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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NKX2-2

Z-value: 0.65

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Transcription factors associated with NKX2-2

Gene Symbol Gene ID Gene Info
NKX2-2
ENSG00000125820.5 NK2 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-2hg19_v2_chr20_-_21494654_214946780.144.9e-01Click!

Activity profile of NKX2-2 motif

Sorted Z-values of NKX2-2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_23654525 0.97 ENST00000399910.1
ENST00000492621.1
C14orf164
chromosome 14 open reading frame 164
chr7_-_22234381 0.96 ENST00000458533.1
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr7_-_22233442 0.90 ENST00000401957.2
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr2_+_152214098 0.88 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr2_+_162087577 0.82 ENST00000439442.1
TANK
TRAF family member-associated NFKB activator
chr2_+_201994569 0.65 ENST00000457277.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr3_-_150920979 0.63 ENST00000309180.5
ENST00000480322.1
GPR171
G protein-coupled receptor 171
chr1_-_41328018 0.61 ENST00000372638.2
CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr11_+_34654011 0.61 ENST00000531794.1
EHF
ets homologous factor
chr19_-_14945933 0.58 ENST00000322301.3
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr18_+_55888767 0.53 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr6_-_55739542 0.52 ENST00000446683.2
BMP5
bone morphogenetic protein 5
chr13_-_20357110 0.51 ENST00000427943.1
PSPC1
paraspeckle component 1
chr21_+_25801041 0.49 ENST00000453784.2
ENST00000423581.1
AP000476.1
AP000476.1
chr2_+_201994208 0.47 ENST00000440180.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr5_+_125758865 0.43 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr5_+_125758813 0.43 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr9_+_131447342 0.40 ENST00000409104.3
SET
SET nuclear oncogene
chr10_-_36813162 0.40 ENST00000440465.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr10_-_36812323 0.35 ENST00000543053.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr13_-_20357057 0.34 ENST00000338910.4
PSPC1
paraspeckle component 1
chr2_+_152266604 0.34 ENST00000430328.2
RIF1
RAP1 interacting factor homolog (yeast)
chr8_+_97597148 0.33 ENST00000521590.1
SDC2
syndecan 2
chr4_-_76957214 0.33 ENST00000306621.3
CXCL11
chemokine (C-X-C motif) ligand 11
chr17_-_3496171 0.33 ENST00000399756.4
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr10_+_89420706 0.33 ENST00000427144.2
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr2_-_197226875 0.33 ENST00000409111.1
HECW2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr17_+_74372662 0.32 ENST00000591651.1
ENST00000545180.1
SPHK1
sphingosine kinase 1
chr10_+_74653330 0.32 ENST00000334011.5
OIT3
oncoprotein induced transcript 3
chr4_-_10686373 0.29 ENST00000442825.2
CLNK
cytokine-dependent hematopoietic cell linker
chrX_-_154033661 0.29 ENST00000393531.1
MPP1
membrane protein, palmitoylated 1, 55kDa
chr5_-_11588907 0.28 ENST00000513598.1
ENST00000503622.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr1_+_120049826 0.28 ENST00000369413.3
ENST00000235547.6
ENST00000528909.1
HSD3B1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chr4_+_95376396 0.27 ENST00000508216.1
ENST00000514743.1
PDLIM5
PDZ and LIM domain 5
chr1_-_159880159 0.26 ENST00000599780.1
AL590560.1
HCG1995379; Uncharacterized protein
chr6_+_28249299 0.26 ENST00000405948.2
PGBD1
piggyBac transposable element derived 1
chr22_-_36220420 0.26 ENST00000473487.2
RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr6_+_28249332 0.26 ENST00000259883.3
PGBD1
piggyBac transposable element derived 1
chr8_-_101962777 0.25 ENST00000395951.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr22_-_50523760 0.25 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr2_-_36779411 0.25 ENST00000406220.1
AC007401.2
Uncharacterized protein
chrM_+_12331 0.25 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr2_+_102953608 0.24 ENST00000311734.2
ENST00000409584.1
IL1RL1
interleukin 1 receptor-like 1
chr4_-_99578789 0.24 ENST00000511651.1
ENST00000505184.1
TSPAN5
tetraspanin 5
chr17_-_67138015 0.23 ENST00000284425.2
ENST00000590645.1
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr9_+_92219919 0.23 ENST00000252506.6
ENST00000375769.1
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr12_+_69202795 0.23 ENST00000539479.1
ENST00000393415.3
ENST00000523991.1
ENST00000543323.1
ENST00000393416.2
MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
chr13_+_25875662 0.23 ENST00000381736.3
ENST00000463407.1
ENST00000381718.3
NUPL1
nucleoporin like 1
chr9_+_91926103 0.23 ENST00000314355.6
CKS2
CDC28 protein kinase regulatory subunit 2
chr3_+_183770835 0.22 ENST00000318351.1
HTR3C
5-hydroxytryptamine (serotonin) receptor 3C, ionotropic
chr1_+_32666188 0.21 ENST00000421922.2
CCDC28B
coiled-coil domain containing 28B
chr5_-_179047881 0.21 ENST00000521173.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr14_-_89878369 0.21 ENST00000553840.1
ENST00000556916.1
FOXN3
forkhead box N3
chr3_+_159943362 0.20 ENST00000326474.3
C3orf80
chromosome 3 open reading frame 80
chr14_+_56584414 0.20 ENST00000559044.1
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr5_+_156887027 0.20 ENST00000435489.2
ENST00000311946.7
NIPAL4
NIPA-like domain containing 4
chr1_+_84630367 0.20 ENST00000370680.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr8_+_94767109 0.20 ENST00000409623.3
ENST00000453906.1
ENST00000521517.1
TMEM67
transmembrane protein 67
chr9_-_85882145 0.19 ENST00000328788.1
FRMD3
FERM domain containing 3
chr4_-_99578776 0.19 ENST00000515287.1
TSPAN5
tetraspanin 5
chr9_-_97356075 0.19 ENST00000375337.3
FBP2
fructose-1,6-bisphosphatase 2
chr3_+_147795932 0.19 ENST00000490465.1
RP11-639B1.1
RP11-639B1.1
chr4_+_88720698 0.19 ENST00000226284.5
IBSP
integrin-binding sialoprotein
chr11_-_107729887 0.19 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr5_-_98262240 0.18 ENST00000284049.3
CHD1
chromodomain helicase DNA binding protein 1
chr10_+_35456444 0.18 ENST00000361599.4
CREM
cAMP responsive element modulator
chr14_+_22964877 0.18 ENST00000390494.1
TRAJ43
T cell receptor alpha joining 43
chr1_-_226926864 0.18 ENST00000429204.1
ENST00000366784.1
ITPKB
inositol-trisphosphate 3-kinase B
chr14_-_100841670 0.18 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
WARS
tryptophanyl-tRNA synthetase
chr7_+_150065278 0.18 ENST00000519397.1
ENST00000479668.1
ENST00000540729.1
REPIN1
replication initiator 1
chr17_+_15604513 0.17 ENST00000481540.1
ZNF286A
Homo sapiens zinc finger protein 286A (ZNF286A), transcript variant 6, mRNA.
chr6_-_55740352 0.17 ENST00000370830.3
BMP5
bone morphogenetic protein 5
chr9_+_99690592 0.17 ENST00000354649.3
NUTM2G
NUT family member 2G
chr2_+_152266392 0.17 ENST00000444746.2
ENST00000453091.2
ENST00000428287.2
ENST00000433166.2
ENST00000420714.3
ENST00000243326.5
ENST00000414861.2
RIF1
RAP1 interacting factor homolog (yeast)
chr10_-_61513146 0.17 ENST00000430431.1
LINC00948
long intergenic non-protein coding RNA 948
chr2_+_202937972 0.17 ENST00000541917.1
ENST00000295844.3
AC079354.1
uncharacterized protein KIAA2012
chr19_-_44174330 0.17 ENST00000340093.3
PLAUR
plasminogen activator, urokinase receptor
chr7_+_142031986 0.17 ENST00000547918.2
TRBV7-1
T cell receptor beta variable 7-1 (non-functional)
chr16_+_23194033 0.17 ENST00000300061.2
SCNN1G
sodium channel, non-voltage-gated 1, gamma subunit
chr7_+_93535866 0.16 ENST00000429473.1
ENST00000430875.1
ENST00000428834.1
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr9_+_116263639 0.16 ENST00000343817.5
RGS3
regulator of G-protein signaling 3
chr4_-_119759795 0.16 ENST00000419654.2
SEC24D
SEC24 family member D
chr12_-_71551652 0.15 ENST00000546561.1
TSPAN8
tetraspanin 8
chr19_-_44174305 0.15 ENST00000601723.1
ENST00000339082.3
PLAUR
plasminogen activator, urokinase receptor
chr14_-_57277163 0.15 ENST00000555006.1
OTX2
orthodenticle homeobox 2
chr9_+_116263778 0.15 ENST00000394646.3
RGS3
regulator of G-protein signaling 3
chrX_+_11777671 0.15 ENST00000380693.3
ENST00000380692.2
MSL3
male-specific lethal 3 homolog (Drosophila)
chr11_+_65266507 0.15 ENST00000544868.1
MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr18_+_9103957 0.15 ENST00000400033.1
NDUFV2
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
chr16_+_53241854 0.15 ENST00000565803.1
CHD9
chromodomain helicase DNA binding protein 9
chr13_+_102104952 0.15 ENST00000376180.3
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr8_-_124749609 0.15 ENST00000262219.6
ENST00000419625.1
ANXA13
annexin A13
chr5_-_11589131 0.15 ENST00000511377.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr7_+_93535817 0.15 ENST00000248572.5
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr9_+_37667978 0.14 ENST00000539465.1
FRMPD1
FERM and PDZ domain containing 1
chr1_-_244006528 0.14 ENST00000336199.5
ENST00000263826.5
AKT3
v-akt murine thymoma viral oncogene homolog 3
chr19_-_39881669 0.14 ENST00000221266.7
PAF1
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
chr19_-_51845378 0.14 ENST00000335624.4
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr19_+_39138320 0.14 ENST00000424234.2
ENST00000390009.3
ENST00000589528.1
ACTN4
actinin, alpha 4
chrX_+_100743031 0.14 ENST00000423738.3
ARMCX4
armadillo repeat containing, X-linked 4
chr8_-_141810634 0.14 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
PTK2
protein tyrosine kinase 2
chr5_+_140800638 0.13 ENST00000398587.2
ENST00000518882.1
PCDHGA11
protocadherin gamma subfamily A, 11
chr14_-_82000140 0.13 ENST00000555824.1
ENST00000557372.1
ENST00000336735.4
SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr10_+_13203543 0.13 ENST00000378714.3
ENST00000479669.1
ENST00000484800.2
MCM10
minichromosome maintenance complex component 10
chr6_+_1080164 0.13 ENST00000314040.1
AL033381.1
Uncharacterized protein; cDNA FLJ34594 fis, clone KIDNE2009109
chr5_+_147443534 0.13 ENST00000398454.1
ENST00000359874.3
ENST00000508733.1
ENST00000256084.7
SPINK5
serine peptidase inhibitor, Kazal type 5
chrX_+_105066524 0.13 ENST00000243300.9
ENST00000428173.2
NRK
Nik related kinase
chr7_-_102715263 0.13 ENST00000379305.3
FBXL13
F-box and leucine-rich repeat protein 13
chr11_+_93479588 0.13 ENST00000526335.1
C11orf54
chromosome 11 open reading frame 54
chr13_+_25875785 0.13 ENST00000381747.3
NUPL1
nucleoporin like 1
chr10_-_61513201 0.12 ENST00000414264.1
ENST00000594536.1
LINC00948
long intergenic non-protein coding RNA 948
chr5_+_56205878 0.12 ENST00000423328.1
SETD9
SET domain containing 9
chr8_+_71485681 0.12 ENST00000391684.1
AC120194.1
AC120194.1
chr12_-_8803128 0.12 ENST00000543467.1
MFAP5
microfibrillar associated protein 5
chr17_-_39254391 0.12 ENST00000333822.4
KRTAP4-8
keratin associated protein 4-8
chr1_-_227505289 0.12 ENST00000366765.3
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chrX_-_153363125 0.12 ENST00000407218.1
ENST00000453960.2
MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr19_-_2427536 0.12 ENST00000591871.1
TIMM13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr4_+_114214125 0.12 ENST00000509550.1
ANK2
ankyrin 2, neuronal
chr7_-_107443652 0.12 ENST00000340010.5
ENST00000422236.2
ENST00000453332.1
SLC26A3
solute carrier family 26 (anion exchanger), member 3
chr1_-_110155671 0.12 ENST00000351050.3
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr7_-_92855762 0.12 ENST00000453812.2
ENST00000394468.2
HEPACAM2
HEPACAM family member 2
chr15_-_56209306 0.11 ENST00000506154.1
ENST00000338963.2
ENST00000508342.1
NEDD4
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
chr9_+_123970052 0.11 ENST00000373823.3
GSN
gelsolin
chr15_+_42841008 0.11 ENST00000260372.3
ENST00000568876.1
ENST00000568846.2
ENST00000562398.1
HAUS2
HAUS augmin-like complex, subunit 2
chr10_+_97759848 0.11 ENST00000424464.1
ENST00000410012.2
ENST00000344386.3
CC2D2B
coiled-coil and C2 domain containing 2B
chr12_+_100750846 0.11 ENST00000323346.5
SLC17A8
solute carrier family 17 (vesicular glutamate transporter), member 8
chr1_+_171810606 0.11 ENST00000358155.4
ENST00000367733.2
ENST00000355305.5
ENST00000367731.1
DNM3
dynamin 3
chr17_+_12569306 0.11 ENST00000425538.1
MYOCD
myocardin
chr4_-_156787425 0.11 ENST00000537611.2
ASIC5
acid-sensing (proton-gated) ion channel family member 5
chr17_+_66521936 0.11 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr12_+_41831485 0.11 ENST00000539469.2
ENST00000298919.7
PDZRN4
PDZ domain containing ring finger 4
chr6_-_110011704 0.11 ENST00000448084.2
AK9
adenylate kinase 9
chr13_+_31506818 0.11 ENST00000380473.3
TEX26
testis expressed 26
chr19_+_39138271 0.11 ENST00000252699.2
ACTN4
actinin, alpha 4
chr2_-_203735586 0.11 ENST00000454326.1
ENST00000432273.1
ENST00000450143.1
ENST00000411681.1
ICA1L
islet cell autoantigen 1,69kDa-like
chr9_-_39239171 0.10 ENST00000358144.2
CNTNAP3
contactin associated protein-like 3
chr12_+_69202975 0.10 ENST00000544561.1
ENST00000393410.1
ENST00000299252.4
ENST00000360430.2
ENST00000517852.1
ENST00000545204.1
ENST00000393413.3
ENST00000350057.5
ENST00000348801.2
ENST00000478070.1
MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
chr1_-_45253377 0.10 ENST00000372207.3
BEST4
bestrophin 4
chr2_-_95787738 0.10 ENST00000272418.2
MRPS5
mitochondrial ribosomal protein S5
chr2_-_145275228 0.10 ENST00000427902.1
ENST00000409487.3
ENST00000470879.1
ENST00000435831.1
ZEB2
zinc finger E-box binding homeobox 2
chr17_+_61086917 0.10 ENST00000424789.2
ENST00000389520.4
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr6_-_110011718 0.10 ENST00000532976.1
AK9
adenylate kinase 9
chr17_-_42143963 0.10 ENST00000585388.1
ENST00000293406.3
LSM12
LSM12 homolog (S. cerevisiae)
chr2_+_192543153 0.10 ENST00000425611.2
NABP1
nucleic acid binding protein 1
chrX_+_47092314 0.10 ENST00000218348.3
USP11
ubiquitin specific peptidase 11
chr19_-_3971050 0.09 ENST00000545797.2
ENST00000596311.1
DAPK3
death-associated protein kinase 3
chr8_+_107738343 0.09 ENST00000521592.1
OXR1
oxidation resistance 1
chrX_-_23761317 0.09 ENST00000492081.1
ENST00000379303.5
ENST00000336430.7
ACOT9
acyl-CoA thioesterase 9
chr2_-_27558270 0.09 ENST00000454704.1
GTF3C2
general transcription factor IIIC, polypeptide 2, beta 110kDa
chr13_-_33112956 0.09 ENST00000505213.1
N4BP2L2
NEDD4 binding protein 2-like 2
chr6_+_32936353 0.09 ENST00000374825.4
BRD2
bromodomain containing 2
chr13_+_111855414 0.09 ENST00000375737.5
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr1_+_180601139 0.09 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr14_+_39703112 0.09 ENST00000555143.1
ENST00000280082.3
MIA2
melanoma inhibitory activity 2
chr1_+_78769549 0.09 ENST00000370758.1
PTGFR
prostaglandin F receptor (FP)
chr1_+_158901329 0.09 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
PYHIN1
pyrin and HIN domain family, member 1
chr1_-_216978709 0.09 ENST00000360012.3
ESRRG
estrogen-related receptor gamma
chr4_-_88450244 0.08 ENST00000503414.1
SPARCL1
SPARC-like 1 (hevin)
chr7_-_102715172 0.08 ENST00000456695.1
ENST00000455112.2
ENST00000440067.1
FBXL13
F-box and leucine-rich repeat protein 13
chr9_+_17135016 0.08 ENST00000425824.1
ENST00000262360.5
ENST00000380641.4
CNTLN
centlein, centrosomal protein
chr12_-_102591604 0.08 ENST00000329406.4
PMCH
pro-melanin-concentrating hormone
chr3_-_123339418 0.08 ENST00000583087.1
MYLK
myosin light chain kinase
chr15_+_54305101 0.08 ENST00000260323.11
ENST00000545554.1
ENST00000537900.1
UNC13C
unc-13 homolog C (C. elegans)
chr2_-_214014959 0.08 ENST00000442445.1
ENST00000457361.1
ENST00000342002.2
IKZF2
IKAROS family zinc finger 2 (Helios)
chrX_+_108779004 0.08 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr11_-_13517565 0.08 ENST00000282091.1
ENST00000529816.1
PTH
parathyroid hormone
chr20_-_13765526 0.08 ENST00000202816.1
ESF1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chrX_+_123095546 0.08 ENST00000371157.3
ENST00000371145.3
ENST00000371144.3
STAG2
stromal antigen 2
chr2_+_170655322 0.08 ENST00000260956.4
ENST00000417292.1
SSB
Sjogren syndrome antigen B (autoantigen La)
chr8_-_134072593 0.08 ENST00000427060.2
SLA
Src-like-adaptor
chr2_-_239198743 0.08 ENST00000440245.1
ENST00000431832.1
PER2
period circadian clock 2
chrX_+_83116142 0.08 ENST00000329312.4
CYLC1
cylicin, basic protein of sperm head cytoskeleton 1
chr15_-_42840961 0.07 ENST00000563454.1
ENST00000397130.3
ENST00000570160.1
ENST00000323443.2
LRRC57
leucine rich repeat containing 57
chr1_-_223308098 0.07 ENST00000342210.6
TLR5
toll-like receptor 5
chr6_-_73935163 0.07 ENST00000370388.3
KHDC1L
KH homology domain containing 1-like
chr3_-_123339343 0.07 ENST00000578202.1
MYLK
myosin light chain kinase
chr15_-_56757329 0.07 ENST00000260453.3
MNS1
meiosis-specific nuclear structural 1
chr5_-_41261540 0.07 ENST00000263413.3
C6
complement component 6
chr6_-_116833500 0.07 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr11_-_11374904 0.07 ENST00000528848.2
CSNK2A3
casein kinase 2, alpha 3 polypeptide
chr5_-_148033726 0.07 ENST00000354217.2
ENST00000314512.6
ENST00000362016.2
HTR4
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
chrX_-_19817869 0.07 ENST00000379698.4
SH3KBP1
SH3-domain kinase binding protein 1
chr2_-_27362263 0.07 ENST00000432962.1
ENST00000335524.3
C2orf53
chromosome 2 open reading frame 53
chrX_+_34960907 0.07 ENST00000329357.5
FAM47B
family with sequence similarity 47, member B
chr14_-_50154921 0.07 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
POLE2
polymerase (DNA directed), epsilon 2, accessory subunit
chr15_+_65843130 0.07 ENST00000569894.1
PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr5_-_148033693 0.07 ENST00000377888.3
ENST00000360693.3
HTR4
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
chr16_+_22501658 0.07 ENST00000415833.2
NPIPB5
nuclear pore complex interacting protein family, member B5
chr1_-_115259337 0.07 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr7_+_115862858 0.06 ENST00000393481.2
TES
testis derived transcript (3 LIM domains)
chr2_-_238323007 0.06 ENST00000295550.4
COL6A3
collagen, type VI, alpha 3
chr11_-_83984231 0.06 ENST00000330014.6
ENST00000537455.1
ENST00000376106.3
ENST00000418306.2
ENST00000531015.1
DLG2
discs, large homolog 2 (Drosophila)
chr8_-_141774467 0.06 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
PTK2
protein tyrosine kinase 2
chr3_-_196911002 0.06 ENST00000452595.1
DLG1
discs, large homolog 1 (Drosophila)
chr4_+_128802016 0.06 ENST00000270861.5
ENST00000515069.1
ENST00000513090.1
ENST00000507249.1
PLK4
polo-like kinase 4
chr4_+_41937131 0.06 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
TMEM33
transmembrane protein 33
chr13_+_50570019 0.06 ENST00000442421.1
TRIM13
tripartite motif containing 13
chr3_+_23847432 0.06 ENST00000346855.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr4_-_10686475 0.06 ENST00000226951.6
CLNK
cytokine-dependent hematopoietic cell linker

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.1 0.8 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.3 GO:1904404 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.1 1.1 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 0.3 GO:1901594 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.1 0.3 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 0.5 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.5 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.1 0.3 GO:0000103 sulfate assimilation(GO:0000103)
0.1 0.2 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
0.1 0.3 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.1 0.2 GO:0061570 dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571)
0.0 0.3 GO:0008218 bioluminescence(GO:0008218)
0.0 0.2 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.0 0.1 GO:0060720 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.0 0.2 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.1 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.1 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560) negative regulation of beta-amyloid clearance(GO:1900222)
0.0 0.2 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.0 0.2 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.3 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.0 GO:0014839 myoblast migration involved in skeletal muscle regeneration(GO:0014839)
0.0 0.1 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.0 0.3 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.9 GO:0030728 ovulation(GO:0030728)
0.0 0.6 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.2 GO:0097338 response to clozapine(GO:0097338)
0.0 0.1 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.1 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.0 0.1 GO:0044858 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.2 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029) common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.1 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.3 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.0 0.3 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.1 GO:0071048 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
0.0 0.1 GO:1900425 regulation of antimicrobial peptide production(GO:0002784) regulation of antibacterial peptide production(GO:0002786) negative regulation of defense response to bacterium(GO:1900425)
0.0 0.1 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.0 0.3 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.1 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.0 0.2 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.1 GO:1900920 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.0 0.0 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.0 0.1 GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010767)
0.0 0.0 GO:0060127 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.0 0.2 GO:0033523 histone H2B ubiquitination(GO:0033523)
0.0 0.2 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.1 GO:0046601 positive regulation of centriole replication(GO:0046601)
0.0 0.3 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.1 GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.2 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.1 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.1 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.4 GO:0046710 GDP metabolic process(GO:0046710)
0.0 0.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0042382 paraspeckles(GO:0042382)
0.1 0.5 GO:0001940 male pronucleus(GO:0001940)
0.1 1.1 GO:0097342 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0 0.1 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.3 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.1 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.0 0.3 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:0033150 cytoskeletal calyx(GO:0033150) acrosomal matrix(GO:0043159)
0.0 0.1 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.1 GO:0071020 post-spliceosomal complex(GO:0071020)
0.0 0.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.2 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.0 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.3 GO:0097381 photoreceptor disc membrane(GO:0097381)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.8 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.3 GO:0061663 NEDD8 ligase activity(GO:0061663)
0.1 0.3 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.1 0.3 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.1 0.3 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 0.2 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 0.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.3 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 0.7 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.6 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.3 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.2 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0 0.2 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.2 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 1.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.2 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.1 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.0 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.2 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.0 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.3 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 0.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0070404 NADH binding(GO:0070404)
0.0 0.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.0 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 0.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.9 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.5 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.1 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.8 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.2 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta