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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for MXI1_MYC_MYCN
Z-value: 2.48
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Transcription factors associated with MXI1_MYC_MYCN
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000119950.16 | MAX interactor 1, dimerization protein | |
| ENSG00000136997.10 | MYC proto-oncogene, bHLH transcription factor | |
| ENSG00000134323.10 | MYCN proto-oncogene, bHLH transcription factor |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYCN | hg19_v2_chr2_+_16080659_16080686 | -0.42 | 3.7e-02 | Click! |
| MXI1 | hg19_v2_chr10_+_111967345_111967442, hg19_v2_chr10_+_111985713_111985774 | -0.37 | 6.9e-02 | Click! |
| MYC | hg19_v2_chr8_+_128748308_128748330, hg19_v2_chr8_+_128748466_128748487 | 0.09 | 6.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_127541679 Show fit | 16.49 |
ENST00000265052.5
|
monoglyceride lipase |
|
| chr3_-_127542051 Show fit | 16.13 |
ENST00000398104.1
|
monoglyceride lipase |
|
| chr15_+_89182178 Show fit | 15.58 |
ENST00000559876.1
|
interferon stimulated exonuclease gene 20kDa |
|
| chr15_+_89182156 Show fit | 15.42 |
ENST00000379224.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr8_+_17354617 Show fit | 14.61 |
ENST00000470360.1
|
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 |
|
| chr8_+_17354587 Show fit | 13.89 |
ENST00000494857.1
ENST00000522656.1 |
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 |
|
| chr15_+_89181974 Show fit | 13.52 |
ENST00000306072.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr3_-_127542021 Show fit | 13.18 |
ENST00000434178.2
|
monoglyceride lipase |
|
| chr10_-_6019552 Show fit | 11.56 |
ENST00000379977.3
ENST00000397251.3 ENST00000397248.2 |
interleukin 15 receptor, alpha |
|
| chr6_+_32811885 Show fit | 10.56 |
ENST00000458296.1
ENST00000413039.1 ENST00000429600.1 ENST00000412095.1 ENST00000415067.1 ENST00000395330.1 |
TAP1 and PSMB8 antisense RNA 1 proteasome (prosome, macropain) subunit, beta type, 9 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MXI1_MYC_MYCN
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.9 | 55.6 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 9.0 | 45.1 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.3 | 32.2 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 9.5 | 28.5 | GO:1903410 | lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410) |
| 1.9 | 18.9 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.2 | 18.5 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.1 | 13.2 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 0.4 | 11.2 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.1 | 11.1 | GO:0071349 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 2.7 | 11.0 | GO:1903438 | regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 65.4 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.7 | 47.6 | GO:0015030 | Cajal body(GO:0015030) |
| 2.7 | 24.0 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.3 | 17.9 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 17.8 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 15.9 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.3 | 14.7 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 14.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 13.4 | GO:0005730 | nucleolus(GO:0005730) |
| 1.1 | 12.8 | GO:0005642 | annulate lamellae(GO:0005642) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 60.3 | GO:0003723 | RNA binding(GO:0003723) |
| 3.1 | 55.4 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 14.8 | 44.5 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 7.1 | 28.5 | GO:0005292 | high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292) |
| 0.8 | 25.9 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 21.0 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.3 | 19.4 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 3.7 | 18.5 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.0 | 13.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.3 | 12.9 | GO:0008536 | Ran GTPase binding(GO:0008536) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.5 | 18.8 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.2 | 14.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.3 | 12.1 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 11.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.3 | 10.8 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 9.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 8.5 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 8.2 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 7.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 68.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 1.8 | 55.1 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.6 | 30.7 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.2 | 21.6 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.3 | 20.3 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.3 | 20.3 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.3 | 19.9 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.6 | 17.3 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.5 | 16.1 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 15.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |