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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for MAZ_ZNF281_GTF2F1
Z-value: 2.68
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Transcription factors associated with MAZ_ZNF281_GTF2F1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000103495.9 | MYC associated zinc finger protein | |
| ENSG00000162702.7 | zinc finger protein 281 | |
| ENSG00000125651.9 | general transcription factor IIF subunit 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GTF2F1 | hg19_v2_chr19_-_6393465_6393479 | -0.66 | 3.1e-04 | Click! |
| ZNF281 | hg19_v2_chr1_-_200379180_200379191 | -0.65 | 5.0e-04 | Click! |
| MAZ | hg19_v2_chr16_+_29819446_29819471 | 0.60 | 1.4e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_58469591 Show fit | 18.14 |
ENST00000589335.1
|
ubiquitin specific peptidase 32 |
|
| chr3_-_18466026 Show fit | 16.83 |
ENST00000417717.2
|
SATB homeobox 1 |
|
| chr13_-_72441315 Show fit | 16.64 |
ENST00000305425.4
ENST00000313174.7 ENST00000354591.4 |
dachshund homolog 1 (Drosophila) |
|
| chr4_-_16900410 Show fit | 16.62 |
ENST00000304523.5
|
LIM domain binding 2 |
|
| chr4_-_16900242 Show fit | 15.65 |
ENST00000502640.1
ENST00000506732.1 |
LIM domain binding 2 |
|
| chr4_-_16900184 Show fit | 15.44 |
ENST00000515064.1
|
LIM domain binding 2 |
|
| chr4_-_16900217 Show fit | 14.34 |
ENST00000441778.2
|
LIM domain binding 2 |
|
| chr2_+_48757278 Show fit | 12.64 |
ENST00000404752.1
ENST00000406226.1 |
stonin 1 |
|
| chr14_-_54423529 Show fit | 12.14 |
ENST00000245451.4
ENST00000559087.1 |
bone morphogenetic protein 4 |
|
| chr5_+_175298573 Show fit | 11.64 |
ENST00000512824.1
|
complexin 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAZ_ZNF281_GTF2F1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 66.4 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 1.3 | 32.0 | GO:0072189 | ureter development(GO:0072189) |
| 3.8 | 26.4 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 3.0 | 24.3 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 1.2 | 21.9 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 5.4 | 21.6 | GO:0003138 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 1.0 | 20.0 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.8 | 19.2 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 1.9 | 19.1 | GO:0097350 | neutrophil clearance(GO:0097350) |
| 3.4 | 17.0 | GO:2000470 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 134.7 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.9 | 30.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 27.9 | GO:0016607 | nuclear speck(GO:0016607) |
| 1.4 | 24.0 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.5 | 21.3 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.2 | 20.7 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 2.5 | 20.0 | GO:0070554 | synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.2 | 18.9 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.5 | 18.2 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 16.2 | GO:0005795 | Golgi stack(GO:0005795) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 78.2 | GO:0003682 | chromatin binding(GO:0003682) |
| 5.6 | 61.8 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.1 | 36.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 27.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 1.6 | 26.5 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.7 | 23.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.9 | 22.4 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 3.5 | 20.9 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.7 | 20.1 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 3.4 | 17.0 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 84.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.6 | 34.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.5 | 30.3 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.4 | 28.7 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.2 | 26.9 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.3 | 19.3 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.3 | 17.8 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 14.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.3 | 14.7 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 14.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 29.1 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.8 | 26.8 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.5 | 21.0 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.3 | 21.0 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.2 | 20.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 20.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.2 | 16.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.2 | 16.2 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 16.1 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.4 | 15.2 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |