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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for MYBL2
Z-value: 1.14
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Transcription factors associated with MYBL2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYBL2 | hg19_v2_chr20_+_42295745_42295797 | 0.06 | 7.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_16900410 Show fit | 2.48 |
ENST00000304523.5
|
LIM domain binding 2 |
|
| chr16_-_30032610 Show fit | 2.47 |
ENST00000574405.1
|
double C2-like domains, alpha |
|
| chr4_-_16900242 Show fit | 2.47 |
ENST00000502640.1
ENST00000506732.1 |
LIM domain binding 2 |
|
| chr10_+_35415719 Show fit | 2.28 |
ENST00000474362.1
ENST00000374721.3 |
cAMP responsive element modulator |
|
| chr10_+_35415978 Show fit | 2.13 |
ENST00000429130.3
ENST00000469949.2 ENST00000460270.1 |
cAMP responsive element modulator |
|
| chr4_+_42399856 Show fit | 1.86 |
ENST00000319234.4
|
shisa family member 3 |
|
| chr7_-_129592471 Show fit | 1.86 |
ENST00000473814.2
ENST00000490974.1 |
ubiquitin-conjugating enzyme E2H |
|
| chr12_+_93964746 Show fit | 1.69 |
ENST00000536696.2
|
suppressor of cytokine signaling 2 |
|
| chrX_-_140786896 Show fit | 1.65 |
ENST00000370515.3
|
SPANX family, member D |
|
| chr12_+_93965609 Show fit | 1.65 |
ENST00000549887.1
ENST00000551556.1 |
suppressor of cytokine signaling 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYBL2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.9 | GO:0010669 | epithelial structure maintenance(GO:0010669) |
| 0.1 | 4.9 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.2 | 4.7 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.0 | 3.4 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.1 | 2.8 | GO:0072189 | ureter development(GO:0072189) |
| 0.0 | 2.6 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.6 | 2.3 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.1 | 2.1 | GO:0060644 | mammary gland epithelial cell differentiation(GO:0060644) |
| 0.1 | 2.0 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 0.0 | 2.0 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.7 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 2.9 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 2.5 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 2.4 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.0 | 1.9 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.3 | 1.6 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 0.0 | 1.6 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 1.6 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 1.5 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 1.3 | GO:0097228 | sperm principal piece(GO:0097228) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 4.9 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.8 | 4.7 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.1 | 4.4 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.2 | 3.6 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 3.0 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 2.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 2.4 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 2.3 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.1 | 2.1 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 1.9 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 4.6 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 2.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 2.5 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 2.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 2.3 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.3 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 1.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.1 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.0 | 4.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 2.9 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 2.5 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 2.3 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 2.3 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 2.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.4 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 1.1 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.1 | 1.0 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |