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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NKX2-3

Z-value: 0.76

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Transcription factors associated with NKX2-3

Gene Symbol Gene ID Gene Info
NKX2-3
ENSG00000119919.9 NK2 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-3hg19_v2_chr10_+_101292684_1012927060.039.0e-01Click!

Activity profile of NKX2-3 motif

Sorted Z-values of NKX2-3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_49813090 2.82 ENST00000249601.4
ARHGAP22
Rho GTPase activating protein 22
chr1_-_89488510 2.41 ENST00000564665.1
ENST00000370481.4
GBP3
guanylate binding protein 3
chr1_+_65613340 1.73 ENST00000546702.1
AK4
adenylate kinase 4
chr14_-_91720224 1.71 ENST00000238699.3
ENST00000531499.2
GPR68
G protein-coupled receptor 68
chr4_-_120550146 1.54 ENST00000354960.3
PDE5A
phosphodiesterase 5A, cGMP-specific
chr19_-_44174330 1.47 ENST00000340093.3
PLAUR
plasminogen activator, urokinase receptor
chr6_-_11382478 1.37 ENST00000397378.3
ENST00000513989.1
ENST00000508546.1
ENST00000504387.1
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr3_-_123512688 1.32 ENST00000475616.1
MYLK
myosin light chain kinase
chr1_+_65613217 1.19 ENST00000545314.1
AK4
adenylate kinase 4
chr11_+_35211429 1.16 ENST00000525688.1
ENST00000278385.6
ENST00000533222.1
CD44
CD44 molecule (Indian blood group)
chr11_+_35211511 1.09 ENST00000524922.1
CD44
CD44 molecule (Indian blood group)
chr16_+_56969284 1.08 ENST00000568358.1
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr18_-_33702078 0.94 ENST00000586829.1
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr17_+_26662597 0.92 ENST00000544907.2
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr17_+_26662730 0.92 ENST00000226225.2
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr2_-_239198743 0.80 ENST00000440245.1
ENST00000431832.1
PER2
period circadian clock 2
chr18_-_74839891 0.79 ENST00000581878.1
MBP
myelin basic protein
chr3_-_150920979 0.78 ENST00000309180.5
ENST00000480322.1
GPR171
G protein-coupled receptor 171
chr6_+_83072923 0.74 ENST00000535040.1
TPBG
trophoblast glycoprotein
chr11_+_94277017 0.72 ENST00000358752.2
FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr11_-_75017734 0.65 ENST00000532525.1
ARRB1
arrestin, beta 1
chr2_-_89597542 0.61 ENST00000465170.1
IGKV1-37
immunoglobulin kappa variable 1-37 (non-functional)
chr6_+_69942298 0.61 ENST00000238918.8
BAI3
brain-specific angiogenesis inhibitor 3
chr7_-_80548667 0.61 ENST00000265361.3
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr3_+_39093481 0.58 ENST00000302313.5
ENST00000544962.1
ENST00000396258.3
ENST00000418020.1
WDR48
WD repeat domain 48
chr10_+_101419187 0.57 ENST00000370489.4
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr1_+_113217043 0.57 ENST00000413052.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr2_+_89923550 0.57 ENST00000509129.1
IGKV1D-37
immunoglobulin kappa variable 1D-37 (non-functional)
chr5_-_142814241 0.56 ENST00000504572.1
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr6_-_137539651 0.56 ENST00000543628.1
IFNGR1
interferon gamma receptor 1
chr11_-_57177586 0.54 ENST00000529411.1
RP11-872D17.8
Uncharacterized protein
chr3_+_149191723 0.54 ENST00000305354.4
TM4SF4
transmembrane 4 L six family member 4
chrX_+_41548259 0.51 ENST00000378138.5
GPR34
G protein-coupled receptor 34
chr14_-_72458326 0.51 ENST00000542853.1
AC005477.1
AC005477.1
chr5_+_179105615 0.50 ENST00000514383.1
CANX
calnexin
chr5_+_169780485 0.49 ENST00000377360.4
KCNIP1
Kv channel interacting protein 1
chr2_+_161993465 0.49 ENST00000457476.1
TANK
TRAF family member-associated NFKB activator
chr2_-_231989808 0.48 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr6_-_32160622 0.48 ENST00000487761.1
ENST00000375040.3
GPSM3
G-protein signaling modulator 3
chr5_+_149569520 0.47 ENST00000230671.2
ENST00000524041.1
SLC6A7
solute carrier family 6 (neurotransmitter transporter), member 7
chr12_-_123187890 0.47 ENST00000328880.5
HCAR2
hydroxycarboxylic acid receptor 2
chrX_+_41548220 0.46 ENST00000378142.4
GPR34
G protein-coupled receptor 34
chr20_-_30539773 0.46 ENST00000202017.4
PDRG1
p53 and DNA-damage regulated 1
chr1_+_113217073 0.45 ENST00000369645.1
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr16_+_8736232 0.45 ENST00000562973.1
METTL22
methyltransferase like 22
chr5_+_49961727 0.45 ENST00000505697.2
ENST00000503750.2
ENST00000514342.2
PARP8
poly (ADP-ribose) polymerase family, member 8
chr1_+_32666188 0.44 ENST00000421922.2
CCDC28B
coiled-coil domain containing 28B
chr12_-_52604607 0.44 ENST00000551894.1
ENST00000553017.1
C12orf80
chromosome 12 open reading frame 80
chr20_-_43729750 0.44 ENST00000537075.1
ENST00000306117.1
KCNS1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
chr19_-_46288917 0.44 ENST00000537879.1
ENST00000596586.1
ENST00000595946.1
DMWD
AC011530.4
dystrophia myotonica, WD repeat containing
Uncharacterized protein
chr6_+_31126291 0.43 ENST00000376257.3
ENST00000376255.4
TCF19
transcription factor 19
chr11_+_57435219 0.43 ENST00000527985.1
ENST00000287169.3
ZDHHC5
zinc finger, DHHC-type containing 5
chr7_+_141463897 0.41 ENST00000247879.2
TAS2R3
taste receptor, type 2, member 3
chr13_-_46756351 0.41 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_+_114163945 0.40 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr4_+_95376396 0.39 ENST00000508216.1
ENST00000514743.1
PDLIM5
PDZ and LIM domain 5
chr4_+_81118647 0.39 ENST00000415738.2
PRDM8
PR domain containing 8
chr5_+_150051149 0.39 ENST00000523553.1
MYOZ3
myozenin 3
chr2_+_36923933 0.38 ENST00000497382.1
ENST00000404084.1
ENST00000379241.3
ENST00000401530.1
VIT
vitrin
chr6_+_83073334 0.37 ENST00000369750.3
TPBG
trophoblast glycoprotein
chr4_-_48082192 0.37 ENST00000507351.1
TXK
TXK tyrosine kinase
chr10_-_104262426 0.37 ENST00000487599.1
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr10_-_36813162 0.37 ENST00000440465.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr3_+_30648066 0.36 ENST00000359013.4
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr3_+_38179969 0.36 ENST00000396334.3
ENST00000417037.2
ENST00000424893.1
ENST00000495303.1
ENST00000443433.2
ENST00000421516.1
MYD88
myeloid differentiation primary response 88
chr3_-_10452359 0.35 ENST00000452124.1
ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr7_+_117251671 0.35 ENST00000468795.1
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr20_-_4795747 0.35 ENST00000379376.2
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr3_-_49761337 0.35 ENST00000535833.1
ENST00000308388.6
ENST00000480687.1
ENST00000308375.6
AMIGO3
GMPPB
adhesion molecule with Ig-like domain 3
GDP-mannose pyrophosphorylase B
chr14_+_22386325 0.34 ENST00000390439.2
TRAV13-2
T cell receptor alpha variable 13-2
chr5_-_58335281 0.33 ENST00000358923.6
PDE4D
phosphodiesterase 4D, cAMP-specific
chr19_+_33865218 0.33 ENST00000585933.2
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr1_-_202129704 0.33 ENST00000476061.1
ENST00000544762.1
ENST00000467283.1
ENST00000464870.1
ENST00000435759.2
ENST00000486116.1
ENST00000543735.1
ENST00000308986.5
ENST00000477625.1
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr11_+_6226782 0.33 ENST00000316375.2
C11orf42
chromosome 11 open reading frame 42
chr11_+_33902189 0.33 ENST00000330381.2
AC132216.1
HCG1785179; PRO1787; Uncharacterized protein
chr6_+_36562132 0.32 ENST00000373715.6
ENST00000339436.7
SRSF3
serine/arginine-rich splicing factor 3
chr3_+_63428982 0.32 ENST00000479198.1
ENST00000460711.1
ENST00000465156.1
SYNPR
synaptoporin
chr10_-_104262460 0.32 ENST00000446605.2
ENST00000369905.4
ENST00000545684.1
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr22_+_38453207 0.31 ENST00000404072.3
ENST00000424694.1
PICK1
protein interacting with PRKCA 1
chr1_+_109632425 0.31 ENST00000338272.8
TMEM167B
transmembrane protein 167B
chr19_-_45579762 0.31 ENST00000303809.2
ZNF296
zinc finger protein 296
chr17_-_41132410 0.31 ENST00000409446.3
ENST00000453594.1
ENST00000409399.1
ENST00000421990.2
PTGES3L
PTGES3L-AARSD1
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr4_+_146403912 0.30 ENST00000507367.1
ENST00000394092.2
ENST00000515385.1
SMAD1
SMAD family member 1
chr17_-_29641084 0.30 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr3_-_122233723 0.30 ENST00000493510.1
ENST00000344337.6
ENST00000476916.1
ENST00000465882.1
KPNA1
karyopherin alpha 1 (importin alpha 5)
chr17_+_41132564 0.29 ENST00000361677.1
ENST00000589705.1
RUNDC1
RUN domain containing 1
chr5_+_150404904 0.29 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr17_-_26662440 0.29 ENST00000578122.1
IFT20
intraflagellar transport 20 homolog (Chlamydomonas)
chr19_-_50979981 0.29 ENST00000595790.1
ENST00000600100.1
FAM71E1
family with sequence similarity 71, member E1
chr7_+_134430212 0.29 ENST00000436461.2
CALD1
caldesmon 1
chr19_-_49955050 0.29 ENST00000262265.5
PIH1D1
PIH1 domain containing 1
chr3_-_122134882 0.28 ENST00000330689.4
WDR5B
WD repeat domain 5B
chr15_-_101142401 0.28 ENST00000314742.8
LINS
lines homolog (Drosophila)
chr1_+_47137544 0.28 ENST00000564373.1
TEX38
testis expressed 38
chr19_+_56187987 0.28 ENST00000411543.2
EPN1
epsin 1
chr1_+_230883128 0.28 ENST00000271971.2
ENST00000354537.1
CAPN9
calpain 9
chr6_+_46761118 0.28 ENST00000230588.4
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chr17_+_12569306 0.27 ENST00000425538.1
MYOCD
myocardin
chr6_-_43027105 0.27 ENST00000230413.5
ENST00000487429.1
ENST00000489623.1
ENST00000468957.1
MRPL2
mitochondrial ribosomal protein L2
chr12_-_123201337 0.27 ENST00000528880.2
HCAR3
hydroxycarboxylic acid receptor 3
chr20_-_23969416 0.27 ENST00000335694.4
GGTLC1
gamma-glutamyltransferase light chain 1
chr17_-_26662464 0.27 ENST00000579419.1
ENST00000585313.1
ENST00000395418.3
ENST00000578985.1
ENST00000577498.1
ENST00000585089.1
ENST00000357896.3
IFT20
intraflagellar transport 20 homolog (Chlamydomonas)
chr12_+_49761147 0.26 ENST00000549298.1
SPATS2
spermatogenesis associated, serine-rich 2
chr1_-_114696472 0.26 ENST00000393296.1
ENST00000369547.1
ENST00000610222.1
SYT6
synaptotagmin VI
chr2_-_492655 0.26 ENST00000427398.1
AC093326.1
AC093326.1
chr1_+_43824669 0.26 ENST00000372462.1
CDC20
cell division cycle 20
chr18_+_32173276 0.26 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
DTNA
dystrobrevin, alpha
chr3_-_47950745 0.26 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr22_+_39101728 0.26 ENST00000216044.5
ENST00000484657.1
GTPBP1
GTP binding protein 1
chr12_+_49761224 0.25 ENST00000553127.1
ENST00000321898.6
SPATS2
spermatogenesis associated, serine-rich 2
chr5_-_59481406 0.25 ENST00000546160.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_+_156693091 0.25 ENST00000318218.6
ENST00000442283.2
ENST00000522463.1
ENST00000521420.1
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr9_+_135906076 0.25 ENST00000372097.5
ENST00000440319.1
GTF3C5
general transcription factor IIIC, polypeptide 5, 63kDa
chr2_+_102803433 0.25 ENST00000264257.2
ENST00000441515.2
IL1RL2
interleukin 1 receptor-like 2
chr10_+_99332198 0.24 ENST00000307518.5
ENST00000298808.5
ENST00000370655.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr14_+_21387508 0.24 ENST00000555624.1
RP11-84C10.2
RP11-84C10.2
chr3_+_182971018 0.24 ENST00000326505.3
B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr8_-_93029520 0.24 ENST00000521553.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr15_-_99791413 0.24 ENST00000394129.2
ENST00000558663.1
ENST00000394135.3
ENST00000561365.1
ENST00000560279.1
TTC23
tetratricopeptide repeat domain 23
chr4_+_48343339 0.24 ENST00000264313.6
SLAIN2
SLAIN motif family, member 2
chr17_-_34808047 0.24 ENST00000592614.1
ENST00000591542.1
ENST00000330458.7
ENST00000341264.6
ENST00000592987.1
ENST00000400684.4
TBC1D3G
TBC1D3H
TBC1 domain family, member 3G
TBC1 domain family, member 3H
chr8_+_11961898 0.23 ENST00000400085.3
ZNF705D
zinc finger protein 705D
chr3_+_30647994 0.23 ENST00000295754.5
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr7_-_2883928 0.23 ENST00000275364.3
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr5_-_115177247 0.22 ENST00000500945.2
ATG12
autophagy related 12
chr2_+_204103663 0.22 ENST00000356079.4
ENST00000429815.2
CYP20A1
cytochrome P450, family 20, subfamily A, polypeptide 1
chr18_-_67624160 0.22 ENST00000581982.1
ENST00000280200.4
CD226
CD226 molecule
chr2_+_219110149 0.22 ENST00000456575.1
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr4_-_36246060 0.22 ENST00000303965.4
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr11_-_62607036 0.22 ENST00000311713.7
ENST00000278856.4
WDR74
WD repeat domain 74
chr10_-_76868931 0.22 ENST00000372700.3
ENST00000473072.2
ENST00000491677.2
ENST00000607131.1
ENST00000372702.3
DUSP13
dual specificity phosphatase 13
chr5_-_148033726 0.22 ENST00000354217.2
ENST00000314512.6
ENST00000362016.2
HTR4
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
chr1_+_47137445 0.22 ENST00000569393.1
ENST00000334122.4
ENST00000415500.1
TEX38
testis expressed 38
chr8_+_24298597 0.21 ENST00000380789.1
ADAM7
ADAM metallopeptidase domain 7
chr4_+_88754069 0.21 ENST00000395102.4
ENST00000497649.2
MEPE
matrix extracellular phosphoglycoprotein
chr14_+_45366518 0.21 ENST00000557112.1
C14orf28
chromosome 14 open reading frame 28
chr11_+_124735282 0.21 ENST00000397801.1
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr5_-_141338627 0.21 ENST00000231484.3
PCDH12
protocadherin 12
chr13_+_75126978 0.21 ENST00000596240.1
ENST00000451336.2
LINC00347
long intergenic non-protein coding RNA 347
chr2_+_161993412 0.21 ENST00000259075.2
ENST00000432002.1
TANK
TRAF family member-associated NFKB activator
chr9_+_131447342 0.21 ENST00000409104.3
SET
SET nuclear oncogene
chr10_+_27793197 0.20 ENST00000356940.6
ENST00000535776.1
RAB18
RAB18, member RAS oncogene family
chr4_-_141677267 0.19 ENST00000442267.2
TBC1D9
TBC1 domain family, member 9 (with GRAM domain)
chr10_-_13523073 0.19 ENST00000440282.1
BEND7
BEN domain containing 7
chr3_-_52002403 0.19 ENST00000490063.1
ENST00000468324.1
ENST00000497653.1
ENST00000484633.1
PCBP4
poly(rC) binding protein 4
chr16_-_31076332 0.19 ENST00000539836.3
ENST00000535577.1
ENST00000442862.2
ZNF668
zinc finger protein 668
chr1_-_151804314 0.19 ENST00000318247.6
RORC
RAR-related orphan receptor C
chr1_+_202317815 0.19 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr19_-_39368887 0.19 ENST00000340740.3
ENST00000591812.1
RINL
Ras and Rab interactor-like
chr17_+_36283971 0.19 ENST00000327454.6
ENST00000378174.5
TBC1D3F
TBC1 domain family, member 3F
chr1_-_205391178 0.19 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
LEMD1
LEM domain containing 1
chr8_+_24298531 0.19 ENST00000175238.6
ADAM7
ADAM metallopeptidase domain 7
chr1_-_26633067 0.19 ENST00000421827.2
ENST00000374215.1
ENST00000374223.1
ENST00000357089.4
ENST00000535108.1
ENST00000314675.7
ENST00000436301.2
ENST00000423664.1
ENST00000374221.3
UBXN11
UBX domain protein 11
chr10_+_17794251 0.19 ENST00000377495.1
ENST00000338221.5
TMEM236
transmembrane protein 236
chr4_-_100212132 0.18 ENST00000209668.2
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr16_-_31076273 0.18 ENST00000426488.2
ZNF668
zinc finger protein 668
chr1_+_46806837 0.18 ENST00000537428.1
NSUN4
NOP2/Sun domain family, member 4
chr21_+_33671160 0.18 ENST00000303645.5
MRAP
melanocortin 2 receptor accessory protein
chr10_+_99332529 0.18 ENST00000455090.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr12_-_120315074 0.18 ENST00000261833.7
ENST00000392521.2
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr9_-_138391692 0.18 ENST00000429260.2
C9orf116
chromosome 9 open reading frame 116
chr3_-_167191814 0.18 ENST00000466903.1
ENST00000264677.4
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr16_-_3450963 0.18 ENST00000573327.1
ENST00000571906.1
ENST00000573830.1
ENST00000439568.2
ENST00000422427.2
ENST00000304926.3
ENST00000396852.4
ZSCAN32
zinc finger and SCAN domain containing 32
chr14_+_94547675 0.18 ENST00000393115.3
ENST00000554166.1
ENST00000556381.1
ENST00000553664.1
ENST00000555341.1
ENST00000557218.1
ENST00000554544.1
ENST00000557066.1
IFI27L1
interferon, alpha-inducible protein 27-like 1
chr4_+_88754113 0.18 ENST00000560249.1
ENST00000540395.1
ENST00000511670.1
ENST00000361056.3
MEPE
matrix extracellular phosphoglycoprotein
chr17_-_36348610 0.18 ENST00000339023.4
ENST00000354664.4
TBC1D3
TBC1 domain family, member 3
chr6_+_131148538 0.18 ENST00000541421.2
SMLR1
small leucine-rich protein 1
chr12_+_6309963 0.18 ENST00000382515.2
CD9
CD9 molecule
chr2_-_95787738 0.17 ENST00000272418.2
MRPS5
mitochondrial ribosomal protein S5
chr1_+_110091189 0.17 ENST00000369851.4
GNAI3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr19_+_42746927 0.17 ENST00000378108.1
AC006486.1
AC006486.1
chr8_-_20040601 0.17 ENST00000265808.7
ENST00000522513.1
SLC18A1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr13_-_44735393 0.17 ENST00000400419.1
SMIM2
small integral membrane protein 2
chr5_-_96518907 0.17 ENST00000508447.1
ENST00000283109.3
RIOK2
RIO kinase 2
chr19_+_39616410 0.17 ENST00000602004.1
ENST00000599470.1
ENST00000321944.4
ENST00000593480.1
ENST00000358301.3
ENST00000593690.1
ENST00000599386.1
PAK4
p21 protein (Cdc42/Rac)-activated kinase 4
chr5_-_148033693 0.17 ENST00000377888.3
ENST00000360693.3
HTR4
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
chr10_-_112678692 0.17 ENST00000605742.1
BBIP1
BBSome interacting protein 1
chr22_+_38004473 0.16 ENST00000414350.3
ENST00000343632.4
GGA1
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr16_-_58663720 0.16 ENST00000564557.1
ENST00000569240.1
ENST00000441024.2
ENST00000569020.1
ENST00000317147.5
CNOT1
CCR4-NOT transcription complex, subunit 1
chr4_-_46911223 0.16 ENST00000396533.1
COX7B2
cytochrome c oxidase subunit VIIb2
chr4_-_57524061 0.16 ENST00000508121.1
HOPX
HOP homeobox
chr11_+_10326612 0.16 ENST00000534464.1
ENST00000530439.1
ENST00000524948.1
ENST00000528655.1
ENST00000526492.1
ENST00000525063.1
ADM
adrenomedullin
chr11_+_120195992 0.16 ENST00000314475.2
ENST00000529187.1
TMEM136
transmembrane protein 136
chr9_-_25678856 0.16 ENST00000358022.3
TUSC1
tumor suppressor candidate 1
chr8_-_20040638 0.16 ENST00000519026.1
ENST00000276373.5
ENST00000440926.1
ENST00000437980.1
SLC18A1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr1_-_240906911 0.16 ENST00000431139.2
RP11-80B9.4
RP11-80B9.4
chr8_+_117963190 0.15 ENST00000427715.2
SLC30A8
solute carrier family 30 (zinc transporter), member 8
chr9_+_125376948 0.15 ENST00000297913.2
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chr15_-_78369994 0.15 ENST00000300584.3
ENST00000409931.3
TBC1D2B
TBC1 domain family, member 2B
chrX_-_108868390 0.15 ENST00000372101.2
KCNE1L
KCNE1-like
chr6_+_131958436 0.15 ENST00000357639.3
ENST00000543135.1
ENST00000427148.2
ENST00000358229.5
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr1_-_68962805 0.15 ENST00000370966.5
DEPDC1
DEP domain containing 1
chr4_-_46911248 0.15 ENST00000355591.3
ENST00000505102.1
COX7B2
cytochrome c oxidase subunit VIIb2
chr12_-_50290839 0.15 ENST00000552863.1
FAIM2
Fas apoptotic inhibitory molecule 2
chr19_-_3478477 0.15 ENST00000591708.1
C19orf77
chromosome 19 open reading frame 77
chr18_+_22040593 0.15 ENST00000256906.4
HRH4
histamine receptor H4
chr14_+_21387491 0.15 ENST00000258817.2
RP11-84C10.2
RP11-84C10.2
chr8_-_74791051 0.14 ENST00000453587.2
ENST00000602969.1
ENST00000602593.1
ENST00000419880.3
ENST00000517608.1
UBE2W
ubiquitin-conjugating enzyme E2W (putative)
chr17_+_29248698 0.14 ENST00000330889.3
ADAP2
ArfGAP with dual PH domains 2
chr14_+_21423611 0.14 ENST00000304625.2
RNASE2
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.3 2.9 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.3 2.3 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2 1.5 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.2 1.7 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.2 0.6 GO:0002514 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.2 0.8 GO:0051941 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.1 1.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.8 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 0.6 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 0.4 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.1 0.7 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.5 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 0.3 GO:1900110 negative regulation of histone H3-K9 dimethylation(GO:1900110) regulation of TORC2 signaling(GO:1903939)
0.1 1.0 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 0.3 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560) negative regulation of beta-amyloid clearance(GO:1900222)
0.1 0.3 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.1 0.2 GO:0070898 RNA polymerase III transcriptional preinitiation complex assembly(GO:0070898)
0.1 0.5 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.1 1.8 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 0.2 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.1 0.6 GO:1902525 regulation of protein monoubiquitination(GO:1902525)
0.1 0.4 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.1 0.6 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.3 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 0.7 GO:0090240 positive regulation of histone H4 acetylation(GO:0090240)
0.1 0.6 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 0.4 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.1 1.8 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.1 0.5 GO:0035524 proline transmembrane transport(GO:0035524)
0.1 1.0 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.1 0.3 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.1 0.7 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.1 0.9 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 0.6 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.3 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.0 0.3 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.3 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.3 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:1904582 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
0.0 0.1 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.0 0.1 GO:0014040 positive regulation of Schwann cell differentiation(GO:0014040)
0.0 0.1 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0 0.1 GO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) negative regulation of osteoclast proliferation(GO:0090291) negative regulation of bone mineralization involved in bone maturation(GO:1900158) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228)
0.0 0.1 GO:0071879 UDP-glucose catabolic process(GO:0006258) positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0 0.3 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.4 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.0 0.5 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.6 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.0 0.2 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.0 0.1 GO:0051790 short-chain fatty acid biosynthetic process(GO:0051790)
0.0 0.3 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.0 0.1 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0 0.2 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.4 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 0.2 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.2 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.2 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.0 0.1 GO:2000870 regulation of progesterone secretion(GO:2000870)
0.0 0.6 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.2 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.0 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.0 0.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.2 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.4 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.2 GO:0009414 response to water deprivation(GO:0009414)
0.0 0.2 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.3 GO:0006069 ethanol oxidation(GO:0006069)
0.0 0.1 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0 0.3 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.3 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.0 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.0 0.1 GO:0021831 embryonic olfactory bulb interneuron precursor migration(GO:0021831)
0.0 0.3 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 0.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.4 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.4 GO:0032098 regulation of appetite(GO:0032098)
0.0 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.0 0.1 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.0 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.0 1.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.0 GO:0021592 midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592)
0.0 0.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.1 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.2 0.6 GO:1902636 kinociliary basal body(GO:1902636)
0.2 1.1 GO:1990037 Lewy body core(GO:1990037)
0.1 1.5 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.7 GO:0002177 manchette(GO:0002177)
0.1 0.8 GO:0033269 internode region of axon(GO:0033269)
0.1 0.2 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 0.4 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.1 0.6 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.5 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.5 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.2 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.3 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.3 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.9 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.7 GO:0031143 pseudopodium(GO:0031143)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.3 GO:0030478 actin cap(GO:0030478)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.3 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 1.3 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.2 GO:0034464 BBSome(GO:0034464)
0.0 0.3 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.9 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.5 1.5 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.2 0.7 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.2 0.5 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.1 0.6 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 0.4 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 1.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.4 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.1 0.7 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.6 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 0.6 GO:0002046 opsin binding(GO:0002046)
0.1 0.6 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.1 0.3 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.1 0.3 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.1 0.2 GO:0001003 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.1 1.8 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.2 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.1 2.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.8 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.7 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 0.3 GO:0070568 guanylyltransferase activity(GO:0070568)
0.1 0.2 GO:0033149 FFAT motif binding(GO:0033149)
0.1 0.4 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 0.4 GO:0051373 FATZ binding(GO:0051373)
0.1 0.4 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 0.2 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.1 1.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.8 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.0 0.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.3 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.5 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.2 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.2 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.5 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.6 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.3 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 1.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.3 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.1 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0048256 flap endonuclease activity(GO:0048256)
0.0 0.1 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.0 0.2 GO:0008430 selenium binding(GO:0008430)
0.0 0.3 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0003696 satellite DNA binding(GO:0003696)
0.0 0.1 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.0 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.6 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0036122 BMP binding(GO:0036122)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.6 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.9 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.4 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 1.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.7 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.6 PID FANCONI PATHWAY Fanconi anemia pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 0.9 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 1.1 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 1.5 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 1.0 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.5 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.6 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.6 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.0 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.6 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.9 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.4 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.1 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 2.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing