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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for NFATC2_NFATC3
Z-value: 0.97
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Transcription factors associated with NFATC2_NFATC3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFATC2 | hg19_v2_chr20_-_50159198_50159299 | 0.60 | 1.5e-03 | Click! |
| NFATC3 | hg19_v2_chr16_+_68119440_68119561 | -0.32 | 1.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFATC2_NFATC3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.0 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.1 | 3.9 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.1 | 3.2 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 2.8 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.0 | 2.8 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.0 | 2.5 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.5 | 2.3 | GO:0033078 | extrathymic T cell differentiation(GO:0033078) |
| 0.5 | 2.0 | GO:2000329 | negative regulation of T-helper 17 cell lineage commitment(GO:2000329) |
| 0.5 | 1.9 | GO:0003409 | optic cup structural organization(GO:0003409) |
| 0.1 | 1.7 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 5.0 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 3.5 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 2.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 1.8 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 1.7 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 1.5 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.1 | 1.5 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 1.1 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 1.0 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.2 | 0.9 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.1 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 3.4 | GO:0032813 | tumor necrosis factor receptor superfamily binding(GO:0032813) |
| 0.1 | 2.8 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.6 | 2.6 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.3 | 2.6 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.4 | 2.1 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.0 | 2.1 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.3 | 1.9 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.1 | 1.8 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 1.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 4.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 2.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 2.1 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.7 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 1.6 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 1.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 1.5 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.9 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 1.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.6 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 1.5 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 1.5 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 1.5 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 1.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 1.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.2 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 1.2 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |