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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NKX2-6

Z-value: 0.91

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Transcription factors associated with NKX2-6

Gene Symbol Gene ID Gene Info
NKX2-6
ENSG00000180053.6 NK2 homeobox 6

Activity profile of NKX2-6 motif

Sorted Z-values of NKX2-6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_113354341 4.65 ENST00000553152.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr10_-_6019984 4.07 ENST00000525219.2
IL15RA
interleukin 15 receptor, alpha
chr10_-_6019552 3.94 ENST00000379977.3
ENST00000397251.3
ENST00000397248.2
IL15RA
interleukin 15 receptor, alpha
chr4_+_89299885 3.83 ENST00000380265.5
ENST00000273960.3
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr3_-_123339343 3.25 ENST00000578202.1
MYLK
myosin light chain kinase
chr3_-_123339418 3.22 ENST00000583087.1
MYLK
myosin light chain kinase
chr3_-_127541194 2.76 ENST00000453507.2
MGLL
monoglyceride lipase
chr10_-_6019455 2.62 ENST00000530685.1
ENST00000397255.3
ENST00000379971.1
ENST00000528354.1
ENST00000397250.2
ENST00000429135.2
IL15RA
interleukin 15 receptor, alpha
chr12_+_56075330 2.34 ENST00000394252.3
METTL7B
methyltransferase like 7B
chr1_+_205225319 2.15 ENST00000329800.7
TMCC2
transmembrane and coiled-coil domain family 2
chr2_-_100721923 1.89 ENST00000356421.2
AFF3
AF4/FMR2 family, member 3
chr4_+_70916119 1.84 ENST00000246896.3
ENST00000511674.1
HTN1
histatin 1
chr2_+_102928009 1.81 ENST00000404917.2
ENST00000447231.1
IL1RL1
interleukin 1 receptor-like 1
chr9_+_96846740 1.50 ENST00000288976.3
PTPDC1
protein tyrosine phosphatase domain containing 1
chr12_-_89919765 1.46 ENST00000541909.1
ENST00000313546.3
POC1B
POC1 centriolar protein B
chr17_-_55911970 1.39 ENST00000581805.1
ENST00000580960.1
RP11-60A24.3
RP11-60A24.3
chr2_-_100721178 1.37 ENST00000409236.2
AFF3
AF4/FMR2 family, member 3
chr12_-_56236690 1.37 ENST00000322569.4
MMP19
matrix metallopeptidase 19
chr8_+_27629459 1.31 ENST00000523566.1
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr3_-_121379739 1.29 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr19_-_44174330 1.24 ENST00000340093.3
PLAUR
plasminogen activator, urokinase receptor
chr1_+_1243947 1.23 ENST00000379031.5
PUSL1
pseudouridylate synthase-like 1
chr1_+_144989309 1.23 ENST00000596396.1
AL590452.1
Uncharacterized protein
chr5_-_59481406 1.21 ENST00000546160.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_-_89919965 1.19 ENST00000548729.1
POC1B-GALNT4
POC1B-GALNT4 readthrough
chr15_-_55563072 1.17 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr19_-_44174305 1.10 ENST00000601723.1
ENST00000339082.3
PLAUR
plasminogen activator, urokinase receptor
chr7_-_107880508 1.02 ENST00000425651.2
NRCAM
neuronal cell adhesion molecule
chr7_+_75544466 0.99 ENST00000421059.1
ENST00000394893.1
ENST00000412521.1
ENST00000414186.1
POR
P450 (cytochrome) oxidoreductase
chr11_+_94277017 0.99 ENST00000358752.2
FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr12_-_89920030 0.95 ENST00000413530.1
ENST00000547474.1
GALNT4
POC1B-GALNT4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
POC1B-GALNT4 readthrough
chr5_+_52083730 0.95 ENST00000282588.6
ENST00000274311.2
ITGA1
PELO
integrin, alpha 1
pelota homolog (Drosophila)
chrX_+_30261847 0.91 ENST00000378981.3
ENST00000397550.1
MAGEB1
melanoma antigen family B, 1
chr4_-_79860506 0.91 ENST00000295462.3
ENST00000380645.4
ENST00000512733.1
PAQR3
progestin and adipoQ receptor family member III
chr2_+_70142189 0.89 ENST00000264444.2
MXD1
MAX dimerization protein 1
chr3_+_171561127 0.84 ENST00000334567.5
ENST00000450693.1
TMEM212
transmembrane protein 212
chr3_+_100428268 0.78 ENST00000240851.4
TFG
TRK-fused gene
chr1_+_156338993 0.78 ENST00000368249.1
ENST00000368246.2
ENST00000537040.1
ENST00000400992.2
ENST00000255013.3
ENST00000451864.2
RHBG
Rh family, B glycoprotein (gene/pseudogene)
chr2_-_69180012 0.77 ENST00000481498.1
GKN2
gastrokine 2
chr3_+_100428316 0.76 ENST00000479672.1
ENST00000476228.1
ENST00000463568.1
TFG
TRK-fused gene
chr14_+_52164820 0.76 ENST00000554167.1
FRMD6
FERM domain containing 6
chr16_+_78056412 0.75 ENST00000299642.4
ENST00000575655.1
CLEC3A
C-type lectin domain family 3, member A
chr17_-_29624343 0.74 ENST00000247271.4
OMG
oligodendrocyte myelin glycoprotein
chr10_+_121652204 0.73 ENST00000369075.3
ENST00000543134.1
SEC23IP
SEC23 interacting protein
chr13_+_44453969 0.73 ENST00000325686.6
LACC1
laccase (multicopper oxidoreductase) domain containing 1
chr12_-_71182695 0.69 ENST00000342084.4
PTPRR
protein tyrosine phosphatase, receptor type, R
chr1_+_19578033 0.69 ENST00000330263.4
MRTO4
mRNA turnover 4 homolog (S. cerevisiae)
chr5_+_34757309 0.68 ENST00000397449.1
RAI14
retinoic acid induced 14
chr16_+_69373323 0.67 ENST00000254940.5
NIP7
NIP7, nucleolar pre-rRNA processing protein
chr3_+_100428188 0.66 ENST00000418917.2
ENST00000490574.1
TFG
TRK-fused gene
chr19_+_42746927 0.64 ENST00000378108.1
AC006486.1
AC006486.1
chr22_-_24096630 0.64 ENST00000248948.3
VPREB3
pre-B lymphocyte 3
chr11_-_104827425 0.64 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr6_+_126102292 0.62 ENST00000368357.3
NCOA7
nuclear receptor coactivator 7
chr13_-_26452679 0.62 ENST00000596729.1
AL138815.2
Uncharacterized protein
chr1_+_16767167 0.59 ENST00000337132.5
NECAP2
NECAP endocytosis associated 2
chr4_-_70080449 0.58 ENST00000446444.1
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr4_-_48082192 0.57 ENST00000507351.1
TXK
TXK tyrosine kinase
chr19_+_52076425 0.55 ENST00000436511.2
ZNF175
zinc finger protein 175
chr19_+_17186577 0.54 ENST00000595618.1
ENST00000594824.1
MYO9B
myosin IXB
chr3_-_48130707 0.54 ENST00000360240.6
ENST00000383737.4
MAP4
microtubule-associated protein 4
chr14_+_23654525 0.53 ENST00000399910.1
ENST00000492621.1
C14orf164
chromosome 14 open reading frame 164
chr5_-_139937895 0.52 ENST00000336283.6
SRA1
steroid receptor RNA activator 1
chr6_+_12007897 0.51 ENST00000437559.1
RP11-456H18.2
RP11-456H18.2
chr7_+_123241908 0.50 ENST00000434204.1
ENST00000437535.1
ENST00000451215.1
ASB15
ankyrin repeat and SOCS box containing 15
chr8_+_20054878 0.49 ENST00000276390.2
ENST00000519667.1
ATP6V1B2
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
chr19_+_496454 0.48 ENST00000346144.4
ENST00000215637.3
ENST00000382683.4
MADCAM1
mucosal vascular addressin cell adhesion molecule 1
chr9_+_131447342 0.47 ENST00000409104.3
SET
SET nuclear oncogene
chr2_-_179567206 0.46 ENST00000414766.1
TTN
titin
chr1_+_158259558 0.46 ENST00000368170.3
CD1C
CD1c molecule
chr11_+_65627865 0.45 ENST00000308110.4
MUS81
MUS81 structure-specific endonuclease subunit
chr4_+_70146217 0.45 ENST00000335568.5
ENST00000511240.1
UGT2B28
UDP glucuronosyltransferase 2 family, polypeptide B28
chr17_-_41116454 0.45 ENST00000427569.2
ENST00000430739.1
AARSD1
alanyl-tRNA synthetase domain containing 1
chr1_+_16767195 0.44 ENST00000504551.2
ENST00000457722.2
ENST00000406746.1
ENST00000443980.2
NECAP2
NECAP endocytosis associated 2
chr20_-_1373606 0.43 ENST00000381715.1
ENST00000439640.2
ENST00000381719.3
FKBP1A
FK506 binding protein 1A, 12kDa
chr1_-_200638964 0.43 ENST00000367348.3
ENST00000447706.2
ENST00000331314.6
DDX59
DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
chr11_+_111126707 0.42 ENST00000280325.4
C11orf53
chromosome 11 open reading frame 53
chr12_+_70219052 0.41 ENST00000552032.2
ENST00000547771.2
MYRFL
myelin regulatory factor-like
chr15_-_41120896 0.41 ENST00000299174.5
ENST00000427255.2
PPP1R14D
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr2_-_175462456 0.40 ENST00000409891.1
ENST00000410117.1
WIPF1
WAS/WASL interacting protein family, member 1
chr4_-_156875003 0.39 ENST00000433477.3
CTSO
cathepsin O
chr1_+_169337172 0.38 ENST00000367807.3
ENST00000367808.3
ENST00000329281.2
ENST00000420531.1
BLZF1
basic leucine zipper nuclear factor 1
chr4_-_170924888 0.37 ENST00000502832.1
ENST00000393704.3
MFAP3L
microfibrillar-associated protein 3-like
chr5_+_140071011 0.37 ENST00000230771.3
ENST00000509299.1
ENST00000503873.1
ENST00000435019.2
ENST00000437649.2
ENST00000432671.2
HARS2
histidyl-tRNA synthetase 2, mitochondrial
chr2_-_163099885 0.37 ENST00000443424.1
FAP
fibroblast activation protein, alpha
chr1_-_173793458 0.37 ENST00000356198.2
CENPL
centromere protein L
chr17_-_34890665 0.37 ENST00000586007.1
MYO19
myosin XIX
chrX_-_132231123 0.37 ENST00000511190.1
USP26
ubiquitin specific peptidase 26
chr11_-_61687739 0.36 ENST00000531922.1
ENST00000301773.5
RAB3IL1
RAB3A interacting protein (rabin3)-like 1
chr22_-_43539346 0.36 ENST00000327555.5
ENST00000290429.6
MCAT
malonyl CoA:ACP acyltransferase (mitochondrial)
chr16_-_69373396 0.36 ENST00000562595.1
ENST00000562081.1
ENST00000306875.4
COG8
component of oligomeric golgi complex 8
chr10_+_135204338 0.36 ENST00000468317.2
RP11-108K14.8
Mitochondrial GTPase 1
chr10_-_27529486 0.36 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr1_+_202431859 0.35 ENST00000391959.3
ENST00000367270.4
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr12_-_50294033 0.35 ENST00000552669.1
FAIM2
Fas apoptotic inhibitory molecule 2
chr11_-_66360548 0.34 ENST00000333861.3
CCDC87
coiled-coil domain containing 87
chr5_+_78407602 0.33 ENST00000274353.5
ENST00000524080.1
BHMT
betaine--homocysteine S-methyltransferase
chr11_-_64527425 0.33 ENST00000377432.3
PYGM
phosphorylase, glycogen, muscle
chrX_+_47053208 0.33 ENST00000442035.1
ENST00000457753.1
ENST00000335972.6
UBA1
ubiquitin-like modifier activating enzyme 1
chr1_+_173793777 0.33 ENST00000239457.5
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr7_+_100466433 0.33 ENST00000429658.1
TRIP6
thyroid hormone receptor interactor 6
chr17_+_60501228 0.33 ENST00000311506.5
METTL2A
methyltransferase like 2A
chr2_-_163100045 0.33 ENST00000188790.4
FAP
fibroblast activation protein, alpha
chr3_-_42003479 0.33 ENST00000420927.1
ULK4
unc-51 like kinase 4
chr2_-_175462934 0.32 ENST00000392546.2
ENST00000436221.1
WIPF1
WAS/WASL interacting protein family, member 1
chr16_-_20367584 0.32 ENST00000570689.1
UMOD
uromodulin
chr6_+_42584847 0.31 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr17_-_2966901 0.30 ENST00000575751.1
OR1D5
olfactory receptor, family 1, subfamily D, member 5
chr15_+_81475047 0.30 ENST00000559388.1
IL16
interleukin 16
chr9_-_137809718 0.30 ENST00000371806.3
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr19_-_51611623 0.30 ENST00000421832.2
CTU1
cytosolic thiouridylase subunit 1
chr12_-_44152551 0.29 ENST00000416848.2
ENST00000550784.1
ENST00000547156.1
ENST00000549868.1
ENST00000553166.1
ENST00000551923.1
ENST00000431332.3
ENST00000344862.5
PUS7L
pseudouridylate synthase 7 homolog (S. cerevisiae)-like
chr17_+_33914276 0.29 ENST00000592545.1
ENST00000538556.1
ENST00000312678.8
ENST00000589344.1
AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr4_+_91048706 0.28 ENST00000509176.1
CCSER1
coiled-coil serine-rich protein 1
chr2_-_69180083 0.28 ENST00000328895.4
GKN2
gastrokine 2
chr22_-_50523760 0.27 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr11_-_105892937 0.27 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
chr7_+_110731062 0.27 ENST00000308478.5
ENST00000451085.1
ENST00000422987.3
ENST00000421101.1
LRRN3
leucine rich repeat neuronal 3
chr22_-_24096562 0.27 ENST00000398465.3
VPREB3
pre-B lymphocyte 3
chr20_+_13202418 0.27 ENST00000262487.4
ISM1
isthmin 1, angiogenesis inhibitor
chr8_+_50824233 0.27 ENST00000522124.1
SNTG1
syntrophin, gamma 1
chr1_-_173793246 0.27 ENST00000345664.6
ENST00000367710.3
CENPL
centromere protein L
chr4_-_73434498 0.27 ENST00000286657.4
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr2_-_179516225 0.26 ENST00000446966.1
ENST00000426232.1
TTN
titin
chr19_+_52074502 0.26 ENST00000545217.1
ENST00000262259.2
ENST00000596504.1
ZNF175
zinc finger protein 175
chr8_-_30706608 0.25 ENST00000256246.2
TEX15
testis expressed 15
chr17_-_7216939 0.25 ENST00000573684.1
GPS2
G protein pathway suppressor 2
chr17_+_33914460 0.24 ENST00000537622.2
AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr5_-_140070897 0.23 ENST00000448240.1
ENST00000438307.2
ENST00000415192.2
ENST00000457527.2
ENST00000307633.3
ENST00000507746.1
ENST00000431330.2
HARS
histidyl-tRNA synthetase
chr6_+_10528560 0.23 ENST00000379597.3
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr6_-_34664612 0.23 ENST00000374023.3
ENST00000374026.3
C6orf106
chromosome 6 open reading frame 106
chr12_-_57039739 0.23 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr14_-_30766223 0.23 ENST00000549360.1
ENST00000508469.2
CTD-2251F13.1
CTD-2251F13.1
chr7_+_23719749 0.22 ENST00000409192.3
ENST00000344962.4
ENST00000409653.1
ENST00000409994.3
FAM221A
family with sequence similarity 221, member A
chr4_+_169418195 0.22 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr14_-_47812321 0.22 ENST00000357362.3
ENST00000486952.2
ENST00000426342.1
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr17_-_34890709 0.21 ENST00000544606.1
MYO19
myosin XIX
chr10_+_18629628 0.21 ENST00000377329.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr19_+_56111680 0.21 ENST00000301073.3
ZNF524
zinc finger protein 524
chr7_-_91509986 0.21 ENST00000456229.1
ENST00000442961.1
ENST00000406735.2
ENST00000419292.1
ENST00000351870.3
MTERF
mitochondrial transcription termination factor
chr1_+_110163202 0.20 ENST00000531203.1
ENST00000256578.3
AMPD2
adenosine monophosphate deaminase 2
chr17_-_34890732 0.20 ENST00000268852.9
MYO19
myosin XIX
chr7_+_121513143 0.20 ENST00000393386.2
PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr3_+_121796697 0.20 ENST00000482356.1
ENST00000393627.2
CD86
CD86 molecule
chr2_-_25565377 0.19 ENST00000264709.3
ENST00000406659.3
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr2_+_12246664 0.19 ENST00000449986.1
AC096559.1
AC096559.1
chr16_-_47493041 0.19 ENST00000565940.2
ITFG1
integrin alpha FG-GAP repeat containing 1
chr17_-_26903900 0.19 ENST00000395319.3
ENST00000581807.1
ENST00000584086.1
ENST00000395321.2
ALDOC
aldolase C, fructose-bisphosphate
chr5_+_140071178 0.19 ENST00000508522.1
ENST00000448069.2
HARS2
histidyl-tRNA synthetase 2, mitochondrial
chr17_-_74049720 0.18 ENST00000602720.1
SRP68
signal recognition particle 68kDa
chr11_+_27062860 0.17 ENST00000528583.1
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr9_+_4839762 0.17 ENST00000448872.2
ENST00000441844.1
RCL1
RNA terminal phosphate cyclase-like 1
chr3_-_113956425 0.17 ENST00000482457.2
ZNF80
zinc finger protein 80
chr14_-_50778872 0.17 ENST00000555610.1
ENST00000261699.4
L2HGDH
L-2-hydroxyglutarate dehydrogenase
chr1_+_173793641 0.17 ENST00000361951.4
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr10_+_32735030 0.17 ENST00000277657.6
ENST00000362006.5
CCDC7
coiled-coil domain containing 7
chr5_+_175487692 0.16 ENST00000510151.1
FAM153B
family with sequence similarity 153, member B
chr2_-_87088995 0.16 ENST00000393759.2
ENST00000349455.3
ENST00000331469.2
ENST00000431506.2
ENST00000393761.2
ENST00000390655.6
CD8B
CD8b molecule
chr3_+_114012819 0.15 ENST00000383671.3
TIGIT
T cell immunoreceptor with Ig and ITIM domains
chr5_-_177210399 0.15 ENST00000510276.1
FAM153A
family with sequence similarity 153, member A
chr17_-_34890759 0.15 ENST00000431794.3
MYO19
myosin XIX
chr11_+_27062502 0.14 ENST00000263182.3
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chrX_+_139791917 0.14 ENST00000607004.1
ENST00000370535.3
LINC00632
long intergenic non-protein coding RNA 632
chr5_-_169725231 0.14 ENST00000046794.5
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr14_+_50779029 0.14 ENST00000245448.6
ATP5S
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
chr17_-_39341594 0.14 ENST00000398472.1
KRTAP4-1
keratin associated protein 4-1
chr20_-_21494654 0.14 ENST00000377142.4
NKX2-2
NK2 homeobox 2
chr9_-_215744 0.13 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr13_+_115000521 0.13 ENST00000252457.5
ENST00000375308.1
CDC16
cell division cycle 16
chr1_+_158223923 0.13 ENST00000289429.5
CD1A
CD1a molecule
chr1_-_78444776 0.13 ENST00000370767.1
ENST00000421641.1
FUBP1
far upstream element (FUSE) binding protein 1
chr1_-_78444738 0.12 ENST00000436586.2
ENST00000370768.2
FUBP1
far upstream element (FUSE) binding protein 1
chr19_+_55385682 0.12 ENST00000391726.3
FCAR
Fc fragment of IgA, receptor for
chr1_-_108231101 0.12 ENST00000544443.1
ENST00000415432.2
VAV3
vav 3 guanine nucleotide exchange factor
chr22_+_42017987 0.12 ENST00000405506.1
XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6
chr8_-_95220775 0.12 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr1_+_113010056 0.12 ENST00000369686.5
WNT2B
wingless-type MMTV integration site family, member 2B
chr19_-_49843539 0.12 ENST00000602554.1
ENST00000358234.4
CTC-301O7.4
CTC-301O7.4
chr1_-_31902614 0.12 ENST00000596131.1
AC114494.1
HCG1787699; Uncharacterized protein
chr15_+_84841242 0.11 ENST00000558195.1
RP11-182J1.16
ubiquitin-conjugating enzyme E2Q family member 2-like
chr3_-_46249878 0.11 ENST00000296140.3
CCR1
chemokine (C-C motif) receptor 1
chr4_+_186317133 0.11 ENST00000507753.1
ANKRD37
ankyrin repeat domain 37
chr7_+_141463897 0.11 ENST00000247879.2
TAS2R3
taste receptor, type 2, member 3
chr1_+_20512568 0.11 ENST00000375099.3
UBXN10
UBX domain protein 10
chr3_-_81811312 0.11 ENST00000429644.2
GBE1
glucan (1,4-alpha-), branching enzyme 1
chr11_-_65624415 0.11 ENST00000524553.1
ENST00000527344.1
CFL1
cofilin 1 (non-muscle)
chr15_-_28344439 0.10 ENST00000431101.1
ENST00000445578.1
ENST00000353809.5
ENST00000382996.2
ENST00000354638.3
OCA2
oculocutaneous albinism II
chr4_+_17579110 0.10 ENST00000606142.1
LAP3
leucine aminopeptidase 3
chr6_-_15586238 0.10 ENST00000462989.2
DTNBP1
dystrobrevin binding protein 1
chr11_+_118958689 0.10 ENST00000535253.1
ENST00000392841.1
HMBS
hydroxymethylbilane synthase
chr14_+_22580233 0.09 ENST00000390454.2
TRAV25
T cell receptor alpha variable 25
chr3_-_39196049 0.09 ENST00000514182.1
CSRNP1
cysteine-serine-rich nuclear protein 1
chr9_+_131452239 0.09 ENST00000372688.4
ENST00000372686.5
SET
SET nuclear oncogene
chr3_-_157824292 0.09 ENST00000483851.2
SHOX2
short stature homeobox 2
chr13_+_115000556 0.08 ENST00000252458.6
CDC16
cell division cycle 16
chr19_-_37663332 0.08 ENST00000392157.2
ZNF585A
zinc finger protein 585A
chr11_-_64684672 0.08 ENST00000377264.3
ENST00000421419.2
ATG2A
autophagy related 2A
chr12_-_50290839 0.07 ENST00000552863.1
FAIM2
Fas apoptotic inhibitory molecule 2
chr1_-_160001737 0.07 ENST00000368090.2
PIGM
phosphatidylinositol glycan anchor biosynthesis, class M
chr12_+_4829507 0.07 ENST00000252318.2
GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.5 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.6 2.3 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.4 2.8 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.3 1.0 GO:0046210 nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210)
0.3 0.8 GO:0006427 histidyl-tRNA aminoacylation(GO:0006427)
0.3 0.8 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.2 1.4 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.2 1.3 GO:0034421 post-translational protein acetylation(GO:0034421)
0.2 1.2 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.2 0.7 GO:0097325 melanocyte proliferation(GO:0097325)
0.2 0.5 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.2 0.9 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.2 1.4 GO:0001554 luteolysis(GO:0001554)
0.1 0.4 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.7 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.1 1.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 1.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 0.5 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.1 0.3 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.1 0.8 GO:0003383 apical constriction(GO:0003383)
0.1 0.5 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.1 0.3 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.1 0.7 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.1 0.6 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.1 1.0 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.5 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.1 0.5 GO:0051012 microtubule sliding(GO:0051012)
0.1 1.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 1.0 GO:0042354 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.1 0.3 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.1 0.2 GO:0045404 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1 0.3 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.1 3.2 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.1 0.3 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.3 GO:0034227 tRNA thio-modification(GO:0034227)
0.1 0.6 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 0.4 GO:0030242 pexophagy(GO:0030242)
0.0 0.6 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 4.5 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.1 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.5 GO:0022417 protein maturation by protein folding(GO:0022417)
0.0 0.3 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 1.8 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.2 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.1 GO:0043324 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0 0.6 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.2 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.1 GO:2000466 negative regulation of glycogen (starch) synthase activity(GO:2000466)
0.0 0.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.1 GO:0060423 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) positive regulation of branching involved in lung morphogenesis(GO:0061047)
0.0 0.2 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.4 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.2 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 2.9 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 1.8 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.2 GO:0070444 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 0.2 GO:0032264 IMP salvage(GO:0032264)
0.0 0.9 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.2 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 0.9 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.1 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.0 0.6 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.3 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.3 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.6 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.7 GO:0042255 ribosome assembly(GO:0042255)
0.0 0.3 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.3 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.5 GO:0090383 phagosome acidification(GO:0090383)
0.0 0.6 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 1.0 GO:0001895 retina homeostasis(GO:0001895)
0.0 0.9 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.4 GO:0030488 tRNA methylation(GO:0030488)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.0 GO:0071438 invadopodium membrane(GO:0071438)
0.3 0.9 GO:0034665 integrin alpha1-beta1 complex(GO:0034665)
0.1 0.5 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 0.5 GO:1990425 ryanodine receptor complex(GO:1990425)
0.1 1.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 2.2 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 1.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.6 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 6.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.3 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 1.0 GO:0043194 axon initial segment(GO:0043194)
0.0 1.6 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.3 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.2 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0036398 TCR signalosome(GO:0036398)
0.0 0.3 GO:0016013 syntrophin complex(GO:0016013)
0.0 1.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.4 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 8.7 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.9 GO:0016459 myosin complex(GO:0016459)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.2 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 1.0 GO:0045178 basal part of cell(GO:0045178)
0.0 0.2 GO:0001741 XY body(GO:0001741)
0.0 1.5 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.3 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 1.0 GO:0032580 Golgi cisterna membrane(GO:0032580)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.6 6.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.5 1.4 GO:0002113 interleukin-33 binding(GO:0002113)
0.4 4.6 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.3 1.0 GO:0047726 iron-cytochrome-c reductase activity(GO:0047726)
0.3 0.8 GO:0004821 histidine-tRNA ligase activity(GO:0004821)
0.2 1.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 0.5 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.2 0.9 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634)
0.2 2.8 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.4 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.3 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.1 0.9 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.5 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.1 1.0 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 1.5 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 0.3 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.1 0.3 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 0.5 GO:0048256 flap endonuclease activity(GO:0048256)
0.1 1.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 9.5 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 0.5 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.6 GO:0030883 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 0.7 GO:0031433 telethonin binding(GO:0031433)
0.1 0.3 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 1.0 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.4 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.0 0.3 GO:0070728 leucine binding(GO:0070728)
0.0 0.2 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.0 1.2 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0019862 IgA binding(GO:0019862)
0.0 0.2 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.6 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.2 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 1.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.7 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.8 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.4 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 0.5 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.3 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.3 GO:0019864 IgG binding(GO:0019864)
0.0 0.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.3 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 1.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 1.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 3.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.3 GO:0005095 GTPase inhibitor activity(GO:0005095)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.8 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.5 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.9 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 2.2 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.1 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.8 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.4 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 4.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.1 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.5 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.6 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway