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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for MAFB
Z-value: 1.08
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Transcription factors associated with MAFB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAFB | hg19_v2_chr20_-_39317868_39317884 | -0.57 | 3.1e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_225907150 Show fit | 5.34 |
ENST00000258390.7
|
dedicator of cytokinesis 10 |
|
| chr5_-_95297534 Show fit | 2.61 |
ENST00000513343.1
ENST00000431061.2 |
elongation factor, RNA polymerase II, 2 |
|
| chr10_+_91087651 Show fit | 2.14 |
ENST00000371818.4
|
interferon-induced protein with tetratricopeptide repeats 3 |
|
| chr5_+_127419449 Show fit | 2.01 |
ENST00000262461.2
ENST00000343225.4 |
solute carrier family 12 (sodium/potassium/chloride transporter), member 2 |
|
| chr12_+_64238539 Show fit | 1.82 |
ENST00000357825.3
|
SLIT-ROBO Rho GTPase activating protein 1 |
|
| chr11_-_72353451 Show fit | 1.80 |
ENST00000376450.3
|
phosphodiesterase 2A, cGMP-stimulated |
|
| chr14_+_32546145 Show fit | 1.77 |
ENST00000556611.1
ENST00000539826.2 |
Rho GTPase activating protein 5 |
|
| chr15_-_40212363 Show fit | 1.71 |
ENST00000299092.3
|
G protein-coupled receptor 176 |
|
| chr14_+_32546485 Show fit | 1.71 |
ENST00000345122.3
ENST00000432921.1 ENST00000433497.1 |
Rho GTPase activating protein 5 |
|
| chr3_-_79816965 Show fit | 1.70 |
ENST00000464233.1
|
roundabout, axon guidance receptor, homolog 1 (Drosophila) |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.7 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.1 | 4.7 | GO:2000810 | regulation of bicellular tight junction assembly(GO:2000810) |
| 0.0 | 3.5 | GO:0042795 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.1 | 3.3 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.1 | 3.3 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.1 | 3.2 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 3.2 | GO:0042303 | molting cycle(GO:0042303) hair cycle(GO:0042633) |
| 0.2 | 3.1 | GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway(GO:0051386) |
| 1.0 | 2.9 | GO:0045062 | extrathymic T cell selection(GO:0045062) |
| 0.0 | 2.8 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.7 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 4.3 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.0 | 4.2 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 3.2 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 3.2 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 2.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.2 | 2.5 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 2.5 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 2.3 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 2.3 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.1 | 4.5 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 3.7 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.1 | 3.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 2.7 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.0 | 2.5 | GO:0019903 | protein phosphatase binding(GO:0019903) |
| 0.2 | 2.3 | GO:0015377 | cation:chloride symporter activity(GO:0015377) |
| 0.0 | 2.3 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.1 | 2.2 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.3 | 2.1 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 4.8 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 4.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 4.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 4.0 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 3.5 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 3.5 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 3.4 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 3.4 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 2.9 | PID ERBB4 PATHWAY | ErbB4 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.3 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 4.9 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 4.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 3.5 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 3.4 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 3.1 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 3.0 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 2.9 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.0 | 2.9 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.1 | 2.7 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |