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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NKX2-5

Z-value: 0.39

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Transcription factors associated with NKX2-5

Gene Symbol Gene ID Gene Info
NKX2-5
ENSG00000183072.9 NK2 homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-5hg19_v2_chr5_-_172662303_172662360-0.462.1e-02Click!

Activity profile of NKX2-5 motif

Sorted Z-values of NKX2-5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_42260861 0.82 ENST00000282030.5
SETBP1
SET binding protein 1
chr15_-_52944231 0.78 ENST00000546305.2
FAM214A
family with sequence similarity 214, member A
chr4_+_156680518 0.69 ENST00000513437.1
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr7_+_142919130 0.62 ENST00000408947.3
TAS2R40
taste receptor, type 2, member 40
chr4_+_144354644 0.54 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr9_-_14313641 0.52 ENST00000380953.1
NFIB
nuclear factor I/B
chr1_-_55352834 0.51 ENST00000371269.3
DHCR24
24-dehydrocholesterol reductase
chr3_-_112356944 0.50 ENST00000461431.1
CCDC80
coiled-coil domain containing 80
chr11_+_64879317 0.47 ENST00000526809.1
ENST00000279263.7
ENST00000524986.1
ENST00000534371.1
ENST00000540748.1
ENST00000525385.1
ENST00000345348.5
ENST00000531321.1
ENST00000529414.1
ENST00000526085.1
ENST00000530750.1
TM7SF2
transmembrane 7 superfamily member 2
chr1_+_76540386 0.37 ENST00000328299.3
ST6GALNAC3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr17_+_58755184 0.37 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
BCAS3
breast carcinoma amplified sequence 3
chr10_-_7513904 0.34 ENST00000420395.1
RP5-1031D4.2
RP5-1031D4.2
chr3_+_124223586 0.32 ENST00000393496.1
KALRN
kalirin, RhoGEF kinase
chrX_+_86772787 0.32 ENST00000373114.4
KLHL4
kelch-like family member 4
chr21_+_17791648 0.32 ENST00000602892.1
ENST00000418813.2
ENST00000435697.1
LINC00478
long intergenic non-protein coding RNA 478
chr1_+_207494853 0.32 ENST00000367064.3
ENST00000367063.2
ENST00000391921.4
ENST00000367067.4
ENST00000314754.8
ENST00000367065.5
ENST00000391920.4
ENST00000367062.4
ENST00000343420.6
CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr21_+_17791838 0.32 ENST00000453910.1
LINC00478
long intergenic non-protein coding RNA 478
chr4_+_81118647 0.30 ENST00000415738.2
PRDM8
PR domain containing 8
chr2_+_219646462 0.29 ENST00000258415.4
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr7_-_27224842 0.27 ENST00000517402.1
HOXA11
homeobox A11
chr7_-_27224795 0.27 ENST00000006015.3
HOXA11
homeobox A11
chr12_+_93772402 0.26 ENST00000546925.1
NUDT4
nudix (nucleoside diphosphate linked moiety X)-type motif 4
chr11_+_108093839 0.25 ENST00000452508.2
ATM
ataxia telangiectasia mutated
chr19_+_1026566 0.25 ENST00000348419.3
ENST00000565096.2
ENST00000562958.2
ENST00000562075.2
ENST00000607102.1
CNN2
calponin 2
chr22_-_29137771 0.24 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
CHEK2
checkpoint kinase 2
chr1_-_22109484 0.21 ENST00000529637.1
USP48
ubiquitin specific peptidase 48
chr12_+_93772326 0.21 ENST00000550056.1
ENST00000549992.1
ENST00000548662.1
ENST00000547014.1
NUDT4
nudix (nucleoside diphosphate linked moiety X)-type motif 4
chr11_-_118436606 0.21 ENST00000530872.1
IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chr17_+_26646121 0.20 ENST00000226230.6
TMEM97
transmembrane protein 97
chr17_+_26646175 0.20 ENST00000583381.1
ENST00000582113.1
ENST00000582384.1
TMEM97
transmembrane protein 97
chr7_-_128415844 0.19 ENST00000249389.2
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr12_+_123717967 0.19 ENST00000536130.1
ENST00000546132.1
C12orf65
chromosome 12 open reading frame 65
chr3_-_149095652 0.19 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chrY_+_16634483 0.19 ENST00000382872.1
NLGN4Y
neuroligin 4, Y-linked
chr9_+_116263778 0.19 ENST00000394646.3
RGS3
regulator of G-protein signaling 3
chr11_-_118436707 0.19 ENST00000264020.2
ENST00000264021.3
IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chr2_+_136289030 0.19 ENST00000409478.1
ENST00000264160.4
ENST00000329971.3
ENST00000438014.1
R3HDM1
R3H domain containing 1
chrX_+_86772707 0.18 ENST00000373119.4
KLHL4
kelch-like family member 4
chr5_+_75699040 0.18 ENST00000274364.6
IQGAP2
IQ motif containing GTPase activating protein 2
chr20_+_57226841 0.18 ENST00000358029.4
ENST00000361830.3
STX16
syntaxin 16
chr8_-_120651020 0.17 ENST00000522826.1
ENST00000520066.1
ENST00000259486.6
ENST00000075322.6
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr3_-_51813009 0.17 ENST00000398780.3
IQCF6
IQ motif containing F6
chr1_+_159796534 0.17 ENST00000289707.5
SLAMF8
SLAM family member 8
chr5_+_122110691 0.17 ENST00000379516.2
ENST00000505934.1
ENST00000514949.1
SNX2
sorting nexin 2
chr9_+_127020202 0.17 ENST00000373600.3
ENST00000320246.5
NEK6
NIMA-related kinase 6
chr1_-_214638146 0.17 ENST00000543945.1
PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr6_-_41715128 0.16 ENST00000356667.4
ENST00000373025.3
ENST00000425343.2
PGC
progastricsin (pepsinogen C)
chr9_+_118950325 0.16 ENST00000534838.1
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr9_+_134065506 0.16 ENST00000483497.2
NUP214
nucleoporin 214kDa
chr9_+_35906176 0.16 ENST00000354323.2
HRCT1
histidine rich carboxyl terminus 1
chr20_-_271304 0.16 ENST00000400269.3
ENST00000360321.2
C20orf96
chromosome 20 open reading frame 96
chr11_+_43702236 0.16 ENST00000531185.1
ENST00000278353.4
HSD17B12
hydroxysteroid (17-beta) dehydrogenase 12
chr1_+_211433275 0.16 ENST00000367005.4
RCOR3
REST corepressor 3
chr11_-_47616210 0.16 ENST00000302514.3
C1QTNF4
C1q and tumor necrosis factor related protein 4
chr16_+_3194211 0.16 ENST00000428155.1
CASP16
caspase 16, apoptosis-related cysteine peptidase (putative)
chr14_-_106830057 0.15 ENST00000390616.2
IGHV4-34
immunoglobulin heavy variable 4-34
chr22_+_40322595 0.15 ENST00000420971.1
ENST00000544756.1
GRAP2
GRB2-related adaptor protein 2
chrX_-_30326445 0.15 ENST00000378963.1
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr22_+_40322623 0.15 ENST00000399090.2
GRAP2
GRB2-related adaptor protein 2
chr2_-_220041617 0.15 ENST00000451647.1
ENST00000360507.5
CNPPD1
cyclin Pas1/PHO80 domain containing 1
chr8_+_133879193 0.15 ENST00000377869.1
ENST00000220616.4
TG
thyroglobulin
chr9_+_116263639 0.15 ENST00000343817.5
RGS3
regulator of G-protein signaling 3
chr12_-_50222187 0.15 ENST00000335999.6
NCKAP5L
NCK-associated protein 5-like
chr20_+_57226284 0.14 ENST00000458280.1
ENST00000355957.5
ENST00000361770.5
ENST00000312283.8
ENST00000412911.1
ENST00000359617.4
ENST00000371141.4
STX16
syntaxin 16
chr20_-_271009 0.14 ENST00000382369.5
C20orf96
chromosome 20 open reading frame 96
chr17_+_48624450 0.14 ENST00000006658.6
ENST00000356488.4
ENST00000393244.3
SPATA20
spermatogenesis associated 20
chr7_+_129007964 0.14 ENST00000460109.1
ENST00000474594.1
ENST00000446212.1
AHCYL2
adenosylhomocysteinase-like 2
chr11_+_118754475 0.13 ENST00000292174.4
CXCR5
chemokine (C-X-C motif) receptor 5
chr17_-_19771216 0.13 ENST00000395544.4
ULK2
unc-51 like autophagy activating kinase 2
chr12_+_56360550 0.13 ENST00000266970.4
CDK2
cyclin-dependent kinase 2
chr20_+_55841819 0.12 ENST00000412321.1
ENST00000426580.1
RP4-813D12.3
RP4-813D12.3
chr7_-_44229022 0.12 ENST00000403799.3
GCK
glucokinase (hexokinase 4)
chr2_-_27545431 0.12 ENST00000233545.2
MPV17
MpV17 mitochondrial inner membrane protein
chr10_+_76586348 0.12 ENST00000372724.1
ENST00000287239.4
ENST00000372714.1
KAT6B
K(lysine) acetyltransferase 6B
chr17_+_27055798 0.12 ENST00000268766.6
NEK8
NIMA-related kinase 8
chr1_-_22109682 0.11 ENST00000400301.1
ENST00000532737.1
USP48
ubiquitin specific peptidase 48
chr19_-_10946949 0.11 ENST00000214869.2
ENST00000591695.1
TMED1
transmembrane emp24 protein transport domain containing 1
chr7_-_37488834 0.11 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr17_+_66521936 0.11 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr22_-_38577782 0.11 ENST00000430886.1
ENST00000332509.3
ENST00000447598.2
ENST00000435484.1
ENST00000402064.1
ENST00000436218.1
PLA2G6
phospholipase A2, group VI (cytosolic, calcium-independent)
chr17_-_8279977 0.11 ENST00000396267.1
KRBA2
KRAB-A domain containing 2
chr14_+_81421355 0.11 ENST00000541158.2
TSHR
thyroid stimulating hormone receptor
chr17_+_46048376 0.11 ENST00000338399.4
CDK5RAP3
CDK5 regulatory subunit associated protein 3
chr22_-_38577731 0.10 ENST00000335539.3
PLA2G6
phospholipase A2, group VI (cytosolic, calcium-independent)
chr12_+_95867727 0.10 ENST00000323666.5
ENST00000546753.1
METAP2
methionyl aminopeptidase 2
chr14_+_81421861 0.10 ENST00000298171.2
TSHR
thyroid stimulating hormone receptor
chr19_+_41313017 0.10 ENST00000595621.1
ENST00000595051.1
EGLN2
egl-9 family hypoxia-inducible factor 2
chr6_+_33378738 0.10 ENST00000374512.3
ENST00000374516.3
PHF1
PHD finger protein 1
chr2_+_201936458 0.10 ENST00000237889.4
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr6_-_134373732 0.10 ENST00000275230.5
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr16_+_77233294 0.10 ENST00000378644.4
SYCE1L
synaptonemal complex central element protein 1-like
chr16_+_68344877 0.10 ENST00000566657.1
ENST00000565745.1
ENST00000569571.1
ENST00000569047.3
ENST00000449359.3
PRMT7
protein arginine methyltransferase 7
chr19_-_14945933 0.10 ENST00000322301.3
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr19_+_14672755 0.09 ENST00000594545.1
TECR
trans-2,3-enoyl-CoA reductase
chr6_-_112115074 0.09 ENST00000368667.2
FYN
FYN oncogene related to SRC, FGR, YES
chrX_-_13835147 0.09 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr2_-_162931052 0.09 ENST00000360534.3
DPP4
dipeptidyl-peptidase 4
chr13_-_41240717 0.09 ENST00000379561.5
FOXO1
forkhead box O1
chr10_+_111967345 0.09 ENST00000332674.5
ENST00000453116.1
MXI1
MAX interactor 1, dimerization protein
chr17_-_8059638 0.09 ENST00000584202.1
ENST00000354903.5
ENST00000577253.1
PER1
period circadian clock 1
chr3_+_42201653 0.09 ENST00000341421.3
ENST00000396175.1
TRAK1
trafficking protein, kinesin binding 1
chr16_+_68344981 0.08 ENST00000441236.1
ENST00000348497.4
ENST00000339507.5
PRMT7
protein arginine methyltransferase 7
chr2_-_96874553 0.08 ENST00000337288.5
ENST00000443962.1
STARD7
StAR-related lipid transfer (START) domain containing 7
chr4_-_2264015 0.08 ENST00000337190.2
MXD4
MAX dimerization protein 4
chr2_+_113403434 0.08 ENST00000272542.3
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr16_+_69458537 0.08 ENST00000515314.1
ENST00000561792.1
ENST00000568237.1
CYB5B
cytochrome b5 type B (outer mitochondrial membrane)
chr1_+_186798073 0.08 ENST00000367466.3
ENST00000442353.2
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr3_-_15374659 0.08 ENST00000426925.1
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr17_-_55911970 0.08 ENST00000581805.1
ENST00000580960.1
RP11-60A24.3
RP11-60A24.3
chr5_-_149792295 0.07 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr19_+_5681011 0.07 ENST00000581893.1
ENST00000411793.2
ENST00000301382.4
ENST00000581773.1
ENST00000423665.2
ENST00000583928.1
ENST00000342970.2
ENST00000422535.2
ENST00000581521.1
ENST00000339423.2
HSD11B1L
hydroxysteroid (11-beta) dehydrogenase 1-like
chr12_+_14518598 0.07 ENST00000261168.4
ENST00000538511.1
ENST00000545723.1
ENST00000543189.1
ENST00000536444.1
ATF7IP
activating transcription factor 7 interacting protein
chr17_-_13505219 0.07 ENST00000284110.1
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr1_+_22962948 0.07 ENST00000374642.3
C1QA
complement component 1, q subcomponent, A chain
chr7_-_99774945 0.06 ENST00000292377.2
GPC2
glypican 2
chr4_-_74853897 0.06 ENST00000296028.3
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr7_-_150675372 0.06 ENST00000262186.5
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr16_+_57769635 0.06 ENST00000379661.3
ENST00000562592.1
ENST00000566726.1
KATNB1
katanin p80 (WD repeat containing) subunit B 1
chr1_+_154301264 0.05 ENST00000341822.2
ATP8B2
ATPase, aminophospholipid transporter, class I, type 8B, member 2
chr5_+_78407602 0.05 ENST00000274353.5
ENST00000524080.1
BHMT
betaine--homocysteine S-methyltransferase
chr18_-_13915530 0.05 ENST00000327606.3
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr15_+_42696992 0.05 ENST00000561817.1
CAPN3
calpain 3, (p94)
chr1_+_154300217 0.05 ENST00000368489.3
ATP8B2
ATPase, aminophospholipid transporter, class I, type 8B, member 2
chr4_-_76861392 0.05 ENST00000505594.1
NAAA
N-acylethanolamine acid amidase
chr3_-_39234074 0.05 ENST00000340369.3
ENST00000421646.1
ENST00000396251.1
XIRP1
xin actin-binding repeat containing 1
chr14_-_21516590 0.05 ENST00000555026.1
NDRG2
NDRG family member 2
chr2_-_187713891 0.04 ENST00000295131.2
ZSWIM2
zinc finger, SWIM-type containing 2
chr12_-_53097247 0.04 ENST00000341809.3
ENST00000537195.1
KRT77
keratin 77
chr12_+_111051902 0.04 ENST00000397655.3
ENST00000471804.2
ENST00000377654.3
ENST00000397659.4
TCTN1
tectonic family member 1
chr7_+_129906660 0.04 ENST00000222481.4
CPA2
carboxypeptidase A2 (pancreatic)
chr1_-_113498943 0.04 ENST00000369626.3
SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr14_+_21467414 0.04 ENST00000554422.1
ENST00000298681.4
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr5_+_140810132 0.04 ENST00000252085.3
PCDHGA12
protocadherin gamma subfamily A, 12
chr8_-_10588010 0.04 ENST00000304501.1
SOX7
SRY (sex determining region Y)-box 7
chr12_+_111051832 0.04 ENST00000550703.2
ENST00000551590.1
TCTN1
tectonic family member 1
chr20_-_44485835 0.03 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
ACOT8
acyl-CoA thioesterase 8
chr3_-_56717246 0.03 ENST00000355628.5
FAM208A
family with sequence similarity 208, member A
chr8_-_95220775 0.03 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr14_+_81421710 0.03 ENST00000342443.6
TSHR
thyroid stimulating hormone receptor
chr14_+_81421921 0.03 ENST00000554263.1
ENST00000554435.1
TSHR
thyroid stimulating hormone receptor
chr5_+_140729649 0.03 ENST00000523390.1
PCDHGB1
protocadherin gamma subfamily B, 1
chr12_-_122712038 0.03 ENST00000413918.1
ENST00000443649.3
DIABLO
diablo, IAP-binding mitochondrial protein
chr17_+_38333263 0.03 ENST00000456989.2
ENST00000543876.1
ENST00000544503.1
ENST00000264644.6
ENST00000538884.1
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr6_+_109169591 0.03 ENST00000368972.3
ENST00000392644.4
ARMC2
armadillo repeat containing 2
chr3_-_123710893 0.02 ENST00000467907.1
ENST00000459660.1
ENST00000495093.1
ENST00000460743.1
ENST00000405845.3
ENST00000484329.1
ENST00000479867.1
ENST00000496145.1
ROPN1
rhophilin associated tail protein 1
chr2_-_85895295 0.02 ENST00000428225.1
ENST00000519937.2
SFTPB
surfactant protein B
chr12_-_49259643 0.02 ENST00000309739.5
RND1
Rho family GTPase 1
chr12_+_4918342 0.02 ENST00000280684.3
ENST00000433855.1
KCNA6
potassium voltage-gated channel, shaker-related subfamily, member 6
chr8_+_145729465 0.02 ENST00000394955.2
GPT
glutamic-pyruvate transaminase (alanine aminotransferase)
chr7_-_28220354 0.02 ENST00000283928.5
JAZF1
JAZF zinc finger 1
chr1_-_26232951 0.02 ENST00000426559.2
ENST00000455785.2
STMN1
stathmin 1
chr10_+_81370689 0.02 ENST00000372308.3
ENST00000398636.3
ENST00000428376.2
ENST00000372313.5
ENST00000419470.2
ENST00000429958.1
ENST00000439264.1
SFTPA1
surfactant protein A1
chr16_+_8814563 0.02 ENST00000425191.2
ENST00000569156.1
ABAT
4-aminobutyrate aminotransferase
chr5_-_74062930 0.02 ENST00000509430.1
ENST00000345239.2
ENST00000427854.2
ENST00000506778.1
GFM2
G elongation factor, mitochondrial 2
chr15_-_42840961 0.02 ENST00000563454.1
ENST00000397130.3
ENST00000570160.1
ENST00000323443.2
LRRC57
leucine rich repeat containing 57
chr5_+_140345820 0.02 ENST00000289269.5
PCDHAC2
protocadherin alpha subfamily C, 2
chr6_-_94129244 0.02 ENST00000369303.4
ENST00000369297.1
EPHA7
EPH receptor A7
chr17_-_29641084 0.02 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr20_-_56285595 0.01 ENST00000395816.3
ENST00000347215.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chr11_-_111175739 0.01 ENST00000532918.1
COLCA1
colorectal cancer associated 1
chr17_+_4699439 0.01 ENST00000270586.3
PSMB6
proteasome (prosome, macropain) subunit, beta type, 6
chr12_-_4553385 0.01 ENST00000543077.1
FGF6
fibroblast growth factor 6
chr1_-_102312517 0.01 ENST00000338858.5
OLFM3
olfactomedin 3
chr17_+_75447326 0.01 ENST00000591088.1
SEPT9
septin 9
chr5_+_55147205 0.01 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
IL31RA
interleukin 31 receptor A
chr2_-_201936302 0.01 ENST00000453765.1
ENST00000452799.1
ENST00000446678.1
ENST00000418596.3
FAM126B
family with sequence similarity 126, member B
chr11_-_19223523 0.01 ENST00000265968.3
CSRP3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr1_-_202858227 0.01 ENST00000367262.3
RABIF
RAB interacting factor
chr6_-_39290316 0.01 ENST00000425054.2
ENST00000373227.4
ENST00000373229.5
ENST00000437525.2
KCNK16
potassium channel, subfamily K, member 16
chr1_-_149982624 0.01 ENST00000417191.1
ENST00000369135.4
OTUD7B
OTU domain containing 7B
chr3_+_111630451 0.01 ENST00000495180.1
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr3_-_111314230 0.01 ENST00000317012.4
ZBED2
zinc finger, BED-type containing 2
chr8_-_72459885 0.01 ENST00000523987.1
RP11-1102P16.1
Uncharacterized protein
chr1_-_207143802 0.01 ENST00000324852.4
ENST00000400962.3
FCAMR
Fc receptor, IgA, IgM, high affinity
chr11_+_120973375 0.01 ENST00000264037.2
TECTA
tectorin alpha
chr10_-_27529486 0.01 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr16_-_30134266 0.00 ENST00000484663.1
ENST00000478356.1
MAPK3
mitogen-activated protein kinase 3
chr5_-_171615315 0.00 ENST00000176763.5
STK10
serine/threonine kinase 10
chr3_-_187388173 0.00 ENST00000287641.3
SST
somatostatin
chrX_-_154299501 0.00 ENST00000369476.3
ENST00000369484.3
MTCP1
CMC4
mature T-cell proliferation 1
C-x(9)-C motif containing 4
chr10_+_133753533 0.00 ENST00000422256.2
PPP2R2D
protein phosphatase 2, regulatory subunit B, delta
chr16_-_18911366 0.00 ENST00000565224.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chrX_-_55057403 0.00 ENST00000396198.3
ENST00000335854.4
ENST00000455688.1
ENST00000330807.5
ALAS2
aminolevulinate, delta-, synthase 2

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.1 0.7 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.1 0.3 GO:1904868 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 0.2 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.5 GO:1901910 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 0.5 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 0.3 GO:1904588 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.1 0.3 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.0 0.3 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.0 0.2 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.0 0.2 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.0 0.1 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.0 0.5 GO:0007501 mesodermal cell fate specification(GO:0007501) embryonic skeletal joint morphogenesis(GO:0060272)
0.0 0.2 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.0 0.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.1 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.0 0.2 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.0 0.3 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.1 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.1 GO:0002905 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.0 0.1 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
0.0 0.1 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.1 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.0 0.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.1 GO:0015705 iodide transport(GO:0015705)
0.0 0.1 GO:0075044 autophagy of host cells involved in interaction with symbiont(GO:0075044) autophagy involved in symbiotic interaction(GO:0075071)
0.0 0.0 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.1 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947)
0.0 0.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.1 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 0.0 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.0 0.1 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.1 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 0.4 GO:0006677 glycosylceramide metabolic process(GO:0006677)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0021523 somatic motor neuron differentiation(GO:0021523) protein localization to ciliary transition zone(GO:1904491)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.0 0.1 GO:0097124 Y chromosome(GO:0000806) cyclin A2-CDK2 complex(GO:0097124) cyclin E1-CDK2 complex(GO:0097134)
0.0 0.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0005602 complement component C1 complex(GO:0005602)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.1 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 0.4 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.5 GO:0052844 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.1 0.4 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.2 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.2 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.3 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 0.3 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.6 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.2 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.7 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.1 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0 0.1 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.2 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.1 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.1 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.5 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.5 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.0 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.0 0.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.8 ST JNK MAPK PATHWAY JNK MAPK Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.5 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.3 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.5 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.5 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.2 REACTOME OPSINS Genes involved in Opsins
0.0 0.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE