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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for MYB
Z-value: 1.50
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Transcription factors associated with MYB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYB | hg19_v2_chr6_+_135502466_135502489, hg19_v2_chr6_+_135502408_135502459 | -0.24 | 2.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 10.4 | GO:0045905 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.1 | 4.9 | GO:0032508 | DNA duplex unwinding(GO:0032508) |
| 0.1 | 4.2 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.5 | 3.9 | GO:0021564 | vagus nerve development(GO:0021564) |
| 0.7 | 3.5 | GO:0035617 | stress granule disassembly(GO:0035617) |
| 0.8 | 3.4 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
| 0.0 | 3.1 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.4 | 3.0 | GO:0030259 | lipid glycosylation(GO:0030259) |
| 0.0 | 3.0 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.6 | 2.8 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 13.0 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.2 | 11.9 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.2 | 3.9 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.2 | 2.8 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.0 | 2.8 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 2.7 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.3 | 2.6 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 2.5 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 2.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 2.4 | GO:0001669 | acrosomal vesicle(GO:0001669) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 10.6 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.0 | 5.1 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.1 | 4.8 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 3.6 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.5 | 3.4 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.1 | 3.3 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.1 | 3.3 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.2 | 2.6 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.4 | 2.5 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.1 | 2.4 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.4 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 4.5 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 3.7 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 3.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 3.0 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 3.0 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 3.0 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 2.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 2.3 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.2 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.0 | 4.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 3.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 3.2 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.1 | 2.9 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 2.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 2.4 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.1 | 2.3 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.1 | 2.3 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |