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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NFKB2

Z-value: 2.07

Motif logo

Transcription factors associated with NFKB2

Gene Symbol Gene ID Gene Info
ENSG00000077150.13 nuclear factor kappa B subunit 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFKB2hg19_v2_chr10_+_104154229_1041543540.901.5e-09Click!

Activity profile of NFKB2 motif

Sorted Z-values of NFKB2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_123691047 14.79 ENST00000373887.3
TNF receptor-associated factor 1
chr4_+_74702214 11.46 ENST00000226317.5
ENST00000515050.1
chemokine (C-X-C motif) ligand 6
chr17_-_34207295 10.42 ENST00000463941.1
ENST00000293272.3
chemokine (C-C motif) ligand 5
chr1_-_209824643 10.07 ENST00000391911.1
ENST00000415782.1
laminin, beta 3
chr4_-_74864386 9.89 ENST00000296027.4
chemokine (C-X-C motif) ligand 5
chr3_+_53195136 9.76 ENST00000394729.2
ENST00000330452.3
protein kinase C, delta
chr19_+_45504688 9.65 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr10_+_104154229 9.61 ENST00000428099.1
ENST00000369966.3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr8_+_90770008 8.12 ENST00000540020.1
receptor-interacting serine-threonine kinase 2
chr19_-_50400212 7.94 ENST00000391826.2
interleukin 4 induced 1
chr5_-_150466692 7.70 ENST00000315050.7
ENST00000523338.1
ENST00000522100.1
TNFAIP3 interacting protein 1
chr8_+_90769967 7.16 ENST00000220751.4
receptor-interacting serine-threonine kinase 2
chr6_+_14117872 7.12 ENST00000379153.3
CD83 molecule
chr14_-_24616426 7.06 ENST00000216802.5
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr6_-_143266297 6.91 ENST00000367603.2
human immunodeficiency virus type I enhancer binding protein 2
chr16_+_50776021 6.63 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
cylindromatosis (turban tumor syndrome)
chr14_-_24615805 6.31 ENST00000560410.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr9_+_115913222 5.68 ENST00000259392.3
solute carrier family 31 (copper transporter), member 2
chr11_-_57335750 5.50 ENST00000340573.4
ubiquitin-conjugating enzyme E2L 6
chr1_-_41328018 5.26 ENST00000372638.2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chrX_+_68048803 5.26 ENST00000204961.4
ephrin-B1
chr5_-_179780312 5.24 ENST00000253778.8
glutamine-fructose-6-phosphate transaminase 2
chr1_-_8000872 5.23 ENST00000377507.3
tumor necrosis factor receptor superfamily, member 9
chr21_+_27011899 5.01 ENST00000425221.2
junctional adhesion molecule 2
chr17_+_40440481 4.83 ENST00000590726.2
ENST00000452307.2
ENST00000444283.1
ENST00000588868.1
signal transducer and activator of transcription 5A
chr8_+_54793454 4.78 ENST00000276500.4
regulator of G-protein signaling 20
chr8_+_54793425 4.73 ENST00000522225.1
regulator of G-protein signaling 20
chr19_-_47734448 4.68 ENST00000439096.2
BCL2 binding component 3
chr19_-_4338783 4.51 ENST00000601482.1
ENST00000600324.1
signal transducing adaptor family member 2
chr4_-_146859623 4.50 ENST00000379448.4
ENST00000513320.1
zinc finger protein 827
chr19_-_4338838 4.50 ENST00000594605.1
signal transducing adaptor family member 2
chr16_+_50775971 4.24 ENST00000311559.9
ENST00000564326.1
ENST00000566206.1
cylindromatosis (turban tumor syndrome)
chr16_+_50775948 4.21 ENST00000569681.1
ENST00000569418.1
ENST00000540145.1
cylindromatosis (turban tumor syndrome)
chr14_-_24615523 4.16 ENST00000559056.1
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr6_-_31324943 4.15 ENST00000412585.2
ENST00000434333.1
major histocompatibility complex, class I, B
chr5_-_95297534 4.14 ENST00000513343.1
ENST00000431061.2
elongation factor, RNA polymerase II, 2
chr4_+_74735102 4.05 ENST00000395761.3
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr1_+_110453109 4.05 ENST00000525659.1
colony stimulating factor 1 (macrophage)
chr6_+_18155560 4.04 ENST00000546309.2
ENST00000388870.2
ENST00000397244.1
lysine (K)-specific demethylase 1B
chr5_-_95297678 3.97 ENST00000237853.4
elongation factor, RNA polymerase II, 2
chr12_-_49259643 3.90 ENST00000309739.5
Rho family GTPase 1
chr19_+_48824711 3.89 ENST00000599704.1
epithelial membrane protein 3
chr1_+_110453203 3.85 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
colony stimulating factor 1 (macrophage)
chr17_-_53499310 3.80 ENST00000262065.3
monocyte to macrophage differentiation-associated
chr12_-_57504069 3.73 ENST00000543873.2
ENST00000554663.1
ENST00000557635.1
signal transducer and activator of transcription 6, interleukin-4 induced
chr6_+_18155632 3.70 ENST00000297792.5
lysine (K)-specific demethylase 1B
chr21_+_27011584 3.63 ENST00000400532.1
ENST00000480456.1
ENST00000312957.5
junctional adhesion molecule 2
chr10_+_13142075 3.61 ENST00000378757.2
ENST00000430081.1
ENST00000378752.3
ENST00000378748.3
optineurin
chr16_+_57653989 3.51 ENST00000567835.1
ENST00000569372.1
ENST00000563548.1
ENST00000562003.1
G protein-coupled receptor 56
chr10_+_13141585 3.50 ENST00000378764.2
optineurin
chr10_+_13142225 3.47 ENST00000378747.3
optineurin
chr16_+_57653854 3.44 ENST00000568908.1
ENST00000568909.1
ENST00000566778.1
ENST00000561988.1
G protein-coupled receptor 56
chr1_+_65613217 3.42 ENST00000545314.1
adenylate kinase 4
chr4_-_74904398 3.37 ENST00000296026.4
chemokine (C-X-C motif) ligand 3
chr2_-_136743169 3.35 ENST00000264161.4
aspartyl-tRNA synthetase
chr20_-_22559211 3.28 ENST00000564492.1
long intergenic non-protein coding RNA 261
chr1_-_47082495 3.18 ENST00000545730.1
ENST00000531769.1
ENST00000319928.3
MAP kinase interacting serine/threonine kinase 1
MOB kinase activator 3C
chr8_-_145582118 2.93 ENST00000455319.2
ENST00000331890.5
F-box and leucine-rich repeat protein 6
chr1_+_110453462 2.80 ENST00000488198.1
colony stimulating factor 1 (macrophage)
chr14_+_24605389 2.79 ENST00000382708.3
ENST00000561435.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr19_+_45147313 2.77 ENST00000406449.4
poliovirus receptor
chr19_+_45147098 2.77 ENST00000425690.3
ENST00000344956.4
ENST00000403059.4
poliovirus receptor
chr8_+_145582231 2.71 ENST00000526338.1
ENST00000402965.1
ENST00000534725.1
ENST00000532887.1
ENST00000329994.2
solute carrier family 52 (riboflavin transporter), member 2
chr20_-_48330377 2.59 ENST00000371711.4
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
chr5_+_60241020 2.59 ENST00000511107.1
ENST00000502658.1
NADH dehydrogenase (ubiquinone) complex I, assembly factor 2
chr10_+_73724123 2.58 ENST00000373115.4
carbohydrate (chondroitin 6) sulfotransferase 3
chr16_+_4674814 2.58 ENST00000415496.1
ENST00000587747.1
ENST00000399577.5
ENST00000588994.1
ENST00000586183.1
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr15_+_63414760 2.56 ENST00000557972.1
lactamase, beta
chr3_+_9691117 2.56 ENST00000353332.5
ENST00000420925.1
ENST00000296003.4
ENST00000351233.5
myotubularin related protein 14
chr19_+_13135790 2.55 ENST00000358552.3
nuclear factor I/X (CCAAT-binding transcription factor)
chr12_-_77272765 2.54 ENST00000547435.1
ENST00000552330.1
ENST00000546966.1
ENST00000311083.5
cysteine and glycine-rich protein 2
chr1_+_170633047 2.53 ENST00000239461.6
ENST00000497230.2
paired related homeobox 1
chr10_-_86001210 2.50 ENST00000372105.3
leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
chr11_+_35639735 2.48 ENST00000317811.4
four jointed box 1 (Drosophila)
chr2_-_136743039 2.43 ENST00000537273.1
aspartyl-tRNA synthetase
chr12_-_322504 2.38 ENST00000424061.2
solute carrier family 6 (neurotransmitter transporter), member 12
chr5_+_176730769 2.36 ENST00000303204.4
ENST00000503216.1
PRELI domain containing 1
chr16_-_81110683 2.28 ENST00000565253.1
ENST00000378611.4
ENST00000299578.5
chromosome 16 open reading frame 46
chr5_+_60240943 2.26 ENST00000296597.5
NADH dehydrogenase (ubiquinone) complex I, assembly factor 2
chr20_-_48532019 2.21 ENST00000289431.5
spermatogenesis associated 2
chr16_-_57318566 2.17 ENST00000569059.1
ENST00000219207.5
plasmolipin
chrX_+_150151824 2.17 ENST00000455596.1
ENST00000448905.2
high mobility group box 3
chr6_+_80341000 2.13 ENST00000369838.4
SH3 domain binding glutamic acid-rich protein like 2
chr7_+_100547156 2.13 ENST00000379458.4
Protein LOC100131514
chr14_+_24605361 2.12 ENST00000206451.6
ENST00000559123.1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr8_+_145582217 2.12 ENST00000530047.1
ENST00000527078.1
solute carrier family 52 (riboflavin transporter), member 2
chr3_+_111717600 2.11 ENST00000273368.4
transgelin 3
chr16_-_4466622 2.11 ENST00000570645.1
ENST00000574025.1
ENST00000572898.1
ENST00000537233.2
ENST00000571059.1
ENST00000251166.4
coronin 7
chr3_+_182971583 2.05 ENST00000460419.1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr1_+_2487800 2.00 ENST00000355716.4
tumor necrosis factor receptor superfamily, member 14
chr3_+_182971018 1.99 ENST00000326505.3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr6_+_44095347 1.98 ENST00000323267.6
transmembrane protein 63B
chr4_-_146859787 1.97 ENST00000508784.1
zinc finger protein 827
chr13_-_73356009 1.96 ENST00000377780.4
ENST00000377767.4
DIS3 mitotic control homolog (S. cerevisiae)
chr22_-_19512893 1.96 ENST00000403084.1
ENST00000413119.2
claudin 5
chr17_-_1389419 1.96 ENST00000575158.1
myosin IC
chrX_-_118986911 1.91 ENST00000276201.2
ENST00000345865.2
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr11_+_6625046 1.91 ENST00000396751.2
integrin-linked kinase
chr5_-_146889619 1.90 ENST00000343218.5
dihydropyrimidinase-like 3
chr11_-_104840093 1.89 ENST00000417440.2
ENST00000444739.2
caspase 4, apoptosis-related cysteine peptidase
chr11_-_75062829 1.87 ENST00000393505.4
arrestin, beta 1
chr4_-_74964904 1.86 ENST00000508487.2
chemokine (C-X-C motif) ligand 2
chr11_+_6624955 1.84 ENST00000299421.4
ENST00000537806.1
integrin-linked kinase
chr3_+_111718036 1.82 ENST00000455401.2
transgelin 3
chr17_+_21191341 1.80 ENST00000526076.2
ENST00000361818.5
ENST00000316920.6
mitogen-activated protein kinase kinase 3
chr5_+_170846640 1.79 ENST00000274625.5
fibroblast growth factor 18
chr19_+_45251804 1.79 ENST00000164227.5
B-cell CLL/lymphoma 3
chr4_-_5890145 1.79 ENST00000397890.2
collapsin response mediator protein 1
chr14_-_51297197 1.78 ENST00000382043.4
ninein (GSK3B interacting protein)
chr17_-_1389228 1.78 ENST00000438665.2
myosin IC
chr5_+_176731572 1.75 ENST00000503853.1
PRELI domain containing 1
chr19_-_55677920 1.75 ENST00000524407.2
ENST00000526003.1
ENST00000534170.1
dynein, axonemal, assembly factor 3
chr1_-_155232047 1.72 ENST00000302631.3
secretory carrier membrane protein 3
chr1_-_151299842 1.65 ENST00000438243.2
ENST00000489223.2
ENST00000368873.1
ENST00000430800.1
ENST00000368872.1
phosphatidylinositol 4-kinase, catalytic, beta
chr2_+_190306159 1.64 ENST00000314761.4
WD repeat domain 75
chr11_-_75062730 1.63 ENST00000420843.2
ENST00000360025.3
arrestin, beta 1
chr3_-_182698381 1.63 ENST00000292782.4
DCN1, defective in cullin neddylation 1, domain containing 1
chr7_-_98467543 1.63 ENST00000345589.4
transmembrane protein 130
chr16_+_70613770 1.61 ENST00000429149.2
ENST00000563721.2
interleukin 34
chr11_-_76381781 1.61 ENST00000260061.5
ENST00000404995.1
leucine rich repeat containing 32
chr7_-_98467489 1.60 ENST00000416379.2
transmembrane protein 130
chr7_-_98467629 1.59 ENST00000339375.4
transmembrane protein 130
chr2_+_64681641 1.58 ENST00000409537.2
lectin, galactoside-binding-like
chr11_-_3862206 1.56 ENST00000351018.4
ras homolog family member G
chr1_+_183441618 1.56 ENST00000507691.2
ENST00000508461.1
ENST00000419169.1
ENST00000347615.2
ENST00000507469.1
ENST00000515829.2
SMG7 nonsense mediated mRNA decay factor
chr10_-_36813162 1.55 ENST00000440465.1
nicotinamide phosphoribosyltransferase-like
chr16_-_66959429 1.55 ENST00000420652.1
ENST00000299759.6
Ras-related associated with diabetes
chr16_-_4465886 1.53 ENST00000539968.1
coronin 7
chr15_+_92396920 1.53 ENST00000318445.6
solute carrier organic anion transporter family, member 3A1
chr20_+_35090150 1.52 ENST00000340491.4
discs, large (Drosophila) homolog-associated protein 4
chr19_-_55677999 1.52 ENST00000532817.1
ENST00000527223.2
ENST00000391720.4
dynein, axonemal, assembly factor 3
chr17_+_76164639 1.48 ENST00000225777.3
ENST00000585591.1
ENST00000589711.1
ENST00000588282.1
ENST00000589168.1
synaptogyrin 2
chr22_-_21984282 1.48 ENST00000398873.3
ENST00000292778.6
YdjC homolog (bacterial)
chr5_-_176730676 1.48 ENST00000393611.2
ENST00000303251.6
ENST00000303270.6
RAB24, member RAS oncogene family
chrX_-_23761317 1.47 ENST00000492081.1
ENST00000379303.5
ENST00000336430.7
acyl-CoA thioesterase 9
chr10_+_118350522 1.47 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
pancreatic lipase-related protein 1
chr10_+_118350468 1.45 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
pancreatic lipase-related protein 1
chr11_+_46639071 1.44 ENST00000580238.1
ENST00000581416.1
ENST00000529655.1
ENST00000533325.1
ENST00000581438.1
ENST00000583249.1
ENST00000530500.1
ENST00000526508.1
ENST00000578626.1
ENST00000577256.1
ENST00000524625.1
ENST00000582547.1
ENST00000359513.4
ENST00000528494.1
autophagy related 13
chr1_+_183441600 1.44 ENST00000367537.3
SMG7 nonsense mediated mRNA decay factor
chr8_+_32406179 1.40 ENST00000405005.3
neuregulin 1
chr16_-_74734742 1.39 ENST00000308807.7
ENST00000573267.1
mixed lineage kinase domain-like
chr14_-_51297837 1.36 ENST00000245441.5
ENST00000389868.3
ENST00000382041.3
ENST00000324330.9
ENST00000453196.1
ENST00000453401.2
ninein (GSK3B interacting protein)
chr1_-_89458287 1.36 ENST00000370485.2
cysteine conjugate-beta lyase 2
chrX_-_15353629 1.36 ENST00000333590.4
ENST00000428964.1
ENST00000542278.1
phosphatidylinositol glycan anchor biosynthesis, class A
chr20_-_62258394 1.35 ENST00000370077.1
glucocorticoid modulatory element binding protein 2
chr17_+_76165213 1.32 ENST00000590201.1
synaptogyrin 2
chr16_-_1429674 1.32 ENST00000403703.1
ENST00000397464.1
ENST00000402641.2
unkempt family zinc finger-like
chr1_-_89458415 1.31 ENST00000321792.5
ENST00000370491.3
RNA binding motif protein, X-linked-like 1
cysteine conjugate-beta lyase 2
chr19_-_10450328 1.30 ENST00000160262.5
intercellular adhesion molecule 3
chr8_+_38677850 1.29 ENST00000518809.1
ENST00000520611.1
transforming, acidic coiled-coil containing protein 1
chr4_-_169239921 1.29 ENST00000514995.1
ENST00000393743.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chrX_+_64887512 1.28 ENST00000360270.5
moesin
chr17_-_42908155 1.26 ENST00000426548.1
ENST00000590758.1
ENST00000591424.1
gap junction protein, gamma 1, 45kDa
chr11_+_58910295 1.26 ENST00000420244.1
family with sequence similarity 111, member A
chr5_+_67511524 1.26 ENST00000521381.1
ENST00000521657.1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr15_+_92937144 1.26 ENST00000539113.1
ENST00000555434.1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr11_+_706113 1.26 ENST00000318562.8
ENST00000533256.1
ENST00000534755.1
EPS8-like 2
chr6_+_135502408 1.26 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
v-myb avian myeloblastosis viral oncogene homolog
chr17_-_3819751 1.25 ENST00000225538.3
purinergic receptor P2X, ligand-gated ion channel, 1
chr18_+_74240610 1.24 ENST00000578092.1
ENST00000578613.1
ENST00000583578.1
long intergenic non-protein coding RNA 908
chr1_+_90287480 1.22 ENST00000394593.3
leucine rich repeat containing 8 family, member D
chr1_+_19578033 1.20 ENST00000330263.4
mRNA turnover 4 homolog (S. cerevisiae)
chr17_-_1395954 1.20 ENST00000359786.5
myosin IC
chr3_+_52232102 1.17 ENST00000469224.1
ENST00000394965.2
ENST00000310271.2
ENST00000484952.1
aminolevulinate, delta-, synthase 1
chr19_+_33072373 1.17 ENST00000586035.1
programmed cell death 5
chr16_+_31119615 1.16 ENST00000394950.3
ENST00000287507.3
ENST00000219794.6
ENST00000561755.1
branched chain ketoacid dehydrogenase kinase
chr9_+_17579084 1.15 ENST00000380607.4
SH3-domain GRB2-like 2
chr12_-_50294033 1.14 ENST00000552669.1
Fas apoptotic inhibitory molecule 2
chr11_-_46142505 1.13 ENST00000524497.1
ENST00000418153.2
PHD finger protein 21A
chr17_+_8924837 1.13 ENST00000173229.2
netrin 1
chr15_-_72767490 1.13 ENST00000565181.1
RP11-1007O24.3
chr3_-_50329990 1.12 ENST00000417626.2
interferon-related developmental regulator 2
chr11_+_58910201 1.12 ENST00000528737.1
family with sequence similarity 111, member A
chr20_-_62462566 1.11 ENST00000245663.4
ENST00000302995.2
zinc finger and BTB domain containing 46
chr19_+_39390587 1.10 ENST00000572515.1
ENST00000392079.3
ENST00000575359.1
ENST00000313582.5
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr17_+_28884130 1.09 ENST00000580161.1
TBC1 domain family, member 29
chr5_+_137203465 1.08 ENST00000239926.4
myotilin
chrX_-_2418936 1.08 ENST00000461691.1
ENST00000381223.4
ENST00000381222.2
ENST00000412516.2
ENST00000334651.5
zinc finger, BED-type containing 1
dehydrogenase/reductase (SDR family) X-linked
chr16_-_4466565 1.07 ENST00000572467.1
ENST00000423908.2
ENST00000572044.1
ENST00000571052.1
CORO7-PAM16 readthrough
coronin 7
chr6_+_137143694 1.06 ENST00000367756.4
ENST00000541292.1
ENST00000318471.4
peroxisomal biogenesis factor 7
chr6_-_43484621 1.06 ENST00000506469.1
ENST00000503972.1
Yip1 domain family, member 3
chr10_-_133795416 1.06 ENST00000540159.1
ENST00000368636.4
BCL2/adenovirus E1B 19kDa interacting protein 3
chr19_+_38794797 1.06 ENST00000301246.5
ENST00000588605.1
chromosome 19 open reading frame 33
chr19_+_45842445 1.06 ENST00000598357.1
Uncharacterized protein
chr14_+_24616588 1.02 ENST00000324103.6
ENST00000559260.1
ring finger protein 31
chr8_+_120079478 1.02 ENST00000332843.2
collectin sub-family member 10 (C-type lectin)
chr2_-_89568263 1.01 ENST00000473726.1
immunoglobulin kappa variable 1-33
chr15_-_89438742 1.01 ENST00000562281.1
ENST00000562889.1
ENST00000359595.3
hyaluronan and proteoglycan link protein 3
chr4_-_860950 1.01 ENST00000511980.1
ENST00000510799.1
cyclin G associated kinase
chr3_-_50329835 1.01 ENST00000429673.2
interferon-related developmental regulator 2
chr5_-_1445539 1.00 ENST00000270349.9
solute carrier family 6 (neurotransmitter transporter), member 3
chr12_-_130388211 0.99 ENST00000422113.2
transmembrane protein 132D
chr12_+_100661156 0.98 ENST00000360820.2
SCY1-like 2 (S. cerevisiae)
chr1_-_146082633 0.98 ENST00000605317.1
ENST00000604938.1
ENST00000339388.5
neuroblastoma breakpoint family, member 11
chr20_+_58713514 0.97 ENST00000432910.1
RP5-1043L13.1
chr22_-_37640456 0.96 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr1_-_150207017 0.96 ENST00000369119.3
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr6_-_43484718 0.95 ENST00000372422.2
Yip1 domain family, member 3
chr2_-_27718052 0.95 ENST00000264703.3
fibronectin type III domain containing 4
chr2_+_89952792 0.95 ENST00000390265.2
immunoglobulin kappa variable 1D-33

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 15.1 GO:1990108 protein linear deubiquitination(GO:1990108)
3.1 15.3 GO:0033091 positive regulation of immature T cell proliferation(GO:0033091)
2.8 11.4 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
2.6 10.4 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
2.4 9.8 GO:0060697 positive regulation of phospholipid catabolic process(GO:0060697)
2.3 11.4 GO:1903971 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
1.9 5.8 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
1.9 7.7 GO:0044501 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
1.8 5.5 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
1.2 4.8 GO:0000255 allantoin metabolic process(GO:0000255)
1.2 10.6 GO:0001920 negative regulation of receptor recycling(GO:0001920)
1.1 32.7 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
1.0 4.8 GO:0032218 riboflavin transport(GO:0032218)
0.9 3.7 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.9 7.1 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.9 5.2 GO:2001183 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.9 7.7 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.8 4.9 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.7 6.6 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.6 1.8 GO:1904617 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.6 4.2 GO:1901857 positive regulation of cellular respiration(GO:1901857)
0.6 5.7 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.5 7.9 GO:1902222 L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.4 1.3 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.4 4.1 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.4 5.2 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.4 2.0 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.4 1.5 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.4 1.1 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.4 9.7 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.4 1.1 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.4 10.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.3 4.8 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.3 3.4 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.3 1.0 GO:1905224 clathrin-coated pit assembly(GO:1905224)
0.3 2.3 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.3 2.0 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.3 1.3 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.3 1.3 GO:0086021 SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021)
0.3 1.2 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.3 3.5 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.3 1.6 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.3 0.5 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.3 0.8 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.2 1.2 GO:0002351 serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554)
0.2 2.0 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.2 3.9 GO:0016322 neuron remodeling(GO:0016322)
0.2 0.7 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.2 2.5 GO:0048664 neuron fate determination(GO:0048664)
0.2 24.2 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.2 0.7 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
0.2 1.8 GO:0035897 proteolysis in other organism(GO:0035897)
0.2 3.1 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.2 1.8 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.2 0.7 GO:0046167 glycerol-3-phosphate biosynthetic process(GO:0046167)
0.2 2.6 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.2 0.6 GO:1900222 regulation of cell growth by extracellular stimulus(GO:0001560) negative regulation of beta-amyloid clearance(GO:1900222)
0.2 0.6 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.2 17.6 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.2 1.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.2 1.3 GO:0022614 membrane to membrane docking(GO:0022614)
0.2 0.7 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.2 1.6 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
0.2 0.7 GO:0002265 astrocyte activation involved in immune response(GO:0002265) positive regulation of lysosomal protein catabolic process(GO:1905167)
0.2 0.5 GO:0003220 left ventricular cardiac muscle tissue morphogenesis(GO:0003220) regulation of AV node cell action potential(GO:0098904)
0.2 2.2 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.2 0.5 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.2 1.1 GO:0045649 regulation of macrophage differentiation(GO:0045649) negative regulation of macrophage differentiation(GO:0045650)
0.2 0.6 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.2 0.9 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.4 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.9 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.1 0.9 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.1 3.8 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 1.1 GO:0033564 Cdc42 protein signal transduction(GO:0032488) anterior/posterior axon guidance(GO:0033564)
0.1 1.0 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.1 0.7 GO:0070836 caveola assembly(GO:0070836)
0.1 3.7 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.1 0.7 GO:0042631 cellular response to water deprivation(GO:0042631)
0.1 0.4 GO:0044209 AMP salvage(GO:0044209)
0.1 0.5 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.1 1.8 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.4 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.1 2.4 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.1 0.2 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1 0.8 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.1 9.0 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.1 4.7 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 1.7 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 8.6 GO:0016266 O-glycan processing(GO:0016266)
0.1 2.4 GO:0032060 bleb assembly(GO:0032060)
0.1 3.3 GO:0044458 motile cilium assembly(GO:0044458)
0.1 0.8 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 5.3 GO:0001755 neural crest cell migration(GO:0001755)
0.1 0.9 GO:0060056 mammary gland involution(GO:0060056)
0.1 0.3 GO:0009386 translational attenuation(GO:0009386)
0.1 0.7 GO:0006477 protein sulfation(GO:0006477)
0.1 1.2 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.1 8.1 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 0.7 GO:0033008 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.1 1.1 GO:0060155 platelet dense granule organization(GO:0060155)
0.1 1.1 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.1 0.6 GO:0002084 protein depalmitoylation(GO:0002084)
0.1 0.3 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.1 1.9 GO:0051764 actin crosslink formation(GO:0051764)
0.1 1.0 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 1.6 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.1 3.8 GO:0019835 cytolysis(GO:0019835)
0.1 0.5 GO:0051639 actin filament network formation(GO:0051639)
0.1 1.3 GO:0051531 NFAT protein import into nucleus(GO:0051531) positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.1 1.6 GO:0045116 protein neddylation(GO:0045116)
0.1 0.2 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
0.1 0.4 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.1 2.1 GO:0010842 retina layer formation(GO:0010842)
0.1 0.9 GO:0042354 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.1 0.3 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659)
0.1 1.0 GO:0042416 dopamine biosynthetic process(GO:0042416)
0.1 0.5 GO:0043313 regulation of neutrophil degranulation(GO:0043313)
0.1 0.3 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.1 2.8 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.1 1.4 GO:0098780 response to mitochondrial depolarisation(GO:0098780)
0.1 0.4 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 0.5 GO:0051660 establishment of centrosome localization(GO:0051660)
0.1 0.6 GO:1903546 receptor localization to nonmotile primary cilium(GO:0097500) protein localization to photoreceptor outer segment(GO:1903546)
0.1 0.6 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.1 0.1 GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
0.1 0.6 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.1 0.6 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.1 0.5 GO:0036155 acylglycerol acyl-chain remodeling(GO:0036155)
0.1 0.5 GO:0009249 protein lipoylation(GO:0009249)
0.1 1.1 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.3 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.1 GO:2000397 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.0 0.4 GO:0019732 antifungal humoral response(GO:0019732)
0.0 0.3 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.0 0.5 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.0 0.9 GO:0034063 stress granule assembly(GO:0034063)
0.0 1.6 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 1.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.4 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.0 0.8 GO:0008595 blastoderm segmentation(GO:0007350) tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0 0.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 3.9 GO:0007004 telomere maintenance via telomerase(GO:0007004)
0.0 0.5 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.0 0.4 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.5 GO:0015732 prostaglandin transport(GO:0015732)
0.0 3.5 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 1.2 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.5 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 1.1 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.0 0.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.3 GO:0090383 phagosome acidification(GO:0090383)
0.0 1.6 GO:0050710 negative regulation of cytokine secretion(GO:0050710)
0.0 0.5 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.7 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 4.8 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 2.4 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 1.4 GO:0090280 positive regulation of calcium ion import(GO:0090280)
0.0 0.9 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 1.3 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.2 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:0002159 desmosome assembly(GO:0002159) endothelial cell-cell adhesion(GO:0071603)
0.0 0.8 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 0.1 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0 0.7 GO:0070266 necroptotic process(GO:0070266)
0.0 0.3 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0 0.8 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 0.1 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.0 0.2 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 1.4 GO:0032392 DNA geometric change(GO:0032392)
0.0 0.6 GO:1901099 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.8 GO:0043486 histone exchange(GO:0043486)
0.0 0.9 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.2 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 1.1 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.5 GO:0006953 acute-phase response(GO:0006953)
0.0 1.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 22.4 GO:0008537 proteasome activator complex(GO:0008537)
2.8 11.4 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
1.9 11.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
1.3 10.2 GO:0005610 laminin-5 complex(GO:0005610)
1.2 4.9 GO:0045160 myosin I complex(GO:0045160)
0.4 3.6 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.4 4.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.3 3.1 GO:0036449 microtubule minus-end(GO:0036449)
0.3 6.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.3 1.3 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.3 0.8 GO:0005873 plus-end kinesin complex(GO:0005873)
0.3 2.6 GO:0060091 kinocilium(GO:0060091)
0.3 14.9 GO:0097542 ciliary tip(GO:0097542)
0.2 1.8 GO:0032010 phagolysosome(GO:0032010)
0.2 1.9 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.2 1.0 GO:0071797 LUBAC complex(GO:0071797)
0.2 0.8 GO:0044308 axonal spine(GO:0044308)
0.2 0.5 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.2 1.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.2 4.8 GO:0031143 pseudopodium(GO:0031143)
0.2 1.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 12.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 1.6 GO:0032584 growth cone membrane(GO:0032584)
0.1 1.8 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 2.0 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 7.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 1.4 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.6 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 7.4 GO:0000786 nucleosome(GO:0000786)
0.1 3.9 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 1.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 2.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.9 GO:0030870 Mre11 complex(GO:0030870)
0.1 1.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 10.4 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 0.7 GO:0044294 dendritic growth cone(GO:0044294)
0.1 1.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 3.7 GO:0043034 costamere(GO:0043034)
0.1 1.0 GO:0016600 flotillin complex(GO:0016600)
0.1 0.5 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.1 0.7 GO:0016589 NURF complex(GO:0016589)
0.1 2.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.6 GO:0016461 unconventional myosin complex(GO:0016461)
0.1 1.5 GO:0001891 phagocytic cup(GO:0001891)
0.1 2.3 GO:0030673 axolemma(GO:0030673)
0.1 0.4 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.5 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.1 6.7 GO:0055037 recycling endosome(GO:0055037)
0.1 8.6 GO:0005923 bicellular tight junction(GO:0005923)
0.1 5.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.5 GO:0032059 bleb(GO:0032059)
0.0 1.0 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 1.0 GO:0005922 connexon complex(GO:0005922)
0.0 0.4 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 2.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 2.8 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.9 GO:0031941 filamentous actin(GO:0031941)
0.0 1.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.9 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 3.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 3.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.3 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 7.6 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.2 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 43.4 GO:0005615 extracellular space(GO:0005615)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 10.9 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 1.2 GO:0005604 basement membrane(GO:0005604)
0.0 2.7 GO:0043209 myelin sheath(GO:0043209)
0.0 1.4 GO:0005884 actin filament(GO:0005884)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 1.0 GO:0005776 autophagosome(GO:0005776)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 1.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.4 GO:0030496 midbody(GO:0030496)
0.0 6.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.1 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 4.4 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.4 GO:0005814 centriole(GO:0005814)
0.0 0.1 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.2 GO:0033268 node of Ranvier(GO:0033268)
0.0 1.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.3 GO:0042383 sarcolemma(GO:0042383)
0.0 0.4 GO:0048786 presynaptic active zone(GO:0048786)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 22.4 GO:0061133 endopeptidase activator activity(GO:0061133)
2.6 7.9 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
2.0 31.6 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
2.0 9.8 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
1.6 13.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
1.5 10.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
1.3 14.8 GO:0030274 LIM domain binding(GO:0030274)
1.3 4.0 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
1.3 7.7 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
1.2 3.5 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
1.2 5.8 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
1.1 14.8 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
1.0 4.8 GO:0032217 riboflavin transporter activity(GO:0032217)
0.9 14.8 GO:0031996 thioesterase binding(GO:0031996)
0.8 6.6 GO:0042296 ISG15 transferase activity(GO:0042296)
0.8 4.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.7 3.4 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.6 1.8 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.6 5.7 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.5 2.0 GO:0004803 transposase activity(GO:0004803)
0.4 2.4 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.4 10.6 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.4 1.2 GO:0016749 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.4 1.2 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.4 3.1 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.4 1.5 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.4 2.1 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.3 1.0 GO:0005330 dopamine:sodium symporter activity(GO:0005330)
0.3 1.3 GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020)
0.3 2.3 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.3 7.8 GO:0031593 polyubiquitin binding(GO:0031593)
0.2 2.6 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.2 1.6 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.2 0.7 GO:0004370 glycerol kinase activity(GO:0004370)
0.2 0.7 GO:0017130 poly(C) RNA binding(GO:0017130)
0.2 1.8 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2 4.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.2 2.6 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 0.7 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.2 0.7 GO:0047708 biotinidase activity(GO:0047708)
0.2 6.8 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 3.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 4.8 GO:0008483 transaminase activity(GO:0008483)
0.2 1.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 1.3 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.2 1.8 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.4 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1 3.7 GO:0031005 filamin binding(GO:0031005)
0.1 0.7 GO:0042954 apolipoprotein receptor activity(GO:0030226) lipoprotein transporter activity(GO:0042954)
0.1 0.5 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.1 0.5 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.1 0.9 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 8.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 1.8 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 1.6 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 3.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 1.1 GO:0008142 oxysterol binding(GO:0008142)
0.1 1.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 0.7 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 1.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 1.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 3.9 GO:0070034 telomerase RNA binding(GO:0070034)
0.1 5.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.8 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 0.9 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 0.4 GO:0002060 purine nucleobase binding(GO:0002060)
0.1 1.7 GO:0050700 CARD domain binding(GO:0050700)
0.1 0.9 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 0.5 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.1 1.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 4.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.2 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.1 0.3 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.1 0.5 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 1.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 0.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 1.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 1.6 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.3 GO:0034057 RNA strand-exchange activity(GO:0034057)
0.1 1.8 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.4 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.1 0.5 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.9 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 0.6 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 1.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.0 GO:0005537 mannose binding(GO:0005537)
0.0 0.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.8 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 1.8 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.0 0.9 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.8 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.5 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 9.5 GO:0001047 core promoter binding(GO:0001047)
0.0 0.6 GO:0000146 microfilament motor activity(GO:0000146)
0.0 1.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 10.8 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 1.1 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 2.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.5 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.5 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.8 GO:0001618 virus receptor activity(GO:0001618)
0.0 3.6 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.5 GO:0016502 purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
0.0 0.5 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.3 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 3.5 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 4.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.2 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 8.0 GO:0005525 GTP binding(GO:0005525)
0.0 0.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.4 GO:0019956 chemokine binding(GO:0019956)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.8 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.4 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.2 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 1.8 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.7 30.4 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.4 10.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.4 19.6 PID CD40 PATHWAY CD40/CD40L signaling
0.3 12.0 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.3 17.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.3 9.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3 4.1 PID IL23 PATHWAY IL23-mediated signaling events
0.2 5.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.2 1.1 PID FAS PATHWAY FAS (CD95) signaling pathway
0.2 10.1 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.2 2.0 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2 8.5 ST G ALPHA I PATHWAY G alpha i Pathway
0.1 5.5 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 13.4 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 5.2 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 6.3 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 29.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 2.6 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.1 4.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 0.3 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 1.3 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 1.1 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 1.1 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 1.3 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.5 ST ADRENERGIC Adrenergic Pathway
0.0 0.9 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 2.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 4.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.3 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 2.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 1.1 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.2 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 2.4 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.7 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.0 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.3 PID AURORA A PATHWAY Aurora A signaling
0.0 1.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.5 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.5 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.6 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.7 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 1.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.6 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 2.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 15.3 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.6 41.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.4 4.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.4 10.7 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.4 20.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3 5.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.3 22.4 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.3 6.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.3 19.1 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.2 3.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 4.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 0.7 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.2 6.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 4.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.2 3.5 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.2 6.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.2 15.9 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization