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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for MECOM

Z-value: 0.70

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Transcription factors associated with MECOM

Gene Symbol Gene ID Gene Info
MECOM
ENSG00000085276.13 MDS1 and EVI1 complex locus

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MECOMhg19_v2_chr3_-_169381183_169381258,
hg19_v2_chr3_-_168864427_168864464		-0.232.7e-01Click!

Activity profile of MECOM motif

Sorted Z-values of MECOM motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_6420565 1.69 ENST00000338312.6
ANGPT2
angiopoietin 2
chr8_-_6420759 1.52 ENST00000523120.1
ANGPT2
angiopoietin 2
chr14_+_22458631 1.50 ENST00000390444.1
TRAV16
T cell receptor alpha variable 16
chr8_-_6420777 1.46 ENST00000415216.1
ANGPT2
angiopoietin 2
chr9_+_82187487 1.11 ENST00000435650.1
ENST00000414465.1
ENST00000376537.4
ENST00000376534.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr8_-_6420930 1.00 ENST00000325203.5
ANGPT2
angiopoietin 2
chr9_-_107690420 0.96 ENST00000423487.2
ENST00000374733.1
ENST00000374736.3
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr5_+_125695805 0.88 ENST00000513040.1
GRAMD3
GRAM domain containing 3
chr17_+_73750699 0.88 ENST00000584939.1
ITGB4
integrin, beta 4
chr6_+_29068386 0.84 ENST00000377171.3
OR2J1
olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene)
chr9_+_82186682 0.79 ENST00000376552.2
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr12_-_9913489 0.77 ENST00000228434.3
ENST00000536709.1
CD69
CD69 molecule
chr1_-_208084729 0.77 ENST00000310833.7
ENST00000356522.4
CD34
CD34 molecule
chr14_-_76447494 0.76 ENST00000238682.3
TGFB3
transforming growth factor, beta 3
chr6_-_154831779 0.73 ENST00000607772.1
CNKSR3
CNKSR family member 3
chr5_+_159895275 0.66 ENST00000517927.1
MIR146A
microRNA 146a
chr9_+_82186872 0.65 ENST00000376544.3
ENST00000376520.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr12_+_20848486 0.64 ENST00000545102.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chrX_+_15525426 0.62 ENST00000342014.6
BMX
BMX non-receptor tyrosine kinase
chr9_-_139293249 0.58 ENST00000298532.2
SNAPC4
small nuclear RNA activating complex, polypeptide 4, 190kDa
chr19_-_36391434 0.54 ENST00000396901.1
ENST00000585925.1
NFKBID
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
chr4_-_76944621 0.54 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr13_+_102142296 0.54 ENST00000376162.3
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr3_-_145968857 0.51 ENST00000433593.2
ENST00000476202.1
ENST00000460885.1
PLSCR4
phospholipid scramblase 4
chr11_-_33891362 0.50 ENST00000395833.3
LMO2
LIM domain only 2 (rhombotin-like 1)
chr12_+_20848377 0.47 ENST00000540354.1
ENST00000266509.2
ENST00000381552.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr13_+_111855414 0.47 ENST00000375737.5
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr18_-_12656715 0.46 ENST00000462226.1
ENST00000497844.2
ENST00000309836.5
ENST00000453447.2
SPIRE1
spire-type actin nucleation factor 1
chr14_+_64680854 0.46 ENST00000458046.2
SYNE2
spectrin repeat containing, nuclear envelope 2
chr12_-_57522813 0.45 ENST00000556155.1
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr12_-_15038779 0.44 ENST00000228938.5
ENST00000539261.1
MGP
matrix Gla protein
chr3_-_145968923 0.44 ENST00000493382.1
ENST00000354952.2
ENST00000383083.2
PLSCR4
phospholipid scramblase 4
chr12_+_20848282 0.43 ENST00000545604.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr15_-_37391507 0.43 ENST00000557796.2
ENST00000397620.2
MEIS2
Meis homeobox 2
chr4_+_155484155 0.42 ENST00000509493.1
FGB
fibrinogen beta chain
chr5_+_140739537 0.42 ENST00000522605.1
PCDHGB2
protocadherin gamma subfamily B, 2
chr15_-_55562479 0.41 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr16_-_71758602 0.40 ENST00000568954.1
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr15_-_55562582 0.40 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chr5_-_115910091 0.40 ENST00000257414.8
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr14_+_23012122 0.39 ENST00000390534.1
TRAJ3
T cell receptor alpha joining 3
chr8_-_80993010 0.39 ENST00000537855.1
ENST00000520527.1
ENST00000517427.1
ENST00000448733.2
ENST00000379097.3
TPD52
tumor protein D52
chr10_+_78078088 0.38 ENST00000496424.2
C10orf11
chromosome 10 open reading frame 11
chr12_-_39734783 0.37 ENST00000552961.1
KIF21A
kinesin family member 21A
chr11_-_73689037 0.35 ENST00000544615.1
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr7_+_35756092 0.35 ENST00000458087.3
AC018647.3
AC018647.3
chr7_+_35756186 0.35 ENST00000430518.1
AC018647.3
AC018647.3
chr11_+_60989688 0.35 ENST00000378149.3
ENST00000422676.2
PGA4
pepsinogen 4, group I (pepsinogen A)
chr19_-_47735918 0.34 ENST00000449228.1
ENST00000300880.7
ENST00000341983.4
BBC3
BCL2 binding component 3
chr15_-_37392086 0.34 ENST00000561208.1
MEIS2
Meis homeobox 2
chr11_+_12115543 0.31 ENST00000537344.1
ENST00000532179.1
ENST00000526065.1
MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr11_-_104769141 0.31 ENST00000508062.1
ENST00000422698.2
CASP12
caspase 12 (gene/pseudogene)
chr1_-_110155671 0.31 ENST00000351050.3
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr1_+_160160283 0.31 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr15_-_83837983 0.31 ENST00000562702.1
HDGFRP3
Hepatoma-derived growth factor-related protein 3
chr11_+_60145967 0.30 ENST00000534016.1
MS4A7
membrane-spanning 4-domains, subfamily A, member 7
chr3_+_119013185 0.30 ENST00000264245.4
ARHGAP31
Rho GTPase activating protein 31
chr1_+_160160346 0.29 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr22_-_31688381 0.29 ENST00000487265.2
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr2_+_242289502 0.28 ENST00000451310.1
SEPT2
septin 2
chr2_+_189839046 0.28 ENST00000304636.3
ENST00000317840.5
COL3A1
collagen, type III, alpha 1
chr6_-_31514516 0.28 ENST00000303892.5
ENST00000483251.1
ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr1_-_17766198 0.27 ENST00000375436.4
RCC2
regulator of chromosome condensation 2
chr6_+_69942298 0.26 ENST00000238918.8
BAI3
brain-specific angiogenesis inhibitor 3
chr1_+_47901689 0.25 ENST00000334793.5
FOXD2
forkhead box D2
chr8_-_27115931 0.25 ENST00000523048.1
STMN4
stathmin-like 4
chr10_+_106034637 0.24 ENST00000401888.2
GSTO2
glutathione S-transferase omega 2
chr15_+_71185148 0.24 ENST00000443425.2
ENST00000560755.1
LRRC49
leucine rich repeat containing 49
chr5_+_118965244 0.24 ENST00000515256.1
ENST00000509264.1
FAM170A
family with sequence similarity 170, member A
chr3_-_27498235 0.24 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr6_+_31515337 0.24 ENST00000376148.4
ENST00000376145.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr1_+_50569575 0.23 ENST00000371827.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr7_+_44240520 0.23 ENST00000496112.1
ENST00000223369.2
YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr1_-_146696901 0.23 ENST00000369272.3
ENST00000441068.2
FMO5
flavin containing monooxygenase 5
chr7_-_33140498 0.23 ENST00000448915.1
RP9
retinitis pigmentosa 9 (autosomal dominant)
chr22_-_30866564 0.23 ENST00000435069.1
ENST00000415957.2
ENST00000540910.1
SEC14L3
SEC14-like 3 (S. cerevisiae)
chr11_+_44748361 0.23 ENST00000533202.1
ENST00000533080.1
ENST00000520358.2
ENST00000520999.2
TSPAN18
tetraspanin 18
chr11_+_60145997 0.22 ENST00000530614.1
ENST00000530027.1
ENST00000530234.2
ENST00000528215.1
ENST00000531787.1
MS4A7
MS4A14
membrane-spanning 4-domains, subfamily A, member 7
membrane-spanning 4-domains, subfamily A, member 14
chr4_-_74847800 0.22 ENST00000296029.3
PF4
platelet factor 4
chr13_+_27844464 0.22 ENST00000241463.4
RASL11A
RAS-like, family 11, member A
chr11_-_18656028 0.21 ENST00000336349.5
SPTY2D1
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr17_-_37308824 0.21 ENST00000415163.1
ENST00000441877.1
ENST00000444911.2
PLXDC1
plexin domain containing 1
chr22_+_30279144 0.20 ENST00000401950.2
ENST00000333027.3
ENST00000445401.1
ENST00000323630.5
ENST00000351488.3
MTMR3
myotubularin related protein 3
chr16_+_71879861 0.20 ENST00000427980.2
ENST00000568581.1
ATXN1L
IST1
ataxin 1-like
increased sodium tolerance 1 homolog (yeast)
chr16_+_10837643 0.20 ENST00000574334.1
ENST00000283027.5
ENST00000433392.2
NUBP1
nucleotide binding protein 1
chr1_+_86934526 0.20 ENST00000394711.1
CLCA1
chloride channel accessory 1
chr6_-_52860171 0.20 ENST00000370963.4
GSTA4
glutathione S-transferase alpha 4
chr2_-_145275228 0.20 ENST00000427902.1
ENST00000409487.3
ENST00000470879.1
ENST00000435831.1
ZEB2
zinc finger E-box binding homeobox 2
chr8_+_62747349 0.19 ENST00000517953.1
ENST00000520097.1
ENST00000519766.1
RP11-705O24.1
RP11-705O24.1
chr5_-_147162078 0.19 ENST00000507386.1
JAKMIP2
janus kinase and microtubule interacting protein 2
chr6_+_27215471 0.19 ENST00000421826.2
PRSS16
protease, serine, 16 (thymus)
chrX_+_10031499 0.19 ENST00000454666.1
WWC3
WWC family member 3
chr6_+_27215494 0.19 ENST00000230582.3
PRSS16
protease, serine, 16 (thymus)
chr10_-_29923893 0.18 ENST00000355867.4
SVIL
supervillin
chr10_-_69455873 0.18 ENST00000433211.2
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr1_-_179834311 0.18 ENST00000553856.1
IFRG15
Homo sapiens torsin A interacting protein 2 (TOR1AIP2), transcript variant 1, mRNA.
chr17_-_66951474 0.18 ENST00000269080.2
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr11_+_61008514 0.18 ENST00000312403.5
PGA5
pepsinogen 5, group I (pepsinogen A)
chr3_+_121774202 0.18 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86
CD86 molecule
chrX_-_101694853 0.17 ENST00000372749.1
NXF2B
nuclear RNA export factor 2B
chr6_+_31514622 0.17 ENST00000376146.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr6_+_29141311 0.17 ENST00000377167.2
OR2J2
olfactory receptor, family 2, subfamily J, member 2
chrX_+_101502170 0.17 ENST00000372757.1
NXF2
nuclear RNA export factor 2
chr3_-_149093499 0.17 ENST00000472441.1
TM4SF1
transmembrane 4 L six family member 1
chr4_-_76598544 0.17 ENST00000515457.1
ENST00000357854.3
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr22_-_31688431 0.17 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr16_+_14280742 0.16 ENST00000341243.5
MKL2
MKL/myocardin-like 2
chr3_-_194393206 0.16 ENST00000265245.5
LSG1
large 60S subunit nuclear export GTPase 1
chr16_+_2867228 0.16 ENST00000005995.3
ENST00000574813.1
PRSS21
protease, serine, 21 (testisin)
chr15_+_52155001 0.15 ENST00000544199.1
TMOD3
tropomodulin 3 (ubiquitous)
chr6_-_52859968 0.15 ENST00000370959.1
GSTA4
glutathione S-transferase alpha 4
chr2_-_157189180 0.15 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr5_+_56471592 0.14 ENST00000511209.1
GPBP1
GC-rich promoter binding protein 1
chr10_+_29577974 0.14 ENST00000375500.3
LYZL1
lysozyme-like 1
chrX_+_30261847 0.14 ENST00000378981.3
ENST00000397550.1
MAGEB1
melanoma antigen family B, 1
chr4_+_155484103 0.14 ENST00000302068.4
FGB
fibrinogen beta chain
chr3_-_193272588 0.14 ENST00000295548.3
ATP13A4
ATPase type 13A4
chr5_-_64920115 0.14 ENST00000381018.3
ENST00000274327.7
TRIM23
tripartite motif containing 23
chr19_-_46366392 0.14 ENST00000598059.1
ENST00000594293.1
ENST00000245934.7
SYMPK
symplekin
chr12_-_12715266 0.14 ENST00000228862.2
DUSP16
dual specificity phosphatase 16
chr19_-_20844343 0.13 ENST00000595405.1
ZNF626
zinc finger protein 626
chr12_+_15699286 0.13 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO
protein tyrosine phosphatase, receptor type, O
chr12_+_12202774 0.13 ENST00000589718.1
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr2_+_44066101 0.13 ENST00000272286.2
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr5_-_138862326 0.13 ENST00000330794.4
TMEM173
transmembrane protein 173
chr20_+_15177480 0.13 ENST00000402914.1
MACROD2
MACRO domain containing 2
chr19_-_41388657 0.13 ENST00000301146.4
ENST00000291764.3
CYP2A7
cytochrome P450, family 2, subfamily A, polypeptide 7
chr12_+_12202785 0.13 ENST00000586576.1
ENST00000464885.2
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr12_+_21207503 0.13 ENST00000545916.1
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr1_+_82266053 0.13 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2
latrophilin 2
chr3_+_152552685 0.13 ENST00000305097.3
P2RY1
purinergic receptor P2Y, G-protein coupled, 1
chr9_+_109213096 0.12 ENST00000425709.1
RP11-308N19.1
RP11-308N19.1
chr7_+_6797288 0.12 ENST00000433859.2
ENST00000359718.3
RSPH10B2
radial spoke head 10 homolog B2 (Chlamydomonas)
chrX_+_135730373 0.12 ENST00000370628.2
CD40LG
CD40 ligand
chr12_+_57522258 0.12 ENST00000553277.1
ENST00000243077.3
LRP1
low density lipoprotein receptor-related protein 1
chr22_-_29137771 0.12 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
CHEK2
checkpoint kinase 2
chrX_+_135730297 0.12 ENST00000370629.2
CD40LG
CD40 ligand
chr8_-_17942432 0.11 ENST00000381733.4
ENST00000314146.10
ASAH1
N-acylsphingosine amidohydrolase (acid ceramidase) 1
chr8_+_134203273 0.11 ENST00000250160.6
WISP1
WNT1 inducible signaling pathway protein 1
chr5_+_140787600 0.11 ENST00000520790.1
PCDHGB6
protocadherin gamma subfamily B, 6
chr9_+_134378289 0.11 ENST00000423007.1
ENST00000404875.2
ENST00000441334.1
ENST00000341012.7
ENST00000372228.3
ENST00000402686.3
ENST00000419118.2
ENST00000541219.1
ENST00000354713.4
ENST00000418774.1
ENST00000415075.1
ENST00000448212.1
ENST00000430619.1
POMT1
protein-O-mannosyltransferase 1
chr17_-_37309480 0.11 ENST00000539608.1
PLXDC1
plexin domain containing 1
chr8_-_39695764 0.11 ENST00000265708.4
ADAM2
ADAM metallopeptidase domain 2
chr12_+_21168630 0.11 ENST00000421593.2
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr11_+_65266507 0.11 ENST00000544868.1
MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr17_-_40346477 0.11 ENST00000593209.1
ENST00000587427.1
ENST00000588352.1
ENST00000414034.3
ENST00000590249.1
GHDC
GH3 domain containing
chr12_+_57522439 0.11 ENST00000338962.4
LRP1
low density lipoprotein receptor-related protein 1
chr3_-_193272741 0.11 ENST00000392443.3
ATP13A4
ATPase type 13A4
chr4_-_88450244 0.11 ENST00000503414.1
SPARCL1
SPARC-like 1 (hevin)
chr4_+_96012614 0.11 ENST00000264568.4
BMPR1B
bone morphogenetic protein receptor, type IB
chr18_+_18943554 0.10 ENST00000580732.2
GREB1L
growth regulation by estrogen in breast cancer-like
chr12_+_53836339 0.10 ENST00000549135.1
PRR13
proline rich 13
chr19_+_36630454 0.10 ENST00000246533.3
CAPNS1
calpain, small subunit 1
chr10_-_18940501 0.10 ENST00000377304.4
NSUN6
NOP2/Sun domain family, member 6
chr2_-_56150910 0.10 ENST00000424836.2
ENST00000438672.1
ENST00000440439.1
ENST00000429909.1
ENST00000424207.1
ENST00000452337.1
ENST00000355426.3
ENST00000439193.1
ENST00000421664.1
EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr16_-_90096309 0.10 ENST00000408886.2
C16orf3
chromosome 16 open reading frame 3
chr8_+_110374683 0.10 ENST00000378402.5
PKHD1L1
polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
chr4_-_76598296 0.10 ENST00000395719.3
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr14_+_24584508 0.10 ENST00000559354.1
ENST00000560459.1
ENST00000559593.1
ENST00000396941.4
ENST00000396936.1
DCAF11
DDB1 and CUL4 associated factor 11
chr7_-_6006768 0.09 ENST00000441023.2
RSPH10B
radial spoke head 10 homolog B (Chlamydomonas)
chr4_+_71200681 0.09 ENST00000273936.5
CABS1
calcium-binding protein, spermatid-specific 1
chr18_-_24722995 0.09 ENST00000581714.1
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr3_-_109035342 0.09 ENST00000478945.1
DPPA2
developmental pluripotency associated 2
chr11_+_47587129 0.09 ENST00000326656.8
ENST00000326674.9
PTPMT1
protein tyrosine phosphatase, mitochondrial 1
chr2_+_97779233 0.09 ENST00000461153.2
ENST00000420699.2
ANKRD36
ankyrin repeat domain 36
chr11_+_47586982 0.09 ENST00000426530.2
ENST00000534775.1
PTPMT1
protein tyrosine phosphatase, mitochondrial 1
chr7_+_44040488 0.09 ENST00000258704.3
SPDYE1
speedy/RINGO cell cycle regulator family member E1
chr2_+_36923830 0.09 ENST00000379242.3
ENST00000389975.3
VIT
vitrin
chr5_+_102201722 0.09 ENST00000274392.9
ENST00000455264.2
PAM
peptidylglycine alpha-amidating monooxygenase
chr19_-_53324884 0.09 ENST00000457749.2
ENST00000414252.2
ENST00000391783.2
ZNF28
zinc finger protein 28
chr15_-_40401062 0.09 ENST00000354670.4
ENST00000559701.1
ENST00000557870.1
ENST00000558774.1
BMF
Bcl2 modifying factor
chr20_+_32782375 0.09 ENST00000568305.1
ASIP
agouti signaling protein
chr3_+_101659682 0.09 ENST00000465215.1
RP11-221J22.1
RP11-221J22.1
chr1_-_98386543 0.09 ENST00000423006.2
ENST00000370192.3
ENST00000306031.5
DPYD
dihydropyrimidine dehydrogenase
chr9_-_13175823 0.09 ENST00000545857.1
MPDZ
multiple PDZ domain protein
chr3_+_57875711 0.09 ENST00000442599.2
SLMAP
sarcolemma associated protein
chr14_-_82089405 0.09 ENST00000554211.1
RP11-799P8.1
RP11-799P8.1
chr8_-_39695719 0.09 ENST00000347580.4
ENST00000379853.2
ENST00000521880.1
ADAM2
ADAM metallopeptidase domain 2
chr3_+_4344988 0.09 ENST00000358065.4
SETMAR
SET domain and mariner transposase fusion gene
chr12_+_72080253 0.08 ENST00000549735.1
TMEM19
transmembrane protein 19
chr4_+_74275057 0.08 ENST00000511370.1
ALB
albumin
chr8_-_114449112 0.08 ENST00000455883.2
ENST00000352409.3
ENST00000297405.5
CSMD3
CUB and Sushi multiple domains 3
chr6_-_130543958 0.08 ENST00000437477.2
ENST00000439090.2
SAMD3
sterile alpha motif domain containing 3
chr1_+_192127578 0.08 ENST00000367460.3
RGS18
regulator of G-protein signaling 18
chr5_+_96211643 0.08 ENST00000437043.3
ENST00000510373.1
ERAP2
endoplasmic reticulum aminopeptidase 2
chr19_-_14316980 0.08 ENST00000361434.3
ENST00000340736.6
LPHN1
latrophilin 1
chr19_+_22235279 0.08 ENST00000594363.1
ENST00000597927.1
ENST00000594947.1
ZNF257
zinc finger protein 257
chr12_-_81763127 0.08 ENST00000541017.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr7_-_8302207 0.07 ENST00000407906.1
ICA1
islet cell autoantigen 1, 69kDa
chr7_-_76039000 0.07 ENST00000275560.3
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr19_-_51611623 0.07 ENST00000421832.2
CTU1
cytosolic thiouridylase subunit 1
chr3_-_139195350 0.07 ENST00000232217.2
RBP2
retinol binding protein 2, cellular
chr6_-_22297730 0.07 ENST00000306482.1
PRL
prolactin
chrX_-_85302531 0.07 ENST00000537751.1
ENST00000358786.4
ENST00000357749.2
CHM
choroideremia (Rab escort protein 1)
chr1_+_15802594 0.07 ENST00000375910.3
CELA2B
chymotrypsin-like elastase family, member 2B
chr17_-_10276319 0.07 ENST00000252172.4
ENST00000418404.3
MYH13
myosin, heavy chain 13, skeletal muscle
chr20_+_36012051 0.07 ENST00000373567.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chrX_+_129473916 0.07 ENST00000545805.1
ENST00000543953.1
ENST00000218197.5
SLC25A14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr11_+_60145948 0.07 ENST00000300184.3
ENST00000358246.1
MS4A7
membrane-spanning 4-domains, subfamily A, member 7
chr18_-_67624160 0.07 ENST00000581982.1
ENST00000280200.4
CD226
CD226 molecule

Network of associatons between targets according to the STRING database.

First level regulatory network of MECOM

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.7 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.2 1.0 GO:0015917 aminophospholipid transport(GO:0015917) regulation of high-density lipoprotein particle assembly(GO:0090107)
0.2 0.6 GO:0003032 detection of oxygen(GO:0003032) uterine wall breakdown(GO:0042704)
0.2 0.8 GO:0044467 glial cell-derived neurotrophic factor secretion(GO:0044467) granulocyte colony-stimulating factor production(GO:0071611) regulation of granulocyte colony-stimulating factor production(GO:0071655) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.1 0.6 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.1 0.8 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.4 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.1 1.5 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 0.3 GO:0019417 sulfur oxidation(GO:0019417)
0.1 0.5 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.1 0.5 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.5 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.1 0.8 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 0.2 GO:1904562 phosphatidylinositol 5-phosphate metabolic process(GO:1904562)
0.1 0.5 GO:0070649 polar body extrusion after meiotic divisions(GO:0040038) formin-nucleated actin cable assembly(GO:0070649)
0.1 0.6 GO:0001865 NK T cell differentiation(GO:0001865)
0.1 0.9 GO:0035878 nail development(GO:0035878)
0.1 0.2 GO:0045404 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1 0.2 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.1 0.6 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.6 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 0.2 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.0 0.1 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.0 0.9 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.2 GO:0018032 protein amidation(GO:0018032)
0.0 0.1 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.1 GO:0010949 negative regulation of intestinal phytosterol absorption(GO:0010949) negative regulation of intestinal cholesterol absorption(GO:0045796) intestinal phytosterol absorption(GO:0060752) negative regulation of intestinal lipid absorption(GO:1904730)
0.0 2.4 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.1 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0 0.5 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.3 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.4 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 0.1 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.0 0.1 GO:0019836 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.0 0.3 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.2 GO:0090487 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.2 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.0 0.4 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.7 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.1 GO:0060406 positive regulation of penile erection(GO:0060406)
0.0 0.1 GO:1904100 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.0 0.1 GO:0019860 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) beta-alanine metabolic process(GO:0019482) thymine metabolic process(GO:0019859) uracil metabolic process(GO:0019860) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.0 0.5 GO:0001502 cartilage condensation(GO:0001502)
0.0 0.1 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.0 0.1 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.5 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0 0.7 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.0 0.3 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.0 0.2 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.1 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.0 0.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.3 GO:0097264 self proteolysis(GO:0097264)
0.0 0.1 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.2 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.1 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.2 GO:0042908 xenobiotic transport(GO:0042908)
0.0 0.1 GO:0034227 tRNA thio-modification(GO:0034227)
0.0 0.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.0 GO:0042727 flavin-containing compound biosynthetic process(GO:0042727)
0.0 0.2 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.4 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 1.0 GO:0008542 visual learning(GO:0008542)
0.0 0.2 GO:0010826 negative regulation of centrosome duplication(GO:0010826) protein localization to cell cortex(GO:0072697)
0.0 0.1 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.0 0.3 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.0 0.0 GO:0043105 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.0 0.0 GO:0036269 swimming behavior(GO:0036269)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0014802 terminal cisterna(GO:0014802)
0.1 0.2 GO:0020005 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) other organism cytoplasm(GO:0097679)
0.1 0.2 GO:0097441 basilar dendrite(GO:0097441)
0.1 0.8 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.5 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 0.5 GO:0000322 storage vacuole(GO:0000322)
0.0 0.6 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.7 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.9 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.7 GO:0046930 pore complex(GO:0046930)
0.0 0.2 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.5 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.2 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0097165 nuclear stress granule(GO:0097165)
0.0 0.3 GO:0097227 sperm annulus(GO:0097227)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0090543 Flemming body(GO:0090543)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.3 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0034188 apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.2 1.5 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 0.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 0.8 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.2 0.5 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 0.2 GO:0030226 apolipoprotein receptor activity(GO:0030226)
0.1 0.2 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 0.2 GO:0090541 MIT domain binding(GO:0090541)
0.1 0.9 GO:0038132 neuregulin binding(GO:0038132)
0.1 5.7 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 0.8 GO:0043199 sulfate binding(GO:0043199)
0.1 0.9 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.4 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 0.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.2 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.2 GO:0016672 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.8 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.1 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.2 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.2 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.1 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.2 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.0 0.1 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0 0.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.2 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.1 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.0 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.0 0.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.5 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0031782 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.0 GO:0034584 piRNA binding(GO:0034584)
0.0 0.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.0 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.0 1.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.3 GO:0071949 FAD binding(GO:0071949)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.9 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.8 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 1.0 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.6 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.9 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.4 ST GAQ PATHWAY G alpha q Pathway
0.0 0.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 1.6 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 1.0 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 2.4 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.8 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.6 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.1 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins