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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for NFIX_NFIB
Z-value: 2.29
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Transcription factors associated with NFIX_NFIB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFIB | hg19_v2_chr9_-_14180778_14180808 | 0.94 | 1.5e-12 | Click! |
| NFIX | hg19_v2_chr19_+_13135790_13135811 | -0.66 | 3.0e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_41614720 Show fit | 19.45 |
ENST00000509277.1
|
LIM and calponin homology domains 1 |
|
| chr4_+_41614909 Show fit | 14.96 |
ENST00000509454.1
ENST00000396595.3 ENST00000381753.4 |
LIM and calponin homology domains 1 |
|
| chr21_+_46020497 Show fit | 8.93 |
ENST00000380102.2
|
keratin associated protein 10-7 |
|
| chr4_-_186697044 Show fit | 8.03 |
ENST00000437304.2
|
sorbin and SH3 domain containing 2 |
|
| chr12_+_79258444 Show fit | 7.53 |
ENST00000261205.4
|
synaptotagmin I |
|
| chr6_-_130031358 Show fit | 6.85 |
ENST00000368149.2
|
Rho GTPase activating protein 18 |
|
| chr11_+_59480899 Show fit | 6.51 |
ENST00000300150.7
|
syntaxin 3 |
|
| chr1_+_162351503 Show fit | 6.48 |
ENST00000458626.2
|
chromosome 1 open reading frame 226 |
|
| chr12_+_79258547 Show fit | 6.28 |
ENST00000457153.2
|
synaptotagmin I |
|
| chr5_-_172198190 Show fit | 6.14 |
ENST00000239223.3
|
dual specificity phosphatase 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFIX_NFIB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 16.7 | GO:1903758 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 0.1 | 15.2 | GO:0031424 | keratinization(GO:0031424) |
| 4.6 | 13.8 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.5 | 11.9 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.4 | 9.3 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 2.7 | 8.0 | GO:0072019 | proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229) |
| 2.7 | 8.0 | GO:0021538 | epithalamus development(GO:0021538) habenula development(GO:0021986) |
| 0.3 | 7.8 | GO:0072189 | ureter development(GO:0072189) |
| 1.1 | 7.7 | GO:0098967 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 0.6 | 7.0 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.5 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 20.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 18.0 | GO:0030018 | Z disc(GO:0030018) |
| 2.7 | 13.7 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 12.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 12.4 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.2 | 12.1 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 10.5 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.3 | 9.9 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 2.7 | 8.2 | GO:0020005 | symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.7 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 19.4 | GO:0003779 | actin binding(GO:0003779) |
| 0.4 | 17.5 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.6 | 16.2 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 14.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 2.3 | 13.9 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.5 | 8.4 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.4 | 8.4 | GO:0015923 | mannosidase activity(GO:0015923) |
| 2.6 | 7.9 | GO:0035379 | carbon dioxide transmembrane transporter activity(GO:0035379) |
| 0.6 | 7.7 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 26.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 13.4 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 12.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 9.8 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.2 | 9.2 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.1 | 7.0 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 6.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.4 | 6.8 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 6.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 6.4 | PID IGF1 PATHWAY | IGF1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 15.6 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.5 | 10.6 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 9.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 9.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 9.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.5 | 7.9 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.5 | 6.8 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.2 | 6.6 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.2 | 6.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 6.4 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |