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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for MIXL1_GSX1_BSX_MEOX2_LHX4
Z-value: 0.71
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Transcription factors associated with MIXL1_GSX1_BSX_MEOX2_LHX4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000185155.7 | Mix paired-like homeobox | |
| ENSG00000169840.4 | GS homeobox 1 | |
| ENSG00000188909.4 | brain specific homeobox | |
| ENSG00000106511.5 | mesenchyme homeobox 2 | |
| ENSG00000121454.4 | LIM homeobox 4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GSX1 | hg19_v2_chr13_+_28366780_28366780 | 0.30 | 1.5e-01 | Click! |
| MEOX2 | hg19_v2_chr7_-_15726296_15726437 | -0.16 | 4.6e-01 | Click! |
| LHX4 | hg19_v2_chr1_+_180199393_180199426 | 0.12 | 5.6e-01 | Click! |
| MIXL1 | hg19_v2_chr1_+_226411319_226411366 | -0.01 | 9.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MIXL1_GSX1_BSX_MEOX2_LHX4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.5 | 2.9 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.2 | 2.9 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.1 | 2.2 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.0 | 2.1 | GO:0042633 | molting cycle(GO:0042303) hair cycle(GO:0042633) |
| 0.3 | 2.0 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.2 | 1.9 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.2 | 1.8 | GO:0061734 | parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734) |
| 0.0 | 1.7 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 1.6 | GO:0032233 | positive regulation of actin filament bundle assembly(GO:0032233) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.3 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.0 | 3.2 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 2.2 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 1.7 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.2 | 1.6 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.0 | 1.4 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.2 | 1.3 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.0 | 1.3 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 1.2 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.3 | 1.1 | GO:0005863 | striated muscle myosin thick filament(GO:0005863) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 3.2 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 2.8 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 2.1 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.4 | 2.0 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.3 | 2.0 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.0 | 1.8 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.0 | 1.5 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 1.4 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 1.4 | GO:0050840 | extracellular matrix binding(GO:0050840) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 2.3 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 1.8 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 1.3 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.2 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 1.1 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.0 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 0.8 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.7 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 2.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 2.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.7 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.2 | 1.6 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 1.6 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 1.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 1.2 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 1.1 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 1.1 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |