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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for MECP2
Z-value: 1.47
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Transcription factors associated with MECP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MECP2 | hg19_v2_chrX_-_153363125_153363182 | -0.22 | 2.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_66638685 Show fit | 2.65 |
ENST00000565003.1
|
CKLF-like MARVEL transmembrane domain containing 3 |
|
| chr6_-_44233361 Show fit | 2.28 |
ENST00000275015.5
|
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon |
|
| chr11_-_45687128 Show fit | 2.12 |
ENST00000308064.2
|
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 |
|
| chr9_-_38069208 Show fit | 2.08 |
ENST00000377707.3
ENST00000377700.4 |
Src homology 2 domain containing adaptor protein B |
|
| chr19_+_10381769 Show fit | 2.04 |
ENST00000423829.2
ENST00000588645.1 |
intercellular adhesion molecule 1 |
|
| chr4_+_156588806 Show fit | 2.02 |
ENST00000513574.1
|
guanylate cyclase 1, soluble, alpha 3 |
|
| chr9_-_123691047 Show fit | 1.95 |
ENST00000373887.3
|
TNF receptor-associated factor 1 |
|
| chr10_+_28966271 Show fit | 1.89 |
ENST00000375533.3
|
BMP and activin membrane-bound inhibitor |
|
| chr20_-_62462566 Show fit | 1.88 |
ENST00000245663.4
ENST00000302995.2 |
zinc finger and BTB domain containing 46 |
|
| chr1_-_935361 Show fit | 1.86 |
ENST00000484667.2
|
hes family bHLH transcription factor 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MECP2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.9 | GO:0018146 | keratan sulfate biosynthetic process(GO:0018146) |
| 0.7 | 4.2 | GO:0052551 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.3 | 3.7 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.0 | 3.6 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 0.2 | 3.5 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.8 | 3.2 | GO:1902462 | regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462) |
| 0.6 | 3.2 | GO:0033489 | cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490) |
| 0.1 | 3.2 | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803) |
| 0.8 | 3.1 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 0.5 | 3.0 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.0 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.2 | 5.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 4.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 3.8 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 3.7 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 3.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 3.5 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.4 | 3.3 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.1 | 3.3 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 3.2 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.9 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.2 | 5.4 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.3 | 4.1 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 3.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 3.7 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 3.4 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.1 | 3.3 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.2 | 3.1 | GO:0048185 | activin binding(GO:0048185) |
| 0.6 | 3.0 | GO:0004306 | ethanolamine-phosphate cytidylyltransferase activity(GO:0004306) |
| 0.0 | 3.0 | GO:0005178 | integrin binding(GO:0005178) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.6 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 5.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 5.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 3.5 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 3.3 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 3.2 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 3.2 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 2.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.3 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.2 | 6.7 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 5.2 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.1 | 4.9 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.1 | 4.5 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 3.9 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.1 | 3.2 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 3.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 2.9 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 2.8 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |