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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NFIA

Z-value: 0.64

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Transcription factors associated with NFIA

Gene Symbol Gene ID Gene Info
NFIA
ENSG00000162599.11 nuclear factor I A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFIAhg19_v2_chr1_+_61547405_61547534,
hg19_v2_chr1_+_61542922_61542955		-0.682.0e-04Click!

Activity profile of NFIA motif

Sorted Z-values of NFIA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_67458357 2.33 ENST00000537194.2
SMAD3
SMAD family member 3
chr3_+_72937182 1.36 ENST00000389617.4
GXYLT2
glucoside xylosyltransferase 2
chr2_+_152214098 1.34 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr1_-_173020056 1.29 ENST00000239468.2
ENST00000404377.3
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr11_+_20044096 1.29 ENST00000533917.1
NAV2
neuron navigator 2
chr4_-_157892055 1.25 ENST00000422544.2
PDGFC
platelet derived growth factor C
chr15_+_67418047 1.10 ENST00000540846.2
SMAD3
SMAD family member 3
chr10_+_24528108 1.02 ENST00000438429.1
KIAA1217
KIAA1217
chr8_+_104384616 1.01 ENST00000520337.1
CTHRC1
collagen triple helix repeat containing 1
chr7_-_19184929 0.97 ENST00000275461.3
FERD3L
Fer3-like bHLH transcription factor
chr6_+_127439749 0.94 ENST00000356698.4
RSPO3
R-spondin 3
chr19_+_41725140 0.91 ENST00000359092.3
AXL
AXL receptor tyrosine kinase
chr14_+_93897272 0.87 ENST00000393151.2
UNC79
unc-79 homolog (C. elegans)
chr7_-_41742697 0.85 ENST00000242208.4
INHBA
inhibin, beta A
chr4_-_114900831 0.80 ENST00000315366.7
ARSJ
arylsulfatase family, member J
chr19_-_41196458 0.76 ENST00000598779.1
NUMBL
numb homolog (Drosophila)-like
chr3_-_123411191 0.72 ENST00000354792.5
ENST00000508240.1
MYLK
myosin light chain kinase
chr11_-_128392085 0.71 ENST00000526145.2
ENST00000531611.1
ENST00000319397.6
ENST00000345075.4
ENST00000535549.1
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr10_-_24770632 0.71 ENST00000596413.1
AL353583.1
AL353583.1
chr1_+_15986364 0.71 ENST00000345034.1
RSC1A1
regulatory solute carrier protein, family 1, member 1
chr11_-_51412448 0.70 ENST00000319760.6
OR4A5
olfactory receptor, family 4, subfamily A, member 5
chr11_+_5423827 0.67 ENST00000332043.1
OR51J1
olfactory receptor, family 51, subfamily J, member 1 (gene/pseudogene)
chr12_-_52911718 0.67 ENST00000548409.1
KRT5
keratin 5
chr6_-_143266297 0.63 ENST00000367603.2
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr2_-_113542063 0.61 ENST00000263339.3
IL1A
interleukin 1, alpha
chr4_-_157892167 0.60 ENST00000541126.1
PDGFC
platelet derived growth factor C
chr2_-_160761179 0.59 ENST00000554112.1
ENST00000553424.1
ENST00000263636.4
ENST00000504764.1
ENST00000505052.1
LY75
LY75-CD302
lymphocyte antigen 75
LY75-CD302 readthrough
chr5_+_133451254 0.59 ENST00000517851.1
ENST00000521639.1
ENST00000522375.1
ENST00000378560.4
ENST00000432532.2
ENST00000520958.1
ENST00000518915.1
ENST00000395023.1
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr18_+_29171689 0.58 ENST00000237014.3
TTR
transthyretin
chr22_+_24990746 0.56 ENST00000456869.1
ENST00000411974.1
GGT1
gamma-glutamyltransferase 1
chr2_+_102953608 0.55 ENST00000311734.2
ENST00000409584.1
IL1RL1
interleukin 1 receptor-like 1
chr10_-_100995603 0.54 ENST00000370552.3
ENST00000370549.1
HPSE2
heparanase 2
chrX_-_83757399 0.54 ENST00000373177.2
ENST00000297977.5
ENST00000506585.2
ENST00000449553.2
HDX
highly divergent homeobox
chr13_+_23755099 0.53 ENST00000537476.1
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr3_-_194188956 0.53 ENST00000256031.4
ENST00000446356.1
ATP13A3
ATPase type 13A3
chr1_+_68150744 0.52 ENST00000370986.4
ENST00000370985.3
GADD45A
growth arrest and DNA-damage-inducible, alpha
chr3_-_192635943 0.52 ENST00000392452.2
MB21D2
Mab-21 domain containing 2
chr7_+_35756092 0.51 ENST00000458087.3
AC018647.3
AC018647.3
chr10_-_100995540 0.51 ENST00000370546.1
ENST00000404542.1
HPSE2
heparanase 2
chr7_+_35756186 0.50 ENST00000430518.1
AC018647.3
AC018647.3
chr2_-_231989808 0.50 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr14_+_93897199 0.50 ENST00000553484.1
UNC79
unc-79 homolog (C. elegans)
chr6_+_123100853 0.49 ENST00000356535.4
FABP7
fatty acid binding protein 7, brain
chr16_+_8891670 0.47 ENST00000268261.4
ENST00000539622.1
ENST00000569958.1
ENST00000537352.1
PMM2
phosphomannomutase 2
chr7_-_105319536 0.46 ENST00000477775.1
ATXN7L1
ataxin 7-like 1
chr7_-_83824169 0.46 ENST00000265362.4
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr7_+_129932974 0.45 ENST00000445470.2
ENST00000222482.4
ENST00000492072.1
ENST00000473956.1
ENST00000493259.1
ENST00000486598.1
CPA4
carboxypeptidase A4
chr3_-_11623804 0.45 ENST00000451674.2
VGLL4
vestigial like 4 (Drosophila)
chr17_+_54671047 0.44 ENST00000332822.4
NOG
noggin
chr10_+_24755416 0.43 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr12_-_53207842 0.43 ENST00000458244.2
KRT4
keratin 4
chr18_-_5396271 0.43 ENST00000579951.1
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr3_+_111260856 0.42 ENST00000352690.4
CD96
CD96 molecule
chr2_-_145277569 0.42 ENST00000303660.4
ZEB2
zinc finger E-box binding homeobox 2
chr1_-_237167718 0.42 ENST00000464121.2
MT1HL1
metallothionein 1H-like 1
chr5_+_161494521 0.42 ENST00000356592.3
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr5_+_140868717 0.42 ENST00000252087.1
PCDHGC5
protocadherin gamma subfamily C, 5
chr19_+_15160130 0.41 ENST00000427043.3
CASP14
caspase 14, apoptosis-related cysteine peptidase
chr18_+_61575200 0.41 ENST00000238508.3
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr19_-_42947121 0.41 ENST00000601181.1
CXCL17
chemokine (C-X-C motif) ligand 17
chr16_-_79634595 0.40 ENST00000326043.4
ENST00000393350.1
MAF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
chr1_+_86934526 0.40 ENST00000394711.1
CLCA1
chloride channel accessory 1
chr14_+_73704201 0.40 ENST00000340738.5
ENST00000427855.1
ENST00000381166.3
PAPLN
papilin, proteoglycan-like sulfated glycoprotein
chr12_-_10251539 0.40 ENST00000420265.2
CLEC1A
C-type lectin domain family 1, member A
chr9_-_32635667 0.39 ENST00000242310.4
TAF1L
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like
chr6_-_32784687 0.39 ENST00000447394.1
ENST00000438763.2
HLA-DOB
major histocompatibility complex, class II, DO beta
chr5_+_161494770 0.39 ENST00000414552.2
ENST00000361925.4
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr12_+_57828521 0.39 ENST00000309668.2
INHBC
inhibin, beta C
chr5_-_36301984 0.39 ENST00000502994.1
ENST00000515759.1
ENST00000296604.3
RANBP3L
RAN binding protein 3-like
chr13_+_23755054 0.39 ENST00000218867.3
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr2_+_159651821 0.38 ENST00000309950.3
ENST00000409042.1
DAPL1
death associated protein-like 1
chr12_-_10251603 0.38 ENST00000457018.2
CLEC1A
C-type lectin domain family 1, member A
chr12_-_52946923 0.38 ENST00000267119.5
KRT71
keratin 71
chr2_-_208989225 0.37 ENST00000264376.4
CRYGD
crystallin, gamma D
chr17_-_10325261 0.37 ENST00000403437.2
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr12_-_10251576 0.36 ENST00000315330.4
CLEC1A
C-type lectin domain family 1, member A
chr7_+_62809239 0.36 ENST00000456890.1
AC006455.1
AC006455.1
chr1_-_205912577 0.36 ENST00000367135.3
ENST00000367134.2
SLC26A9
solute carrier family 26 (anion exchanger), member 9
chr17_+_34430980 0.36 ENST00000250151.4
CCL4
chemokine (C-C motif) ligand 4
chr7_-_25702669 0.36 ENST00000446840.1
AC003090.1
AC003090.1
chr7_-_99381884 0.35 ENST00000336411.2
CYP3A4
cytochrome P450, family 3, subfamily A, polypeptide 4
chr14_+_96722539 0.35 ENST00000553356.1
BDKRB1
bradykinin receptor B1
chr14_-_85996332 0.35 ENST00000380722.1
RP11-497E19.1
RP11-497E19.1
chr6_+_55039050 0.35 ENST00000370862.3
HCRTR2
hypocretin (orexin) receptor 2
chr1_-_111150048 0.35 ENST00000485317.1
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chrX_+_69642881 0.35 ENST00000453994.2
ENST00000536730.1
ENST00000538649.1
ENST00000374382.3
GDPD2
glycerophosphodiester phosphodiesterase domain containing 2
chr22_-_48943199 0.34 ENST00000407505.3
CTA-299D3.8
Uncharacterized protein
chr8_+_32579341 0.34 ENST00000519240.1
ENST00000539990.1
NRG1
neuregulin 1
chr11_+_193065 0.34 ENST00000342878.2
SCGB1C1
secretoglobin, family 1C, member 1
chr17_-_39093672 0.34 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr11_-_85397167 0.34 ENST00000316398.3
CCDC89
coiled-coil domain containing 89
chr11_-_123185475 0.33 ENST00000527774.1
ENST00000527533.1
RP11-109E10.1
RP11-109E10.1
chr2_-_49381646 0.33 ENST00000346173.3
ENST00000406846.2
FSHR
follicle stimulating hormone receptor
chr2_-_49381572 0.33 ENST00000454032.1
ENST00000304421.4
FSHR
follicle stimulating hormone receptor
chr14_-_61124977 0.33 ENST00000554986.1
SIX1
SIX homeobox 1
chr14_+_77582905 0.33 ENST00000557408.1
TMEM63C
transmembrane protein 63C
chr18_+_59000815 0.33 ENST00000262717.4
CDH20
cadherin 20, type 2
chr1_+_95975672 0.33 ENST00000440116.2
ENST00000456933.1
RP11-286B14.1
RP11-286B14.1
chr9_-_98784042 0.32 ENST00000412122.2
LINC00092
long intergenic non-protein coding RNA 92
chr7_+_134528635 0.32 ENST00000445569.2
CALD1
caldesmon 1
chr2_-_190044480 0.32 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr11_+_62556596 0.32 ENST00000526546.1
TMEM179B
transmembrane protein 179B
chr19_-_40724246 0.32 ENST00000311308.6
TTC9B
tetratricopeptide repeat domain 9B
chr19_+_46806856 0.32 ENST00000300862.3
HIF3A
hypoxia inducible factor 3, alpha subunit
chr2_-_31637560 0.32 ENST00000379416.3
XDH
xanthine dehydrogenase
chrX_+_22050546 0.31 ENST00000379374.4
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr10_-_14050522 0.31 ENST00000342409.2
FRMD4A
FERM domain containing 4A
chr5_+_74807581 0.31 ENST00000241436.4
ENST00000352007.5
POLK
polymerase (DNA directed) kappa
chr1_-_111148241 0.31 ENST00000440270.1
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr18_+_61143994 0.31 ENST00000382771.4
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr17_-_10421853 0.31 ENST00000226207.5
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr10_+_99609996 0.31 ENST00000370602.1
GOLGA7B
golgin A7 family, member B
chr12_-_53045948 0.31 ENST00000309680.3
KRT2
keratin 2
chr19_+_36249044 0.31 ENST00000444637.2
ENST00000396908.4
ENST00000544099.1
C19orf55
chromosome 19 open reading frame 55
chr11_+_77774897 0.30 ENST00000281030.2
THRSP
thyroid hormone responsive
chrX_-_69479654 0.30 ENST00000374519.2
P2RY4
pyrimidinergic receptor P2Y, G-protein coupled, 4
chr16_+_6533729 0.30 ENST00000551752.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr5_+_132208014 0.30 ENST00000296877.2
LEAP2
liver expressed antimicrobial peptide 2
chr6_-_136847099 0.30 ENST00000438100.2
MAP7
microtubule-associated protein 7
chr17_-_1733114 0.30 ENST00000305513.7
SMYD4
SET and MYND domain containing 4
chr12_+_20848282 0.30 ENST00000545604.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr16_-_20364122 0.29 ENST00000396138.4
ENST00000577168.1
UMOD
uromodulin
chr16_-_20364030 0.29 ENST00000396134.2
ENST00000573567.1
ENST00000570757.1
ENST00000424589.1
ENST00000302509.4
ENST00000571174.1
ENST00000576688.1
UMOD
uromodulin
chr19_+_46801639 0.29 ENST00000244303.6
ENST00000339613.2
ENST00000533145.1
ENST00000472815.1
HIF3A
hypoxia inducible factor 3, alpha subunit
chr12_+_20848377 0.29 ENST00000540354.1
ENST00000266509.2
ENST00000381552.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr20_+_42965626 0.29 ENST00000217043.2
R3HDML
R3H domain containing-like
chr3_-_37216055 0.29 ENST00000336686.4
LRRFIP2
leucine rich repeat (in FLII) interacting protein 2
chr16_-_66785497 0.29 ENST00000440564.2
ENST00000379482.2
ENST00000443351.2
ENST00000566150.1
DYNC1LI2
dynein, cytoplasmic 1, light intermediate chain 2
chr7_-_8302298 0.29 ENST00000446305.1
ICA1
islet cell autoantigen 1, 69kDa
chr12_+_113229543 0.28 ENST00000447659.2
RPH3A
rabphilin 3A homolog (mouse)
chr15_+_36994210 0.28 ENST00000562489.1
C15orf41
chromosome 15 open reading frame 41
chr19_+_11651942 0.28 ENST00000587087.1
CNN1
calponin 1, basic, smooth muscle
chr10_-_104597286 0.28 ENST00000369887.3
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr1_-_114429997 0.28 ENST00000471267.1
ENST00000393320.3
BCL2L15
BCL2-like 15
chr13_+_97874574 0.28 ENST00000343600.4
ENST00000345429.6
ENST00000376673.3
MBNL2
muscleblind-like splicing regulator 2
chr2_+_43864387 0.28 ENST00000282406.4
PLEKHH2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr14_+_97925151 0.27 ENST00000554862.1
ENST00000554260.1
ENST00000499910.2
CTD-2506J14.1
CTD-2506J14.1
chr17_+_29664830 0.27 ENST00000444181.2
ENST00000417592.2
NF1
neurofibromin 1
chr12_+_101188718 0.27 ENST00000299222.9
ENST00000392977.3
ANO4
anoctamin 4
chr4_-_48271802 0.27 ENST00000381501.3
TEC
tec protein tyrosine kinase
chr12_-_122238464 0.27 ENST00000546227.1
RHOF
ras homolog family member F (in filopodia)
chr12_+_113229737 0.27 ENST00000551052.1
ENST00000415485.3
RPH3A
rabphilin 3A homolog (mouse)
chr1_+_107683436 0.27 ENST00000370068.1
NTNG1
netrin G1
chr1_+_26759295 0.27 ENST00000430232.1
DHDDS
dehydrodolichyl diphosphate synthase
chr17_+_7461613 0.27 ENST00000438470.1
ENST00000436057.1
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr3_-_155011483 0.27 ENST00000489090.1
RP11-451G4.2
RP11-451G4.2
chr4_+_37962018 0.26 ENST00000504686.1
PTTG2
pituitary tumor-transforming 2
chr12_+_100897130 0.26 ENST00000551379.1
ENST00000188403.7
ENST00000551184.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr14_+_23845995 0.26 ENST00000359320.3
CMTM5
CKLF-like MARVEL transmembrane domain containing 5
chr4_-_76928641 0.26 ENST00000264888.5
CXCL9
chemokine (C-X-C motif) ligand 9
chr11_-_83393457 0.26 ENST00000404783.3
DLG2
discs, large homolog 2 (Drosophila)
chr11_-_84634447 0.26 ENST00000532653.1
DLG2
discs, large homolog 2 (Drosophila)
chr3_+_119013185 0.26 ENST00000264245.4
ARHGAP31
Rho GTPase activating protein 31
chr6_+_150920999 0.26 ENST00000367328.1
ENST00000367326.1
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr11_-_84634217 0.25 ENST00000524982.1
DLG2
discs, large homolog 2 (Drosophila)
chr16_-_19725899 0.25 ENST00000567367.1
KNOP1
lysine-rich nucleolar protein 1
chr19_+_12949251 0.25 ENST00000251472.4
MAST1
microtubule associated serine/threonine kinase 1
chr17_-_37764128 0.25 ENST00000302584.4
NEUROD2
neuronal differentiation 2
chr13_-_40177261 0.25 ENST00000379589.3
LHFP
lipoma HMGIC fusion partner
chr2_+_234296792 0.25 ENST00000409813.3
DGKD
diacylglycerol kinase, delta 130kDa
chr6_+_64281906 0.25 ENST00000370651.3
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chrX_+_52926322 0.25 ENST00000430150.2
ENST00000452021.2
ENST00000412319.1
FAM156B
family with sequence similarity 156, member B
chr1_-_243326612 0.25 ENST00000492145.1
ENST00000490813.1
ENST00000464936.1
CEP170
centrosomal protein 170kDa
chr5_+_67586465 0.24 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_+_107683644 0.24 ENST00000370067.1
NTNG1
netrin G1
chr20_+_30407105 0.24 ENST00000375994.2
MYLK2
myosin light chain kinase 2
chr1_-_235098935 0.24 ENST00000423175.1
RP11-443B7.1
RP11-443B7.1
chr7_-_99381798 0.24 ENST00000415003.1
ENST00000354593.2
CYP3A4
cytochrome P450, family 3, subfamily A, polypeptide 4
chr20_+_30407151 0.24 ENST00000375985.4
MYLK2
myosin light chain kinase 2
chr4_+_71263599 0.24 ENST00000399575.2
PROL1
proline rich, lacrimal 1
chr2_-_214013353 0.23 ENST00000451136.2
ENST00000421754.2
ENST00000374327.4
ENST00000413091.3
IKZF2
IKAROS family zinc finger 2 (Helios)
chr16_-_4401258 0.23 ENST00000577031.1
PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr11_-_26593677 0.23 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr1_+_11539204 0.23 ENST00000294484.6
ENST00000389575.3
PTCHD2
patched domain containing 2
chr6_+_13925098 0.23 ENST00000488300.1
ENST00000544682.1
ENST00000420478.2
RNF182
ring finger protein 182
chr1_+_209878182 0.22 ENST00000367027.3
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr8_-_79717750 0.22 ENST00000263851.4
ENST00000379113.2
IL7
interleukin 7
chr17_-_39538550 0.22 ENST00000394001.1
KRT34
keratin 34
chr20_-_14318248 0.22 ENST00000378053.3
ENST00000341420.4
FLRT3
fibronectin leucine rich transmembrane protein 3
chr3_+_19189946 0.22 ENST00000328405.2
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr11_-_118023490 0.22 ENST00000324727.4
SCN4B
sodium channel, voltage-gated, type IV, beta subunit
chr11_-_58343319 0.22 ENST00000395074.2
LPXN
leupaxin
chr2_+_115919684 0.22 ENST00000310323.8
DPP10
dipeptidyl-peptidase 10 (non-functional)
chrX_+_49832231 0.22 ENST00000376108.3
CLCN5
chloride channel, voltage-sensitive 5
chr4_-_105416039 0.22 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr13_-_46716969 0.22 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr12_+_69864129 0.22 ENST00000547219.1
ENST00000299293.2
ENST00000549921.1
ENST00000550316.1
ENST00000548154.1
ENST00000547414.1
ENST00000550389.1
ENST00000550937.1
ENST00000549092.1
ENST00000550169.1
FRS2
fibroblast growth factor receptor substrate 2
chr11_-_26593779 0.22 ENST00000529533.1
MUC15
mucin 15, cell surface associated
chr11_-_59383617 0.22 ENST00000263847.1
OSBP
oxysterol binding protein
chr2_-_33824336 0.22 ENST00000431950.1
ENST00000403368.1
ENST00000441530.2
FAM98A
family with sequence similarity 98, member A
chr4_+_71248795 0.22 ENST00000304915.3
SMR3B
submaxillary gland androgen regulated protein 3B
chr1_+_34632484 0.21 ENST00000373374.3
C1orf94
chromosome 1 open reading frame 94
chr11_+_63870660 0.21 ENST00000246841.3
FLRT1
fibronectin leucine rich transmembrane protein 1
chrX_+_122993657 0.21 ENST00000434753.3
ENST00000430625.1
XIAP
X-linked inhibitor of apoptosis
chr7_-_56160625 0.21 ENST00000446428.1
ENST00000432123.1
ENST00000452681.2
ENST00000537360.1
PHKG1
phosphorylase kinase, gamma 1 (muscle)
chr12_+_56114151 0.21 ENST00000547072.1
ENST00000552930.1
ENST00000257895.5
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr11_-_85338311 0.21 ENST00000376104.2
DLG2
discs, large homolog 2 (Drosophila)
chr5_-_138718973 0.21 ENST00000353963.3
ENST00000348729.3
SLC23A1
solute carrier family 23 (ascorbic acid transporter), member 1
chr5_-_146258205 0.21 ENST00000394413.3
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr12_+_10331605 0.21 ENST00000298530.3
TMEM52B
transmembrane protein 52B

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.4 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.3 1.3 GO:2000329 negative regulation of T-helper 17 cell lineage commitment(GO:2000329)
0.3 0.9 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.3 0.8 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.2 1.4 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.2 0.6 GO:1902530 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.2 1.3 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.2 0.7 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.2 0.5 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.2 1.3 GO:0021564 vagus nerve development(GO:0021564)
0.2 0.8 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.1 0.1 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.1 0.7 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.1 0.6 GO:0036378 alkaloid catabolic process(GO:0009822) calcitriol biosynthetic process from calciol(GO:0036378)
0.1 0.1 GO:1900158 negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.1 0.7 GO:0021633 optic nerve structural organization(GO:0021633)
0.1 0.4 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.1 1.0 GO:0033504 floor plate development(GO:0033504)
0.1 0.5 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.1 0.3 GO:0044278 cell wall disruption in other organism(GO:0044278)
0.1 0.3 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.6 GO:2000391 positive regulation of neutrophil extravasation(GO:2000391)
0.1 0.5 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 0.5 GO:0048880 sensory system development(GO:0048880)
0.1 0.6 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 0.3 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.1 1.0 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.1 0.3 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.1 0.7 GO:0030578 PML body organization(GO:0030578)
0.1 0.3 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.1 0.3 GO:0090293 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.1 0.4 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.1 0.3 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.1 1.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 0.3 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1 2.2 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1 0.3 GO:0021779 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 0.3 GO:0046110 xanthine metabolic process(GO:0046110)
0.1 0.5 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.1 0.3 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716) melanocyte proliferation(GO:0097325)
0.1 1.0 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.4 GO:0021767 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.2 GO:0070904 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.1 1.2 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 0.3 GO:1904640 response to methionine(GO:1904640)
0.1 0.3 GO:1904383 response to sodium phosphate(GO:1904383)
0.1 0.8 GO:0014820 tonic smooth muscle contraction(GO:0014820)
0.1 0.2 GO:1903970 regulation of interleukin-4-mediated signaling pathway(GO:1902214) negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.1 0.2 GO:0060133 somatotropin secreting cell development(GO:0060133)
0.1 0.3 GO:0042746 regulation of circadian sleep/wake cycle, wakefulness(GO:0010840) circadian sleep/wake cycle, wakefulness(GO:0042746)
0.1 0.2 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.1 0.6 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.1 0.2 GO:0008050 female courtship behavior(GO:0008050)
0.1 0.4 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 0.4 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.1 0.4 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 1.5 GO:0030728 ovulation(GO:0030728)
0.0 0.4 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.2 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.6 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.3 GO:0010909 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.2 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.2 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.8 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.2 GO:0061056 sclerotome development(GO:0061056)
0.0 0.2 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.2 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 0.2 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.0 0.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.2 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.2 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.3 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.3 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0 0.7 GO:0060134 prepulse inhibition(GO:0060134)
0.0 0.7 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.3 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.5 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 0.1 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.1 GO:1990928 response to amino acid starvation(GO:1990928)
0.0 1.1 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.1 GO:0015785 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.0 0.9 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 0.1 GO:0046166 glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.0 0.1 GO:0043605 cellular amide catabolic process(GO:0043605)
0.0 0.2 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.2 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.0 0.1 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.0 0.1 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.0 0.4 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0 0.3 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.5 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.2 GO:0003344 pericardium morphogenesis(GO:0003344)
0.0 0.1 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.0 0.1 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.0 0.1 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.1 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.2 GO:0071313 cellular response to caffeine(GO:0071313)
0.0 0.1 GO:0060722 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.0 0.1 GO:0072086 specification of loop of Henle identity(GO:0072086)
0.0 0.2 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.1 GO:2000812 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) regulation of barbed-end actin filament capping(GO:2000812) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.2 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.1 GO:1902725 regulation of skeletal muscle tissue growth(GO:0048631) negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.1 GO:0071205 superior temporal gyrus development(GO:0071109) protein localization to juxtaparanode region of axon(GO:0071205)
0.0 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.2 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.1 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.0 0.4 GO:0090026 positive regulation of macrophage chemotaxis(GO:0010759) positive regulation of monocyte chemotaxis(GO:0090026)
0.0 0.5 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.1 GO:0032417 positive regulation of sodium:proton antiporter activity(GO:0032417)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.3 GO:0086016 AV node cell action potential(GO:0086016) AV node cell to bundle of His cell signaling(GO:0086027)
0.0 0.3 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.2 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.2 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.6 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.2 GO:1904469 positive regulation of tumor necrosis factor secretion(GO:1904469)
0.0 0.1 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.2 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.3 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 0.3 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.0 0.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.3 GO:0006853 carnitine shuttle(GO:0006853)
0.0 0.2 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 0.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0097106 postsynaptic density organization(GO:0097106)
0.0 0.2 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.1 GO:0009449 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.2 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 0.1 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
0.0 0.1 GO:0001575 globoside metabolic process(GO:0001575)
0.0 0.0 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.2 GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901620)
0.0 0.1 GO:0043307 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil activation(GO:0043307) eosinophil degranulation(GO:0043308)
0.0 0.3 GO:0051642 centrosome localization(GO:0051642)
0.0 0.1 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.1 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0 0.2 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.0 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.0 0.0 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.0 0.0 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.0 0.4 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.0 GO:1902174 positive regulation of keratinocyte apoptotic process(GO:1902174)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0060613 fat pad development(GO:0060613)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150) negative regulation of ATPase activity(GO:0032780)
0.0 0.4 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 0.2 GO:0044126 regulation of growth of symbiont in host(GO:0044126)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.3 0.8 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.9 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 2.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 0.2 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 1.1 GO:0033643 host cell part(GO:0033643)
0.1 1.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.4 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.5 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.5 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.3 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.2 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.1 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.0 0.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.3 GO:0030478 actin cap(GO:0030478)
0.0 0.9 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 1.4 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.2 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.4 GO:0032982 myosin filament(GO:0032982)
0.0 0.1 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 1.2 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.0 GO:0043293 apoptosome(GO:0043293)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.3 GO:0030673 axolemma(GO:0030673)
0.0 0.0 GO:0031905 early endosome lumen(GO:0031905)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.4 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.3 0.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 1.0 GO:0030305 heparanase activity(GO:0030305)
0.2 1.4 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.2 0.6 GO:0002113 interleukin-33 binding(GO:0002113)
0.2 0.7 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.1 0.6 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.1 1.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.3 GO:0004947 bradykinin receptor activity(GO:0004947)
0.1 0.3 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.1 0.3 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.1 0.3 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.3 GO:0016499 orexin receptor activity(GO:0016499)
0.1 0.4 GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.1 0.2 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.7 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 0.2 GO:0015229 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.1 1.9 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 0.6 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 0.2 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 1.0 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.4 GO:0050682 AF-2 domain binding(GO:0050682)
0.1 0.4 GO:0017018 myosin phosphatase activity(GO:0017018)
0.1 1.0 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 0.2 GO:0031751 D4 dopamine receptor binding(GO:0031751)
0.1 0.8 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.1 0.3 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 0.2 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.1 0.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.2 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.1 0.6 GO:0008430 selenium binding(GO:0008430)
0.0 0.2 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.4 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 1.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0097677 STAT family protein binding(GO:0097677)
0.0 2.0 GO:0005109 frizzled binding(GO:0005109)
0.0 0.3 GO:0071553 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0 0.8 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.8 GO:0019864 IgG binding(GO:0019864)
0.0 0.5 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.2 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.0 0.2 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.1 GO:0070984 SET domain binding(GO:0070984)
0.0 0.2 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.3 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.7 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.5 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 0.5 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.3 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.0 0.2 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.6 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.2 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.6 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 1.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.8 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.1 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.4 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.6 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.4 GO:0070513 death domain binding(GO:0070513)
0.0 0.3 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.5 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.1 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.0 0.3 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.7 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.4 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.7 GO:0008200 ion channel inhibitor activity(GO:0008200) channel inhibitor activity(GO:0016248)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.1 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.1 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 3.1 GO:0005125 cytokine activity(GO:0005125)
0.0 0.1 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.4 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.1 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.8 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.3 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.3 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.3 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.3 PID EPO PATHWAY EPO signaling pathway
0.0 1.2 PID ALK1 PATHWAY ALK1 signaling events
0.0 1.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 2.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.0 PID BMP PATHWAY BMP receptor signaling
0.0 0.5 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.6 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.9 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 1.0 PID AURORA B PATHWAY Aurora B signaling
0.0 0.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.2 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 1.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 0.7 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.8 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.5 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.5 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.5 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.5 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.6 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.3 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.8 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 1.9 REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM Genes involved in Heparan sulfate/heparin (HS-GAG) metabolism
0.0 0.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.2 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.6 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.3 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.3 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.6 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.6 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.0 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis