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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for MAFF_MAFG
Z-value: 0.72
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Transcription factors associated with MAFF_MAFG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAFG | hg19_v2_chr17_-_79885576_79885624 | -0.47 | 1.9e-02 | Click! |
| MAFF | hg19_v2_chr22_+_38609538_38609547 | -0.05 | 8.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_132455118 Show fit | 2.46 |
ENST00000458028.1
|
long intergenic non-protein coding RNA 1013 |
|
| chr13_-_44453826 Show fit | 1.85 |
ENST00000444614.3
|
coiled-coil domain containing 122 |
|
| chr6_+_132455526 Show fit | 1.80 |
ENST00000443303.1
|
long intergenic non-protein coding RNA 1013 |
|
| chr16_+_31539197 Show fit | 1.64 |
ENST00000564707.1
|
alpha hemoglobin stabilizing protein |
|
| chr8_+_9046503 Show fit | 1.64 |
ENST00000512942.2
|
RP11-10A14.5 |
|
| chr10_-_7513904 Show fit | 1.63 |
ENST00000420395.1
|
RP5-1031D4.2 |
|
| chr2_-_86094764 Show fit | 1.54 |
ENST00000393808.3
|
ST3 beta-galactoside alpha-2,3-sialyltransferase 5 |
|
| chrX_-_63005405 Show fit | 1.50 |
ENST00000374878.1
ENST00000437457.2 |
Cdc42 guanine nucleotide exchange factor (GEF) 9 |
|
| chr16_+_4838412 Show fit | 1.49 |
ENST00000589327.1
|
small integral membrane protein 22 |
|
| chr21_+_17909594 Show fit | 1.38 |
ENST00000441820.1
ENST00000602280.1 |
long intergenic non-protein coding RNA 478 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFF_MAFG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | GO:0020027 | hemoglobin metabolic process(GO:0020027) |
| 0.1 | 1.5 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.1 | 1.4 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.0 | 1.3 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 1.2 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) sebaceous gland development(GO:0048733) |
| 0.1 | 1.1 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.0 | 1.1 | GO:0022900 | electron transport chain(GO:0022900) |
| 0.0 | 1.0 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.2 | 0.9 | GO:0071874 | cellular response to norepinephrine stimulus(GO:0071874) |
| 0.1 | 0.9 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.9 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 1.6 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 1.1 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 1.1 | GO:0032982 | myosin filament(GO:0032982) |
| 0.1 | 0.9 | GO:1990812 | growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812) |
| 0.0 | 0.9 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 0.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 0.6 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.1 | 0.5 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.1 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.3 | 1.9 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.0 | 1.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 1.5 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 0.1 | 1.3 | GO:0031432 | titin binding(GO:0031432) |
| 0.0 | 1.2 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.3 | 1.1 | GO:0022865 | transmembrane electron transfer carrier(GO:0022865) |
| 0.1 | 1.1 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.1 | 0.9 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.1 | 0.9 | GO:0051425 | PTB domain binding(GO:0051425) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.2 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.8 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 0.5 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.4 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.3 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 0.1 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.5 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 1.2 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 1.2 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.0 | 1.1 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 1.0 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 1.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.9 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 0.8 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |