ISMARA results: MLXIPL

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for MLXIPL

Z-value: 0.94

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Transcription factors associated with MLXIPL

Gene Symbol	Gene ID	Gene Info
MLXIPL Ensembl NCBI GeneCards UniProt NextProt	ENSG00000009950.11	MLX interacting protein like

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MLXIPL	hg19_v2_chr7_-_73038867_73038878, hg19_v2_chr7_-_73038822_73038862	-0.04	8.6e-01	Click!

Activity profile of MLXIPL motif

Sorted Z-values of MLXIPL motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_-_30032610 Show fit	2.02	ENST00000574405.1	DOC2A Ensembl NCBI GeneCards UniProt NextProt Show fit	double C2-like domains, alpha
chr10_+_81466084 Show fit	1.71	ENST00000342531.2	NUTM2B Ensembl NCBI GeneCards UniProt NextProt Show fit	NUT family member 2B
chr1_+_25944341 Show fit	1.52	ENST00000263979.3	MAN1C1 Ensembl NCBI GeneCards UniProt NextProt Show fit	mannosidase, alpha, class 1C, member 1
chr7_+_74072288 Show fit	1.52	ENST00000443166.1	GTF2I Ensembl NCBI GeneCards UniProt NextProt Show fit	general transcription factor IIi
chr4_-_123843597 Show fit	1.35	ENST00000510735.1 ENST00000304430.5	NUDT6 Ensembl NCBI GeneCards UniProt NextProt Show fit	nudix (nucleoside diphosphate linked moiety X)-type motif 6
chr10_-_131762105 Show fit	1.17	ENST00000368648.3 ENST00000355311.5	EBF3 Ensembl NCBI GeneCards UniProt NextProt Show fit	early B-cell factor 3
chr12_-_42877726 Show fit	1.14	ENST00000548696.1	PRICKLE1 Ensembl NCBI GeneCards UniProt NextProt Show fit	prickle homolog 1 (Drosophila)
chr2_+_233925064 Show fit	1.14	ENST00000359570.5 ENST00000538935.1	INPP5D Ensembl NCBI GeneCards UniProt NextProt Show fit	inositol polyphosphate-5-phosphatase, 145kDa
chr2_+_8822113 Show fit	1.07	ENST00000396290.1 ENST00000331129.3	ID2 Ensembl NCBI GeneCards UniProt NextProt Show fit	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr9_-_74675521 Show fit	1.03	ENST00000377024.3	C9orf57 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 9 open reading frame 57

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MLXIPL

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.6	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	2.1	GO:0070268	cornification(GO:0070268)
0.4	1.9	GO:0014886	transition between slow and fast fiber(GO:0014886)
0.4	1.7	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.4	1.6	GO:0003095	pressure natriuresis(GO:0003095)
0.1	1.6	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	1.6	GO:0006910	phagocytosis, recognition(GO:0006910)
0.3	1.5	GO:1904381	Golgi apparatus mannose trimming(GO:1904381)
0.1	1.5	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.1	1.5	GO:0061003	positive regulation of dendritic spine morphogenesis(GO:0061003)

Showing 1 to 10 of 491 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.8	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	2.2	GO:0005882	intermediate filament(GO:0005882)
0.1	2.1	GO:0043020	NADPH oxidase complex(GO:0043020)
0.4	1.7	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	1.7	GO:0042571	immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571)
0.0	1.4	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1	1.2	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	1.2	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.0	1.2	GO:0031430	M band(GO:0031430)
0.0	1.2	GO:0032588	trans-Golgi network membrane(GO:0032588)

Showing 1 to 10 of 147 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	2.5	GO:0008083	growth factor activity(GO:0008083)
0.2	2.3	GO:0019826	oxygen sensor activity(GO:0019826)
0.0	2.1	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	1.8	GO:0017075	syntaxin-1 binding(GO:0017075)
0.4	1.6	GO:0018685	alkane 1-monooxygenase activity(GO:0018685)
0.1	1.6	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.1	1.6	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	1.6	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1	1.5	GO:0005132	type I interferon receptor binding(GO:0005132)

Showing 1 to 10 of 307 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.2	PID ATM PATHWAY	ATM pathway
0.0	1.8	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.0	1.6	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	1.5	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	1.5	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.1	1.3	PID ARF6 PATHWAY	Arf6 signaling events
0.0	1.2	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	1.0	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	1.0	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	0.9	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III

Showing 1 to 10 of 45 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.2	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.0	2.2	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.0	1.6	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	1.6	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	1.6	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	1.5	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.1	1.3	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	1.3	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	1.3	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.0	1.3	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression

Showing 1 to 10 of 73 entries

Results for MLXIPL

Z-value: 0.94

Motif logo

Transcription factors associated with MLXIPL

Activity-expression correlation:

Activity profile of MLXIPL motif

Sorted Z-values of MLXIPL motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MLXIPL

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: