Project

Inflammatory response time course, HUVEC (Wada et al., 2009)

Navigation
Downloads

Results for NKX1-1

Z-value: 0.34

Motif logo

logo of

Transcription factors associated with NKX1-1

Gene Symbol Gene ID Gene Info
NKX1-1
ENSG00000235608.1 NK1 homeobox 1

Activity profile of NKX1-1 motif

Sorted Z-values of NKX1-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_8822113 0.96 ENST00000396290.1
ENST00000331129.3
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr19_+_32897009 0.46 ENST00000342179.5
ENST00000586427.1
DPY19L3
dpy-19-like 3 (C. elegans)
chr19_+_32896697 0.44 ENST00000586987.1
DPY19L3
dpy-19-like 3 (C. elegans)
chr7_+_12727250 0.43 ENST00000404894.1
ARL4A
ADP-ribosylation factor-like 4A
chr7_+_99717230 0.41 ENST00000262932.3
CNPY4
canopy FGF signaling regulator 4
chr3_-_105588231 0.38 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr4_-_54232144 0.36 ENST00000388940.4
ENST00000503450.1
ENST00000401642.3
SCFD2
sec1 family domain containing 2
chr1_+_155278539 0.32 ENST00000447866.1
FDPS
farnesyl diphosphate synthase
chr1_+_155278625 0.32 ENST00000368356.4
ENST00000356657.6
FDPS
farnesyl diphosphate synthase
chr13_+_36050881 0.29 ENST00000537702.1
NBEA
neurobeachin
chr4_-_103682145 0.27 ENST00000226578.4
MANBA
mannosidase, beta A, lysosomal
chr2_+_217524323 0.26 ENST00000456764.1
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr10_-_1095050 0.25 ENST00000381344.3
IDI1
isopentenyl-diphosphate delta isomerase 1
chr17_-_27418537 0.24 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr3_-_105587879 0.23 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr1_+_174843548 0.22 ENST00000478442.1
ENST00000465412.1
RABGAP1L
RAB GTPase activating protein 1-like
chr7_+_99647389 0.22 ENST00000543588.1
ENST00000292450.4
ENST00000456748.2
ZSCAN21
zinc finger and SCAN domain containing 21
chr7_+_2559399 0.19 ENST00000222725.5
ENST00000359574.3
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chrX_+_55026763 0.19 ENST00000374987.3
APEX2
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
chr3_+_158519654 0.17 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
MFSD1
major facilitator superfamily domain containing 1
chr2_-_97405775 0.16 ENST00000264963.4
ENST00000537039.1
ENST00000377079.4
ENST00000426463.2
ENST00000534882.1
LMAN2L
lectin, mannose-binding 2-like
chr17_+_59489112 0.16 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr11_-_124981475 0.15 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
TMEM218
transmembrane protein 218
chr17_+_45286387 0.15 ENST00000572316.1
ENST00000354968.1
ENST00000576874.1
ENST00000536623.2
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr12_+_28410128 0.15 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr9_+_116225999 0.15 ENST00000317613.6
RGS3
regulator of G-protein signaling 3
chr4_-_66536196 0.14 ENST00000511294.1
EPHA5
EPH receptor A5
chr1_-_51796987 0.14 ENST00000262676.5
TTC39A
tetratricopeptide repeat domain 39A
chr4_+_87515454 0.14 ENST00000427191.2
ENST00000436978.1
ENST00000502971.1
PTPN13
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
chr17_+_45286706 0.14 ENST00000393450.1
ENST00000572303.1
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr8_+_26371763 0.13 ENST00000521913.1
DPYSL2
dihydropyrimidinase-like 2
chr5_+_66300446 0.12 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr3_-_52567792 0.12 ENST00000307092.4
ENST00000422318.2
ENST00000459839.1
NT5DC2
5'-nucleotidase domain containing 2
chrX_-_153363188 0.12 ENST00000303391.6
MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr7_-_6048650 0.12 ENST00000382321.4
ENST00000406569.3
PMS2
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr11_-_47198380 0.11 ENST00000419701.2
ENST00000526342.1
ENST00000528444.1
ENST00000530596.1
ENST00000525398.1
ENST00000319543.6
ENST00000426335.2
ENST00000527927.1
ENST00000525314.1
ARFGAP2
ADP-ribosylation factor GTPase activating protein 2
chr7_-_6048702 0.11 ENST00000265849.7
PMS2
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr6_+_26501449 0.11 ENST00000244513.6
BTN1A1
butyrophilin, subfamily 1, member A1
chr1_+_100818009 0.10 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
CDC14A
cell division cycle 14A
chr8_+_98656693 0.10 ENST00000519934.1
MTDH
metadherin
chr1_-_201140673 0.10 ENST00000367333.2
TMEM9
transmembrane protein 9
chr1_+_161691353 0.10 ENST00000367948.2
FCRLB
Fc receptor-like B
chr19_+_11071546 0.10 ENST00000358026.2
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr9_+_34646624 0.09 ENST00000450095.2
ENST00000556278.1
GALT
GALT
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr13_+_78315295 0.09 ENST00000351546.3
SLAIN1
SLAIN motif family, member 1
chr17_-_57232596 0.09 ENST00000581068.1
ENST00000330137.7
SKA2
spindle and kinetochore associated complex subunit 2
chr9_+_34646651 0.09 ENST00000378842.3
GALT
galactose-1-phosphate uridylyltransferase
chr12_+_7014126 0.09 ENST00000415834.1
ENST00000436789.1
LRRC23
leucine rich repeat containing 23
chr14_-_81425828 0.09 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128
centrosomal protein 128kDa
chr7_-_86849883 0.08 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr1_-_151762943 0.08 ENST00000368825.3
ENST00000368823.1
ENST00000458431.2
ENST00000368827.6
ENST00000368824.3
TDRKH
tudor and KH domain containing
chr3_+_57261743 0.07 ENST00000288266.3
APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr20_-_17662705 0.07 ENST00000455029.2
RRBP1
ribosome binding protein 1
chr12_+_102513950 0.07 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chr17_-_57232525 0.06 ENST00000583380.1
ENST00000580541.1
ENST00000578105.1
ENST00000437036.2
SKA2
spindle and kinetochore associated complex subunit 2
chr3_-_59035673 0.06 ENST00000491845.1
ENST00000472469.1
ENST00000471288.1
ENST00000295966.7
C3orf67
chromosome 3 open reading frame 67
chr15_-_64385981 0.06 ENST00000557835.1
ENST00000380290.3
ENST00000559950.1
FAM96A
family with sequence similarity 96, member A
chrX_-_153363125 0.06 ENST00000407218.1
ENST00000453960.2
MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr11_-_71823715 0.06 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr11_-_71823796 0.06 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr15_-_64386120 0.05 ENST00000300030.3
FAM96A
family with sequence similarity 96, member A
chr1_+_100818156 0.05 ENST00000336454.3
CDC14A
cell division cycle 14A
chr14_-_106066376 0.05 ENST00000412518.1
ENST00000428654.1
ENST00000427543.1
ENST00000420153.1
ENST00000577108.1
ENST00000576077.1
AL928742.12
IGHE
AL928742.12
immunoglobulin heavy constant epsilon
chr5_-_22853429 0.05 ENST00000504376.2
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr7_-_99716952 0.05 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr17_-_8055747 0.05 ENST00000317276.4
ENST00000581703.1
PER1
period circadian clock 1
chr19_+_36249057 0.05 ENST00000301165.5
ENST00000536950.1
ENST00000537459.1
ENST00000421853.2
C19orf55
chromosome 19 open reading frame 55
chr10_-_56561022 0.04 ENST00000373965.2
ENST00000414778.1
ENST00000395438.1
ENST00000409834.1
ENST00000395445.1
ENST00000395446.1
ENST00000395442.1
ENST00000395440.1
ENST00000395432.2
ENST00000361849.3
ENST00000395433.1
ENST00000320301.6
ENST00000395430.1
ENST00000437009.1
PCDH15
protocadherin-related 15
chr7_-_73256838 0.04 ENST00000297873.4
WBSCR27
Williams Beuren syndrome chromosome region 27
chr4_-_66536057 0.04 ENST00000273854.3
EPHA5
EPH receptor A5
chr17_-_44657017 0.04 ENST00000573185.1
ENST00000570550.1
ENST00000445552.2
ENST00000336125.5
ENST00000329240.4
ENST00000337845.7
ARL17A
ADP-ribosylation factor-like 17A
chr12_+_7014064 0.04 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr7_+_26331541 0.04 ENST00000416246.1
ENST00000338523.4
ENST00000412416.1
SNX10
sorting nexin 10
chr12_+_7013897 0.04 ENST00000007969.8
ENST00000323702.5
LRRC23
leucine rich repeat containing 23
chr18_-_44181442 0.03 ENST00000398722.4
LOXHD1
lipoxygenase homology domains 1
chr3_+_186288454 0.03 ENST00000265028.3
DNAJB11
DnaJ (Hsp40) homolog, subfamily B, member 11
chr8_+_98656336 0.03 ENST00000336273.3
MTDH
metadherin
chr10_-_56560939 0.03 ENST00000373955.1
PCDH15
protocadherin-related 15
chr19_+_41256764 0.03 ENST00000243563.3
ENST00000601253.1
ENST00000597353.1
ENST00000599362.1
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr1_-_28969517 0.03 ENST00000263974.4
ENST00000373824.4
TAF12
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
chr10_+_120789223 0.03 ENST00000425699.1
NANOS1
nanos homolog 1 (Drosophila)
chr10_+_99205894 0.03 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr17_-_44439084 0.03 ENST00000575960.1
ENST00000575698.1
ENST00000571246.1
ENST00000434041.2
ENST00000570618.1
ENST00000450673.3
ARL17B
ADP-ribosylation factor-like 17B
chr10_+_5238793 0.03 ENST00000263126.1
AKR1C4
aldo-keto reductase family 1, member C4
chr10_+_99205959 0.02 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr12_+_16500599 0.02 ENST00000535309.1
ENST00000540056.1
ENST00000396209.1
ENST00000540126.1
MGST1
microsomal glutathione S-transferase 1
chr16_+_640055 0.02 ENST00000568586.1
ENST00000538492.1
ENST00000248139.3
RAB40C
RAB40C, member RAS oncogene family
chr17_+_57232690 0.02 ENST00000262293.4
PRR11
proline rich 11
chr12_+_16500037 0.02 ENST00000536371.1
ENST00000010404.2
MGST1
microsomal glutathione S-transferase 1
chr12_+_102514019 0.02 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
PARPBP
PARP1 binding protein
chr22_+_22730353 0.02 ENST00000390296.2
IGLV5-45
immunoglobulin lambda variable 5-45
chr16_-_11036300 0.02 ENST00000331808.4
DEXI
Dexi homolog (mouse)
chr3_+_23851928 0.02 ENST00000467766.1
ENST00000424381.1
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chrX_+_72783026 0.01 ENST00000373504.6
ENST00000373502.5
CHIC1
cysteine-rich hydrophobic domain 1
chr22_-_39151463 0.01 ENST00000405510.1
ENST00000433561.1
SUN2
Sad1 and UNC84 domain containing 2
chr12_-_50790267 0.01 ENST00000327337.5
ENST00000543111.1
FAM186A
family with sequence similarity 186, member A
chr6_-_82957433 0.01 ENST00000306270.7
IBTK
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr2_-_167232484 0.01 ENST00000375387.4
ENST00000303354.6
ENST00000409672.1
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr7_-_27239703 0.01 ENST00000222753.4
HOXA13
homeobox A13
chr9_+_124329336 0.01 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr12_-_91451758 0.01 ENST00000266719.3
KERA
keratocan
chr5_+_150226085 0.01 ENST00000522154.1
IRGM
immunity-related GTPase family, M
chr4_+_128554081 0.00 ENST00000335251.6
ENST00000296461.5
INTU
inturned planar cell polarity protein
chr16_-_66864806 0.00 ENST00000566336.1
ENST00000394074.2
ENST00000563185.2
ENST00000359087.4
ENST00000379463.2
ENST00000565535.1
ENST00000290810.3
NAE1
NEDD8 activating enzyme E1 subunit 1
chr7_-_99717463 0.00 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr10_+_1095416 0.00 ENST00000358220.1
WDR37
WD repeat domain 37
chr12_+_16500571 0.00 ENST00000543076.1
ENST00000396210.3
MGST1
microsomal glutathione S-transferase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 0.6 GO:0045337 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.1 0.9 GO:0018317 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 0.2 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.1 0.2 GO:0009405 pathogenesis(GO:0009405)
0.0 0.2 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.0 0.6 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.2 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.1 GO:0007068 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.0 0.3 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.0 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.0 0.2 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.2 GO:0090160 Golgi to lysosome transport(GO:0090160)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0071547 piP-body(GO:0071547)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 0.3 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.1 0.2 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0 0.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.0 0.9 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.4 GO:0005537 mannose binding(GO:0005537)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.2 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 0.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID CD40 PATHWAY CD40/CD40L signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.6 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers