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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NKX2-1

Z-value: 0.51

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Transcription factors associated with NKX2-1

Gene Symbol Gene ID Gene Info
NKX2-1
ENSG00000136352.13 NK2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-1hg19_v2_chr14_-_36989336_369893540.252.2e-01Click!

Activity profile of NKX2-1 motif

Sorted Z-values of NKX2-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_15735925 1.01 ENST00000427824.1
RP3-467K16.4
RP3-467K16.4
chr2_-_225266743 0.96 ENST00000409685.3
FAM124B
family with sequence similarity 124B
chr2_-_225266711 0.96 ENST00000389874.3
FAM124B
family with sequence similarity 124B
chr22_+_24891210 0.86 ENST00000382760.2
UPB1
ureidopropionase, beta
chr2_-_157189180 0.81 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr16_+_640201 0.65 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr18_+_42260861 0.65 ENST00000282030.5
SETBP1
SET binding protein 1
chr13_-_41240717 0.55 ENST00000379561.5
FOXO1
forkhead box O1
chrX_+_86772787 0.54 ENST00000373114.4
KLHL4
kelch-like family member 4
chr8_-_16859690 0.49 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr7_-_120497178 0.46 ENST00000441017.1
ENST00000424710.1
ENST00000433758.1
TSPAN12
tetraspanin 12
chr18_-_24283586 0.40 ENST00000579458.1
U3
Small nucleolar RNA U3
chr2_-_105882585 0.40 ENST00000595531.1
AC012360.2
LOC644617 protein; Uncharacterized protein
chr20_-_36793663 0.35 ENST00000536701.1
ENST00000536724.1
TGM2
transglutaminase 2
chr9_-_14313641 0.35 ENST00000380953.1
NFIB
nuclear factor I/B
chr1_+_214163033 0.34 ENST00000607425.1
PROX1
prospero homeobox 1
chr19_+_1065922 0.33 ENST00000539243.2
HMHA1
histocompatibility (minor) HA-1
chr6_-_134373732 0.32 ENST00000275230.5
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr15_+_77287426 0.32 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr9_-_97356075 0.30 ENST00000375337.3
FBP2
fructose-1,6-bisphosphatase 2
chr21_-_35016231 0.30 ENST00000438788.1
CRYZL1
crystallin, zeta (quinone reductase)-like 1
chrX_+_86772707 0.28 ENST00000373119.4
KLHL4
kelch-like family member 4
chr4_+_55524085 0.28 ENST00000412167.2
ENST00000288135.5
KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
chr6_+_31674639 0.28 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
LY6G6F
MEGT1
lymphocyte antigen 6 complex, locus G6F
HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr8_-_38326119 0.27 ENST00000356207.5
ENST00000326324.6
FGFR1
fibroblast growth factor receptor 1
chr6_+_32121218 0.25 ENST00000414204.1
ENST00000361568.2
ENST00000395523.1
PPT2
palmitoyl-protein thioesterase 2
chrX_-_70474499 0.25 ENST00000353904.2
ZMYM3
zinc finger, MYM-type 3
chr6_+_32121789 0.24 ENST00000437001.2
ENST00000375137.2
PPT2
palmitoyl-protein thioesterase 2
chr12_+_25205446 0.24 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr17_+_61086917 0.23 ENST00000424789.2
ENST00000389520.4
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr1_+_66999268 0.23 ENST00000371039.1
ENST00000424320.1
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr7_-_105332084 0.23 ENST00000472195.1
ATXN7L1
ataxin 7-like 1
chr12_+_18414446 0.23 ENST00000433979.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr15_-_43029252 0.22 ENST00000563260.1
ENST00000356231.3
CDAN1
codanin 1
chr1_+_178694300 0.21 ENST00000367635.3
RALGPS2
Ral GEF with PH domain and SH3 binding motif 2
chr5_+_140345820 0.21 ENST00000289269.5
PCDHAC2
protocadherin alpha subfamily C, 2
chrX_-_70473957 0.21 ENST00000373984.3
ENST00000314425.5
ENST00000373982.1
ZMYM3
zinc finger, MYM-type 3
chr8_+_37654693 0.21 ENST00000412232.2
GPR124
G protein-coupled receptor 124
chr15_+_57511609 0.20 ENST00000543579.1
ENST00000537840.1
ENST00000343827.3
TCF12
transcription factor 12
chr7_+_65338230 0.20 ENST00000360768.3
VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr11_-_105948129 0.20 ENST00000526793.1
KBTBD3
kelch repeat and BTB (POZ) domain containing 3
chr14_+_63671577 0.20 ENST00000555125.1
RHOJ
ras homolog family member J
chr20_-_56285595 0.19 ENST00000395816.3
ENST00000347215.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chr17_+_66521936 0.19 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr6_-_160679905 0.18 ENST00000366953.3
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chr7_-_142583506 0.18 ENST00000359396.3
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr17_-_34195889 0.18 ENST00000311880.2
C17orf66
chromosome 17 open reading frame 66
chr5_-_134783038 0.18 ENST00000503143.2
C5orf20
chromosome 5 open reading frame 20
chr17_-_34195862 0.18 ENST00000592980.1
ENST00000587626.1
C17orf66
chromosome 17 open reading frame 66
chr4_+_144354644 0.17 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chrX_-_32173579 0.16 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr8_-_28747424 0.16 ENST00000523436.1
ENST00000397363.4
ENST00000521777.1
ENST00000520184.1
ENST00000521022.1
INTS9
integrator complex subunit 9
chr16_+_58533951 0.16 ENST00000566192.1
ENST00000565088.1
ENST00000568640.1
ENST00000563978.1
ENST00000569923.1
ENST00000356752.4
ENST00000563799.1
ENST00000562999.1
ENST00000570248.1
ENST00000562731.1
ENST00000568424.1
NDRG4
NDRG family member 4
chr17_+_61571746 0.15 ENST00000579409.1
ACE
angiotensin I converting enzyme
chr16_-_29757272 0.15 ENST00000329410.3
C16orf54
chromosome 16 open reading frame 54
chr1_-_62190793 0.15 ENST00000371177.2
ENST00000606498.1
TM2D1
TM2 domain containing 1
chr11_-_105948040 0.15 ENST00000534815.1
KBTBD3
kelch repeat and BTB (POZ) domain containing 3
chr2_+_99797542 0.15 ENST00000338148.3
ENST00000512183.2
MRPL30
C2orf15
mitochondrial ribosomal protein L30
chromosome 2 open reading frame 15
chr12_+_25205666 0.15 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr16_-_28222797 0.14 ENST00000569951.1
ENST00000565698.1
XPO6
exportin 6
chr17_+_4613918 0.14 ENST00000574954.1
ENST00000346341.2
ENST00000572457.1
ENST00000381488.6
ENST00000412477.3
ENST00000571428.1
ENST00000575877.1
ARRB2
arrestin, beta 2
chr7_-_27224842 0.14 ENST00000517402.1
HOXA11
homeobox A11
chr17_-_60005365 0.14 ENST00000444766.3
INTS2
integrator complex subunit 2
chr19_+_751122 0.14 ENST00000215582.6
MISP
mitotic spindle positioning
chr16_-_28223166 0.14 ENST00000304658.5
XPO6
exportin 6
chr12_+_93772402 0.13 ENST00000546925.1
NUDT4
nudix (nucleoside diphosphate linked moiety X)-type motif 4
chr12_+_50478977 0.13 ENST00000381513.4
SMARCD1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr7_-_27224795 0.13 ENST00000006015.3
HOXA11
homeobox A11
chr1_+_228337553 0.13 ENST00000366714.2
GJC2
gap junction protein, gamma 2, 47kDa
chr12_+_93772326 0.13 ENST00000550056.1
ENST00000549992.1
ENST00000548662.1
ENST00000547014.1
NUDT4
nudix (nucleoside diphosphate linked moiety X)-type motif 4
chr12_+_25205568 0.13 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr19_-_39390350 0.12 ENST00000447739.1
ENST00000358931.5
ENST00000407552.1
SIRT2
sirtuin 2
chr2_+_99797636 0.12 ENST00000409145.1
MRPL30
mitochondrial ribosomal protein L30
chr11_+_46193466 0.12 ENST00000533793.1
RP11-702F3.3
RP11-702F3.3
chr2_+_136289030 0.12 ENST00000409478.1
ENST00000264160.4
ENST00000329971.3
ENST00000438014.1
R3HDM1
R3H domain containing 1
chr11_+_66512303 0.12 ENST00000532565.2
C11orf80
chromosome 11 open reading frame 80
chr12_-_10978957 0.12 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr1_-_68698222 0.11 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr1_+_151512775 0.11 ENST00000368849.3
ENST00000392712.3
ENST00000353024.3
ENST00000368848.2
ENST00000538902.1
TUFT1
tuftelin 1
chr16_-_20416053 0.11 ENST00000302451.4
PDILT
protein disulfide isomerase-like, testis expressed
chrX_-_134478012 0.11 ENST00000370766.3
ZNF75D
zinc finger protein 75D
chrX_-_70474377 0.11 ENST00000373978.1
ENST00000373981.1
ZMYM3
zinc finger, MYM-type 3
chr8_+_62200509 0.11 ENST00000519846.1
ENST00000518592.1
ENST00000325897.4
CLVS1
clavesin 1
chr6_+_42883727 0.11 ENST00000304672.1
ENST00000441198.1
ENST00000446507.1
PTCRA
pre T-cell antigen receptor alpha
chr19_-_10679644 0.11 ENST00000393599.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr15_-_42448788 0.11 ENST00000382396.4
ENST00000397272.3
PLA2G4F
phospholipase A2, group IVF
chr1_-_38397384 0.11 ENST00000373027.1
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr1_-_17380630 0.10 ENST00000375499.3
SDHB
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
chr22_-_30925150 0.10 ENST00000437871.1
SEC14L6
SEC14-like 6 (S. cerevisiae)
chr15_+_69452959 0.10 ENST00000261858.2
GLCE
glucuronic acid epimerase
chr22_+_24999114 0.10 ENST00000412658.1
ENST00000445029.1
ENST00000419133.1
ENST00000400382.1
ENST00000438643.2
ENST00000452551.1
ENST00000400383.1
ENST00000412898.1
ENST00000400380.1
ENST00000455483.1
ENST00000430289.1
GGT1
gamma-glutamyltransferase 1
chr7_-_95064264 0.10 ENST00000536183.1
ENST00000433091.2
ENST00000222572.3
PON2
paraoxonase 2
chr15_-_33360085 0.10 ENST00000334528.9
FMN1
formin 1
chr8_-_114389353 0.10 ENST00000343508.3
CSMD3
CUB and Sushi multiple domains 3
chr16_+_640055 0.09 ENST00000568586.1
ENST00000538492.1
ENST00000248139.3
RAB40C
RAB40C, member RAS oncogene family
chr1_-_41487383 0.09 ENST00000302946.8
ENST00000372613.2
ENST00000439569.2
ENST00000397197.2
SLFNL1
schlafen-like 1
chr1_-_41487415 0.09 ENST00000372611.1
SLFNL1
schlafen-like 1
chr11_+_105948216 0.09 ENST00000278618.4
AASDHPPT
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr16_-_20556492 0.09 ENST00000568098.1
ACSM2B
acyl-CoA synthetase medium-chain family member 2B
chr19_+_48972459 0.09 ENST00000427476.1
CYTH2
cytohesin 2
chr3_+_4535155 0.09 ENST00000544951.1
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr2_-_152118352 0.09 ENST00000331426.5
RBM43
RNA binding motif protein 43
chr20_+_58152524 0.09 ENST00000359926.3
PHACTR3
phosphatase and actin regulator 3
chr11_+_60223225 0.08 ENST00000524807.1
ENST00000345732.4
MS4A1
membrane-spanning 4-domains, subfamily A, member 1
chr6_-_26056695 0.08 ENST00000343677.2
HIST1H1C
histone cluster 1, H1c
chr6_-_71012773 0.08 ENST00000370496.3
ENST00000357250.6
COL9A1
collagen, type IX, alpha 1
chr16_+_12995614 0.08 ENST00000423335.2
SHISA9
shisa family member 9
chr21_+_45773515 0.08 ENST00000397932.2
ENST00000300481.9
TRPM2
transient receptor potential cation channel, subfamily M, member 2
chr2_+_119699742 0.08 ENST00000327097.4
MARCO
macrophage receptor with collagenous structure
chr1_-_175712829 0.08 ENST00000367674.2
TNR
tenascin R
chr2_+_128848740 0.07 ENST00000375990.3
UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr1_-_17338386 0.07 ENST00000341676.5
ENST00000452699.1
ATP13A2
ATPase type 13A2
chr11_+_66512089 0.07 ENST00000524551.1
ENST00000525908.1
ENST00000360962.4
ENST00000346672.4
ENST00000527634.1
ENST00000540737.1
C11orf80
chromosome 11 open reading frame 80
chr1_-_156051789 0.07 ENST00000532414.2
MEX3A
mex-3 RNA binding family member A
chr6_-_39399087 0.07 ENST00000229913.5
ENST00000541946.1
ENST00000394362.1
KIF6
kinesin family member 6
chr19_+_38924316 0.07 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
RYR1
ryanodine receptor 1 (skeletal)
chr19_-_36231437 0.07 ENST00000591748.1
IGFLR1
IGF-like family receptor 1
chr3_+_187930719 0.07 ENST00000312675.4
LPP
LIM domain containing preferred translocation partner in lipoma
chr19_-_51336443 0.07 ENST00000598673.1
KLK15
kallikrein-related peptidase 15
chr20_+_59654146 0.07 ENST00000441660.1
RP5-827L5.1
RP5-827L5.1
chr14_+_81421710 0.06 ENST00000342443.6
TSHR
thyroid stimulating hormone receptor
chr12_+_6961279 0.06 ENST00000229268.8
ENST00000389231.5
ENST00000542087.1
USP5
ubiquitin specific peptidase 5 (isopeptidase T)
chr2_-_187713891 0.06 ENST00000295131.2
ZSWIM2
zinc finger, SWIM-type containing 2
chr8_-_141810634 0.06 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
PTK2
protein tyrosine kinase 2
chr8_+_70404996 0.06 ENST00000402687.4
ENST00000419716.3
SULF1
sulfatase 1
chr2_+_119699864 0.06 ENST00000541757.1
ENST00000412481.1
MARCO
macrophage receptor with collagenous structure
chr15_-_66790146 0.06 ENST00000316634.5
SNAPC5
small nuclear RNA activating complex, polypeptide 5, 19kDa
chr8_+_22019168 0.06 ENST00000318561.3
ENST00000521315.1
ENST00000437090.2
ENST00000520605.1
ENST00000522109.1
ENST00000524255.1
ENST00000523296.1
ENST00000518615.1
SFTPC
surfactant protein C
chr14_+_81421921 0.06 ENST00000554263.1
ENST00000554435.1
TSHR
thyroid stimulating hormone receptor
chr15_-_44955842 0.06 ENST00000427534.2
ENST00000559193.1
ENST00000261866.7
ENST00000535302.2
ENST00000558319.1
SPG11
spastic paraplegia 11 (autosomal recessive)
chr3_+_184056614 0.06 ENST00000453072.1
FAM131A
family with sequence similarity 131, member A
chr17_+_40610862 0.06 ENST00000393829.2
ENST00000546249.1
ENST00000537728.1
ENST00000264649.6
ENST00000585525.1
ENST00000343619.4
ENST00000544137.1
ENST00000589727.1
ENST00000587824.1
ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr8_-_62602327 0.06 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr12_-_21810726 0.06 ENST00000396076.1
LDHB
lactate dehydrogenase B
chr6_+_25652501 0.05 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr1_+_207277590 0.05 ENST00000367070.3
C4BPA
complement component 4 binding protein, alpha
chr11_+_60223312 0.05 ENST00000532491.1
ENST00000532073.1
ENST00000534668.1
ENST00000528313.1
ENST00000533306.1
MS4A1
membrane-spanning 4-domains, subfamily A, member 1
chr1_-_153599426 0.05 ENST00000392622.1
S100A13
S100 calcium binding protein A13
chr10_+_111967345 0.05 ENST00000332674.5
ENST00000453116.1
MXI1
MAX interactor 1, dimerization protein
chr18_+_33877654 0.05 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
FHOD3
formin homology 2 domain containing 3
chr8_+_94752349 0.05 ENST00000391680.1
RBM12B-AS1
RBM12B antisense RNA 1
chr12_-_21810765 0.05 ENST00000450584.1
ENST00000350669.1
LDHB
lactate dehydrogenase B
chr5_+_131705438 0.05 ENST00000245407.3
SLC22A5
solute carrier family 22 (organic cation/carnitine transporter), member 5
chr9_-_7800067 0.05 ENST00000358227.4
TMEM261
transmembrane protein 261
chr3_+_121311966 0.05 ENST00000338040.4
FBXO40
F-box protein 40
chr10_-_81320151 0.04 ENST00000372325.2
ENST00000372327.5
ENST00000417041.1
SFTPA2
surfactant protein A2
chr17_+_46048376 0.04 ENST00000338399.4
CDK5RAP3
CDK5 regulatory subunit associated protein 3
chr9_+_33290491 0.04 ENST00000379540.3
ENST00000379521.4
ENST00000318524.6
NFX1
nuclear transcription factor, X-box binding 1
chr20_+_30407105 0.04 ENST00000375994.2
MYLK2
myosin light chain kinase 2
chr20_+_30407151 0.04 ENST00000375985.4
MYLK2
myosin light chain kinase 2
chr20_-_45142154 0.04 ENST00000347606.4
ENST00000457685.2
ZNF334
zinc finger protein 334
chr17_-_47492164 0.04 ENST00000512041.2
ENST00000446735.1
ENST00000504124.1
PHB
prohibitin
chr1_-_175712665 0.04 ENST00000263525.2
TNR
tenascin R
chr1_-_115259337 0.04 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr3_+_4535025 0.03 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr4_-_54930790 0.03 ENST00000263921.3
CHIC2
cysteine-rich hydrophobic domain 2
chr17_-_47492236 0.03 ENST00000434917.2
ENST00000300408.3
ENST00000511832.1
ENST00000419140.2
PHB
prohibitin
chr17_-_46035187 0.03 ENST00000300557.2
PRR15L
proline rich 15-like
chr2_+_220299547 0.03 ENST00000312358.7
SPEG
SPEG complex locus
chr18_+_54814288 0.02 ENST00000585477.1
BOD1L2
biorientation of chromosomes in cell division 1-like 2
chr15_-_43559055 0.02 ENST00000220420.5
ENST00000349114.4
TGM5
transglutaminase 5
chr3_-_114790179 0.02 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr7_+_150782945 0.02 ENST00000463381.1
AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr19_+_39390320 0.02 ENST00000576510.1
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr12_+_56401268 0.02 ENST00000262032.5
IKZF4
IKAROS family zinc finger 4 (Eos)
chr5_-_137548997 0.02 ENST00000505120.1
ENST00000394886.2
ENST00000394884.3
CDC23
cell division cycle 23
chr1_-_153517473 0.02 ENST00000368715.1
S100A4
S100 calcium binding protein A4
chr10_+_102222798 0.02 ENST00000343737.5
WNT8B
wingless-type MMTV integration site family, member 8B
chrX_+_22056165 0.02 ENST00000535894.1
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr16_+_57126428 0.02 ENST00000290776.8
CPNE2
copine II
chrX_-_153236620 0.01 ENST00000369984.4
HCFC1
host cell factor C1 (VP16-accessory protein)
chr11_-_65325430 0.01 ENST00000322147.4
LTBP3
latent transforming growth factor beta binding protein 3
chr16_+_57126482 0.01 ENST00000537605.1
ENST00000535318.2
CPNE2
copine II
chr19_-_54804173 0.01 ENST00000391744.3
ENST00000251390.3
LILRA3
leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
chr16_-_58663720 0.01 ENST00000564557.1
ENST00000569240.1
ENST00000441024.2
ENST00000569020.1
ENST00000317147.5
CNOT1
CCR4-NOT transcription complex, subunit 1
chr3_+_39149145 0.01 ENST00000301819.6
ENST00000431162.2
TTC21A
tetratricopeptide repeat domain 21A
chr19_+_48972265 0.01 ENST00000452733.2
CYTH2
cytohesin 2
chr17_-_3499125 0.01 ENST00000399759.3
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr11_-_88796803 0.00 ENST00000418177.2
ENST00000455756.2
GRM5
glutamate receptor, metabotropic 5
chr2_-_85895295 0.00 ENST00000428225.1
ENST00000519937.2
SFTPB
surfactant protein B
chr13_+_95364963 0.00 ENST00000438290.2
SOX21-AS1
SOX21 antisense RNA 1 (head to head)
chr19_+_40477062 0.00 ENST00000455878.2
PSMC4
proteasome (prosome, macropain) 26S subunit, ATPase, 4
chr6_-_42858534 0.00 ENST00000408925.2
C6orf226
chromosome 6 open reading frame 226
chr8_-_67341208 0.00 ENST00000499642.1
RP11-346I3.4
RP11-346I3.4
chr6_+_43968306 0.00 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223
chromosome 6 open reading frame 223
chr1_+_24019099 0.00 ENST00000443624.1
ENST00000458455.1
RPL11
ribosomal protein L11
chr22_+_50986462 0.00 ENST00000395676.2
KLHDC7B
kelch domain containing 7B
chr22_+_35653445 0.00 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMGXB4
HMG box domain containing 4
chr7_-_121944491 0.00 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1
FEZ family zinc finger 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.2 0.9 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 0.3 GO:0018262 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.1 0.3 GO:0090425 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.6 GO:1902617 response to fluoride(GO:1902617)
0.1 0.3 GO:0038162 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162)
0.1 0.3 GO:1903465 vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830)
0.1 0.3 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.1 0.5 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.1 0.2 GO:0032485 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.0 0.3 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.5 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.3 GO:1901911 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.1 GO:1900195 positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.0 0.2 GO:1903597 negative regulation of gap junction assembly(GO:1903597)
0.0 0.1 GO:1904351 negative regulation of protein catabolic process in the vacuole(GO:1904351) negative regulation of lysosomal protein catabolic process(GO:1905166)
0.0 0.1 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.1 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0 0.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.1 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.1 GO:0097359 UDP-glucosylation(GO:0097359)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.1 GO:0048690 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.0 0.3 GO:0007501 mesodermal cell fate specification(GO:0007501)
0.0 0.2 GO:1901374 acetate ester transport(GO:1901374)
0.0 0.2 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.3 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.2 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.5 GO:0010842 retina layer formation(GO:0010842)
0.0 0.3 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.0 0.2 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.1 GO:2000259 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0 0.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.2 GO:2001135 regulation of endocytic recycling(GO:2001135)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0072534 perineuronal net(GO:0072534)
0.0 0.1 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.1 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.1 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.0 0.2 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:1990425 ryanodine receptor complex(GO:1990425)
0.0 0.3 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 1.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0072687 chromatin silencing complex(GO:0005677) meiotic spindle(GO:0072687)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0 0.5 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0031859 platelet activating factor receptor binding(GO:0031859)
0.0 0.2 GO:0008513 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.3 GO:0052846 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.0 0.1 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.0 0.2 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.0 0.3 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0051538 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.0 0.1 GO:0046573 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0 0.3 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.2 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 0.1 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.0 0.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.3 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.6 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 0.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.1 GO:1903763 gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.1 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.1 GO:1903135 cupric ion binding(GO:1903135)
0.0 0.0 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.8 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.3 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination