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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for NFKB2
Z-value: 2.07
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Transcription factors associated with NFKB2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFKB2 | hg19_v2_chr10_+_104154229_104154354 | 0.90 | 1.5e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFKB2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 32.7 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.2 | 24.2 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.2 | 17.6 | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803) |
| 3.1 | 15.3 | GO:0033091 | positive regulation of immature T cell proliferation(GO:0033091) |
| 5.0 | 15.1 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 2.8 | 11.4 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 2.3 | 11.4 | GO:1903971 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 1.2 | 10.6 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 2.6 | 10.4 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
| 0.4 | 10.2 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 43.4 | GO:0005615 | extracellular space(GO:0005615) |
| 3.7 | 22.4 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.3 | 14.9 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.2 | 12.1 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 2.8 | 11.4 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 1.9 | 11.4 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.0 | 10.9 | GO:0000323 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.1 | 10.4 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 1.3 | 10.2 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.1 | 8.6 | GO:0005923 | bicellular tight junction(GO:0005923) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 31.6 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 2.8 | 22.4 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 1.3 | 14.8 | GO:0030274 | LIM domain binding(GO:0030274) |
| 1.1 | 14.8 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.9 | 14.8 | GO:0031996 | thioesterase binding(GO:0031996) |
| 1.6 | 13.1 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.0 | 10.8 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.4 | 10.6 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 1.5 | 10.4 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 2.0 | 9.8 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 30.4 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 29.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 19.6 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.3 | 17.4 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 13.4 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.3 | 12.0 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.4 | 10.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 10.1 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.3 | 9.1 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 8.5 | ST G ALPHA I PATHWAY | G alpha i Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 41.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 22.4 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.4 | 20.6 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.3 | 19.1 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.2 | 15.9 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.9 | 15.3 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.4 | 10.7 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.1 | 9.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 6.7 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.2 | 6.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |