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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NKX2-4

Z-value: 0.57

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Transcription factors associated with NKX2-4

Gene Symbol Gene ID Gene Info
NKX2-4
ENSG00000125816.4 NK2 homeobox 4

Activity profile of NKX2-4 motif

Sorted Z-values of NKX2-4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_102651343 1.73 ENST00000279441.4
ENST00000539681.1
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr15_+_67430339 1.26 ENST00000439724.3
SMAD3
SMAD family member 3
chr7_-_47579188 1.25 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
TNS3
tensin 3
chr12_-_71182695 1.22 ENST00000342084.4
PTPRR
protein tyrosine phosphatase, receptor type, R
chr3_-_107777208 1.22 ENST00000398258.3
CD47
CD47 molecule
chr5_-_61031495 1.15 ENST00000506550.1
ENST00000512882.2
CTD-2170G1.2
CTD-2170G1.2
chr2_+_161993465 1.09 ENST00000457476.1
TANK
TRAF family member-associated NFKB activator
chr1_-_85870177 0.96 ENST00000542148.1
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr7_+_134551583 0.95 ENST00000435928.1
CALD1
caldesmon 1
chrX_-_154563889 0.91 ENST00000369449.2
ENST00000321926.4
CLIC2
chloride intracellular channel 2
chr7_-_115608304 0.83 ENST00000457268.1
TFEC
transcription factor EC
chr7_+_129932974 0.82 ENST00000445470.2
ENST00000222482.4
ENST00000492072.1
ENST00000473956.1
ENST00000493259.1
ENST00000486598.1
CPA4
carboxypeptidase A4
chr19_+_45504688 0.81 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr4_-_80994619 0.80 ENST00000404191.1
ANTXR2
anthrax toxin receptor 2
chr13_-_43566301 0.79 ENST00000398762.3
ENST00000313640.7
ENST00000313624.7
EPSTI1
epithelial stromal interaction 1 (breast)
chr1_+_144989309 0.79 ENST00000596396.1
AL590452.1
Uncharacterized protein
chr1_+_205225319 0.75 ENST00000329800.7
TMCC2
transmembrane and coiled-coil domain family 2
chr1_-_89591749 0.72 ENST00000370466.3
GBP2
guanylate binding protein 2, interferon-inducible
chr12_+_10658201 0.70 ENST00000322446.3
EIF2S3L
Putative eukaryotic translation initiation factor 2 subunit 3-like protein
chr2_+_161993412 0.70 ENST00000259075.2
ENST00000432002.1
TANK
TRAF family member-associated NFKB activator
chr18_-_33702078 0.67 ENST00000586829.1
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr4_-_80994471 0.66 ENST00000295465.4
ANTXR2
anthrax toxin receptor 2
chr19_+_10765699 0.65 ENST00000590009.1
ILF3
interleukin enhancer binding factor 3, 90kDa
chrX_+_144908928 0.64 ENST00000408967.2
TMEM257
transmembrane protein 257
chr22_+_41697520 0.64 ENST00000352645.4
ZC3H7B
zinc finger CCCH-type containing 7B
chr16_+_1730338 0.62 ENST00000566691.1
ENST00000382710.4
HN1L
hematological and neurological expressed 1-like
chr21_+_40177143 0.61 ENST00000360214.3
ETS2
v-ets avian erythroblastosis virus E26 oncogene homolog 2
chr4_+_86748898 0.58 ENST00000509300.1
ARHGAP24
Rho GTPase activating protein 24
chr6_+_83072923 0.56 ENST00000535040.1
TPBG
trophoblast glycoprotein
chr15_-_55541227 0.56 ENST00000566877.1
RAB27A
RAB27A, member RAS oncogene family
chr2_-_37899323 0.55 ENST00000295324.3
ENST00000457889.1
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr12_-_48500085 0.54 ENST00000549518.1
SENP1
SUMO1/sentrin specific peptidase 1
chr17_-_40264692 0.53 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr4_+_96012614 0.52 ENST00000264568.4
BMPR1B
bone morphogenetic protein receptor, type IB
chr2_-_202562716 0.52 ENST00000428900.2
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr11_-_105892937 0.51 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
chr14_+_51955831 0.49 ENST00000356218.4
FRMD6
FERM domain containing 6
chr4_+_86749045 0.49 ENST00000514229.1
ARHGAP24
Rho GTPase activating protein 24
chr19_-_55669093 0.49 ENST00000344887.5
TNNI3
troponin I type 3 (cardiac)
chr7_-_92463210 0.48 ENST00000265734.4
CDK6
cyclin-dependent kinase 6
chr8_+_104310661 0.47 ENST00000522566.1
FZD6
frizzled family receptor 6
chr7_+_151038850 0.47 ENST00000355851.4
ENST00000566856.1
ENST00000470229.1
NUB1
negative regulator of ubiquitin-like proteins 1
chr5_-_13944652 0.46 ENST00000265104.4
DNAH5
dynein, axonemal, heavy chain 5
chr4_-_103746683 0.44 ENST00000504211.1
ENST00000508476.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr6_+_37225540 0.43 ENST00000373491.3
TBC1D22B
TBC1 domain family, member 22B
chr6_+_126240442 0.42 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
NCOA7
nuclear receptor coactivator 7
chr3_+_173116225 0.41 ENST00000457714.1
NLGN1
neuroligin 1
chr6_+_83073334 0.41 ENST00000369750.3
TPBG
trophoblast glycoprotein
chr11_-_85780853 0.40 ENST00000531930.1
ENST00000528398.1
PICALM
phosphatidylinositol binding clathrin assembly protein
chr2_+_162016916 0.40 ENST00000405852.1
TANK
TRAF family member-associated NFKB activator
chr11_+_35965531 0.40 ENST00000528989.1
ENST00000524419.1
ENST00000315571.5
LDLRAD3
low density lipoprotein receptor class A domain containing 3
chr6_+_153552455 0.39 ENST00000392385.2
AL590867.1
Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog
chr19_+_36235964 0.38 ENST00000587708.2
PSENEN
presenilin enhancer gamma secretase subunit
chr11_-_85779971 0.37 ENST00000393346.3
PICALM
phosphatidylinositol binding clathrin assembly protein
chr2_-_197226875 0.37 ENST00000409111.1
HECW2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr2_-_175462456 0.37 ENST00000409891.1
ENST00000410117.1
WIPF1
WAS/WASL interacting protein family, member 1
chr3_+_30647994 0.37 ENST00000295754.5
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr8_+_31496809 0.36 ENST00000518104.1
ENST00000519301.1
NRG1
neuregulin 1
chr12_+_75874460 0.35 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr5_-_59481406 0.35 ENST00000546160.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_+_173302222 0.35 ENST00000361589.4
NLGN1
neuroligin 1
chr18_+_55816546 0.35 ENST00000435432.2
ENST00000357895.5
ENST00000586263.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr1_-_156721502 0.35 ENST00000357325.5
HDGF
hepatoma-derived growth factor
chr2_-_100759037 0.34 ENST00000317233.4
ENST00000423966.1
ENST00000416492.1
AFF3
AF4/FMR2 family, member 3
chr5_-_160279207 0.34 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr4_-_103747011 0.34 ENST00000350435.7
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr17_+_42923686 0.34 ENST00000591513.1
HIGD1B
HIG1 hypoxia inducible domain family, member 1B
chr20_-_21494654 0.34 ENST00000377142.4
NKX2-2
NK2 homeobox 2
chr4_-_103746924 0.34 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr10_+_60094735 0.33 ENST00000373910.4
UBE2D1
ubiquitin-conjugating enzyme E2D 1
chr19_+_7733929 0.33 ENST00000221515.2
RETN
resistin
chr5_-_98262240 0.32 ENST00000284049.3
CHD1
chromodomain helicase DNA binding protein 1
chr1_-_217250231 0.31 ENST00000493748.1
ENST00000463665.1
ESRRG
estrogen-related receptor gamma
chr1_-_13390765 0.31 ENST00000357367.2
PRAMEF8
PRAME family member 8
chr6_+_45390222 0.31 ENST00000359524.5
RUNX2
runt-related transcription factor 2
chr5_+_137419581 0.30 ENST00000506684.1
ENST00000504809.1
ENST00000398754.1
WNT8A
wingless-type MMTV integration site family, member 8A
chr11_-_85780086 0.29 ENST00000532317.1
ENST00000528256.1
ENST00000526033.1
PICALM
phosphatidylinositol binding clathrin assembly protein
chr15_-_88799661 0.29 ENST00000360948.2
ENST00000357724.2
ENST00000355254.2
ENST00000317501.3
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr12_+_124069070 0.28 ENST00000262225.3
ENST00000438031.2
TMED2
transmembrane emp24 domain trafficking protein 2
chr6_+_12007897 0.28 ENST00000437559.1
RP11-456H18.2
RP11-456H18.2
chr5_+_154135029 0.28 ENST00000518297.1
LARP1
La ribonucleoprotein domain family, member 1
chr1_+_175036966 0.28 ENST00000239462.4
TNN
tenascin N
chr10_+_105005644 0.28 ENST00000441178.2
RP11-332O19.5
ribulose-5-phosphate-3-epimerase-like 1
chr4_+_71063641 0.28 ENST00000514097.1
ODAM
odontogenic, ameloblast asssociated
chr3_-_88108212 0.27 ENST00000482016.1
CGGBP1
CGG triplet repeat binding protein 1
chr1_-_89458287 0.27 ENST00000370485.2
CCBL2
cysteine conjugate-beta lyase 2
chr1_-_85040090 0.27 ENST00000370630.5
CTBS
chitobiase, di-N-acetyl-
chr4_+_71263599 0.26 ENST00000399575.2
PROL1
proline rich, lacrimal 1
chr1_-_47407097 0.26 ENST00000457840.2
CYP4A11
cytochrome P450, family 4, subfamily A, polypeptide 11
chr21_-_15918618 0.26 ENST00000400564.1
ENST00000400566.1
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chrX_-_30993201 0.25 ENST00000288422.2
ENST00000378932.2
TAB3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr2_+_183982238 0.25 ENST00000442895.2
ENST00000446612.1
ENST00000409798.1
NUP35
nucleoporin 35kDa
chr20_-_43280325 0.25 ENST00000537820.1
ADA
adenosine deaminase
chr11_+_60699222 0.25 ENST00000536409.1
TMEM132A
transmembrane protein 132A
chrX_-_138914394 0.25 ENST00000327569.3
ENST00000361648.2
ENST00000370543.1
ENST00000359686.2
ATP11C
ATPase, class VI, type 11C
chr16_-_21877629 0.24 ENST00000544693.1
NPIPB4
nuclear pore complex interacting protein family, member B4
chr1_-_204183071 0.24 ENST00000308302.3
GOLT1A
golgi transport 1A
chr10_-_48055018 0.24 ENST00000426610.2
ASAH2C
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2C
chr18_+_11851383 0.23 ENST00000526991.2
CHMP1B
charged multivesicular body protein 1B
chr7_+_116139424 0.23 ENST00000222693.4
CAV2
caveolin 2
chrX_+_70443050 0.23 ENST00000361726.6
GJB1
gap junction protein, beta 1, 32kDa
chr21_-_35884573 0.23 ENST00000399286.2
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr22_-_50524298 0.23 ENST00000311597.5
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr1_-_95391315 0.23 ENST00000545882.1
ENST00000415017.1
CNN3
calponin 3, acidic
chr11_+_60524426 0.23 ENST00000528170.1
ENST00000337911.4
ENST00000405633.3
MS4A15
membrane-spanning 4-domains, subfamily A, member 15
chr10_+_98592674 0.22 ENST00000356016.3
ENST00000371097.4
LCOR
ligand dependent nuclear receptor corepressor
chr15_+_63354769 0.22 ENST00000558910.1
TPM1
tropomyosin 1 (alpha)
chr1_-_241520525 0.22 ENST00000366565.1
RGS7
regulator of G-protein signaling 7
chr10_-_69455873 0.22 ENST00000433211.2
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr6_-_152639479 0.22 ENST00000356820.4
SYNE1
spectrin repeat containing, nuclear envelope 1
chr2_+_37571845 0.22 ENST00000537448.1
QPCT
glutaminyl-peptide cyclotransferase
chr16_+_81272287 0.21 ENST00000425577.2
ENST00000564552.1
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr2_+_162272605 0.21 ENST00000389554.3
TBR1
T-box, brain, 1
chr8_+_66955648 0.21 ENST00000522619.1
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr19_-_20748541 0.21 ENST00000427401.4
ENST00000594419.1
ZNF737
zinc finger protein 737
chr1_-_205419053 0.20 ENST00000367154.1
LEMD1
LEM domain containing 1
chr17_+_60501228 0.20 ENST00000311506.5
METTL2A
methyltransferase like 2A
chr3_+_15045419 0.20 ENST00000406272.2
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr15_+_63334831 0.20 ENST00000288398.6
ENST00000358278.3
ENST00000560445.1
ENST00000403994.3
ENST00000357980.4
ENST00000559556.1
ENST00000559397.1
ENST00000267996.7
ENST00000560970.1
TPM1
tropomyosin 1 (alpha)
chr11_+_61717842 0.20 ENST00000449131.2
BEST1
bestrophin 1
chr10_+_99332529 0.20 ENST00000455090.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr11_-_119993979 0.20 ENST00000524816.3
ENST00000525327.1
TRIM29
tripartite motif containing 29
chr6_-_152958521 0.19 ENST00000367255.5
ENST00000265368.4
ENST00000448038.1
ENST00000341594.5
SYNE1
spectrin repeat containing, nuclear envelope 1
chr10_-_61495760 0.19 ENST00000395347.1
SLC16A9
solute carrier family 16, member 9
chr8_+_11141925 0.19 ENST00000221086.3
MTMR9
myotubularin related protein 9
chr10_+_21823243 0.19 ENST00000307729.7
ENST00000377091.2
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr1_-_21606013 0.18 ENST00000357071.4
ECE1
endothelin converting enzyme 1
chr16_+_22516172 0.18 ENST00000543407.1
NPIPB5
nuclear pore complex interacting protein family, member B5
chr3_+_137906154 0.18 ENST00000466749.1
ENST00000358441.2
ENST00000489213.1
ARMC8
armadillo repeat containing 8
chr13_-_108870623 0.18 ENST00000405925.1
LIG4
ligase IV, DNA, ATP-dependent
chr14_-_71067360 0.18 ENST00000554963.1
ENST00000430055.2
ENST00000440435.2
ENST00000256379.5
MED6
mediator complex subunit 6
chr8_+_37594103 0.18 ENST00000397228.2
ERLIN2
ER lipid raft associated 2
chr16_+_77822427 0.18 ENST00000302536.2
VAT1L
vesicle amine transport 1-like
chr6_-_131277510 0.18 ENST00000525193.1
ENST00000527659.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr12_+_21168630 0.18 ENST00000421593.2
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr10_-_121296045 0.18 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr4_-_87028478 0.18 ENST00000515400.1
ENST00000395157.3
MAPK10
mitogen-activated protein kinase 10
chr2_-_209054709 0.17 ENST00000449053.1
ENST00000451346.1
ENST00000341287.4
C2orf80
chromosome 2 open reading frame 80
chr5_+_147443534 0.17 ENST00000398454.1
ENST00000359874.3
ENST00000508733.1
ENST00000256084.7
SPINK5
serine peptidase inhibitor, Kazal type 5
chr7_+_143174966 0.17 ENST00000408916.1
TAS2R41
taste receptor, type 2, member 41
chr1_-_241520385 0.17 ENST00000366564.1
RGS7
regulator of G-protein signaling 7
chr4_+_111397216 0.17 ENST00000265162.5
ENPEP
glutamyl aminopeptidase (aminopeptidase A)
chr10_+_81272287 0.17 ENST00000520547.2
EIF5AL1
eukaryotic translation initiation factor 5A-like 1
chrX_+_78200913 0.17 ENST00000171757.2
P2RY10
purinergic receptor P2Y, G-protein coupled, 10
chr6_-_134861089 0.17 ENST00000606039.1
RP11-557H15.4
RP11-557H15.4
chr4_-_174320687 0.17 ENST00000296506.3
SCRG1
stimulator of chondrogenesis 1
chr1_-_100643765 0.17 ENST00000370137.1
ENST00000370138.1
ENST00000342895.3
LRRC39
leucine rich repeat containing 39
chr4_+_39699664 0.17 ENST00000261427.5
ENST00000510934.1
ENST00000295963.6
UBE2K
ubiquitin-conjugating enzyme E2K
chr14_-_104028595 0.17 ENST00000337322.4
ENST00000445922.2
BAG5
BCL2-associated athanogene 5
chr5_-_34919094 0.17 ENST00000341754.4
RAD1
RAD1 homolog (S. pombe)
chr10_+_52094298 0.16 ENST00000595931.1
AC069547.1
HCG1745369; PRO3073; Uncharacterized protein
chr1_-_42801540 0.16 ENST00000372573.1
FOXJ3
forkhead box J3
chr19_-_49016418 0.16 ENST00000270238.3
LMTK3
lemur tyrosine kinase 3
chrX_+_78200829 0.16 ENST00000544091.1
P2RY10
purinergic receptor P2Y, G-protein coupled, 10
chr2_-_37544209 0.16 ENST00000234179.2
PRKD3
protein kinase D3
chr3_+_189349162 0.16 ENST00000264731.3
ENST00000382063.4
ENST00000418709.2
ENST00000320472.5
ENST00000392460.3
ENST00000440651.2
TP63
tumor protein p63
chr13_-_108867846 0.16 ENST00000442234.1
LIG4
ligase IV, DNA, ATP-dependent
chr2_-_49381646 0.16 ENST00000346173.3
ENST00000406846.2
FSHR
follicle stimulating hormone receptor
chr16_-_3450963 0.15 ENST00000573327.1
ENST00000571906.1
ENST00000573830.1
ENST00000439568.2
ENST00000422427.2
ENST00000304926.3
ENST00000396852.4
ZSCAN32
zinc finger and SCAN domain containing 32
chr12_-_322504 0.15 ENST00000424061.2
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr6_+_12958137 0.15 ENST00000457702.2
ENST00000379345.2
PHACTR1
phosphatase and actin regulator 1
chr11_-_10715502 0.15 ENST00000547195.1
MRVI1
murine retrovirus integration site 1 homolog
chr1_-_155271213 0.15 ENST00000342741.4
PKLR
pyruvate kinase, liver and RBC
chr8_+_26247878 0.15 ENST00000518611.1
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr14_-_81893734 0.15 ENST00000555447.1
STON2
stonin 2
chr6_+_12007963 0.15 ENST00000607445.1
RP11-456H18.2
RP11-456H18.2
chr4_-_175443943 0.15 ENST00000296522.6
HPGD
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr18_+_21032781 0.15 ENST00000339486.3
RIOK3
RIO kinase 3
chr8_-_6914251 0.15 ENST00000330590.2
DEFA5
defensin, alpha 5, Paneth cell-specific
chr2_+_204571198 0.15 ENST00000374481.3
ENST00000458610.2
ENST00000324106.8
CD28
CD28 molecule
chr18_+_9136758 0.15 ENST00000383440.2
ENST00000262126.4
ENST00000577992.1
ANKRD12
ankyrin repeat domain 12
chr3_+_4535155 0.14 ENST00000544951.1
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr12_+_8975061 0.14 ENST00000299698.7
A2ML1
alpha-2-macroglobulin-like 1
chr6_-_39282329 0.14 ENST00000373231.4
KCNK17
potassium channel, subfamily K, member 17
chrX_+_49020882 0.14 ENST00000454342.1
MAGIX
MAGI family member, X-linked
chr15_-_86338100 0.14 ENST00000536947.1
KLHL25
kelch-like family member 25
chr10_-_104001231 0.14 ENST00000370002.3
PITX3
paired-like homeodomain 3
chr8_+_41347915 0.14 ENST00000518270.1
ENST00000520817.1
GOLGA7
golgin A7
chr11_-_19223523 0.14 ENST00000265968.3
CSRP3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr11_+_14926543 0.14 ENST00000523376.1
CALCB
calcitonin-related polypeptide beta
chrX_-_110655391 0.14 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr19_-_10047219 0.14 ENST00000264833.4
OLFM2
olfactomedin 2
chr13_-_96705624 0.14 ENST00000376747.3
ENST00000376712.4
ENST00000397618.3
ENST00000376714.3
UGGT2
UDP-glucose glycoprotein glucosyltransferase 2
chr5_+_161494770 0.14 ENST00000414552.2
ENST00000361925.4
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr3_+_68053359 0.14 ENST00000478136.1
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr1_+_152974218 0.14 ENST00000331860.3
ENST00000443178.1
ENST00000295367.4
SPRR3
small proline-rich protein 3
chr6_+_159071015 0.13 ENST00000360448.3
SYTL3
synaptotagmin-like 3
chr11_+_77774897 0.13 ENST00000281030.2
THRSP
thyroid hormone responsive
chr14_+_22356029 0.13 ENST00000390437.2
TRAV12-2
T cell receptor alpha variable 12-2
chr17_+_28804380 0.13 ENST00000225724.5
ENST00000451249.2
ENST00000467337.2
ENST00000581721.1
ENST00000414833.2
GOSR1
golgi SNAP receptor complex member 1
chr11_-_10715287 0.13 ENST00000423302.2
MRVI1
murine retrovirus integration site 1 homolog
chr14_-_96830207 0.13 ENST00000359933.4
ATG2B
autophagy related 2B
chr2_+_219110149 0.13 ENST00000456575.1
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr13_+_111767650 0.13 ENST00000449979.1
ENST00000370623.3
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr1_+_15986364 0.13 ENST00000345034.1
RSC1A1
regulatory solute carrier protein, family 1, member 1
chr19_+_52264449 0.13 ENST00000599326.1
ENST00000598953.1
FPR2
formyl peptide receptor 2
chr14_-_23058063 0.13 ENST00000538631.1
ENST00000543337.1
ENST00000250498.4
DAD1
defender against cell death 1
chr6_-_9933500 0.13 ENST00000492169.1
OFCC1
orofacial cleft 1 candidate 1
chr18_-_28622699 0.13 ENST00000360428.4
DSC3
desmocollin 3
chr6_-_39282221 0.13 ENST00000453413.2
KCNK17
potassium channel, subfamily K, member 17

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.3 1.3 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.3 0.8 GO:0099545 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.2 1.2 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.2 0.7 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.2 1.1 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1 0.4 GO:0002661 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.1 0.5 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 0.3 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.3 GO:0051102 DNA ligation involved in DNA recombination(GO:0051102)
0.1 0.3 GO:2000870 positive regulation of female gonad development(GO:2000196) regulation of progesterone secretion(GO:2000870)
0.1 0.5 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.6 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.1 0.3 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.1 0.3 GO:0048687 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.1 0.6 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.4 GO:0003095 pressure natriuresis(GO:0003095)
0.1 0.3 GO:0046103 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.1 0.2 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.1 0.3 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 0.5 GO:0003383 apical constriction(GO:0003383)
0.1 0.3 GO:1901355 response to rapamycin(GO:1901355)
0.1 0.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 1.0 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
0.1 1.2 GO:0008228 opsonization(GO:0008228)
0.1 0.5 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 0.9 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.1 0.3 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.1 0.2 GO:0051598 meiotic recombination checkpoint(GO:0051598)
0.1 0.5 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.1 0.4 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 0.4 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 0.8 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 0.1 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.0 0.3 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.2 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.1 GO:0097359 UDP-glucosylation(GO:0097359)
0.0 0.1 GO:0002325 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.0 0.2 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.0 0.2 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.0 0.3 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.4 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.7 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.1 GO:0097070 ductus arteriosus closure(GO:0097070)
0.0 0.1 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.0 0.6 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.2 GO:0021764 amygdala development(GO:0021764)
0.0 0.8 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.2 GO:0044789 receptor-mediated endocytosis of virus by host cell(GO:0019065) modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) endocytosis involved in viral entry into host cell(GO:0075509)
0.0 0.3 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.2 GO:0042640 anagen(GO:0042640)
0.0 0.1 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.0 0.1 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.3 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.0 0.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.2 GO:0061083 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.0 0.2 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.1 GO:1900111 positive regulation of histone H3-K9 dimethylation(GO:1900111)
0.0 0.4 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.2 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.1 GO:0007343 egg activation(GO:0007343)
0.0 0.1 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.0 0.1 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 0.2 GO:0002005 angiotensin catabolic process in blood(GO:0002005)
0.0 0.2 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.5 GO:0021670 lateral ventricle development(GO:0021670)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.1 GO:0051941 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.0 0.2 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.1 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 0.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 1.4 GO:1901998 toxin transport(GO:1901998)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 1.2 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.2 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.2 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
0.0 0.1 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.0 0.2 GO:0016264 gap junction assembly(GO:0016264)
0.0 0.1 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.0 0.1 GO:0032811 negative regulation of epinephrine secretion(GO:0032811) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.0 1.1 GO:0035666 TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.0 0.1 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 0.2 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.1 GO:1902748 melanocyte migration(GO:0097324) positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.2 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.0 0.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.4 GO:0007220 Notch receptor processing(GO:0007220)
0.0 1.6 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.1 GO:0003335 corneocyte development(GO:0003335)
0.0 0.2 GO:1904903 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.1 GO:2000314 regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.0 0.2 GO:0002863 positive regulation of inflammatory response to antigenic stimulus(GO:0002863)
0.0 0.2 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.2 GO:0072584 caveolin-mediated endocytosis(GO:0072584)
0.0 0.3 GO:1903817 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.7 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.0 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.0 0.3 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.0 0.3 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.1 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.0 0.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.0 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.2 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.2 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.0 0.2 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.1 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.1 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.0 GO:0045645 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.0 0.1 GO:0015747 urate transport(GO:0015747)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.2 1.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.5 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 0.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 1.0 GO:0030478 actin cap(GO:0030478)
0.1 0.4 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.5 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.4 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.1 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.0 0.4 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.3 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.2 GO:0070847 core mediator complex(GO:0070847)
0.0 0.5 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.0 0.2 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.4 GO:0032059 muscle thin filament tropomyosin(GO:0005862) bleb(GO:0032059)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.2 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.1 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.3 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.1 GO:0000322 storage vacuole(GO:0000322)
0.0 1.3 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.0 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.1 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 1.3 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.1 GO:0002178 palmitoyltransferase complex(GO:0002178)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.3 1.3 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.2 0.5 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 1.0 GO:0016403 dimethylargininase activity(GO:0016403)
0.1 1.2 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.1 0.4 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.1 0.4 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 0.5 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 1.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.2 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.1 0.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.5 GO:0030172 troponin C binding(GO:0030172)
0.1 0.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.0 0.3 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 1.2 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.1 GO:0005124 scavenger receptor binding(GO:0005124)
0.0 0.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.2 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.0 1.0 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.2 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.1 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.0 0.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.5 GO:0031433 telethonin binding(GO:0031433)
0.0 0.1 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.3 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 0.1 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0001026 TFIIIB-type transcription factor activity(GO:0001026)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 1.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.1 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.2 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.4 GO:0004568 chitinase activity(GO:0004568)
0.0 0.2 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.0 0.2 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.4 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.3 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.3 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.3 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.0 0.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.6 GO:0005521 lamin binding(GO:0005521)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.2 GO:0042731 PH domain binding(GO:0042731)
0.0 0.3 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.2 GO:0089720 caspase binding(GO:0089720)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.0 GO:0038131 neuregulin receptor activity(GO:0038131)
0.0 0.1 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 0.1 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.3 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.5 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.3 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 1.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.0 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.0 0.1 GO:0008503 benzodiazepine receptor activity(GO:0008503)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.7 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.0 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.7 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.2 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.8 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.3 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 1.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.4 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.4 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 1.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.3 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.2 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.7 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 0.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling