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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for MYF6
Z-value: 1.44
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Transcription factors associated with MYF6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYF6 | hg19_v2_chr12_+_81101277_81101321 | -0.01 | 9.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYF6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 16.2 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.0 | 11.0 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 2.5 | 7.6 | GO:0048391 | apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007) |
| 0.0 | 7.4 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 7.4 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.1 | 6.9 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.2 | 6.6 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 1.0 | 6.1 | GO:0060399 | positive regulation of growth hormone receptor signaling pathway(GO:0060399) |
| 0.3 | 4.9 | GO:0009313 | oligosaccharide catabolic process(GO:0009313) |
| 0.5 | 4.3 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 11.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 7.1 | GO:0045095 | keratin filament(GO:0045095) |
| 0.2 | 6.5 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 5.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 4.6 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 4.3 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 4.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 1.0 | 4.0 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.0 | 4.0 | GO:0005795 | Golgi stack(GO:0005795) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 16.0 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.8 | 10.1 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.8 | 10.0 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 8.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.2 | 8.0 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 7.4 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.1 | 5.0 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 4.2 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 4.2 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.4 | 4.0 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 7.2 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 5.7 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 4.7 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 4.4 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 4.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 4.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 3.9 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.1 | 3.7 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 3.7 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 7.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.2 | 6.1 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 5.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.4 | 5.0 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 5.0 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 4.6 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 4.3 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 4.2 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.1 | 3.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |