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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for MLX_USF2_USF1_PAX2
Z-value: 2.25
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Transcription factors associated with MLX_USF2_USF1_PAX2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000108788.7 | MAX dimerization protein MLX | |
| ENSG00000105698.11 | upstream transcription factor 2, c-fos interacting | |
| ENSG00000158773.10 | upstream transcription factor 1 | |
| ENSG00000075891.17 | paired box 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PAX2 | hg19_v2_chr10_+_102505468_102505546 | 0.60 | 1.5e-03 | Click! |
| USF1 | hg19_v2_chr1_-_161014731_161014788, hg19_v2_chr1_-_161015752_161015778 | -0.55 | 4.4e-03 | Click! |
| MLX | hg19_v2_chr17_+_40719073_40719092 | -0.50 | 1.1e-02 | Click! |
| USF2 | hg19_v2_chr19_+_35759968_35760042 | 0.36 | 7.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_221051699 Show fit | 15.23 |
ENST00000366903.6
|
H2.0-like homeobox |
|
| chr14_-_54420133 Show fit | 13.50 |
ENST00000559501.1
ENST00000558984.1 |
bone morphogenetic protein 4 |
|
| chr8_+_120220561 Show fit | 11.58 |
ENST00000276681.6
|
mal, T-cell differentiation protein 2 (gene/pseudogene) |
|
| chr17_-_46688334 Show fit | 11.47 |
ENST00000239165.7
|
homeobox B7 |
|
| chr14_-_54955721 Show fit | 9.57 |
ENST00000554908.1
|
glia maturation factor, beta |
|
| chr3_-_122512619 Show fit | 9.54 |
ENST00000383659.1
ENST00000306103.2 |
HSPB (heat shock 27kDa) associated protein 1 |
|
| chr17_-_58469591 Show fit | 9.45 |
ENST00000589335.1
|
ubiquitin specific peptidase 32 |
|
| chr11_+_67159416 Show fit | 9.19 |
ENST00000307980.2
ENST00000544620.1 |
RAD9 homolog A (S. pombe) |
|
| chr11_+_59522837 Show fit | 8.96 |
ENST00000437946.2
|
syntaxin 3 |
|
| chr11_-_18343669 Show fit | 8.51 |
ENST00000396253.3
ENST00000349215.3 ENST00000438420.2 |
Hermansky-Pudlak syndrome 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MLX_USF2_USF1_PAX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 19.8 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 2.4 | 14.6 | GO:1903756 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 0.1 | 14.3 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.5 | 14.1 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 4.5 | 13.5 | GO:0048392 | apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007) |
| 0.7 | 13.5 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 3.3 | 13.3 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 1.4 | 13.0 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
| 1.7 | 12.1 | GO:0098967 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 0.5 | 12.1 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 45.8 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.2 | 14.4 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.1 | 13.8 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 4.4 | 13.1 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.1 | 12.9 | GO:0030018 | Z disc(GO:0030018) |
| 0.3 | 12.4 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 3.0 | 12.1 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
| 0.1 | 12.1 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 11.4 | GO:0016607 | nuclear speck(GO:0016607) |
| 1.9 | 11.3 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 37.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 24.0 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.4 | 23.7 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.2 | 20.8 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 14.9 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.2 | 14.1 | GO:0005507 | copper ion binding(GO:0005507) |
| 2.3 | 13.8 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 1.0 | 13.5 | GO:0039706 | co-receptor binding(GO:0039706) BMP receptor binding(GO:0070700) |
| 0.3 | 13.0 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 1.2 | 12.8 | GO:0030274 | LIM domain binding(GO:0030274) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 12.4 | PID BMP PATHWAY | BMP receptor signaling |
| 0.2 | 11.9 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 10.6 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.1 | 9.9 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.2 | 9.4 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.1 | 9.4 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 8.7 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 8.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 8.0 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 22.3 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.5 | 12.9 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.3 | 11.7 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.5 | 11.5 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.3 | 11.5 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.4 | 10.6 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.4 | 10.5 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.6 | 10.1 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.5 | 9.1 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.2 | 8.1 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |