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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NANOG

Z-value: 0.46

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Transcription factors associated with NANOG

Gene Symbol Gene ID Gene Info
NANOG
ENSG00000111704.6 Nanog homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NANOGhg19_v2_chr12_+_7941989_7942014-0.638.3e-04Click!

Activity profile of NANOG motif

Sorted Z-values of NANOG motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_16900184 1.82 ENST00000515064.1
LDB2
LIM domain binding 2
chr4_-_16900217 1.80 ENST00000441778.2
LDB2
LIM domain binding 2
chr4_-_16900242 1.72 ENST00000502640.1
ENST00000506732.1
LDB2
LIM domain binding 2
chr4_-_16900410 1.48 ENST00000304523.5
LDB2
LIM domain binding 2
chr12_-_123201337 1.16 ENST00000528880.2
HCAR3
hydroxycarboxylic acid receptor 3
chr3_-_93692781 0.95 ENST00000394236.3
PROS1
protein S (alpha)
chr3_+_32147997 0.88 ENST00000282541.5
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr15_-_78526855 0.83 ENST00000541759.1
ENST00000558130.1
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr12_-_123187890 0.75 ENST00000328880.5
HCAR2
hydroxycarboxylic acid receptor 2
chr1_+_210406121 0.71 ENST00000367012.3
SERTAD4
SERTA domain containing 4
chr6_-_119031228 0.61 ENST00000392500.3
ENST00000368488.5
ENST00000434604.1
CEP85L
centrosomal protein 85kDa-like
chr12_-_53901266 0.52 ENST00000609999.1
ENST00000267017.3
NPFF
neuropeptide FF-amide peptide precursor
chr2_+_45878790 0.48 ENST00000306156.3
PRKCE
protein kinase C, epsilon
chr7_+_150382781 0.47 ENST00000223293.5
ENST00000474605.1
GIMAP2
GTPase, IMAP family member 2
chr6_+_155537771 0.46 ENST00000275246.7
TIAM2
T-cell lymphoma invasion and metastasis 2
chr19_-_13213662 0.44 ENST00000264824.4
LYL1
lymphoblastic leukemia derived sequence 1
chr10_+_129845823 0.44 ENST00000306042.5
PTPRE
protein tyrosine phosphatase, receptor type, E
chr2_+_87769459 0.43 ENST00000414030.1
ENST00000437561.1
LINC00152
long intergenic non-protein coding RNA 152
chr6_+_148663729 0.42 ENST00000367467.3
SASH1
SAM and SH3 domain containing 1
chr2_-_240322643 0.41 ENST00000345617.3
HDAC4
histone deacetylase 4
chr19_-_42806919 0.41 ENST00000595530.1
ENST00000538771.1
ENST00000601865.1
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr12_-_25055177 0.41 ENST00000538118.1
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr14_+_21156915 0.39 ENST00000397990.4
ENST00000555597.1
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr2_-_112237835 0.38 ENST00000442293.1
ENST00000439494.1
MIR4435-1HG
MIR4435-1 host gene (non-protein coding)
chr13_+_108922228 0.38 ENST00000542136.1
TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr8_-_27469196 0.37 ENST00000546343.1
ENST00000560566.1
CLU
clusterin
chr19_-_42806723 0.36 ENST00000262890.3
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr3_-_49851313 0.35 ENST00000333486.3
UBA7
ubiquitin-like modifier activating enzyme 7
chr8_-_27468842 0.35 ENST00000523500.1
CLU
clusterin
chr19_-_42806444 0.35 ENST00000594989.1
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr8_-_27468945 0.34 ENST00000405140.3
CLU
clusterin
chr1_-_147245484 0.33 ENST00000271348.2
GJA5
gap junction protein, alpha 5, 40kDa
chr14_-_98444438 0.33 ENST00000512901.2
C14orf64
chromosome 14 open reading frame 64
chr6_+_26087509 0.33 ENST00000397022.3
ENST00000353147.5
ENST00000352392.4
ENST00000349999.4
ENST00000317896.7
ENST00000357618.5
ENST00000470149.1
ENST00000336625.8
ENST00000461397.1
ENST00000488199.1
HFE
hemochromatosis
chr17_+_7387677 0.31 ENST00000322644.6
POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr3_-_149093499 0.30 ENST00000472441.1
TM4SF1
transmembrane 4 L six family member 1
chr16_+_31494323 0.29 ENST00000569576.1
ENST00000330498.3
SLC5A2
solute carrier family 5 (sodium/glucose cotransporter), member 2
chr4_-_16077741 0.28 ENST00000447510.2
ENST00000540805.1
ENST00000539194.1
PROM1
prominin 1
chr17_-_34417479 0.27 ENST00000225245.5
CCL3
chemokine (C-C motif) ligand 3
chr19_-_42806842 0.26 ENST00000596265.1
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr10_+_69644404 0.26 ENST00000212015.6
SIRT1
sirtuin 1
chr17_-_7387524 0.24 ENST00000311403.4
ZBTB4
zinc finger and BTB domain containing 4
chr1_-_205649580 0.24 ENST00000367145.3
SLC45A3
solute carrier family 45, member 3
chr3_+_132379154 0.24 ENST00000468022.1
ENST00000473651.1
ENST00000494238.2
UBA5
ubiquitin-like modifier activating enzyme 5
chr16_+_68573640 0.24 ENST00000398253.2
ENST00000573161.1
ZFP90
ZFP90 zinc finger protein
chr12_-_31743901 0.24 ENST00000354285.4
DENND5B
DENN/MADD domain containing 5B
chr3_+_107244229 0.23 ENST00000456419.1
ENST00000402163.2
BBX
bobby sox homolog (Drosophila)
chr1_-_47655686 0.23 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr18_+_13218769 0.23 ENST00000399848.3
ENST00000361205.4
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr16_+_640055 0.23 ENST00000568586.1
ENST00000538492.1
ENST00000248139.3
RAB40C
RAB40C, member RAS oncogene family
chrX_-_107019181 0.22 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
TSC22D3
TSC22 domain family, member 3
chr19_+_42381173 0.22 ENST00000221972.3
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr20_+_37554955 0.22 ENST00000217429.4
FAM83D
family with sequence similarity 83, member D
chr2_-_97405775 0.22 ENST00000264963.4
ENST00000537039.1
ENST00000377079.4
ENST00000426463.2
ENST00000534882.1
LMAN2L
lectin, mannose-binding 2-like
chrX_-_118827333 0.21 ENST00000360156.7
ENST00000354228.4
ENST00000489216.1
ENST00000354416.3
ENST00000394610.1
ENST00000343984.5
SEPT6
septin 6
chrX_-_133931164 0.21 ENST00000370790.1
ENST00000298090.6
FAM122B
family with sequence similarity 122B
chr4_+_166248775 0.21 ENST00000261507.6
ENST00000507013.1
ENST00000393766.2
ENST00000504317.1
MSMO1
methylsterol monooxygenase 1
chr2_+_170590321 0.20 ENST00000392647.2
KLHL23
kelch-like family member 23
chr17_-_72542278 0.20 ENST00000330793.1
CD300C
CD300c molecule
chr1_-_202129105 0.20 ENST00000367279.4
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr14_+_67999999 0.20 ENST00000329153.5
PLEKHH1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr6_+_90272027 0.19 ENST00000522441.1
ANKRD6
ankyrin repeat domain 6
chr2_-_69664586 0.19 ENST00000303698.3
ENST00000394305.1
ENST00000410022.2
NFU1
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
chr19_-_54327542 0.19 ENST00000391775.3
ENST00000324134.6
ENST00000535162.1
ENST00000351894.4
ENST00000354278.3
ENST00000391773.1
ENST00000345770.5
ENST00000391772.1
NLRP12
NLR family, pyrin domain containing 12
chr18_+_3262954 0.19 ENST00000584539.1
MYL12B
myosin, light chain 12B, regulatory
chr1_-_202129704 0.18 ENST00000476061.1
ENST00000544762.1
ENST00000467283.1
ENST00000464870.1
ENST00000435759.2
ENST00000486116.1
ENST00000543735.1
ENST00000308986.5
ENST00000477625.1
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr7_+_102715315 0.18 ENST00000428183.2
ENST00000323716.3
ENST00000441711.2
ENST00000454559.1
ENST00000425331.1
ENST00000541300.1
ARMC10
armadillo repeat containing 10
chr6_-_20212630 0.18 ENST00000324607.7
ENST00000541730.1
ENST00000536798.1
MBOAT1
membrane bound O-acyltransferase domain containing 1
chr16_+_68573116 0.18 ENST00000570495.1
ENST00000563169.2
ENST00000564323.1
ENST00000562156.1
ENST00000573685.1
ZFP90
ZFP90 zinc finger protein
chr17_+_43224684 0.18 ENST00000332499.2
HEXIM1
hexamethylene bis-acetamide inducible 1
chr6_-_107077347 0.17 ENST00000369063.3
ENST00000539449.1
RTN4IP1
reticulon 4 interacting protein 1
chr3_-_134369853 0.17 ENST00000508956.1
ENST00000503669.1
ENST00000423778.2
KY
kyphoscoliosis peptidase
chr17_+_75372165 0.17 ENST00000427674.2
SEPT9
septin 9
chrX_+_103173457 0.17 ENST00000419165.1
TMSB15B
thymosin beta 15B
chr6_-_33714667 0.17 ENST00000293756.4
IP6K3
inositol hexakisphosphate kinase 3
chr6_+_292051 0.17 ENST00000344450.5
DUSP22
dual specificity phosphatase 22
chr1_+_159272111 0.16 ENST00000368114.1
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr1_+_27719148 0.16 ENST00000374024.3
GPR3
G protein-coupled receptor 3
chr16_-_70719925 0.16 ENST00000338779.6
MTSS1L
metastasis suppressor 1-like
chr1_+_47264711 0.15 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
CYP4B1
cytochrome P450, family 4, subfamily B, polypeptide 1
chr9_-_99381660 0.15 ENST00000375240.3
ENST00000463569.1
CDC14B
cell division cycle 14B
chr1_+_161551101 0.15 ENST00000367962.4
ENST00000367960.5
ENST00000403078.3
ENST00000428605.2
FCGR2B
Fc fragment of IgG, low affinity IIb, receptor (CD32)
chr6_-_33714752 0.15 ENST00000451316.1
IP6K3
inositol hexakisphosphate kinase 3
chr7_+_131012605 0.14 ENST00000446815.1
ENST00000352689.6
MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr6_+_151561085 0.14 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr11_-_67205538 0.14 ENST00000326294.3
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr20_-_3762087 0.14 ENST00000379756.3
SPEF1
sperm flagellar 1
chr22_+_31090793 0.13 ENST00000332585.6
ENST00000382310.3
ENST00000446658.2
OSBP2
oxysterol binding protein 2
chr22_+_41487711 0.13 ENST00000263253.7
EP300
E1A binding protein p300
chr1_+_173837214 0.13 ENST00000367704.1
ZBTB37
zinc finger and BTB domain containing 37
chr17_+_7905912 0.13 ENST00000254854.4
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr14_+_23842018 0.13 ENST00000397242.2
ENST00000329715.2
IL25
interleukin 25
chr15_+_44580955 0.12 ENST00000345795.2
ENST00000360824.3
CASC4
cancer susceptibility candidate 4
chr19_+_51273721 0.11 ENST00000270590.4
GPR32
G protein-coupled receptor 32
chr4_+_154073469 0.11 ENST00000441616.1
TRIM2
tripartite motif containing 2
chr12_+_69080734 0.11 ENST00000378905.2
NUP107
nucleoporin 107kDa
chr6_+_26087646 0.11 ENST00000309234.6
HFE
hemochromatosis
chr22_-_42084863 0.10 ENST00000401959.1
ENST00000355257.3
NHP2L1
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
chr15_+_44580899 0.10 ENST00000559222.1
ENST00000299957.6
CASC4
cancer susceptibility candidate 4
chr6_-_43021437 0.10 ENST00000265348.3
CUL7
cullin 7
chr1_+_161632937 0.10 ENST00000236937.9
ENST00000367961.4
ENST00000358671.5
FCGR2B
Fc fragment of IgG, low affinity IIb, receptor (CD32)
chr15_+_78832747 0.10 ENST00000560217.1
ENST00000044462.7
ENST00000559082.1
ENST00000559948.1
ENST00000413382.2
ENST00000559146.1
ENST00000558281.1
PSMA4
proteasome (prosome, macropain) subunit, alpha type, 4
chr1_-_145589424 0.10 ENST00000334513.5
NUDT17
nudix (nucleoside diphosphate linked moiety X)-type motif 17
chrX_+_44703249 0.10 ENST00000339042.4
DUSP21
dual specificity phosphatase 21
chrX_+_47092314 0.09 ENST00000218348.3
USP11
ubiquitin specific peptidase 11
chr19_+_50084561 0.09 ENST00000246794.5
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr8_+_9413410 0.09 ENST00000520408.1
ENST00000310430.6
ENST00000522110.1
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr22_-_30662828 0.09 ENST00000403463.1
ENST00000215781.2
OSM
oncostatin M
chr19_+_6372444 0.09 ENST00000245812.3
ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr3_-_98241358 0.09 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
CLDND1
claudin domain containing 1
chr12_-_57410304 0.09 ENST00000441881.1
ENST00000458521.2
TAC3
tachykinin 3
chr6_+_52226897 0.09 ENST00000442253.2
PAQR8
progestin and adipoQ receptor family member VIII
chr16_-_75301886 0.09 ENST00000393422.2
BCAR1
breast cancer anti-estrogen resistance 1
chr19_+_15197791 0.08 ENST00000209540.2
OR1I1
olfactory receptor, family 1, subfamily I, member 1
chr8_-_91095099 0.08 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chrX_+_134124968 0.08 ENST00000330288.4
SMIM10
small integral membrane protein 10
chr5_+_139493665 0.08 ENST00000331327.3
PURA
purine-rich element binding protein A
chr16_+_30759700 0.08 ENST00000328273.7
PHKG2
phosphorylase kinase, gamma 2 (testis)
chr10_-_70092671 0.08 ENST00000358769.2
ENST00000432941.1
ENST00000495025.2
PBLD
phenazine biosynthesis-like protein domain containing
chr6_-_43021612 0.07 ENST00000535468.1
CUL7
cullin 7
chr2_-_198650037 0.07 ENST00000392296.4
BOLL
boule-like RNA-binding protein
chr3_-_52567792 0.07 ENST00000307092.4
ENST00000422318.2
ENST00000459839.1
NT5DC2
5'-nucleotidase domain containing 2
chr10_+_5566916 0.06 ENST00000315238.1
CALML3
calmodulin-like 3
chr20_+_36974759 0.06 ENST00000217407.2
LBP
lipopolysaccharide binding protein
chr5_-_55290773 0.06 ENST00000502326.3
ENST00000381298.2
IL6ST
interleukin 6 signal transducer (gp130, oncostatin M receptor)
chr16_+_640201 0.06 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr19_-_39926555 0.06 ENST00000599539.1
ENST00000339471.4
ENST00000601655.1
ENST00000251453.3
RPS16
ribosomal protein S16
chr10_+_102891048 0.06 ENST00000467928.2
TLX1
T-cell leukemia homeobox 1
chr18_+_3262415 0.06 ENST00000581193.1
ENST00000400175.5
MYL12B
myosin, light chain 12B, regulatory
chr8_-_42751820 0.06 ENST00000526349.1
ENST00000527424.1
ENST00000534961.1
ENST00000319073.4
RNF170
ring finger protein 170
chrX_+_103357202 0.06 ENST00000537356.3
ZCCHC18
zinc finger, CCHC domain containing 18
chr20_+_43343517 0.06 ENST00000372865.4
WISP2
WNT1 inducible signaling pathway protein 2
chr19_+_37825614 0.05 ENST00000591259.1
ENST00000590582.1
HKR1
HKR1, GLI-Kruppel zinc finger family member
chr19_-_36870087 0.05 ENST00000270001.7
ZFP14
ZFP14 zinc finger protein
chr4_+_154074217 0.05 ENST00000437508.2
TRIM2
tripartite motif containing 2
chr1_+_173837488 0.05 ENST00000427304.1
ENST00000432989.1
ENST00000367702.1
ZBTB37
zinc finger and BTB domain containing 37
chr12_-_52946923 0.05 ENST00000267119.5
KRT71
keratin 71
chr10_+_64133934 0.05 ENST00000395254.3
ENST00000395255.3
ENST00000410046.3
ZNF365
zinc finger protein 365
chr20_+_43343476 0.04 ENST00000372868.2
WISP2
WNT1 inducible signaling pathway protein 2
chr10_-_1034237 0.04 ENST00000381466.1
AL359878.1
Uncharacterized protein
chr1_-_155959853 0.04 ENST00000462460.2
ENST00000368316.1
ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr19_+_8455200 0.04 ENST00000601897.1
ENST00000594216.1
RAB11B
RAB11B, member RAS oncogene family
chr17_-_56606664 0.04 ENST00000580844.1
SEPT4
septin 4
chr6_+_88032299 0.04 ENST00000608353.1
ENST00000392863.1
ENST00000229570.5
ENST00000608525.1
ENST00000608868.1
SMIM8
small integral membrane protein 8
chr16_+_6069072 0.04 ENST00000547605.1
ENST00000550418.1
ENST00000553186.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr3_+_23847394 0.03 ENST00000306627.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chrX_+_85403445 0.03 ENST00000373131.1
DACH2
dachshund homolog 2 (Drosophila)
chr2_+_64681641 0.03 ENST00000409537.2
LGALSL
lectin, galactoside-binding-like
chr12_-_69080590 0.03 ENST00000433116.2
ENST00000500695.2
RP11-637A17.2
RP11-637A17.2
chr6_-_136610911 0.03 ENST00000530767.1
ENST00000527759.1
ENST00000527536.1
ENST00000529826.1
ENST00000531224.1
ENST00000353331.4
BCLAF1
BCL2-associated transcription factor 1
chr1_+_36348790 0.03 ENST00000373204.4
AGO1
argonaute RISC catalytic component 1
chrX_-_120066151 0.03 ENST00000419982.2
ENST00000416816.1
CT47A12
cancer/testis antigen family 47, member A12
chr6_-_131277510 0.03 ENST00000525193.1
ENST00000527659.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr15_+_73976715 0.03 ENST00000558689.1
ENST00000560786.2
ENST00000561213.1
ENST00000563584.1
ENST00000561416.1
CD276
CD276 molecule
chr19_-_39926268 0.02 ENST00000599705.1
RPS16
ribosomal protein S16
chr20_+_43343886 0.02 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr22_+_26565440 0.02 ENST00000404234.3
ENST00000529632.2
ENST00000360929.3
ENST00000248933.6
ENST00000343706.4
SEZ6L
seizure related 6 homolog (mouse)-like
chr19_+_41816053 0.02 ENST00000269967.3
CCDC97
coiled-coil domain containing 97
chr21_-_34960930 0.01 ENST00000437395.1
DONSON
downstream neighbor of SON
chr1_+_203097407 0.01 ENST00000367235.1
ADORA1
adenosine A1 receptor
chr4_+_123300121 0.01 ENST00000446706.1
ENST00000296513.2
ADAD1
adenosine deaminase domain containing 1 (testis-specific)
chrX_-_120119638 0.01 ENST00000434414.1
ENST00000433030.1
ENST00000371280.3
CT47A1
cancer/testis antigen family 47, member A1
chrX_+_85403487 0.01 ENST00000373125.4
DACH2
dachshund homolog 2 (Drosophila)
chr13_+_108921977 0.01 ENST00000430559.1
ENST00000375887.4
TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr2_+_171673072 0.00 ENST00000358196.3
ENST00000375272.1
GAD1
glutamate decarboxylase 1 (brain, 67kDa)
chr12_-_123215306 0.00 ENST00000356987.2
ENST00000436083.2
HCAR1
hydroxycarboxylic acid receptor 1
chr5_+_138089100 0.00 ENST00000520339.1
ENST00000355078.5
ENST00000302763.7
ENST00000518910.1
CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr8_-_102181718 0.00 ENST00000565617.1
KB-1460A1.5
KB-1460A1.5

Network of associatons between targets according to the STRING database.

First level regulatory network of NANOG

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.2 6.8 GO:0010669 epithelial structure maintenance(GO:0010669)
0.2 1.1 GO:0061518 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.2 0.5 GO:0035669 TRAM-dependent toll-like receptor signaling pathway(GO:0035668) TRAM-dependent toll-like receptor 4 signaling pathway(GO:0035669)
0.1 0.4 GO:1904437 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) regulation of T cell antigen processing and presentation(GO:0002625) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)
0.1 0.5 GO:0070253 somatostatin secretion(GO:0070253)
0.1 0.8 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.1 0.3 GO:0098904 pulmonary valve formation(GO:0003193) regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) foramen ovale closure(GO:0035922) regulation of AV node cell action potential(GO:0098904) regulation of bundle of His cell action potential(GO:0098905)
0.1 0.3 GO:0001172 transcription, RNA-templated(GO:0001172)
0.1 0.3 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.1 0.4 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.1 0.2 GO:0043318 negative regulation of dendritic cell antigen processing and presentation(GO:0002605) regulation of cytotoxic T cell degranulation(GO:0043317) negative regulation of cytotoxic T cell degranulation(GO:0043318)
0.1 0.2 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.1 0.4 GO:0002636 positive regulation of germinal center formation(GO:0002636) B cell costimulation(GO:0031296)
0.1 0.3 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.1 0.4 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1 0.4 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 0.9 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.1 0.2 GO:0001812 regulation of type I hypersensitivity(GO:0001810) positive regulation of type I hypersensitivity(GO:0001812) type I hypersensitivity(GO:0016068)
0.0 0.2 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.0 0.4 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.3 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 0.4 GO:0034983 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) peptidyl-lysine deacetylation(GO:0034983)
0.0 0.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.2 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.2 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.0 0.2 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.7 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.1 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875) protein auto-ADP-ribosylation(GO:0070213)
0.0 0.2 GO:0018879 biphenyl metabolic process(GO:0018879)
0.0 0.1 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.0 0.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:0009624 response to nematode(GO:0009624) eosinophil differentiation(GO:0030222)
0.0 0.1 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.0 0.2 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.1 GO:0035502 metanephric part of ureteric bud development(GO:0035502)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.4 GO:1990357 terminal web(GO:1990357)
0.1 1.1 GO:0097418 neurofibrillary tangle(GO:0097418)
0.1 0.4 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.1 0.2 GO:0005940 septin ring(GO:0005940) septin collar(GO:0032173)
0.1 0.3 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.2 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.2 GO:1990393 3M complex(GO:1990393)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 0.3 GO:0000974 Prp19 complex(GO:0000974)
0.0 6.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.1 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 6.8 GO:0030274 LIM domain binding(GO:0030274)
0.3 1.4 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.1 0.3 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.1 0.5 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.1 0.3 GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020)
0.1 0.4 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.1 0.2 GO:0008506 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 0.2 GO:0071566 UFM1 activating enzyme activity(GO:0071566)
0.1 0.3 GO:0052839 inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.1 0.4 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 0.3 GO:0043398 HLH domain binding(GO:0043398)
0.1 0.2 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.4 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 0.4 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 0.3 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.1 1.1 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.2 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.4 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.3 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.2 GO:0043426 MRF binding(GO:0043426)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.1 GO:0004915 interleukin-6 receptor activity(GO:0004915) leukemia inhibitory factor receptor activity(GO:0004923) interleukin-6 binding(GO:0019981)
0.0 0.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.4 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.2 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.2 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.0 0.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.2 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.2 GO:0005537 mannose binding(GO:0005537)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.1 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.5 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.8 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.3 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis