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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NKX1-2_RAX

Z-value: 0.44

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Transcription factors associated with NKX1-2_RAX

Gene Symbol Gene ID Gene Info
NKX1-2
ENSG00000229544.6 NK1 homeobox 2
RAX
ENSG00000134438.9 retina and anterior neural fold homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RAXhg19_v2_chr18_-_56940611_569406600.077.5e-01Click!

Activity profile of NKX1-2_RAX motif

Sorted Z-values of NKX1-2_RAX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_26440700 1.49 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr11_-_102651343 1.40 ENST00000279441.4
ENST00000539681.1
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr6_+_26402465 1.38 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr5_-_35938674 1.03 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
CAPSL
calcyphosine-like
chr21_-_37914898 0.78 ENST00000399136.1
CLDN14
claudin 14
chr11_+_33061543 0.76 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
TCP11L1
t-complex 11, testis-specific-like 1
chr6_+_34204642 0.69 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr2_-_220264703 0.67 ENST00000519905.1
ENST00000523282.1
ENST00000434339.1
ENST00000457935.1
DNPEP
aspartyl aminopeptidase
chr11_+_5710919 0.64 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr19_-_6424783 0.61 ENST00000398148.3
KHSRP
KH-type splicing regulatory protein
chr19_-_3557570 0.59 ENST00000355415.2
MFSD12
major facilitator superfamily domain containing 12
chr14_-_53258314 0.57 ENST00000216410.3
ENST00000557604.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr7_+_138145076 0.57 ENST00000343526.4
TRIM24
tripartite motif containing 24
chr5_-_20575959 0.57 ENST00000507958.1
CDH18
cadherin 18, type 2
chr6_+_26402517 0.55 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr17_-_40337470 0.55 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr10_-_4285923 0.52 ENST00000418372.1
ENST00000608792.1
LINC00702
long intergenic non-protein coding RNA 702
chr14_+_32798462 0.42 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr5_-_159546396 0.39 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chr16_-_28608364 0.39 ENST00000533150.1
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr6_+_26365443 0.36 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr15_+_64680003 0.36 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr14_+_103851712 0.33 ENST00000440884.3
ENST00000416682.2
ENST00000429436.2
ENST00000303622.9
MARK3
MAP/microtubule affinity-regulating kinase 3
chr3_+_129247479 0.31 ENST00000296271.3
RHO
rhodopsin
chr7_+_70597109 0.31 ENST00000333538.5
WBSCR17
Williams-Beuren syndrome chromosome region 17
chr7_+_100770328 0.30 ENST00000223095.4
ENST00000445463.2
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr7_+_120628731 0.30 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr2_-_239197201 0.30 ENST00000254658.3
PER2
period circadian clock 2
chr2_-_239197238 0.29 ENST00000254657.3
PER2
period circadian clock 2
chrX_+_30261847 0.29 ENST00000378981.3
ENST00000397550.1
MAGEB1
melanoma antigen family B, 1
chr11_-_111741994 0.29 ENST00000398006.2
ALG9
ALG9, alpha-1,2-mannosyltransferase
chrX_-_77225135 0.28 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr12_-_12837423 0.28 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr10_+_24755416 0.26 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr2_+_187371440 0.25 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chr11_-_3859089 0.25 ENST00000396979.1
RHOG
ras homolog family member G
chr7_-_121944491 0.24 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1
FEZ family zinc finger 1
chr11_-_59383617 0.23 ENST00000263847.1
OSBP
oxysterol binding protein
chr9_-_5339873 0.23 ENST00000223862.1
ENST00000223858.4
RLN1
relaxin 1
chr16_-_28608424 0.23 ENST00000335715.4
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr12_+_112279782 0.21 ENST00000550735.2
MAPKAPK5
mitogen-activated protein kinase-activated protein kinase 5
chr10_-_99205607 0.21 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
EXOSC1
exosome component 1
chr20_-_50722183 0.21 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr1_+_62439037 0.21 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr1_+_160370344 0.20 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr14_+_74034310 0.20 ENST00000538782.1
ACOT2
acyl-CoA thioesterase 2
chr4_+_110736659 0.19 ENST00000394631.3
ENST00000226796.6
GAR1
GAR1 ribonucleoprotein
chr19_+_48949030 0.18 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr6_+_53883708 0.18 ENST00000514921.1
ENST00000274897.5
ENST00000370877.2
MLIP
muscular LMNA-interacting protein
chr1_-_151804314 0.18 ENST00000318247.6
RORC
RAR-related orphan receptor C
chr3_-_191000172 0.17 ENST00000427544.2
UTS2B
urotensin 2B
chr3_-_151034734 0.17 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chrX_+_19362011 0.16 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr15_+_94899183 0.16 ENST00000557742.1
MCTP2
multiple C2 domains, transmembrane 2
chr2_-_74619152 0.16 ENST00000440727.1
ENST00000409240.1
DCTN1
dynactin 1
chr10_-_92681033 0.16 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr5_+_66300446 0.16 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr11_+_71900572 0.15 ENST00000312293.4
FOLR1
folate receptor 1 (adult)
chr10_+_124913930 0.15 ENST00000368858.5
BUB3
BUB3 mitotic checkpoint protein
chr10_+_99205894 0.14 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr6_-_167040731 0.14 ENST00000265678.4
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr16_-_48281305 0.14 ENST00000356608.2
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr10_+_99205959 0.14 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr4_-_74486217 0.14 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr1_-_92952433 0.14 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor
chr19_+_54641444 0.14 ENST00000221232.5
ENST00000358389.3
CNOT3
CCR4-NOT transcription complex, subunit 3
chrX_-_8139308 0.13 ENST00000317103.4
VCX2
variable charge, X-linked 2
chr4_+_66536248 0.13 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
RP11-807H7.1
chr6_+_30687978 0.13 ENST00000327892.8
ENST00000435534.1
TUBB
tubulin, beta class I
chr4_-_103749105 0.13 ENST00000394801.4
ENST00000394804.2
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr11_+_71900703 0.13 ENST00000393681.2
FOLR1
folate receptor 1 (adult)
chr2_-_89597542 0.13 ENST00000465170.1
IGKV1-37
immunoglobulin kappa variable 1-37 (non-functional)
chr10_+_124913793 0.13 ENST00000368865.4
ENST00000538238.1
ENST00000368859.2
BUB3
BUB3 mitotic checkpoint protein
chr9_+_124329336 0.13 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr22_-_32651326 0.12 ENST00000266086.4
SLC5A4
solute carrier family 5 (glucose activated ion channel), member 4
chr10_+_124914285 0.12 ENST00000407911.2
BUB3
BUB3 mitotic checkpoint protein
chr4_-_103748880 0.12 ENST00000453744.2
ENST00000349311.8
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr2_-_169887827 0.11 ENST00000263817.6
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr2_+_105050794 0.11 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
AC013402.2
long intergenic non-protein coding RNA 1102
chr15_+_93443419 0.11 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr4_-_103749313 0.11 ENST00000394803.5
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr19_-_46285736 0.11 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
DMPK
dystrophia myotonica-protein kinase
chr14_+_32798547 0.11 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chrX_-_6453159 0.11 ENST00000381089.3
ENST00000398729.1
VCX3A
variable charge, X-linked 3A
chr7_-_107443652 0.11 ENST00000340010.5
ENST00000422236.2
ENST00000453332.1
SLC26A3
solute carrier family 26 (anion exchanger), member 3
chrX_-_13835147 0.10 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr5_+_63802109 0.10 ENST00000334025.2
RGS7BP
regulator of G-protein signaling 7 binding protein
chr8_-_42623747 0.10 ENST00000534622.1
CHRNA6
cholinergic receptor, nicotinic, alpha 6 (neuronal)
chr3_-_11685345 0.10 ENST00000430365.2
VGLL4
vestigial like 4 (Drosophila)
chr2_-_74618964 0.10 ENST00000417090.1
ENST00000409868.1
DCTN1
dynactin 1
chr6_-_82957433 0.10 ENST00000306270.7
IBTK
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr7_+_21582638 0.09 ENST00000409508.3
ENST00000328843.6
DNAH11
dynein, axonemal, heavy chain 11
chr9_+_34646651 0.09 ENST00000378842.3
GALT
galactose-1-phosphate uridylyltransferase
chr4_-_103749205 0.09 ENST00000508249.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr1_-_152386732 0.09 ENST00000271835.3
CRNN
cornulin
chr1_+_186265399 0.08 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4
proteoglycan 4
chr9_+_135937365 0.08 ENST00000372080.4
ENST00000351304.7
CEL
carboxyl ester lipase
chr10_+_18549645 0.08 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr19_+_11071546 0.08 ENST00000358026.2
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr9_+_34646624 0.08 ENST00000450095.2
ENST00000556278.1
GALT
GALT
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr17_-_4938712 0.07 ENST00000254853.5
ENST00000424747.1
SLC52A1
solute carrier family 52 (riboflavin transporter), member 1
chr3_+_23851928 0.07 ENST00000467766.1
ENST00000424381.1
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr6_+_154360476 0.07 ENST00000428397.2
OPRM1
opioid receptor, mu 1
chr2_+_210517895 0.07 ENST00000447185.1
MAP2
microtubule-associated protein 2
chrM_+_9207 0.07 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr1_-_67266939 0.06 ENST00000304526.2
INSL5
insulin-like 5
chr11_+_60383204 0.06 ENST00000412599.1
ENST00000320202.4
LINC00301
long intergenic non-protein coding RNA 301
chr19_-_3985455 0.06 ENST00000309311.6
EEF2
eukaryotic translation elongation factor 2
chr3_+_186560476 0.06 ENST00000320741.2
ENST00000444204.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr3_+_186560462 0.06 ENST00000412955.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr1_+_192605252 0.06 ENST00000391995.2
ENST00000543215.1
RGS13
regulator of G-protein signaling 13
chr6_+_160542870 0.06 ENST00000324965.4
ENST00000457470.2
SLC22A1
solute carrier family 22 (organic cation transporter), member 1
chr12_+_32832203 0.06 ENST00000553257.1
ENST00000549701.1
ENST00000358214.5
ENST00000266481.6
ENST00000551476.1
ENST00000550154.1
ENST00000547312.1
ENST00000414834.2
ENST00000381000.4
ENST00000548750.1
DNM1L
dynamin 1-like
chr10_-_105845674 0.06 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr17_+_57232690 0.06 ENST00000262293.4
PRR11
proline rich 11
chr3_+_183853052 0.06 ENST00000273783.3
ENST00000432569.1
ENST00000444495.1
EIF2B5
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
chr17_-_39216344 0.05 ENST00000391418.2
KRTAP2-3
keratin associated protein 2-3
chr7_-_87856280 0.05 ENST00000490437.1
ENST00000431660.1
SRI
sorcin
chr7_-_87856303 0.05 ENST00000394641.3
SRI
sorcin
chr3_+_140396881 0.05 ENST00000286349.3
TRIM42
tripartite motif containing 42
chr16_-_55866997 0.05 ENST00000360526.3
ENST00000361503.4
CES1
carboxylesterase 1
chr3_+_51851612 0.04 ENST00000456080.1
IQCF3
IQ motif containing F3
chr18_-_44181442 0.04 ENST00000398722.4
LOXHD1
lipoxygenase homology domains 1
chr8_+_29605825 0.04 ENST00000522158.1
AC145110.1
AC145110.1
chr1_-_153123345 0.04 ENST00000368748.4
SPRR2G
small proline-rich protein 2G
chr17_-_33390667 0.04 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr20_-_1447547 0.04 ENST00000476071.1
NSFL1C
NSFL1 (p97) cofactor (p47)
chr8_-_29605625 0.04 ENST00000506121.3
LINC00589
long intergenic non-protein coding RNA 589
chr20_-_1447467 0.04 ENST00000353088.2
ENST00000350991.4
NSFL1C
NSFL1 (p97) cofactor (p47)
chr14_+_55494323 0.04 ENST00000339298.2
SOCS4
suppressor of cytokine signaling 4
chr12_+_8309630 0.04 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr12_+_82347498 0.03 ENST00000550506.1
RP11-362A1.1
RP11-362A1.1
chr14_+_55493920 0.03 ENST00000395472.2
ENST00000555846.1
SOCS4
suppressor of cytokine signaling 4
chr19_+_37742773 0.03 ENST00000438770.2
ENST00000591116.1
ENST00000592712.1
AC012309.5
AC012309.5
chr10_+_35894338 0.03 ENST00000321660.1
GJD4
gap junction protein, delta 4, 40.1kDa
chr4_+_77356248 0.03 ENST00000296043.6
SHROOM3
shroom family member 3
chr11_-_65625678 0.03 ENST00000308162.5
CFL1
cofilin 1 (non-muscle)
chr5_+_150226085 0.03 ENST00000522154.1
IRGM
immunity-related GTPase family, M
chr4_-_10686475 0.03 ENST00000226951.6
CLNK
cytokine-dependent hematopoietic cell linker
chr16_-_20702578 0.02 ENST00000307493.4
ENST00000219151.4
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr8_+_105235572 0.02 ENST00000523362.1
RIMS2
regulating synaptic membrane exocytosis 2
chr9_+_125132803 0.02 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr6_+_154360357 0.02 ENST00000330432.7
ENST00000360422.4
OPRM1
opioid receptor, mu 1
chr9_-_21368075 0.02 ENST00000449498.1
IFNA13
interferon, alpha 13
chr2_+_74682150 0.02 ENST00000233331.7
ENST00000431187.1
ENST00000409917.1
ENST00000409493.2
INO80B
INO80 complex subunit B
chr17_-_39341594 0.02 ENST00000398472.1
KRTAP4-1
keratin associated protein 4-1
chr15_+_93447675 0.02 ENST00000536619.1
CHD2
chromodomain helicase DNA binding protein 2
chr6_-_94129244 0.02 ENST00000369303.4
ENST00000369297.1
EPHA7
EPH receptor A7
chr2_-_86422095 0.01 ENST00000254636.5
IMMT
inner membrane protein, mitochondrial
chr17_-_10372875 0.01 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chrX_+_135618258 0.01 ENST00000440515.1
ENST00000456412.1
VGLL1
vestigial like 1 (Drosophila)
chr7_-_99717463 0.00 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr2_+_166095898 0.00 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chrX_+_114827818 0.00 ENST00000420625.2
PLS3
plastin 3
chr2_+_27008865 0.00 ENST00000335756.4
ENST00000233505.8
CENPA
centromere protein A

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-2_RAX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 0.6 GO:1900920 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.1 0.3 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.6 GO:0006041 glucosamine metabolic process(GO:0006041)
0.1 0.3 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.1 0.5 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 2.3 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.5 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.6 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.3 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 0.2 GO:0060490 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 0.6 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.1 0.2 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.1 0.2 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.0 0.1 GO:0070105 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.1 GO:0097018 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.3 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 0.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.8 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.6 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.1 GO:0061358 negative regulation of Wnt protein secretion(GO:0061358)
0.0 0.1 GO:0090149 synaptic vesicle recycling via endosome(GO:0036466) mitochondrial membrane fission(GO:0090149)
0.0 0.2 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.2 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.1 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:0007068 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.0 1.4 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.1 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.1 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.1 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 1.5 GO:0002456 T cell mediated immunity(GO:0002456)
0.0 0.0 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.0 0.2 GO:0044126 regulation of growth of symbiont in host(GO:0044126)
0.0 0.1 GO:0051610 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0033597 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
0.1 0.6 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.5 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.2 GO:0072589 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.8 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 0.1 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.3 GO:0005869 dynactin complex(GO:0005869)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.6 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.1 0.3 GO:0061714 folic acid receptor activity(GO:0061714)
0.1 0.3 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 0.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.6 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.7 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.4 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.2 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.7 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0038047 beta-endorphin receptor activity(GO:0004979) morphine receptor activity(GO:0038047)
0.0 0.1 GO:0004771 sterol esterase activity(GO:0004771)
0.0 0.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.2 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.1 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.4 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 1.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.6 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.8 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 1.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME OPSINS Genes involved in Opsins
0.0 0.3 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.6 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.6 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.0 0.8 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP