 GO:0005471 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.0 0.1 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.6 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling