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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for NFKB1
Z-value: 2.94
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Transcription factors associated with NFKB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFKB1 | hg19_v2_chr4_+_103423055_103423112 | 0.87 | 1.7e-08 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_29527702 Show fit | 32.34 |
ENST00000377050.4
|
ubiquitin D |
|
| chr4_-_76944621 Show fit | 30.23 |
ENST00000306602.1
|
chemokine (C-X-C motif) ligand 10 |
|
| chr6_-_31550192 Show fit | 28.45 |
ENST00000429299.2
ENST00000446745.2 |
lymphotoxin beta (TNF superfamily, member 3) |
|
| chr19_+_45504688 Show fit | 25.90 |
ENST00000221452.8
ENST00000540120.1 ENST00000505236.1 |
v-rel avian reticuloendotheliosis viral oncogene homolog B |
|
| chr2_+_228678550 Show fit | 22.48 |
ENST00000409189.3
ENST00000358813.4 |
chemokine (C-C motif) ligand 20 |
|
| chr10_+_104154229 Show fit | 22.34 |
ENST00000428099.1
ENST00000369966.3 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
|
| chr4_-_76957214 Show fit | 19.76 |
ENST00000306621.3
|
chemokine (C-X-C motif) ligand 11 |
|
| chr5_-_150466692 Show fit | 18.41 |
ENST00000315050.7
ENST00000523338.1 ENST00000522100.1 |
TNFAIP3 interacting protein 1 |
|
| chr11_+_102188224 Show fit | 17.78 |
ENST00000263464.3
|
baculoviral IAP repeat containing 3 |
|
| chr11_+_102188272 Show fit | 16.38 |
ENST00000532808.1
|
baculoviral IAP repeat containing 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFKB1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 58.7 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 5.2 | 52.5 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 12.2 | 48.8 | GO:0052027 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 9.0 | 44.9 | GO:1902228 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 4.9 | 44.0 | GO:0042090 | interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075) |
| 3.8 | 34.2 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 11.3 | 33.9 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 6.5 | 32.3 | GO:0070842 | aggresome assembly(GO:0070842) |
| 10.1 | 30.4 | GO:0045062 | extrathymic T cell selection(GO:0045062) |
| 0.3 | 28.7 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 129.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 55.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 7.5 | 44.9 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 5.0 | 39.7 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.1 | 36.1 | GO:0045121 | membrane raft(GO:0045121) |
| 0.6 | 33.9 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.5 | 32.3 | GO:0016235 | aggresome(GO:0016235) |
| 7.0 | 28.0 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.0 | 24.1 | GO:0005912 | adherens junction(GO:0005912) |
| 0.9 | 22.6 | GO:0005614 | interstitial matrix(GO:0005614) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 70.4 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 10.5 | 52.5 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 4.6 | 50.5 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 3.0 | 47.6 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 5.6 | 44.9 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.7 | 34.2 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 1.7 | 33.7 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.7 | 28.3 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.1 | 26.7 | GO:0004386 | helicase activity(GO:0004386) |
| 0.1 | 25.6 | GO:0001047 | core promoter binding(GO:0001047) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 127.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 2.2 | 116.3 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 1.0 | 64.3 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 1.4 | 47.7 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 1.5 | 44.9 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 1.0 | 36.0 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 19.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.3 | 18.4 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.5 | 15.9 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.3 | 15.0 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 123.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.6 | 88.6 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 1.6 | 34.5 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 0.4 | 30.8 | REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 0.5 | 23.2 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 1.1 | 22.1 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.8 | 15.9 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.4 | 15.3 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.3 | 15.3 | REACTOME CA DEPENDENT EVENTS | Genes involved in Ca-dependent events |
| 0.5 | 15.2 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |