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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NFATC4

Z-value: 1.58

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Transcription factors associated with NFATC4

Gene Symbol Gene ID Gene Info
ENSG00000100968.9 nuclear factor of activated T cells 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFATC4hg19_v2_chr14_+_24837226_248375470.405.0e-02Click!

Activity profile of NFATC4 motif

Sorted Z-values of NFATC4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_156587853 14.64 ENST00000506455.1
ENST00000511108.1
guanylate cyclase 1, soluble, alpha 3
chr13_-_72441315 13.01 ENST00000305425.4
ENST00000313174.7
ENST00000354591.4
dachshund homolog 1 (Drosophila)
chr4_+_156587979 10.17 ENST00000511507.1
guanylate cyclase 1, soluble, alpha 3
chr4_+_156588115 10.01 ENST00000455639.2
guanylate cyclase 1, soluble, alpha 3
chr4_+_156588249 9.97 ENST00000393832.3
guanylate cyclase 1, soluble, alpha 3
chr10_-_116444371 9.35 ENST00000533213.2
ENST00000369252.4
actin binding LIM protein 1
chr3_-_149051444 6.76 ENST00000296059.2
transmembrane 4 L six family member 18
chr4_+_41540160 6.75 ENST00000503057.1
ENST00000511496.1
LIM and calponin homology domains 1
chr12_+_27396901 6.49 ENST00000541191.1
ENST00000389032.3
serine/threonine kinase 38 like
chr3_-_18480260 6.23 ENST00000454909.2
SATB homeobox 1
chr1_+_164528866 6.05 ENST00000420696.2
pre-B-cell leukemia homeobox 1
chr13_-_72440901 5.82 ENST00000359684.2
dachshund homolog 1 (Drosophila)
chr1_+_61869748 5.32 ENST00000357977.5
nuclear factor I/A
chr4_-_70626314 4.86 ENST00000510821.1
sulfotransferase family, cytosolic, 1B, member 1
chr3_-_149051194 4.21 ENST00000470080.1
transmembrane 4 L six family member 18
chr12_+_51318513 3.99 ENST00000332160.4
methyltransferase like 7A
chr1_+_61547894 3.91 ENST00000403491.3
nuclear factor I/A
chr14_-_30396948 3.80 ENST00000331968.5
protein kinase D1
chr10_-_131762105 3.72 ENST00000368648.3
ENST00000355311.5
early B-cell factor 3
chr10_-_33623564 3.56 ENST00000374875.1
ENST00000374822.4
neuropilin 1
chr14_-_92413353 3.47 ENST00000556154.1
fibulin 5
chr1_+_78470530 3.40 ENST00000370763.5
DnaJ (Hsp40) homolog, subfamily B, member 4
chr1_+_82266053 3.39 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
latrophilin 2
chr22_-_29107919 3.25 ENST00000434810.1
ENST00000456369.1
checkpoint kinase 2
chr12_-_9268707 3.09 ENST00000318602.7
alpha-2-macroglobulin
chr12_+_13349650 2.97 ENST00000256951.5
ENST00000431267.2
ENST00000542474.1
ENST00000544053.1
epithelial membrane protein 1
chr12_-_59314246 2.69 ENST00000320743.3
leucine-rich repeats and immunoglobulin-like domains 3
chr2_+_191208196 2.60 ENST00000392329.2
ENST00000322522.4
ENST00000430311.1
ENST00000541441.1
inositol polyphosphate-1-phosphatase
chr2_+_173600514 2.57 ENST00000264111.6
Rap guanine nucleotide exchange factor (GEF) 4
chr15_-_52587945 2.55 ENST00000443683.2
ENST00000558479.1
ENST00000261839.7
myosin VC
chr19_+_11200038 2.52 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
low density lipoprotein receptor
chr1_-_145470383 2.50 ENST00000369314.1
ENST00000369313.3
polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like
chr2_+_173600565 2.50 ENST00000397081.3
Rap guanine nucleotide exchange factor (GEF) 4
chr3_-_27764190 2.43 ENST00000537516.1
eomesodermin
chr5_-_88178964 2.42 ENST00000513252.1
ENST00000508569.1
ENST00000510942.1
ENST00000506554.1
myocyte enhancer factor 2C
chr5_-_88179017 2.34 ENST00000514028.1
ENST00000514015.1
ENST00000503075.1
ENST00000437473.2
myocyte enhancer factor 2C
chr8_-_19459993 2.32 ENST00000454498.2
ENST00000520003.1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr12_+_9142131 2.31 ENST00000356986.3
ENST00000266551.4
killer cell lectin-like receptor subfamily G, member 1
chr11_+_123986069 2.30 ENST00000456829.2
ENST00000361352.5
ENST00000449321.1
ENST00000392748.1
ENST00000360334.4
ENST00000392744.4
von Willebrand factor A domain containing 5A
chr14_-_74551096 2.30 ENST00000350259.4
aldehyde dehydrogenase 6 family, member A1
chr21_+_17791648 2.25 ENST00000602892.1
ENST00000418813.2
ENST00000435697.1
long intergenic non-protein coding RNA 478
chrX_+_86772787 2.23 ENST00000373114.4
kelch-like family member 4
chr21_+_17791838 2.16 ENST00000453910.1
long intergenic non-protein coding RNA 478
chr7_-_120498357 2.14 ENST00000415871.1
ENST00000222747.3
ENST00000430985.1
tetraspanin 12
chrX_+_46433193 2.12 ENST00000276055.3
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
chr14_+_21156915 2.11 ENST00000397990.4
ENST00000555597.1
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr9_-_13165457 2.11 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
multiple PDZ domain protein
chr12_+_57482665 2.10 ENST00000300131.3
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr14_-_89883412 2.04 ENST00000557258.1
forkhead box N3
chr14_+_100531615 2.02 ENST00000392920.3
Enah/Vasp-like
chr14_-_30396802 1.99 ENST00000415220.2
protein kinase D1
chr8_+_98900132 1.97 ENST00000520016.1
matrilin 2
chr11_+_66824276 1.92 ENST00000308831.2
ras homolog family member D
chr8_+_70404996 1.78 ENST00000402687.4
ENST00000419716.3
sulfatase 1
chr22_-_39548627 1.77 ENST00000216133.5
chromobox homolog 7
chr12_-_10007448 1.75 ENST00000538152.1
C-type lectin domain family 2, member B
chr17_-_38938786 1.73 ENST00000301656.3
keratin 27
chr5_-_112630598 1.71 ENST00000302475.4
mutated in colorectal cancers
chr3_-_112329110 1.61 ENST00000479368.1
coiled-coil domain containing 80
chr7_-_64023410 1.61 ENST00000447137.2
zinc finger protein 680
chr22_+_38201114 1.61 ENST00000340857.2
H1 histone family, member 0
chr19_+_39759154 1.53 ENST00000331982.5
interferon, lambda 2
chr14_+_38677123 1.53 ENST00000267377.2
somatostatin receptor 1
chr12_+_101988774 1.53 ENST00000545503.2
ENST00000536007.1
ENST00000541119.1
ENST00000361466.2
ENST00000551300.1
ENST00000550270.1
myosin binding protein C, slow type
chr2_-_101767715 1.51 ENST00000376840.4
ENST00000409318.1
TBC1 domain family, member 8 (with GRAM domain)
chr20_-_45985172 1.49 ENST00000536340.1
zinc finger, MYND-type containing 8
chr20_+_33464238 1.47 ENST00000360596.2
acyl-CoA synthetase short-chain family member 2
chr9_-_113100088 1.45 ENST00000374510.4
ENST00000423740.2
ENST00000374511.3
ENST00000374507.4
thioredoxin domain containing 8 (spermatozoa)
chr19_-_39735646 1.45 ENST00000413851.2
interferon, lambda 3
chr11_+_101983176 1.45 ENST00000524575.1
Yes-associated protein 1
chr8_+_28747884 1.37 ENST00000287701.10
ENST00000444075.1
ENST00000403668.2
ENST00000519662.1
ENST00000558662.1
ENST00000523613.1
ENST00000560599.1
ENST00000397358.3
homeobox containing 1
chr17_+_36584662 1.35 ENST00000431231.2
ENST00000437668.3
Rho GTPase activating protein 23
chrX_+_86772707 1.35 ENST00000373119.4
kelch-like family member 4
chr8_-_28747424 1.32 ENST00000523436.1
ENST00000397363.4
ENST00000521777.1
ENST00000520184.1
ENST00000521022.1
integrator complex subunit 9
chr1_+_162602244 1.27 ENST00000367922.3
ENST00000367921.3
discoidin domain receptor tyrosine kinase 2
chr5_+_36152163 1.27 ENST00000274255.6
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr11_-_124981475 1.27 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
transmembrane protein 218
chr5_+_36152091 1.26 ENST00000274254.5
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr5_-_42812143 1.26 ENST00000514985.1
selenoprotein P, plasma, 1
chr14_-_74551172 1.26 ENST00000553458.1
aldehyde dehydrogenase 6 family, member A1
chr5_+_140254884 1.26 ENST00000398631.2
protocadherin alpha 12
chr1_+_158979792 1.24 ENST00000359709.3
ENST00000430894.2
interferon, gamma-inducible protein 16
chr10_-_126694575 1.24 ENST00000334808.6
C-terminal binding protein 2
chr12_+_101988627 1.24 ENST00000547405.1
ENST00000452455.2
ENST00000441232.1
ENST00000360610.2
ENST00000392934.3
ENST00000547509.1
ENST00000361685.2
ENST00000549145.1
ENST00000553190.1
myosin binding protein C, slow type
chr8_-_28747717 1.23 ENST00000416984.2
integrator complex subunit 9
chr3_-_149375783 1.22 ENST00000467467.1
ENST00000460517.1
ENST00000360632.3
WW domain containing transcription regulator 1
chr8_+_11666649 1.21 ENST00000528643.1
ENST00000525777.1
farnesyl-diphosphate farnesyltransferase 1
chr2_-_191115229 1.20 ENST00000409820.2
ENST00000410045.1
3-hydroxyisobutyryl-CoA hydrolase
chr14_-_75593708 1.20 ENST00000557673.1
ENST00000238616.5
NIMA-related kinase 9
chr20_-_45985414 1.19 ENST00000461685.1
ENST00000372023.3
ENST00000540497.1
ENST00000435836.1
ENST00000471951.2
ENST00000352431.2
ENST00000396281.4
ENST00000355972.4
ENST00000360911.3
zinc finger, MYND-type containing 8
chr20_+_35201993 1.17 ENST00000373872.4
TGFB-induced factor homeobox 2
chr19_+_30863271 1.17 ENST00000355537.3
zinc finger protein 536
chr1_+_36789335 1.16 ENST00000373137.2
RP11-268J15.5
chr20_-_45985464 1.15 ENST00000458360.2
ENST00000262975.4
zinc finger, MYND-type containing 8
chr6_+_90272027 1.12 ENST00000522441.1
ankyrin repeat domain 6
chr4_+_144434584 1.10 ENST00000283131.3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chrX_+_10124977 1.09 ENST00000380833.4
chloride channel, voltage-sensitive 4
chr9_+_134065506 1.07 ENST00000483497.2
nucleoporin 214kDa
chr17_+_7792101 1.07 ENST00000358181.4
ENST00000330494.7
chromodomain helicase DNA binding protein 3
chr17_+_76311791 1.07 ENST00000586321.1
AC061992.2
chr2_+_189839046 1.06 ENST00000304636.3
ENST00000317840.5
collagen, type III, alpha 1
chr17_+_37793318 1.06 ENST00000336308.5
StAR-related lipid transfer (START) domain containing 3
chr1_-_52521831 1.05 ENST00000371626.4
thioredoxin domain containing 12 (endoplasmic reticulum)
chr6_+_155537771 1.04 ENST00000275246.7
T-cell lymphoma invasion and metastasis 2
chr3_-_27763803 1.04 ENST00000449599.1
eomesodermin
chr7_+_138943265 1.03 ENST00000483726.1
ubinuclein 2
chr17_+_73452545 1.03 ENST00000314256.7
KIAA0195
chr2_+_220306745 1.01 ENST00000431523.1
ENST00000396698.1
ENST00000396695.2
SPEG complex locus
chr1_-_68698197 1.01 ENST00000370973.2
ENST00000370971.1
wntless Wnt ligand secretion mediator
chr2_-_97405775 1.00 ENST00000264963.4
ENST00000537039.1
ENST00000377079.4
ENST00000426463.2
ENST00000534882.1
lectin, mannose-binding 2-like
chr4_-_89744457 1.00 ENST00000395002.2
family with sequence similarity 13, member A
chr11_+_65190245 0.99 ENST00000499732.1
ENST00000501122.2
ENST00000601801.1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr8_-_120685608 0.98 ENST00000427067.2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr17_+_37793378 0.98 ENST00000544210.2
ENST00000581894.1
ENST00000394250.4
ENST00000579479.1
ENST00000577248.1
ENST00000580611.1
StAR-related lipid transfer (START) domain containing 3
chr1_+_164529004 0.96 ENST00000559240.1
ENST00000367897.1
ENST00000540236.1
ENST00000401534.1
pre-B-cell leukemia homeobox 1
chr2_-_242089677 0.96 ENST00000405260.1
PAS domain containing serine/threonine kinase
chr15_+_32933866 0.96 ENST00000300175.4
ENST00000413748.2
ENST00000494364.1
ENST00000497208.1
secretogranin V (7B2 protein)
chr10_-_62704005 0.96 ENST00000337910.5
Rho-related BTB domain containing 1
chr5_+_118812237 0.95 ENST00000513628.1
hydroxysteroid (17-beta) dehydrogenase 4
chr2_+_27301435 0.94 ENST00000380320.4
elastin microfibril interfacer 1
chr5_+_118812294 0.94 ENST00000509514.1
hydroxysteroid (17-beta) dehydrogenase 4
chrX_-_134478012 0.94 ENST00000370766.3
zinc finger protein 75D
chr14_+_85996507 0.94 ENST00000554746.1
fibronectin leucine rich transmembrane protein 2
chr4_-_166034029 0.93 ENST00000306480.6
transmembrane protein 192
chr17_+_58499844 0.93 ENST00000269127.4
chromosome 17 open reading frame 64
chr14_+_75988768 0.93 ENST00000286639.6
basic leucine zipper transcription factor, ATF-like
chr3_+_15643476 0.92 ENST00000436193.1
ENST00000383778.4
biotinidase
chrX_-_20236970 0.91 ENST00000379548.4
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr3_-_58200398 0.91 ENST00000318316.3
ENST00000460422.1
ENST00000483681.1
deoxyribonuclease I-like 3
chr11_+_36616355 0.91 ENST00000532470.2
chromosome 11 open reading frame 74
chr6_-_26235206 0.91 ENST00000244534.5
histone cluster 1, H1d
chr5_+_43603229 0.91 ENST00000344920.4
ENST00000512996.2
nicotinamide nucleotide transhydrogenase
chr15_+_65914260 0.91 ENST00000261892.6
ENST00000339868.6
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr15_-_59665062 0.90 ENST00000288235.4
myosin IE
chr20_-_17539456 0.90 ENST00000544874.1
ENST00000377868.2
beaded filament structural protein 1, filensin
chr1_+_158979686 0.89 ENST00000368132.3
ENST00000295809.7
interferon, gamma-inducible protein 16
chr1_+_158979680 0.88 ENST00000368131.4
ENST00000340979.6
interferon, gamma-inducible protein 16
chr18_-_60986962 0.88 ENST00000333681.4
B-cell CLL/lymphoma 2
chr2_+_204193101 0.88 ENST00000430418.1
ENST00000424558.1
ENST00000261016.6
abl-interactor 2
chr11_-_62474803 0.87 ENST00000533982.1
ENST00000360796.5
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr10_-_11574274 0.86 ENST00000277575.5
USP6 N-terminal like
chr1_+_163038565 0.85 ENST00000421743.2
regulator of G-protein signaling 4
chrX_+_129473916 0.85 ENST00000545805.1
ENST00000543953.1
ENST00000218197.5
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr14_-_92588246 0.85 ENST00000329559.3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr13_+_114462193 0.84 ENST00000375353.3
transmembrane protein 255B
chrX_-_77041685 0.83 ENST00000373344.5
ENST00000395603.3
alpha thalassemia/mental retardation syndrome X-linked
chr2_+_204193149 0.81 ENST00000422511.2
abl-interactor 2
chrX_-_63425561 0.79 ENST00000374869.3
ENST00000330258.3
APC membrane recruitment protein 1
chr14_-_68162464 0.79 ENST00000553384.1
ENST00000557726.1
ENST00000381346.4
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr1_-_155881156 0.79 ENST00000539040.1
ENST00000368323.3
Ras-like without CAAX 1
chr15_-_37393406 0.79 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
Meis homeobox 2
chr6_-_110736742 0.77 ENST00000368924.3
ENST00000368923.3
D-aspartate oxidase
chrX_-_139015153 0.77 ENST00000370557.1
ATPase, class VI, type 11C
chr3_-_98241760 0.77 ENST00000507874.1
ENST00000502299.1
ENST00000508659.1
ENST00000510545.1
ENST00000511667.1
ENST00000394185.2
ENST00000394181.2
ENST00000508902.1
ENST00000341181.6
ENST00000437922.1
ENST00000394180.2
claudin domain containing 1
chr2_+_204193129 0.77 ENST00000417864.1
abl-interactor 2
chr17_+_45331184 0.77 ENST00000559488.1
ENST00000571680.1
ENST00000435993.2
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
chr5_+_74011328 0.76 ENST00000513336.1
hexosaminidase B (beta polypeptide)
chr5_+_154238149 0.75 ENST00000519430.1
ENST00000520671.1
ENST00000521583.1
ENST00000518028.1
ENST00000519404.1
ENST00000519394.1
ENST00000518775.1
CCR4-NOT transcription complex, subunit 8
chr5_-_42811986 0.75 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
selenoprotein P, plasma, 1
chr3_-_114035026 0.74 ENST00000570269.1
RP11-553L6.5
chr17_-_5026397 0.74 ENST00000250076.3
zinc finger protein 232
chr15_-_90892669 0.74 ENST00000412799.2
GABA(A) receptors associated protein like 3, pseudogene
chr6_-_27841289 0.73 ENST00000355981.2
histone cluster 1, H4l
chr1_-_246357029 0.73 ENST00000391836.2
SET and MYND domain containing 3
chr14_+_54863739 0.72 ENST00000541304.1
cyclin-dependent kinase inhibitor 3
chr2_+_204192942 0.72 ENST00000295851.5
ENST00000261017.5
abl-interactor 2
chr17_-_17740287 0.71 ENST00000355815.4
ENST00000261646.5
sterol regulatory element binding transcription factor 1
chr14_+_85996471 0.71 ENST00000330753.4
fibronectin leucine rich transmembrane protein 2
chr3_+_98451093 0.70 ENST00000483910.1
ENST00000460774.1
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr14_+_54863682 0.69 ENST00000543789.2
ENST00000442975.2
ENST00000458126.2
ENST00000556102.2
cyclin-dependent kinase inhibitor 3
chr2_-_179343226 0.69 ENST00000434643.2
FK506 binding protein 7
chr4_-_72649763 0.68 ENST00000513476.1
group-specific component (vitamin D binding protein)
chr4_-_84256024 0.67 ENST00000311412.5
heparanase
chr9_+_128509624 0.67 ENST00000342287.5
ENST00000373487.4
pre-B-cell leukemia homeobox 3
chr1_-_161039753 0.67 ENST00000368015.1
Rho GTPase activating protein 30
chr7_-_99679324 0.67 ENST00000292393.5
ENST00000413658.2
ENST00000412947.1
ENST00000441298.1
ENST00000449785.1
ENST00000299667.4
ENST00000424697.1
zinc finger protein 3
chr2_-_179343268 0.67 ENST00000424785.2
FK506 binding protein 7
chr1_-_234667504 0.66 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
chr5_+_43602750 0.66 ENST00000505678.2
ENST00000512422.1
ENST00000264663.5
nicotinamide nucleotide transhydrogenase
chr7_+_73442422 0.65 ENST00000358929.4
ENST00000431562.1
ENST00000320492.7
ENST00000438906.1
elastin
chr19_+_41869894 0.65 ENST00000413014.2
transmembrane protein 91
chr1_-_161039647 0.65 ENST00000368013.3
Rho GTPase activating protein 30
chr11_-_110460409 0.65 ENST00000529591.1
Rho GTPase activating protein 20
chr11_+_22696314 0.64 ENST00000532398.1
ENST00000433790.1
growth arrest-specific 2
chr1_-_169599353 0.64 ENST00000367793.2
ENST00000367794.2
ENST00000367792.2
ENST00000367791.2
ENST00000367788.2
selectin P (granule membrane protein 140kDa, antigen CD62)
chr1_-_169599314 0.64 ENST00000367786.2
ENST00000458599.2
ENST00000367795.2
ENST00000263686.6
selectin P (granule membrane protein 140kDa, antigen CD62)
chr17_+_38024417 0.64 ENST00000348931.4
ENST00000583811.1
ENST00000584588.1
ENST00000377940.3
zona pellucida binding protein 2
chr3_-_114790179 0.63 ENST00000462705.1
zinc finger and BTB domain containing 20
chr7_+_73442457 0.63 ENST00000438880.1
ENST00000414324.1
ENST00000380562.4
elastin
chr16_-_86588627 0.63 ENST00000565482.1
ENST00000564364.1
ENST00000561989.1
ENST00000543303.2
ENST00000381214.5
ENST00000360900.6
ENST00000322911.6
ENST00000546093.1
ENST00000569000.1
ENST00000562994.1
ENST00000561522.1
methenyltetrahydrofolate synthetase domain containing
chr14_+_54863667 0.62 ENST00000335183.6
cyclin-dependent kinase inhibitor 3
chr7_+_73442487 0.62 ENST00000380575.4
ENST00000380584.4
ENST00000458204.1
ENST00000357036.5
ENST00000417091.1
ENST00000429192.1
ENST00000442310.1
ENST00000380553.4
ENST00000380576.5
ENST00000428787.1
ENST00000320399.6
elastin
chr19_-_17488143 0.62 ENST00000599426.1
ENST00000252590.4
plasmalemma vesicle associated protein
chr19_-_2427863 0.62 ENST00000215570.3
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr3_+_130279178 0.61 ENST00000358511.6
ENST00000453409.2
collagen, type VI, alpha 6
chr6_+_122720681 0.60 ENST00000368455.4
ENST00000452194.1
heat shock transcription factor 2
chr12_+_57916584 0.60 ENST00000546632.1
ENST00000549623.1
ENST00000431731.2
methyl-CpG binding domain protein 6
chr6_-_41715128 0.59 ENST00000356667.4
ENST00000373025.3
ENST00000425343.2
progastricsin (pepsinogen C)
chr7_-_64023441 0.59 ENST00000309683.6
zinc finger protein 680
chr17_+_16120512 0.59 ENST00000581006.1
ENST00000584797.1
ENST00000498772.2
ENST00000225609.5
ENST00000395844.4
ENST00000477745.1
phosphatidylinositol glycan anchor biosynthesis, class L

Network of associatons between targets according to the STRING database.

First level regulatory network of NFATC4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.5 44.8 GO:0052565 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
2.4 18.8 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
1.2 4.8 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
1.2 3.5 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.1 3.2 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.9 3.6 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.8 5.8 GO:0089700 protein kinase D signaling(GO:0089700)
0.8 4.1 GO:1904835 vestibulocochlear nerve structural organization(GO:0021649) neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) positive regulation of retinal ganglion cell axon guidance(GO:1902336) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.6 3.8 GO:1903758 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.6 2.5 GO:0090118 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) positive regulation of lysosomal protein catabolic process(GO:1905167)
0.6 2.9 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.6 2.3 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.5 2.7 GO:0032474 otolith morphogenesis(GO:0032474)
0.4 1.8 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.4 6.7 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.4 1.5 GO:0019413 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.4 2.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.4 2.1 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.3 9.2 GO:0072189 ureter development(GO:0072189)
0.3 1.9 GO:0036111 very long-chain fatty-acyl-CoA metabolic process(GO:0036111)
0.3 1.6 GO:0006740 NADPH regeneration(GO:0006740)
0.3 0.9 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.3 1.5 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.3 1.2 GO:0006574 valine catabolic process(GO:0006574)
0.3 3.2 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.3 0.9 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.3 0.6 GO:0002625 regulation of T cell antigen processing and presentation(GO:0002625)
0.3 1.6 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.3 7.0 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.3 3.5 GO:0048251 elastic fiber assembly(GO:0048251)
0.3 0.8 GO:2000777 positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.3 0.8 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.3 1.0 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.2 1.2 GO:0006696 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.2 3.1 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.2 2.5 GO:0016584 nucleosome positioning(GO:0016584)
0.2 0.8 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.2 2.7 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.2 2.0 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.2 4.9 GO:0006068 ethanol catabolic process(GO:0006068)
0.2 1.0 GO:0086053 AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
0.2 0.8 GO:0072161 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.2 1.4 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.2 0.5 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.2 2.1 GO:0001675 acrosome assembly(GO:0001675)
0.2 1.9 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.2 0.8 GO:0007619 courtship behavior(GO:0007619)
0.1 0.6 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.1 2.5 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 3.0 GO:0032060 bleb assembly(GO:0032060)
0.1 1.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.4 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.1 0.9 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.1 1.3 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.1 1.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 1.0 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.1 1.5 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 2.1 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.1 10.7 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 0.3 GO:0044029 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 0.9 GO:0051552 flavone metabolic process(GO:0051552)
0.1 0.5 GO:1904383 response to sodium phosphate(GO:1904383)
0.1 2.6 GO:0016180 snRNA processing(GO:0016180)
0.1 0.6 GO:0002760 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.1 0.7 GO:0007386 compartment pattern specification(GO:0007386)
0.1 2.0 GO:0009642 response to light intensity(GO:0009642)
0.1 0.4 GO:0014859 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.1 0.3 GO:0007418 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.1 0.5 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.1 0.8 GO:0002329 pre-B cell differentiation(GO:0002329)
0.1 1.9 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.1 1.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 0.2 GO:0060152 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.1 0.4 GO:0048850 hypophysis morphogenesis(GO:0048850)
0.1 1.4 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 1.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.3 GO:1903679 adenosine to inosine editing(GO:0006382) regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
0.1 1.0 GO:1902745 positive regulation of lamellipodium organization(GO:1902745) positive regulation of lamellipodium morphogenesis(GO:2000394)
0.1 0.2 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.1 2.6 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.1 0.3 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.2 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.1 0.3 GO:1902896 terminal web assembly(GO:1902896)
0.1 1.2 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 0.9 GO:0070307 lens fiber cell development(GO:0070307)
0.1 0.6 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.3 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.1 2.1 GO:0010842 retina layer formation(GO:0010842)
0.1 1.0 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 0.3 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.1 1.7 GO:0031069 hair follicle morphogenesis(GO:0031069)
0.1 0.3 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 1.2 GO:0002320 lymphoid progenitor cell differentiation(GO:0002320)
0.1 5.1 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.1 3.0 GO:0032731 positive regulation of interleukin-1 beta production(GO:0032731)
0.1 0.3 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.1 0.3 GO:1904995 negative regulation of leukocyte tethering or rolling(GO:1903237) negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995)
0.1 0.4 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.1 0.3 GO:0060737 prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.1 0.4 GO:1903232 melanosome assembly(GO:1903232)
0.1 0.3 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 0.2 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
0.1 0.2 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.1 0.3 GO:0035672 oligopeptide transmembrane transport(GO:0035672)
0.1 0.5 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 0.2 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.1 GO:0032416 negative regulation of sodium:proton antiporter activity(GO:0032416)
0.0 0.5 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.0 0.5 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.0 0.8 GO:0006768 biotin metabolic process(GO:0006768)
0.0 0.4 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.2 GO:0048539 bone marrow development(GO:0048539)
0.0 0.7 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.5 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 1.3 GO:0097503 sialylation(GO:0097503)
0.0 0.4 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 3.1 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 1.0 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.0 2.5 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.5 GO:0002347 response to tumor cell(GO:0002347)
0.0 0.6 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.9 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.0 0.0 GO:0007521 muscle cell fate determination(GO:0007521)
0.0 0.9 GO:0050995 negative regulation of lipid catabolic process(GO:0050995)
0.0 0.5 GO:0032754 positive regulation of interleukin-5 production(GO:0032754)
0.0 0.6 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.0 0.2 GO:0003062 regulation of heart rate by chemical signal(GO:0003062)
0.0 0.2 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0 0.2 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.0 0.2 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 2.1 GO:0007077 mitotic nuclear envelope disassembly(GO:0007077)
0.0 0.2 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0 2.2 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 0.1 GO:0001507 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.0 0.4 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 1.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 2.6 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 0.9 GO:0070207 protein homotrimerization(GO:0070207)
0.0 1.6 GO:0031102 neuron projection regeneration(GO:0031102)
0.0 0.6 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.4 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.8 GO:0002385 mucosal immune response(GO:0002385)
0.0 0.9 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 1.1 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 0.2 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.4 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.1 GO:2000546 positive regulation of fat cell proliferation(GO:0070346) positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.3 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.9 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.4 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.3 GO:0045008 depyrimidination(GO:0045008)
0.0 0.7 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.0 0.3 GO:0090312 positive regulation of protein deacetylation(GO:0090312)
0.0 0.2 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 0.1 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 2.0 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.0 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.7 GO:0051180 vitamin transport(GO:0051180)
0.0 0.3 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:0007207 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 1.5 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.2 GO:0044351 macropinocytosis(GO:0044351)
0.0 0.8 GO:0006968 cellular defense response(GO:0006968)
0.0 1.1 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 0.1 GO:0019530 taurine metabolic process(GO:0019530)
0.0 0.0 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.0 0.6 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.0 0.1 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.0 0.8 GO:0045638 negative regulation of myeloid cell differentiation(GO:0045638)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 44.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.8 2.5 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.6 5.9 GO:0071953 elastic fiber(GO:0071953)
0.5 4.1 GO:0097443 sorting endosome(GO:0097443)
0.4 1.4 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.4 1.1 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.4 2.1 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.3 0.8 GO:0031933 telomeric heterochromatin(GO:0031933)
0.3 1.1 GO:0031213 RSF complex(GO:0031213)
0.2 3.2 GO:0031209 SCAR complex(GO:0031209)
0.2 2.6 GO:0032039 integrator complex(GO:0032039)
0.2 0.8 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.2 0.5 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.1 0.9 GO:1990357 terminal web(GO:1990357)
0.1 6.5 GO:0000421 autophagosome membrane(GO:0000421)
0.1 2.9 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.1 5.0 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 1.8 GO:0035102 PRC1 complex(GO:0035102)
0.1 1.2 GO:0097470 ribbon synapse(GO:0097470)
0.1 2.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 1.3 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 3.0 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 1.8 GO:0044232 organelle membrane contact site(GO:0044232)
0.1 2.3 GO:0032982 myosin filament(GO:0032982)
0.1 0.6 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 0.3 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.1 0.8 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 8.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.8 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.1 1.0 GO:0008091 spectrin(GO:0008091)
0.1 0.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.0 2.0 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.5 GO:0032584 growth cone membrane(GO:0032584)
0.0 3.0 GO:0043198 dendritic shaft(GO:0043198)
0.0 2.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 3.3 GO:0016459 myosin complex(GO:0016459)
0.0 20.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.0 GO:0005922 connexon complex(GO:0005922)
0.0 1.1 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 2.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.1 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279)
0.0 1.2 GO:0008305 integrin complex(GO:0008305)
0.0 0.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.4 GO:0010369 chromocenter(GO:0010369)
0.0 3.3 GO:0005604 basement membrane(GO:0005604)
0.0 0.6 GO:0005861 troponin complex(GO:0005861)
0.0 0.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.3 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 2.4 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 3.2 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 1.1 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 1.7 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 2.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.5 GO:0005811 lipid particle(GO:0005811)
0.0 0.5 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.9 GO:0016235 aggresome(GO:0016235)
0.0 0.5 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.5 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.1 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.4 GO:0097542 ciliary tip(GO:0097542)
0.0 1.8 GO:0005795 Golgi stack(GO:0005795)
0.0 0.1 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.3 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 44.8 GO:0004383 guanylate cyclase activity(GO:0004383)
1.1 18.8 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
1.0 3.1 GO:0019959 interleukin-8 binding(GO:0019959)
0.8 2.3 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.5 1.6 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.4 2.5 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.4 6.4 GO:0003680 AT DNA binding(GO:0003680)
0.3 3.5 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.3 1.3 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.3 1.9 GO:0044594 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594)
0.3 0.9 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.3 1.5 GO:0004994 somatostatin receptor activity(GO:0004994)
0.3 1.2 GO:0004310 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.3 2.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.3 2.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.3 0.9 GO:0030626 U12 snRNA binding(GO:0030626)
0.3 1.8 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 1.5 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.3 0.8 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.3 1.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 1.0 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.2 2.6 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.2 0.9 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.2 0.9 GO:0047708 biotinidase activity(GO:0047708)
0.2 5.8 GO:0004697 protein kinase C activity(GO:0004697)
0.2 1.3 GO:0042806 fucose binding(GO:0042806)
0.2 0.8 GO:0015616 DNA translocase activity(GO:0015616)
0.2 1.0 GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.2 4.9 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.2 1.2 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.2 0.9 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 1.3 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1 1.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 4.6 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.6 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.1 2.4 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.1 2.8 GO:0031432 titin binding(GO:0031432)
0.1 3.6 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 0.5 GO:0005042 netrin receptor activity(GO:0005042)
0.1 1.4 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 0.7 GO:0005499 vitamin D binding(GO:0005499)
0.1 2.0 GO:0005522 profilin binding(GO:0005522)
0.1 3.8 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.3 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.1 1.0 GO:0042731 PH domain binding(GO:0042731)
0.1 0.3 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.1 0.4 GO:0035650 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.1 0.8 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.1 5.1 GO:0030552 cAMP binding(GO:0030552)
0.1 3.4 GO:0001671 ATPase activator activity(GO:0001671)
0.1 1.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 2.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.8 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 1.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 0.2 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.1 0.3 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.1 0.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.5 GO:0016403 dimethylargininase activity(GO:0016403)
0.1 0.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.2 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.1 1.3 GO:0016289 CoA hydrolase activity(GO:0016289)
0.1 1.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 1.6 GO:0017127 cholesterol transporter activity(GO:0017127)
0.1 0.4 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.1 0.1 GO:1990763 arrestin family protein binding(GO:1990763)
0.1 1.0 GO:0005537 mannose binding(GO:0005537)
0.0 0.3 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 1.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 2.5 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 1.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.3 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 1.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.3 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.1 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.0 0.2 GO:0032810 sterol response element binding(GO:0032810)
0.0 2.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.6 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 3.5 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 0.5 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.4 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.3 GO:0048156 tau protein binding(GO:0048156)
0.0 0.4 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.3 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.9 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.7 GO:0031404 chloride ion binding(GO:0031404)
0.0 0.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.9 GO:0001972 retinoic acid binding(GO:0001972)
0.0 1.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 21.0 GO:0003779 actin binding(GO:0003779)
0.0 0.8 GO:0071949 FAD binding(GO:0071949)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 13.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.0 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.0 0.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 1.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.5 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.5 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.2 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.6 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 1.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 1.1 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.2 GO:0019763 immunoglobulin receptor activity(GO:0019763) IgE binding(GO:0019863)
0.0 5.2 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.1 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 4.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.1 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.9 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 3.3 GO:0008168 methyltransferase activity(GO:0008168)
0.0 0.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.2 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.2 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.5 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 0.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 9.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 5.9 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 6.0 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 6.1 PID IGF1 PATHWAY IGF1 pathway
0.1 7.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 2.0 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 2.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.9 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.9 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 2.1 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.0 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 0.9 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 1.3 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.3 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.0 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.4 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.7 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 3.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.2 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 1.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.6 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 45.0 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.3 9.8 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.3 4.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 4.8 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 2.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 4.9 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 3.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 3.1 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 3.1 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 4.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 5.1 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 3.9 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 2.5 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 1.9 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 2.0 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 7.1 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 1.2 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 2.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 0.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 0.2 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.1 0.8 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.1 1.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 2.9 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.5 REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0 1.7 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.9 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 1.2 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 2.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.8 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.1 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involve