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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for MEF2C

Z-value: 0.89

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Transcription factors associated with MEF2C

Gene Symbol Gene ID Gene Info
MEF2C
ENSG00000081189.9 myocyte enhancer factor 2C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MEF2Chg19_v2_chr5_-_88179302_881793190.592.0e-03Click!

Activity profile of MEF2C motif

Sorted Z-values of MEF2C motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_8543393 9.74 ENST00000157600.3
ENST00000415597.1
ENST00000535732.1
LMCD1
LIM and cysteine-rich domains 1
chr3_+_8543561 8.17 ENST00000397386.3
LMCD1
LIM and cysteine-rich domains 1
chr4_-_186697044 7.83 ENST00000437304.2
SORBS2
sorbin and SH3 domain containing 2
chr5_-_111091948 6.94 ENST00000447165.2
NREP
neuronal regeneration related protein
chr3_+_8543533 6.71 ENST00000454244.1
LMCD1
LIM and cysteine-rich domains 1
chr4_+_41362796 5.55 ENST00000508501.1
ENST00000512946.1
ENST00000313860.7
ENST00000512632.1
ENST00000512820.1
LIMCH1
LIM and calponin homology domains 1
chr3_+_193853927 4.55 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr15_-_70994612 3.96 ENST00000558758.1
ENST00000379983.2
ENST00000560441.1
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr4_-_186696425 3.85 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2
sorbin and SH3 domain containing 2
chr4_+_41614909 3.64 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
LIMCH1
LIM and calponin homology domains 1
chr6_-_76203345 3.53 ENST00000393004.2
FILIP1
filamin A interacting protein 1
chr4_+_41614720 3.34 ENST00000509277.1
LIMCH1
LIM and calponin homology domains 1
chr7_+_30951461 3.33 ENST00000311813.4
AQP1
aquaporin 1 (Colton blood group)
chr9_+_127054217 3.00 ENST00000394199.2
ENST00000546191.1
NEK6
NIMA-related kinase 6
chr6_-_76203454 2.82 ENST00000237172.7
FILIP1
filamin A interacting protein 1
chr1_+_221051699 2.77 ENST00000366903.6
HLX
H2.0-like homeobox
chr2_-_157198860 2.71 ENST00000409572.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr12_+_52445191 2.57 ENST00000243050.1
ENST00000394825.1
ENST00000550763.1
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr15_-_69113218 2.42 ENST00000560303.1
ENST00000465139.2
ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr15_-_52970820 2.36 ENST00000261844.7
ENST00000399202.4
ENST00000562135.1
FAM214A
family with sequence similarity 214, member A
chr11_+_7597639 2.18 ENST00000533792.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr8_-_17533838 2.02 ENST00000400046.1
MTUS1
microtubule associated tumor suppressor 1
chr1_+_90098606 1.78 ENST00000370454.4
LRRC8C
leucine rich repeat containing 8 family, member C
chr21_+_17909594 1.60 ENST00000441820.1
ENST00000602280.1
LINC00478
long intergenic non-protein coding RNA 478
chr2_+_173686303 1.60 ENST00000397087.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr2_+_179184955 1.57 ENST00000315022.2
OSBPL6
oxysterol binding protein-like 6
chr6_+_136172820 1.55 ENST00000308191.6
PDE7B
phosphodiesterase 7B
chr2_+_148778570 1.53 ENST00000407073.1
MBD5
methyl-CpG binding domain protein 5
chr10_-_7513904 1.51 ENST00000420395.1
RP5-1031D4.2
RP5-1031D4.2
chr13_-_67802549 1.49 ENST00000328454.5
ENST00000377865.2
PCDH9
protocadherin 9
chr17_+_7758374 1.35 ENST00000301599.6
ENST00000574668.1
TMEM88
transmembrane protein 88
chrX_+_135278908 1.27 ENST00000539015.1
ENST00000370683.1
FHL1
four and a half LIM domains 1
chr12_-_46766577 1.23 ENST00000256689.5
SLC38A2
solute carrier family 38, member 2
chr3_+_135741576 1.19 ENST00000334546.2
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr4_-_39640513 1.12 ENST00000511809.1
ENST00000505729.1
SMIM14
small integral membrane protein 14
chr1_-_59249732 1.10 ENST00000371222.2
JUN
jun proto-oncogene
chrX_+_135279179 1.01 ENST00000370676.3
FHL1
four and a half LIM domains 1
chr12_-_118406028 0.98 ENST00000425217.1
KSR2
kinase suppressor of ras 2
chr1_+_145524891 0.97 ENST00000369304.3
ITGA10
integrin, alpha 10
chr4_-_25865159 0.97 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr7_+_75931861 0.91 ENST00000248553.6
HSPB1
heat shock 27kDa protein 1
chr9_-_33402506 0.87 ENST00000377425.4
ENST00000537089.1
ENST00000297988.1
ENST00000539936.1
ENST00000541274.1
AQP7
aquaporin 7
chr22_-_51016846 0.87 ENST00000312108.7
ENST00000395650.2
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr4_-_138453606 0.85 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
PCDH18
protocadherin 18
chr2_+_179149636 0.84 ENST00000409631.1
OSBPL6
oxysterol binding protein-like 6
chr9_+_5231413 0.82 ENST00000239316.4
INSL4
insulin-like 4 (placenta)
chr22_-_51017084 0.80 ENST00000360719.2
ENST00000457250.1
ENST00000440709.1
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr2_+_33661382 0.78 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr16_+_12058961 0.76 ENST00000053243.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr16_+_12059050 0.75 ENST00000396495.3
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr2_+_109204743 0.75 ENST00000332345.6
LIMS1
LIM and senescent cell antigen-like domains 1
chr2_+_109204909 0.71 ENST00000393310.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr16_-_31439735 0.66 ENST00000287490.4
COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chr21_-_35016231 0.66 ENST00000438788.1
CRYZL1
crystallin, zeta (quinone reductase)-like 1
chr7_+_80231466 0.64 ENST00000309881.7
ENST00000534394.1
CD36
CD36 molecule (thrombospondin receptor)
chr11_+_1942580 0.63 ENST00000381558.1
TNNT3
troponin T type 3 (skeletal, fast)
chr13_+_76378357 0.63 ENST00000489941.2
ENST00000525373.1
LMO7
LIM domain 7
chr8_+_1993152 0.63 ENST00000262113.4
MYOM2
myomesin 2
chr5_-_137475071 0.62 ENST00000265191.2
NME5
NME/NM23 family member 5
chr8_+_145162629 0.61 ENST00000323662.8
KIAA1875
KIAA1875
chr4_+_129730779 0.61 ENST00000226319.6
PHF17
jade family PHD finger 1
chr14_-_94421923 0.60 ENST00000555507.1
ASB2
ankyrin repeat and SOCS box containing 2
chrX_-_50386648 0.59 ENST00000460112.3
SHROOM4
shroom family member 4
chr1_+_228395755 0.58 ENST00000284548.11
ENST00000570156.2
ENST00000422127.1
ENST00000366707.4
ENST00000366709.4
OBSCN
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
chr1_+_201979645 0.58 ENST00000367284.5
ENST00000367283.3
ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr8_-_94029882 0.58 ENST00000520686.1
TRIQK
triple QxxK/R motif containing
chr10_+_63661053 0.57 ENST00000279873.7
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr11_-_18034701 0.57 ENST00000265965.5
SERGEF
secretion regulating guanine nucleotide exchange factor
chr1_+_26485511 0.56 ENST00000374268.3
FAM110D
family with sequence similarity 110, member D
chr3_-_39234074 0.56 ENST00000340369.3
ENST00000421646.1
ENST00000396251.1
XIRP1
xin actin-binding repeat containing 1
chr11_+_57308979 0.53 ENST00000457912.1
SMTNL1
smoothelin-like 1
chr8_+_1993173 0.52 ENST00000523438.1
MYOM2
myomesin 2
chr11_+_1940786 0.52 ENST00000278317.6
ENST00000381561.4
ENST00000381548.3
ENST00000360603.3
ENST00000381549.3
TNNT3
troponin T type 3 (skeletal, fast)
chr3_+_159570722 0.49 ENST00000482804.1
SCHIP1
schwannomin interacting protein 1
chr11_+_65266507 0.49 ENST00000544868.1
MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr1_+_230193521 0.49 ENST00000543760.1
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr10_-_3827371 0.49 ENST00000469435.1
KLF6
Kruppel-like factor 6
chr7_+_120629653 0.47 ENST00000450913.2
ENST00000340646.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr10_-_62704005 0.47 ENST00000337910.5
RHOBTB1
Rho-related BTB domain containing 1
chr17_-_34625719 0.47 ENST00000422211.2
ENST00000542124.1
CCL3L1
chemokine (C-C motif) ligand 3-like 1
chr11_+_1940925 0.47 ENST00000453458.1
ENST00000381557.2
ENST00000381589.3
ENST00000381579.3
ENST00000381563.4
ENST00000344578.4
TNNT3
troponin T type 3 (skeletal, fast)
chr8_+_107282368 0.46 ENST00000521369.2
RP11-395G23.3
RP11-395G23.3
chr17_-_34524157 0.45 ENST00000378354.4
ENST00000394484.1
CCL3L3
chemokine (C-C motif) ligand 3-like 3
chr10_-_104179682 0.45 ENST00000406432.1
PSD
pleckstrin and Sec7 domain containing
chr22_-_31328881 0.45 ENST00000445980.1
MORC2
MORC family CW-type zinc finger 2
chr3_+_179370517 0.45 ENST00000263966.3
USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr3_+_141106458 0.42 ENST00000509883.1
ZBTB38
zinc finger and BTB domain containing 38
chr13_+_111766897 0.41 ENST00000317133.5
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr3_-_156878540 0.40 ENST00000461804.1
CCNL1
cyclin L1
chr7_+_18535893 0.39 ENST00000432645.2
ENST00000441542.2
HDAC9
histone deacetylase 9
chr9_-_21995249 0.39 ENST00000494262.1
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr3_-_30936153 0.38 ENST00000454381.3
ENST00000282538.5
GADL1
glutamate decarboxylase-like 1
chr4_+_86699834 0.38 ENST00000395183.2
ARHGAP24
Rho GTPase activating protein 24
chr3_+_113616317 0.36 ENST00000440446.2
ENST00000488680.1
GRAMD1C
GRAM domain containing 1C
chr13_+_76334498 0.36 ENST00000534657.1
LMO7
LIM domain 7
chr5_+_138609782 0.35 ENST00000361059.2
ENST00000514694.1
ENST00000504203.1
ENST00000502929.1
ENST00000394800.2
ENST00000509644.1
ENST00000505016.1
MATR3
matrin 3
chr3_-_112360116 0.35 ENST00000206423.3
ENST00000439685.2
CCDC80
coiled-coil domain containing 80
chr1_-_713985 0.34 ENST00000428504.1
RP11-206L10.2
RP11-206L10.2
chr5_-_66492562 0.34 ENST00000256447.4
CD180
CD180 molecule
chr7_+_80267973 0.34 ENST00000394788.3
ENST00000447544.2
CD36
CD36 molecule (thrombospondin receptor)
chr4_-_143767428 0.33 ENST00000513000.1
ENST00000509777.1
ENST00000503927.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr13_+_76378305 0.33 ENST00000526371.1
ENST00000526528.1
LMO7
LIM domain 7
chr3_-_38071122 0.33 ENST00000334661.4
PLCD1
phospholipase C, delta 1
chr3_+_52448539 0.33 ENST00000461861.1
PHF7
PHD finger protein 7
chr8_+_104831554 0.33 ENST00000408894.2
RIMS2
regulating synaptic membrane exocytosis 2
chr14_+_56046990 0.32 ENST00000438792.2
ENST00000395314.3
ENST00000395308.1
KTN1
kinectin 1 (kinesin receptor)
chr2_-_151344172 0.32 ENST00000375734.2
ENST00000263895.4
ENST00000454202.1
RND3
Rho family GTPase 3
chr4_-_143227088 0.32 ENST00000511838.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr3_+_46924829 0.31 ENST00000313049.5
PTH1R
parathyroid hormone 1 receptor
chr18_-_77276057 0.31 ENST00000597412.1
AC018445.1
Uncharacterized protein
chr8_+_107282389 0.31 ENST00000577661.1
ENST00000445937.1
RP11-395G23.3
OXR1
RP11-395G23.3
oxidation resistance 1
chr8_+_76452097 0.31 ENST00000396423.2
HNF4G
hepatocyte nuclear factor 4, gamma
chr8_-_62602327 0.31 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr19_-_51220176 0.31 ENST00000359082.3
ENST00000293441.1
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr7_+_39125365 0.30 ENST00000559001.1
ENST00000464276.2
POU6F2
POU class 6 homeobox 2
chr10_+_14880157 0.30 ENST00000378372.3
HSPA14
heat shock 70kDa protein 14
chr12_-_102874102 0.30 ENST00000392905.2
IGF1
insulin-like growth factor 1 (somatomedin C)
chr14_+_56046914 0.29 ENST00000413890.2
ENST00000395309.3
ENST00000554567.1
ENST00000555498.1
KTN1
kinectin 1 (kinesin receptor)
chr15_+_80364901 0.29 ENST00000560228.1
ENST00000559835.1
ENST00000559775.1
ENST00000558688.1
ENST00000560392.1
ENST00000560976.1
ENST00000558272.1
ENST00000558390.1
ZFAND6
zinc finger, AN1-type domain 6
chr3_+_127634069 0.28 ENST00000405109.1
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr18_+_3252265 0.28 ENST00000580887.1
ENST00000536605.1
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr2_+_30569506 0.27 ENST00000421976.2
AC109642.1
AC109642.1
chr15_+_40531621 0.27 ENST00000560346.1
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr3_+_54157480 0.27 ENST00000490478.1
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chrX_-_109683446 0.26 ENST00000372057.1
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr8_-_42234745 0.26 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr15_+_78558523 0.26 ENST00000446172.2
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr17_-_10276319 0.26 ENST00000252172.4
ENST00000418404.3
MYH13
myosin, heavy chain 13, skeletal muscle
chr18_-_19283649 0.26 ENST00000584464.1
ENST00000578270.1
ABHD3
abhydrolase domain containing 3
chr7_+_5919458 0.24 ENST00000416608.1
OCM
oncomodulin
chr15_+_42651691 0.24 ENST00000357568.3
ENST00000349748.3
ENST00000318023.7
ENST00000397163.3
CAPN3
calpain 3, (p94)
chr8_-_66701319 0.24 ENST00000379419.4
PDE7A
phosphodiesterase 7A
chrX_+_37545012 0.23 ENST00000378616.3
XK
X-linked Kx blood group (McLeod syndrome)
chr6_+_44194762 0.23 ENST00000371708.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr6_+_152128371 0.23 ENST00000443427.1
ESR1
estrogen receptor 1
chr11_+_1860682 0.22 ENST00000381906.1
TNNI2
troponin I type 2 (skeletal, fast)
chr13_-_30881134 0.21 ENST00000380617.3
ENST00000441394.1
KATNAL1
katanin p60 subunit A-like 1
chr7_-_105332084 0.21 ENST00000472195.1
ATXN7L1
ataxin 7-like 1
chr2_+_65663812 0.21 ENST00000606978.1
ENST00000377977.3
ENST00000536804.1
AC074391.1
AC074391.1
chr20_-_896960 0.21 ENST00000381922.3
ENST00000546022.1
ANGPT4
angiopoietin 4
chr13_+_76334567 0.20 ENST00000321797.8
LMO7
LIM domain 7
chr4_+_169418255 0.20 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr2_+_103378472 0.20 ENST00000412401.2
TMEM182
transmembrane protein 182
chr11_+_1860832 0.20 ENST00000252898.7
TNNI2
troponin I type 2 (skeletal, fast)
chr7_-_150884873 0.20 ENST00000377867.3
ASB10
ankyrin repeat and SOCS box containing 10
chr5_-_11589131 0.20 ENST00000511377.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr6_+_152128686 0.19 ENST00000206249.3
ESR1
estrogen receptor 1
chr1_-_226187013 0.19 ENST00000272091.7
SDE2
SDE2 telomere maintenance homolog (S. pombe)
chr13_+_76334795 0.19 ENST00000526202.1
ENST00000465261.2
LMO7
LIM domain 7
chr19_-_49926698 0.18 ENST00000270631.1
PTH2
parathyroid hormone 2
chr17_-_79900255 0.18 ENST00000330655.3
ENST00000582198.1
MYADML2
PYCR1
myeloid-associated differentiation marker-like 2
pyrroline-5-carboxylate reductase 1
chr19_-_1021113 0.17 ENST00000333175.5
ENST00000356663.3
TMEM259
transmembrane protein 259
chr10_-_104178857 0.17 ENST00000020673.5
PSD
pleckstrin and Sec7 domain containing
chr9_-_74980113 0.17 ENST00000376962.5
ENST00000376960.4
ENST00000237937.3
ZFAND5
zinc finger, AN1-type domain 5
chr14_+_39736582 0.17 ENST00000556148.1
ENST00000348007.3
CTAGE5
CTAGE family, member 5
chr15_+_40531243 0.16 ENST00000558055.1
ENST00000455577.2
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr7_-_150946015 0.16 ENST00000262188.8
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr17_-_79881408 0.16 ENST00000392366.3
MAFG
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
chr1_-_156460391 0.16 ENST00000360595.3
MEF2D
myocyte enhancer factor 2D
chr10_+_88428370 0.16 ENST00000372066.3
ENST00000263066.6
ENST00000372056.4
ENST00000310944.6
ENST00000361373.4
ENST00000542786.1
LDB3
LIM domain binding 3
chr1_+_201617264 0.16 ENST00000367296.4
NAV1
neuron navigator 1
chrX_-_30327495 0.16 ENST00000453287.1
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr3_+_141106643 0.15 ENST00000514251.1
ZBTB38
zinc finger and BTB domain containing 38
chr14_+_76776957 0.15 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chr16_+_6069072 0.15 ENST00000547605.1
ENST00000550418.1
ENST00000553186.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr1_+_24018269 0.15 ENST00000374550.3
RPL11
ribosomal protein L11
chr7_-_22862406 0.15 ENST00000372879.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr5_+_53751445 0.15 ENST00000302005.1
HSPB3
heat shock 27kDa protein 3
chr8_-_95565673 0.14 ENST00000437199.1
ENST00000297591.5
ENST00000421249.2
KIAA1429
KIAA1429
chr1_+_203097407 0.14 ENST00000367235.1
ADORA1
adenosine A1 receptor
chr4_-_140098339 0.14 ENST00000394235.2
ELF2
E74-like factor 2 (ets domain transcription factor)
chr3_-_46904918 0.13 ENST00000395869.1
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr15_+_78830023 0.13 ENST00000599596.1
AC027228.1
HCG2005369; Uncharacterized protein
chr9_+_70971815 0.13 ENST00000396392.1
ENST00000396396.1
PGM5
phosphoglucomutase 5
chr10_+_88428206 0.13 ENST00000429277.2
ENST00000458213.2
ENST00000352360.5
LDB3
LIM domain binding 3
chr3_-_149510553 0.13 ENST00000462519.2
ENST00000446160.1
ENST00000383050.3
ANKUB1
ankyrin repeat and ubiquitin domain containing 1
chr7_-_22862448 0.12 ENST00000358435.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr3_-_46904946 0.12 ENST00000292327.4
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr10_+_118083919 0.12 ENST00000333254.3
CCDC172
coiled-coil domain containing 172
chr1_-_917497 0.12 ENST00000433179.2
C1orf170
chromosome 1 open reading frame 170
chr17_+_37821593 0.12 ENST00000578283.1
TCAP
titin-cap
chr1_-_201391149 0.12 ENST00000555948.1
ENST00000556362.1
TNNI1
troponin I type 1 (skeletal, slow)
chr22_+_41487711 0.12 ENST00000263253.7
EP300
E1A binding protein p300
chr21_+_35552978 0.11 ENST00000428914.2
ENST00000609062.1
ENST00000609947.1
LINC00310
long intergenic non-protein coding RNA 310
chr2_-_211168332 0.10 ENST00000341685.4
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr1_-_917466 0.10 ENST00000341290.2
C1orf170
chromosome 1 open reading frame 170
chr22_-_37215523 0.09 ENST00000216200.5
PVALB
parvalbumin
chr2_-_231825668 0.09 ENST00000392039.2
GPR55
G protein-coupled receptor 55
chr8_-_49834299 0.09 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr14_-_23652849 0.09 ENST00000316902.7
ENST00000469263.1
ENST00000525062.1
ENST00000524758.1
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr11_+_12766583 0.09 ENST00000361985.2
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr21_+_39628852 0.08 ENST00000398938.2
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr12_+_52203789 0.08 ENST00000599343.1
AC068987.1
HCG1997999; cDNA FLJ33996 fis, clone DFNES2008881
chr8_-_49833978 0.08 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr8_+_95565947 0.08 ENST00000523011.1
RP11-267M23.4
RP11-267M23.4
chr7_-_124569991 0.08 ENST00000446993.1
ENST00000357628.3
ENST00000393329.1
POT1
protection of telomeres 1
chr17_-_10372875 0.08 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr17_-_45899126 0.08 ENST00000007414.3
ENST00000392507.3
OSBPL7
oxysterol binding protein-like 7
chr16_+_31225337 0.08 ENST00000322122.3
TRIM72
tripartite motif containing 72
chr3_-_101039402 0.07 ENST00000193391.7
IMPG2
interphotoreceptor matrix proteoglycan 2

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2C

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0045608 trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of timing of neuron differentiation(GO:0060164) negative regulation of pro-B cell differentiation(GO:2000974)
1.1 3.3 GO:0072229 carbon dioxide transmembrane transport(GO:0035378) proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229)
1.0 24.9 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.9 2.7 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.4 11.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.4 2.6 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.3 2.8 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.3 1.1 GO:0035026 leading edge cell differentiation(GO:0035026)
0.3 1.5 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.2 0.9 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.1 0.4 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.1 0.6 GO:0036309 protein localization to M-band(GO:0036309)
0.1 1.0 GO:0055096 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1 1.2 GO:0032328 alanine transport(GO:0032328)
0.1 0.9 GO:0015793 glycerol transport(GO:0015793)
0.1 0.5 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.1 0.3 GO:0050894 determination of affect(GO:0050894)
0.1 0.3 GO:0048867 ganglion mother cell fate determination(GO:0007402) stem cell fate determination(GO:0048867)
0.1 0.6 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 0.2 GO:0031133 regulation of axon diameter(GO:0031133)
0.1 0.3 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.3 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.1 3.2 GO:2000772 regulation of cellular senescence(GO:2000772)
0.1 1.5 GO:0006853 carnitine shuttle(GO:0006853)
0.1 0.3 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.1 0.2 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563) negative regulation of response to alcohol(GO:1901420)
0.1 5.4 GO:1901222 regulation of NIK/NF-kappaB signaling(GO:1901222)
0.1 0.2 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.6 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 2.5 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.1 GO:0032900 regulation of nucleoside transport(GO:0032242) negative regulation of neurotrophin production(GO:0032900)
0.0 0.2 GO:0015862 uridine transport(GO:0015862)
0.0 2.4 GO:0043486 histone exchange(GO:0043486)
0.0 0.6 GO:0060056 mammary gland involution(GO:0060056)
0.0 0.2 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.0 2.3 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.4 GO:0060523 prostate epithelial cord elongation(GO:0060523) mammary gland branching involved in pregnancy(GO:0060745) epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0 1.8 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.2 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.0 0.3 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.0 0.4 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.2 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.0 0.4 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 1.6 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.2 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.0 0.3 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.1 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.0 0.2 GO:0051013 microtubule severing(GO:0051013)
0.0 0.1 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.0 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0 0.1 GO:0060722 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.0 0.1 GO:0080009 mRNA methylation(GO:0080009)
0.0 0.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.1 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0 0.3 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 1.5 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.0 0.3 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.0 0.6 GO:0016577 histone demethylation(GO:0016577)
0.0 0.3 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 0.5 GO:0045907 positive regulation of vasoconstriction(GO:0045907)
0.0 0.7 GO:1901661 quinone metabolic process(GO:1901661)
0.0 0.3 GO:0072662 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.0 0.2 GO:0030238 male sex determination(GO:0030238)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0020005 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
0.3 1.0 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.1 1.1 GO:0035976 AP1 complex(GO:0035976)
0.1 1.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.5 GO:0010369 chromocenter(GO:0010369)
0.1 0.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 1.1 GO:0005861 troponin complex(GO:0005861)
0.0 11.2 GO:0030018 Z disc(GO:0030018)
0.0 0.8 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 1.3 GO:0016460 myosin II complex(GO:0016460)
0.0 0.3 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.4 GO:0000322 storage vacuole(GO:0000322)
0.0 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.4 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.1 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 1.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 20.3 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.1 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 3.0 GO:0000922 spindle pole(GO:0000922)
0.0 0.2 GO:0043194 axon initial segment(GO:0043194)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 6.2 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.4 1.6 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.4 11.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.3 1.7 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.2 0.9 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.2 0.9 GO:0015254 glycerol channel activity(GO:0015254)
0.2 1.0 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.2 1.0 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 3.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 0.4 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 0.3 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1 0.3 GO:0031877 somatostatin receptor binding(GO:0031877)
0.1 1.8 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 0.4 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.1 2.4 GO:0046965 retinoid X receptor binding(GO:0046965)
0.1 0.7 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.1 0.6 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 0.3 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.1 23.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 0.3 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.1 2.5 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.1 GO:0070538 oleic acid binding(GO:0070538)
0.1 1.6 GO:0030552 cAMP binding(GO:0030552)
0.1 0.4 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.3 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 3.0 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 1.1 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.9 GO:0031432 titin binding(GO:0031432)
0.0 0.2 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 0.8 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.2 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.1 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 3.7 GO:0051087 chaperone binding(GO:0051087)
0.0 0.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.6 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.3 GO:0015266 protein channel activity(GO:0015266)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0051373 FATZ binding(GO:0051373)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.4 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 1.4 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 0.1 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0 0.5 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 2.4 GO:0042393 histone binding(GO:0042393)
0.0 0.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.5 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 2.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 2.8 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 1.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.0 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 1.9 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.2 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.5 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 4.9 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 5.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.7 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 1.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.2 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 3.1 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 1.0 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 0.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 2.3 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.8 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)