ISMARA results: MYOD1

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for MYOD1

Z-value: 0.71

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Transcription factors associated with MYOD1

Gene Symbol	Gene ID	Gene Info
MYOD1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000129152.3	myogenic differentiation 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MYOD1	hg19_v2_chr11_+_17741111_17741124	-0.06	7.8e-01	Click!

Activity profile of MYOD1 motif

Sorted Z-values of MYOD1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_+_39382900 Show fit	8.26	ENST00000377721.3 ENST00000455970.2	KRTAP9-2 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin associated protein 9-2
chr17_+_39394250 Show fit	3.31	ENST00000254072.6	KRTAP9-8 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin associated protein 9-8
chr17_+_68165657 Show fit	1.61	ENST00000243457.3	KCNJ2 Ensembl NCBI GeneCards UniProt NextProt Show fit	potassium inwardly-rectifying channel, subfamily J, member 2
chr17_-_42277203 Show fit	1.23	ENST00000587097.1	ATXN7L3 Ensembl NCBI GeneCards UniProt NextProt Show fit	ataxin 7-like 3
chr22_-_37882395 Show fit	1.22	ENST00000416983.3 ENST00000424765.2 ENST00000356998.3	MFNG Ensembl NCBI GeneCards UniProt NextProt Show fit	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr16_-_46864955 Show fit	1.20	ENST00000565112.1	C16orf87 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 16 open reading frame 87
chr11_-_33891362 Show fit	1.18	ENST00000395833.3	LMO2 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain only 2 (rhombotin-like 1)
chr15_+_57668695 Show fit	1.13	ENST00000281282.5	CGNL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	cingulin-like 1
chr5_+_139027877 Show fit	1.13	ENST00000302517.3	CXXC5 Ensembl NCBI GeneCards UniProt NextProt Show fit	CXXC finger protein 5
chr11_+_128634589 Show fit	1.11	ENST00000281428.8	FLI1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Fli-1 proto-oncogene, ETS transcription factor

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MYOD1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.5	GO:0031424	keratinization(GO:0031424)
0.3	2.5	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.7	2.0	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.4	1.6	GO:0090076	relaxation of skeletal muscle(GO:0090076)
0.0	1.5	GO:0019933	cAMP-mediated signaling(GO:0019933)
0.2	1.4	GO:0048630	skeletal muscle tissue growth(GO:0048630)
0.3	1.3	GO:0021592	fourth ventricle development(GO:0021592)
0.1	1.3	GO:0042789	mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.3	1.2	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.1	1.2	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)

Showing 1 to 10 of 133 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.6	GO:0045095	keratin filament(GO:0045095)
0.4	2.0	GO:0060200	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1	1.9	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	1.5	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.3	1.3	GO:0097513	myosin II filament(GO:0097513)
0.0	1.3	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.1	1.2	GO:0000124	SAGA complex(GO:0000124)
0.2	1.1	GO:1990393	3M complex(GO:1990393)
0.1	1.0	GO:0061689	tricellular tight junction(GO:0061689)
0.0	0.9	GO:0043205	microfibril(GO:0001527) fibril(GO:0043205)

Showing 1 to 10 of 53 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	2.5	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.3	1.9	GO:0030348	syntaxin-3 binding(GO:0030348)
0.1	1.9	GO:0022848	acetylcholine-gated cation channel activity(GO:0022848)
0.1	1.8	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.1	1.6	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	1.5	GO:0051393	alpha-actinin binding(GO:0051393)
0.0	1.5	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	1.4	GO:0030552	cAMP binding(GO:0030552)
0.0	1.4	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
0.3	1.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)

Showing 1 to 10 of 103 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
2.0	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
1.0	PID TRAIL PATHWAY	TRAIL signaling pathway
0.8	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.8	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.8	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.5	PID IFNG PATHWAY	IFN-gamma pathway
0.5	ST GA12 PATHWAY	G alpha 12 Pathway
0.5	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.4	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	2.0	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.1	1.9	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0	1.7	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	1.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	1.3	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	1.1	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.8	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.8	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.7	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA

Showing 1 to 10 of 25 entries

Results for MYOD1

Z-value: 0.71

Motif logo

Transcription factors associated with MYOD1

Activity-expression correlation:

Activity profile of MYOD1 motif

Sorted Z-values of MYOD1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MYOD1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: