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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for MEF2D_MEF2A

Z-value: 0.66

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Transcription factors associated with MEF2D_MEF2A

Gene Symbol Gene ID Gene Info
MEF2D
ENSG00000116604.13 myocyte enhancer factor 2D
MEF2A
ENSG00000068305.13 myocyte enhancer factor 2A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MEF2Dhg19_v2_chr1_-_156470556_1564706430.203.3e-01Click!
MEF2Ahg19_v2_chr15_+_100106244_100106292-0.203.4e-01Click!

Activity profile of MEF2D_MEF2A motif

Sorted Z-values of MEF2D_MEF2A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_52445191 2.57 ENST00000243050.1
ENST00000394825.1
ENST00000550763.1
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr1_+_221051699 1.71 ENST00000366903.6
HLX
H2.0-like homeobox
chr2_-_157198860 1.25 ENST00000409572.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr2_-_208031542 1.10 ENST00000423015.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr1_-_201391149 0.98 ENST00000555948.1
ENST00000556362.1
TNNI1
troponin I type 1 (skeletal, slow)
chr2_-_208030647 0.89 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr6_-_55739542 0.85 ENST00000446683.2
BMP5
bone morphogenetic protein 5
chr19_+_45973120 0.81 ENST00000592811.1
ENST00000586615.1
FOSB
FBJ murine osteosarcoma viral oncogene homolog B
chr6_+_136172820 0.75 ENST00000308191.6
PDE7B
phosphodiesterase 7B
chr1_-_169703203 0.68 ENST00000333360.7
ENST00000367781.4
ENST00000367782.4
ENST00000367780.4
ENST00000367779.4
SELE
selectin E
chr5_-_88179302 0.66 ENST00000504921.2
MEF2C
myocyte enhancer factor 2C
chr5_+_53751445 0.64 ENST00000302005.1
HSPB3
heat shock 27kDa protein 3
chr3_+_8543393 0.58 ENST00000157600.3
ENST00000415597.1
ENST00000535732.1
LMCD1
LIM and cysteine-rich domains 1
chr8_+_40010989 0.56 ENST00000315792.3
C8orf4
chromosome 8 open reading frame 4
chr5_+_173316341 0.55 ENST00000520867.1
ENST00000334035.5
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr7_-_22259845 0.54 ENST00000420196.1
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr6_-_6007200 0.54 ENST00000244766.2
NRN1
neuritin 1
chr2_+_33661382 0.50 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr8_+_1993152 0.48 ENST00000262113.4
MYOM2
myomesin 2
chr3_+_8543561 0.48 ENST00000397386.3
LMCD1
LIM and cysteine-rich domains 1
chr9_-_97356075 0.46 ENST00000375337.3
FBP2
fructose-1,6-bisphosphatase 2
chr5_-_137475071 0.45 ENST00000265191.2
NME5
NME/NM23 family member 5
chr17_+_68165657 0.45 ENST00000243457.3
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr8_+_1993173 0.44 ENST00000523438.1
MYOM2
myomesin 2
chr15_-_70994612 0.39 ENST00000558758.1
ENST00000379983.2
ENST00000560441.1
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr3_+_8543533 0.39 ENST00000454244.1
LMCD1
LIM and cysteine-rich domains 1
chr12_+_12938541 0.39 ENST00000356591.4
APOLD1
apolipoprotein L domain containing 1
chr6_-_76203345 0.39 ENST00000393004.2
FILIP1
filamin A interacting protein 1
chr19_+_35630344 0.38 ENST00000455515.2
FXYD1
FXYD domain containing ion transport regulator 1
chr9_+_127054217 0.38 ENST00000394199.2
ENST00000546191.1
NEK6
NIMA-related kinase 6
chr9_+_116327326 0.37 ENST00000342620.5
RGS3
regulator of G-protein signaling 3
chr17_+_7758374 0.37 ENST00000301599.6
ENST00000574668.1
TMEM88
transmembrane protein 88
chr10_-_75415825 0.35 ENST00000394810.2
SYNPO2L
synaptopodin 2-like
chr4_-_186697044 0.35 ENST00000437304.2
SORBS2
sorbin and SH3 domain containing 2
chr11_+_57308979 0.33 ENST00000457912.1
SMTNL1
smoothelin-like 1
chr4_+_41362796 0.33 ENST00000508501.1
ENST00000512946.1
ENST00000313860.7
ENST00000512632.1
ENST00000512820.1
LIMCH1
LIM and calponin homology domains 1
chr2_-_106054952 0.33 ENST00000336660.5
ENST00000393352.3
ENST00000607522.1
FHL2
four and a half LIM domains 2
chr19_+_35630022 0.32 ENST00000589209.1
FXYD1
FXYD domain containing ion transport regulator 1
chr2_-_165424973 0.32 ENST00000543549.1
GRB14
growth factor receptor-bound protein 14
chr19_+_35629702 0.32 ENST00000351325.4
FXYD1
FXYD domain containing ion transport regulator 1
chr20_+_42574317 0.31 ENST00000358131.5
TOX2
TOX high mobility group box family member 2
chr1_+_84630645 0.31 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr7_-_41742697 0.30 ENST00000242208.4
INHBA
inhibin, beta A
chr1_+_95583479 0.30 ENST00000455656.1
ENST00000604534.1
TMEM56
RP11-57H12.6
transmembrane protein 56
TMEM56-RWDD3 readthrough
chr4_-_186696425 0.30 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2
sorbin and SH3 domain containing 2
chr10_+_28966271 0.29 ENST00000375533.3
BAMBI
BMP and activin membrane-bound inhibitor
chr12_-_9268707 0.29 ENST00000318602.7
A2M
alpha-2-macroglobulin
chr1_+_145524891 0.29 ENST00000369304.3
ITGA10
integrin, alpha 10
chr11_+_7597639 0.29 ENST00000533792.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_+_114522049 0.29 ENST00000369551.1
ENST00000320334.4
OLFML3
olfactomedin-like 3
chr5_-_111091948 0.28 ENST00000447165.2
NREP
neuronal regeneration related protein
chr3_+_138067521 0.28 ENST00000494949.1
MRAS
muscle RAS oncogene homolog
chr7_-_150884332 0.28 ENST00000275838.1
ENST00000422024.1
ENST00000434669.1
ASB10
ankyrin repeat and SOCS box containing 10
chr1_+_35258592 0.27 ENST00000342280.4
ENST00000450137.1
GJA4
gap junction protein, alpha 4, 37kDa
chr11_-_47399942 0.27 ENST00000227163.4
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr9_-_134151915 0.25 ENST00000372271.3
FAM78A
family with sequence similarity 78, member A
chr1_-_201390846 0.25 ENST00000367312.1
ENST00000555340.2
ENST00000361379.4
TNNI1
troponin I type 1 (skeletal, slow)
chr10_-_3827417 0.25 ENST00000497571.1
ENST00000542957.1
KLF6
Kruppel-like factor 6
chr20_+_61147651 0.25 ENST00000370527.3
ENST00000370524.2
C20orf166
chromosome 20 open reading frame 166
chr15_-_52944231 0.25 ENST00000546305.2
FAM214A
family with sequence similarity 214, member A
chr3_-_156878540 0.25 ENST00000461804.1
CCNL1
cyclin L1
chr21_+_17909594 0.25 ENST00000441820.1
ENST00000602280.1
LINC00478
long intergenic non-protein coding RNA 478
chr7_-_150884873 0.24 ENST00000377867.3
ASB10
ankyrin repeat and SOCS box containing 10
chr10_-_72141330 0.24 ENST00000395011.1
ENST00000395010.1
LRRC20
leucine rich repeat containing 20
chr10_-_75410771 0.24 ENST00000372873.4
SYNPO2L
synaptopodin 2-like
chr11_-_47400078 0.23 ENST00000378538.3
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr22_+_26138108 0.22 ENST00000536101.1
ENST00000335473.7
ENST00000407587.2
MYO18B
myosin XVIIIB
chr8_-_70745575 0.21 ENST00000524945.1
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr2_+_148778570 0.21 ENST00000407073.1
MBD5
methyl-CpG binding domain protein 5
chr14_-_65409438 0.21 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr4_-_76823681 0.21 ENST00000286719.7
PPEF2
protein phosphatase, EF-hand calcium binding domain 2
chr12_-_131200810 0.21 ENST00000536002.1
ENST00000544034.1
RIMBP2
RP11-662M24.2
RIMS binding protein 2
RP11-662M24.2
chr12_-_111358372 0.20 ENST00000548438.1
ENST00000228841.8
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr1_-_40137710 0.19 ENST00000235628.1
NT5C1A
5'-nucleotidase, cytosolic IA
chr9_+_5450503 0.19 ENST00000381573.4
ENST00000381577.3
CD274
CD274 molecule
chr14_-_65409502 0.19 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr2_+_170366203 0.19 ENST00000284669.1
KLHL41
kelch-like family member 41
chr10_-_6104253 0.19 ENST00000256876.6
ENST00000379954.1
ENST00000379959.3
IL2RA
interleukin 2 receptor, alpha
chr8_+_107282389 0.19 ENST00000577661.1
ENST00000445937.1
RP11-395G23.3
OXR1
RP11-395G23.3
oxidation resistance 1
chr5_-_141704566 0.19 ENST00000344120.4
ENST00000434127.2
SPRY4
sprouty homolog 4 (Drosophila)
chr12_+_15699286 0.18 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO
protein tyrosine phosphatase, receptor type, O
chr17_-_79900255 0.18 ENST00000330655.3
ENST00000582198.1
MYADML2
PYCR1
myeloid-associated differentiation marker-like 2
pyrroline-5-carboxylate reductase 1
chr12_-_22094159 0.18 ENST00000538350.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr4_-_39640513 0.18 ENST00000511809.1
ENST00000505729.1
SMIM14
small integral membrane protein 14
chr2_+_161993465 0.18 ENST00000457476.1
TANK
TRAF family member-associated NFKB activator
chr14_+_103589789 0.18 ENST00000558056.1
ENST00000560869.1
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr2_+_168043793 0.18 ENST00000409273.1
ENST00000409605.1
XIRP2
xin actin-binding repeat containing 2
chr2_+_179149636 0.18 ENST00000409631.1
OSBPL6
oxysterol binding protein-like 6
chr2_+_161993412 0.17 ENST00000259075.2
ENST00000432002.1
TANK
TRAF family member-associated NFKB activator
chr20_+_44657845 0.17 ENST00000243964.3
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr1_+_26348259 0.17 ENST00000374280.3
EXTL1
exostosin-like glycosyltransferase 1
chr10_-_3827371 0.17 ENST00000469435.1
KLF6
Kruppel-like factor 6
chr2_-_219696511 0.17 ENST00000439262.2
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr8_+_95565947 0.17 ENST00000523011.1
RP11-267M23.4
RP11-267M23.4
chr3_-_108248169 0.17 ENST00000273353.3
MYH15
myosin, heavy chain 15
chr5_+_67584174 0.17 ENST00000320694.8
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr4_-_143767428 0.17 ENST00000513000.1
ENST00000509777.1
ENST00000503927.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr1_+_90098606 0.16 ENST00000370454.4
LRRC8C
leucine rich repeat containing 8 family, member C
chr15_+_76352178 0.16 ENST00000388942.3
C15orf27
chromosome 15 open reading frame 27
chrX_+_105192423 0.16 ENST00000540278.1
NRK
Nik related kinase
chr1_-_223853348 0.16 ENST00000366872.5
CAPN8
calpain 8
chr12_+_21207503 0.16 ENST00000545916.1
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr14_+_100150622 0.15 ENST00000261835.3
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr13_+_76378305 0.15 ENST00000526371.1
ENST00000526528.1
LMO7
LIM domain 7
chr2_+_162087577 0.15 ENST00000439442.1
TANK
TRAF family member-associated NFKB activator
chr4_-_114682224 0.15 ENST00000342666.5
ENST00000515496.1
ENST00000514328.1
ENST00000508738.1
ENST00000379773.2
CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr4_-_25865159 0.15 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr15_+_78558523 0.15 ENST00000446172.2
DNAJA4
DnaJ (Hsp40) homolog, subfamily A, member 4
chr19_+_56713670 0.15 ENST00000534327.1
ZSCAN5C
zinc finger and SCAN domain containing 5C
chr15_-_83474806 0.15 ENST00000541889.1
ENST00000334574.8
ENST00000561368.1
FSD2
fibronectin type III and SPRY domain containing 2
chr4_-_143227088 0.15 ENST00000511838.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr8_+_7716700 0.15 ENST00000454911.2
ENST00000326625.5
SPAG11A
sperm associated antigen 11A
chr7_+_30951461 0.14 ENST00000311813.4
AQP1
aquaporin 1 (Colton blood group)
chr11_-_47400062 0.14 ENST00000533030.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr6_+_152128686 0.14 ENST00000206249.3
ESR1
estrogen receptor 1
chr6_+_152128371 0.14 ENST00000443427.1
ESR1
estrogen receptor 1
chr9_-_104145795 0.14 ENST00000259407.2
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr3_+_54157480 0.13 ENST00000490478.1
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr14_+_23842018 0.13 ENST00000397242.2
ENST00000329715.2
IL25
interleukin 25
chr15_+_80364901 0.13 ENST00000560228.1
ENST00000559835.1
ENST00000559775.1
ENST00000558688.1
ENST00000560392.1
ENST00000560976.1
ENST00000558272.1
ENST00000558390.1
ZFAND6
zinc finger, AN1-type domain 6
chr12_+_81101277 0.13 ENST00000228641.3
MYF6
myogenic factor 6 (herculin)
chr18_+_3252206 0.13 ENST00000578562.2
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr10_+_50507232 0.13 ENST00000374144.3
C10orf71
chromosome 10 open reading frame 71
chr21_-_34185944 0.13 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr3_+_193853927 0.13 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr20_+_44035847 0.13 ENST00000372712.2
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr14_+_72052983 0.13 ENST00000358550.2
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr1_+_201979645 0.13 ENST00000367284.5
ENST00000367283.3
ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr13_-_67802549 0.13 ENST00000328454.5
ENST00000377865.2
PCDH9
protocadherin 9
chr18_-_53070913 0.13 ENST00000568186.1
ENST00000564228.1
TCF4
transcription factor 4
chr7_-_37488834 0.13 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chrX_+_70521584 0.12 ENST00000373829.3
ENST00000538820.1
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr5_-_42812143 0.12 ENST00000514985.1
SEPP1
selenoprotein P, plasma, 1
chr3_+_188664988 0.12 ENST00000433971.1
TPRG1
tumor protein p63 regulated 1
chr10_+_50507181 0.12 ENST00000323868.4
C10orf71
chromosome 10 open reading frame 71
chr3_+_132843652 0.12 ENST00000508711.1
TMEM108
transmembrane protein 108
chr14_-_57277163 0.12 ENST00000555006.1
OTX2
orthodenticle homeobox 2
chr3_-_30936153 0.12 ENST00000454381.3
ENST00000282538.5
GADL1
glutamate decarboxylase-like 1
chr10_-_115423792 0.12 ENST00000369360.3
ENST00000360478.3
ENST00000359988.3
ENST00000369358.4
NRAP
nebulin-related anchoring protein
chr11_+_112832133 0.12 ENST00000524665.1
NCAM1
neural cell adhesion molecule 1
chr1_-_46642154 0.12 ENST00000540385.1
PIK3R3
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
chr1_-_25756638 0.12 ENST00000349320.3
RHCE
Rh blood group, CcEe antigens
chr17_+_7461613 0.12 ENST00000438470.1
ENST00000436057.1
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr16_+_8768422 0.12 ENST00000268251.8
ENST00000564714.1
ABAT
4-aminobutyrate aminotransferase
chrX_-_50386648 0.12 ENST00000460112.3
SHROOM4
shroom family member 4
chr3_-_137834436 0.12 ENST00000327532.2
ENST00000467030.1
DZIP1L
DAZ interacting zinc finger protein 1-like
chr5_-_156772729 0.12 ENST00000312349.4
FNDC9
fibronectin type III domain containing 9
chr6_-_76203454 0.11 ENST00000237172.7
FILIP1
filamin A interacting protein 1
chr3_-_155011483 0.11 ENST00000489090.1
RP11-451G4.2
RP11-451G4.2
chr3_-_196242233 0.11 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr16_+_3194211 0.11 ENST00000428155.1
CASP16
caspase 16, apoptosis-related cysteine peptidase (putative)
chr1_-_115238207 0.11 ENST00000520113.2
ENST00000369538.3
ENST00000353928.6
AMPD1
adenosine monophosphate deaminase 1
chr8_-_17533838 0.11 ENST00000400046.1
MTUS1
microtubule associated tumor suppressor 1
chr3_+_111630451 0.11 ENST00000495180.1
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr17_+_7788104 0.11 ENST00000380358.4
CHD3
chromodomain helicase DNA binding protein 3
chr18_-_44181442 0.11 ENST00000398722.4
LOXHD1
lipoxygenase homology domains 1
chr8_-_21669826 0.10 ENST00000517328.1
GFRA2
GDNF family receptor alpha 2
chr2_+_44502597 0.10 ENST00000260649.6
ENST00000409387.1
SLC3A1
solute carrier family 3 (amino acid transporter heavy chain), member 1
chr12_-_22094336 0.10 ENST00000326684.4
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr16_+_12059050 0.10 ENST00000396495.3
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr8_-_7309887 0.10 ENST00000458665.1
ENST00000528168.1
SPAG11B
sperm associated antigen 11B
chr6_-_134373732 0.10 ENST00000275230.5
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr16_+_12058961 0.10 ENST00000053243.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr11_+_1942580 0.09 ENST00000381558.1
TNNT3
troponin T type 3 (skeletal, fast)
chr10_+_90354503 0.09 ENST00000531458.1
LIPJ
lipase, family member J
chr12_+_80750134 0.09 ENST00000546620.1
OTOGL
otogelin-like
chr17_-_38821373 0.09 ENST00000394052.3
KRT222
keratin 222
chr6_+_159290917 0.09 ENST00000367072.1
C6orf99
chromosome 6 open reading frame 99
chr14_-_102704783 0.09 ENST00000522534.1
MOK
MOK protein kinase
chr3_+_138067314 0.09 ENST00000423968.2
MRAS
muscle RAS oncogene homolog
chr6_+_41021027 0.09 ENST00000244669.2
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr12_-_55367361 0.09 ENST00000532804.1
ENST00000531122.1
ENST00000533446.1
TESPA1
thymocyte expressed, positive selection associated 1
chr22_-_31328881 0.09 ENST00000445980.1
MORC2
MORC family CW-type zinc finger 2
chr10_-_62704005 0.09 ENST00000337910.5
RHOBTB1
Rho-related BTB domain containing 1
chr18_-_35145981 0.09 ENST00000420428.2
ENST00000412753.1
CELF4
CUGBP, Elav-like family member 4
chr9_-_33402506 0.09 ENST00000377425.4
ENST00000537089.1
ENST00000297988.1
ENST00000539936.1
ENST00000541274.1
AQP7
aquaporin 7
chr8_-_95565673 0.09 ENST00000437199.1
ENST00000297591.5
ENST00000421249.2
KIAA1429
KIAA1429
chr11_+_3666335 0.09 ENST00000250693.1
ART1
ADP-ribosyltransferase 1
chrX_-_133792480 0.09 ENST00000359237.4
PLAC1
placenta-specific 1
chr11_+_129245796 0.09 ENST00000281437.4
BARX2
BARX homeobox 2
chr1_+_12524965 0.08 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr10_-_31146615 0.08 ENST00000444692.2
ZNF438
zinc finger protein 438
chr8_+_27183033 0.08 ENST00000420218.2
PTK2B
protein tyrosine kinase 2 beta
chr8_+_27182862 0.08 ENST00000521164.1
ENST00000346049.5
PTK2B
protein tyrosine kinase 2 beta
chr16_-_71610985 0.08 ENST00000355962.4
TAT
tyrosine aminotransferase
chrX_-_128657457 0.08 ENST00000371121.3
ENST00000371123.1
ENST00000371122.4
SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chrX_-_18690210 0.08 ENST00000379984.3
RS1
retinoschisin 1
chr6_+_50061315 0.08 ENST00000415106.1
RP11-397G17.1
RP11-397G17.1
chr8_-_13372395 0.08 ENST00000276297.4
ENST00000511869.1
DLC1
deleted in liver cancer 1
chr11_+_112832090 0.08 ENST00000533760.1
NCAM1
neural cell adhesion molecule 1
chr6_+_159291090 0.08 ENST00000367073.4
ENST00000608817.1
C6orf99
chromosome 6 open reading frame 99
chr7_-_11871815 0.08 ENST00000423059.4
THSD7A
thrombospondin, type I, domain containing 7A
chr22_+_25595817 0.08 ENST00000215855.2
ENST00000404334.1
CRYBB3
crystallin, beta B3
chr8_+_74903580 0.08 ENST00000284818.2
ENST00000518893.1
LY96
lymphocyte antigen 96
chr3_+_113616317 0.07 ENST00000440446.2
ENST00000488680.1
GRAMD1C
GRAM domain containing 1C
chr3_+_159570722 0.07 ENST00000482804.1
SCHIP1
schwannomin interacting protein 1
chr18_+_3252265 0.07 ENST00000580887.1
ENST00000536605.1
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr8_-_62602327 0.07 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr18_-_64271363 0.07 ENST00000262150.2
CDH19
cadherin 19, type 2
chr20_+_32581525 0.07 ENST00000246194.3
ENST00000413297.1
RALY
RALY heterogeneous nuclear ribonucleoprotein

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2D_MEF2A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.8 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.3 0.9 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.2 1.7 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.2 1.0 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.2 0.7 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.2 0.6 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 0.5 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.1 0.4 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.1 0.3 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.1 0.5 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.6 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.1 0.3 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.1 0.2 GO:0090260 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 0.2 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.1 1.4 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 0.4 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.1 GO:0072019 carbon dioxide transmembrane transport(GO:0035378) proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229)
0.0 0.8 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.0 0.3 GO:0097338 response to clozapine(GO:0097338)
0.0 0.2 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.2 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.1 GO:2000974 trochlear nerve development(GO:0021558) auditory receptor cell fate determination(GO:0042668) negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of timing of neuron differentiation(GO:0060164) negative regulation of pro-B cell differentiation(GO:2000974)
0.0 0.2 GO:2000538 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0 0.6 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.2 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.0 0.5 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.3 GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0 0.1 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) positive regulation of prolactin secretion(GO:1902722) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.0 0.2 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.0 0.7 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.8 GO:0051412 response to corticosterone(GO:0051412)
0.0 0.2 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.0 0.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.4 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.1 GO:0046373 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.0 0.1 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.0 0.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:1903595 positive regulation of histamine secretion by mast cell(GO:1903595)
0.0 0.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.1 GO:0030222 eosinophil differentiation(GO:0030222)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.1 GO:0015811 L-cystine transport(GO:0015811) basic amino acid transmembrane transport(GO:1990822)
0.0 0.3 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.0 0.1 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.0 0.0 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.0 0.4 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:0019530 taurine metabolic process(GO:0019530)
0.0 0.1 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.7 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.0 GO:0032242 regulation of nucleoside transport(GO:0032242) negative regulation of neurotrophin production(GO:0032900)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.0 0.2 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.0 0.2 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.0 0.1 GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) regulation of relaxation of cardiac muscle(GO:1901897) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.0 0.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.0 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.2 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.1 GO:0015793 glycerol transport(GO:0015793)
0.0 0.1 GO:0080009 mRNA methylation(GO:0080009)
0.0 0.1 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.1 GO:0032264 IMP salvage(GO:0032264)
0.0 0.0 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.0 0.1 GO:0060056 mammary gland involution(GO:0060056)
0.0 0.2 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.2 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.2 GO:0051601 exocyst localization(GO:0051601)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1 0.3 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.0 0.1 GO:0020003 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
0.0 0.3 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 1.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.2 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.0 0.2 GO:0005927 muscle tendon junction(GO:0005927)
0.0 0.6 GO:0005861 troponin complex(GO:0005861)
0.0 0.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:0045293 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.1 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.3 GO:0019959 interleukin-8 binding(GO:0019959)
0.1 0.5 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.3 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.1 0.9 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.2 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 0.6 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.1 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.0 0.3 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.2 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.0 0.7 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.5 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.7 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.2 GO:0017161 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 1.1 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 0.3 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.2 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.2 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.1 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.0 0.1 GO:0032145 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.0 0.1 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.1 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.3 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 1.9 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.4 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0 0.1 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.0 0.5 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.6 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.6 GO:0005112 Notch binding(GO:0005112)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.2 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.1 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.0 0.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.0 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.0 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.0 0.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.4 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.0 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.1 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.1 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.0 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0 0.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.1 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.0 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.1 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.5 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.4 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.6 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.3 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.3 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.5 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels