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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NKX2-8

Z-value: 0.45

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Transcription factors associated with NKX2-8

Gene Symbol Gene ID Gene Info
NKX2-8
ENSG00000136327.6 NK2 homeobox 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-8hg19_v2_chr14_-_37051798_37051831-0.331.1e-01Click!

Activity profile of NKX2-8 motif

Sorted Z-values of NKX2-8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_88872176 0.65 ENST00000569140.1
CDT1
chromatin licensing and DNA replication factor 1
chr4_-_70080449 0.46 ENST00000446444.1
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr1_+_74701062 0.31 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr3_+_126423045 0.30 ENST00000290913.3
ENST00000508789.1
CHCHD6
coiled-coil-helix-coiled-coil-helix domain containing 6
chr11_+_5410607 0.28 ENST00000328611.3
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr3_-_116163830 0.24 ENST00000333617.4
LSAMP
limbic system-associated membrane protein
chr2_-_29297127 0.23 ENST00000331664.5
C2orf71
chromosome 2 open reading frame 71
chr5_+_3596168 0.22 ENST00000302006.3
IRX1
iroquois homeobox 1
chr3_+_111717600 0.22 ENST00000273368.4
TAGLN3
transgelin 3
chr11_-_107590383 0.22 ENST00000525934.1
ENST00000531293.1
SLN
sarcolipin
chr18_-_44336998 0.21 ENST00000315087.7
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr3_+_111717511 0.21 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr20_+_31619454 0.19 ENST00000349552.1
BPIFB6
BPI fold containing family B, member 6
chr19_-_38720354 0.18 ENST00000416611.1
DPF1
D4, zinc and double PHD fingers family 1
chr15_+_93749295 0.17 ENST00000599897.1
AC112693.2
AC112693.2
chrX_-_69479654 0.17 ENST00000374519.2
P2RY4
pyrimidinergic receptor P2Y, G-protein coupled, 4
chr14_-_107131560 0.16 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr6_-_32145861 0.16 ENST00000336984.6
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr12_-_12837423 0.15 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr12_-_75603482 0.15 ENST00000341669.3
ENST00000298972.1
ENST00000350228.2
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chrX_-_70326455 0.15 ENST00000374251.5
CXorf65
chromosome X open reading frame 65
chr14_-_107049312 0.15 ENST00000390627.2
IGHV3-53
immunoglobulin heavy variable 3-53
chr12_-_75603202 0.15 ENST00000393288.2
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr11_-_72353451 0.15 ENST00000376450.3
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr12_-_75603643 0.15 ENST00000549446.1
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chrX_-_110655306 0.15 ENST00000371993.2
DCX
doublecortin
chr7_+_129847688 0.15 ENST00000297819.3
SSMEM1
serine-rich single-pass membrane protein 1
chr16_-_66952742 0.14 ENST00000565235.2
ENST00000568632.1
ENST00000565796.1
CDH16
cadherin 16, KSP-cadherin
chrX_-_151143140 0.14 ENST00000393914.3
ENST00000370328.3
ENST00000370325.1
GABRE
gamma-aminobutyric acid (GABA) A receptor, epsilon
chr17_+_73642486 0.14 ENST00000579469.1
SMIM6
small integral membrane protein 6
chr12_+_25205666 0.14 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr3_+_67048721 0.14 ENST00000295568.4
ENST00000484414.1
ENST00000460576.1
ENST00000417314.2
KBTBD8
kelch repeat and BTB (POZ) domain containing 8
chr10_-_135171178 0.14 ENST00000368551.1
FUOM
fucose mutarotase
chr4_+_76481258 0.14 ENST00000311623.4
ENST00000435974.2
C4orf26
chromosome 4 open reading frame 26
chr12_-_75603236 0.13 ENST00000540018.1
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr11_-_5364809 0.13 ENST00000300773.2
OR51B5
olfactory receptor, family 51, subfamily B, member 5
chr16_-_66952779 0.13 ENST00000570262.1
ENST00000394055.3
ENST00000299752.4
CDH16
cadherin 16, KSP-cadherin
chr3_-_58613323 0.13 ENST00000474531.1
ENST00000465970.1
FAM107A
family with sequence similarity 107, member A
chr17_+_73642315 0.13 ENST00000556126.2
SMIM6
small integral membrane protein 6
chr4_+_184826418 0.12 ENST00000308497.4
ENST00000438269.1
STOX2
storkhead box 2
chrX_-_110654147 0.12 ENST00000358070.4
DCX
doublecortin
chr17_+_76227391 0.12 ENST00000586400.1
ENST00000421688.1
ENST00000374946.3
TMEM235
transmembrane protein 235
chr5_-_176056974 0.12 ENST00000510387.1
ENST00000506696.1
SNCB
synuclein, beta
chr8_+_23430157 0.12 ENST00000399967.3
FP15737
FP15737
chr21_+_33671264 0.12 ENST00000339944.4
MRAP
melanocortin 2 receptor accessory protein
chr12_+_60058458 0.11 ENST00000548610.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr5_-_101834712 0.11 ENST00000506729.1
ENST00000389019.3
ENST00000379810.1
SLCO6A1
solute carrier organic anion transporter family, member 6A1
chr1_+_16348525 0.11 ENST00000331433.4
CLCNKA
chloride channel, voltage-sensitive Ka
chr4_+_37245799 0.11 ENST00000309447.5
KIAA1239
KIAA1239
chr5_-_101834617 0.11 ENST00000513675.1
ENST00000379807.3
SLCO6A1
solute carrier organic anion transporter family, member 6A1
chr12_+_66218903 0.11 ENST00000393577.3
HMGA2
high mobility group AT-hook 2
chr1_-_155006224 0.11 ENST00000368424.3
DCST2
DC-STAMP domain containing 2
chr17_+_73472575 0.11 ENST00000375248.5
KIAA0195
KIAA0195
chr14_-_106552755 0.10 ENST00000390600.2
IGHV3-9
immunoglobulin heavy variable 3-9
chr3_+_108855558 0.10 ENST00000467240.1
ENST00000477643.1
ENST00000479039.1
ENST00000593799.1
RP11-59E19.1
RP11-59E19.1
chr2_-_159313214 0.10 ENST00000409889.1
ENST00000283233.5
ENST00000536771.1
CCDC148
coiled-coil domain containing 148
chr16_+_32063311 0.10 ENST00000426099.1
AC142381.1
AC142381.1
chr3_-_196242233 0.10 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr19_+_34856141 0.10 ENST00000586425.1
GPI
glucose-6-phosphate isomerase
chr12_+_121416489 0.10 ENST00000541395.1
ENST00000544413.1
HNF1A
HNF1 homeobox A
chr3_-_114790179 0.10 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr3_+_173302222 0.10 ENST00000361589.4
NLGN1
neuroligin 1
chr2_-_46385 0.10 ENST00000327669.4
FAM110C
family with sequence similarity 110, member C
chr1_+_180165672 0.09 ENST00000443059.1
QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr14_-_107199464 0.09 ENST00000433072.2
IGHV3-72
immunoglobulin heavy variable 3-72
chr14_-_24732368 0.09 ENST00000544573.1
TGM1
transglutaminase 1
chr11_+_35211429 0.09 ENST00000525688.1
ENST00000278385.6
ENST00000533222.1
CD44
CD44 molecule (Indian blood group)
chr14_-_58894223 0.09 ENST00000555593.1
TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr15_-_28419569 0.09 ENST00000569772.1
HERC2
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr14_-_58894332 0.09 ENST00000395159.2
TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr16_-_18468926 0.09 ENST00000545114.1
RP11-1212A22.4
LOC339047 protein; Nuclear pore complex-interacting protein family member A3; Nuclear pore complex-interacting protein family member A5; Protein PKD1P1
chr12_-_49504655 0.09 ENST00000551782.1
ENST00000267102.8
LMBR1L
limb development membrane protein 1-like
chr12_-_49504623 0.09 ENST00000550137.1
ENST00000547382.1
LMBR1L
limb development membrane protein 1-like
chr10_+_71078595 0.09 ENST00000359426.6
HK1
hexokinase 1
chr6_-_32806506 0.09 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr3_-_178984759 0.09 ENST00000349697.2
ENST00000497599.1
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr22_+_38453207 0.08 ENST00000404072.3
ENST00000424694.1
PICK1
protein interacting with PRKCA 1
chr15_-_56757329 0.08 ENST00000260453.3
MNS1
meiosis-specific nuclear structural 1
chr12_+_66218598 0.08 ENST00000541363.1
HMGA2
high mobility group AT-hook 2
chr17_-_79623597 0.08 ENST00000574024.1
ENST00000331056.5
PDE6G
phosphodiesterase 6G, cGMP-specific, rod, gamma
chr11_-_133826852 0.08 ENST00000533871.2
ENST00000321016.8
IGSF9B
immunoglobulin superfamily, member 9B
chr14_-_106586656 0.08 ENST00000390602.2
IGHV3-13
immunoglobulin heavy variable 3-13
chr19_-_44259136 0.08 ENST00000270066.6
SMG9
SMG9 nonsense mediated mRNA decay factor
chr6_+_125524785 0.08 ENST00000392482.2
TPD52L1
tumor protein D52-like 1
chr8_+_67405794 0.08 ENST00000522977.1
ENST00000480005.1
C8orf46
chromosome 8 open reading frame 46
chr6_-_55740352 0.08 ENST00000370830.3
BMP5
bone morphogenetic protein 5
chr3_+_63953415 0.08 ENST00000484332.1
ATXN7
ataxin 7
chr22_+_29834572 0.08 ENST00000354373.2
RFPL1
ret finger protein-like 1
chr1_+_113010056 0.08 ENST00000369686.5
WNT2B
wingless-type MMTV integration site family, member 2B
chr13_+_108921977 0.08 ENST00000430559.1
ENST00000375887.4
TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr7_-_156803329 0.08 ENST00000252971.6
MNX1
motor neuron and pancreas homeobox 1
chr16_-_33647696 0.07 ENST00000558425.1
ENST00000569103.2
RP11-812E19.9
Uncharacterized protein
chr14_-_106068065 0.07 ENST00000390541.2
IGHE
immunoglobulin heavy constant epsilon
chr3_-_53164423 0.07 ENST00000467048.1
ENST00000394738.3
ENST00000296292.3
RFT1
RFT1 homolog (S. cerevisiae)
chr6_+_69942298 0.07 ENST00000238918.8
BAI3
brain-specific angiogenesis inhibitor 3
chr6_-_137113604 0.07 ENST00000359015.4
MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr14_-_106994333 0.07 ENST00000390624.2
IGHV3-48
immunoglobulin heavy variable 3-48
chrX_-_63450480 0.07 ENST00000362002.2
ASB12
ankyrin repeat and SOCS box containing 12
chr9_+_6328360 0.07 ENST00000381428.1
ENST00000314556.3
TPD52L3
tumor protein D52-like 3
chr16_+_88493879 0.07 ENST00000565624.1
ENST00000437464.1
ZNF469
zinc finger protein 469
chr13_-_103346854 0.07 ENST00000267273.6
METTL21C
methyltransferase like 21C
chr1_+_173793777 0.07 ENST00000239457.5
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chrX_-_64196307 0.07 ENST00000545618.1
ZC4H2
zinc finger, C4H2 domain containing
chr2_+_207024306 0.07 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr1_-_104238912 0.07 ENST00000330330.5
AMY1B
amylase, alpha 1B (salivary)
chrX_-_64196376 0.07 ENST00000447788.2
ZC4H2
zinc finger, C4H2 domain containing
chr20_-_48530230 0.07 ENST00000422556.1
SPATA2
spermatogenesis associated 2
chr12_-_11548496 0.07 ENST00000389362.4
ENST00000565533.1
ENST00000546254.1
PRB2
PRB1
proline-rich protein BstNI subfamily 2
proline-rich protein BstNI subfamily 1
chr15_+_97326659 0.07 ENST00000558553.1
SPATA8
spermatogenesis associated 8
chr12_+_25205446 0.07 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr17_-_8198636 0.07 ENST00000577745.1
ENST00000579192.1
ENST00000396278.1
SLC25A35
solute carrier family 25, member 35
chr10_+_118305435 0.07 ENST00000369221.2
PNLIP
pancreatic lipase
chr7_+_30634297 0.07 ENST00000389266.3
GARS
glycyl-tRNA synthetase
chr5_+_149737202 0.07 ENST00000451292.1
ENST00000377797.3
ENST00000445265.2
ENST00000323668.7
ENST00000439160.2
ENST00000394269.3
ENST00000427724.2
ENST00000504761.2
ENST00000513346.1
ENST00000515516.1
TCOF1
Treacher Collins-Franceschetti syndrome 1
chr6_-_133084580 0.07 ENST00000525270.1
ENST00000530536.1
ENST00000524919.1
VNN2
vanin 2
chr3_-_47950745 0.07 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr14_-_106573756 0.07 ENST00000390601.2
IGHV3-11
immunoglobulin heavy variable 3-11 (gene/pseudogene)
chr16_+_33006369 0.06 ENST00000425181.3
IGHV3OR16-10
immunoglobulin heavy variable 3/OR16-10 (non-functional)
chr8_+_128426535 0.06 ENST00000465342.2
POU5F1B
POU class 5 homeobox 1B
chr4_-_69111401 0.06 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr10_-_118032697 0.06 ENST00000439649.3
GFRA1
GDNF family receptor alpha 1
chr18_-_24722995 0.06 ENST00000581714.1
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr15_-_99057551 0.06 ENST00000558256.1
FAM169B
family with sequence similarity 169, member B
chrX_+_144908928 0.06 ENST00000408967.2
TMEM257
transmembrane protein 257
chr8_+_125551338 0.06 ENST00000276689.3
ENST00000518008.1
ENST00000522532.1
ENST00000517367.1
NDUFB9
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa
chr9_-_21166659 0.06 ENST00000380225.1
IFNA21
interferon, alpha 21
chr16_-_3350614 0.06 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chr6_+_52051171 0.06 ENST00000340057.1
IL17A
interleukin 17A
chr7_+_75028199 0.06 ENST00000437796.1
TRIM73
tripartite motif containing 73
chr14_+_22670455 0.06 ENST00000390460.1
TRAV26-2
T cell receptor alpha variable 26-2
chr12_+_25205568 0.06 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr6_-_39290744 0.06 ENST00000507712.1
KCNK16
potassium channel, subfamily K, member 16
chr15_-_35047166 0.06 ENST00000290374.4
GJD2
gap junction protein, delta 2, 36kDa
chrX_-_64196351 0.06 ENST00000374839.3
ZC4H2
zinc finger, C4H2 domain containing
chr13_+_28712614 0.06 ENST00000380958.3
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr16_+_67034456 0.06 ENST00000540579.1
CES4A
carboxylesterase 4A
chr22_-_50523760 0.06 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr2_+_79252822 0.06 ENST00000272324.5
REG3G
regenerating islet-derived 3 gamma
chr16_+_33629600 0.05 ENST00000562905.2
IGHV3OR16-13
immunoglobulin heavy variable 3/OR16-13 (non-functional)
chr17_+_46184911 0.05 ENST00000580219.1
ENST00000452859.2
ENST00000393405.2
ENST00000439357.2
ENST00000359238.2
SNX11
sorting nexin 11
chr11_-_118095801 0.05 ENST00000356289.5
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr22_-_32341336 0.05 ENST00000248984.3
C22orf24
chromosome 22 open reading frame 24
chr14_+_58765103 0.05 ENST00000355431.3
ENST00000348476.3
ENST00000395168.3
ARID4A
AT rich interactive domain 4A (RBP1-like)
chr14_+_22356029 0.05 ENST00000390437.2
TRAV12-2
T cell receptor alpha variable 12-2
chr19_+_51630287 0.05 ENST00000599948.1
SIGLEC9
sialic acid binding Ig-like lectin 9
chr11_-_10715117 0.05 ENST00000527509.2
MRVI1
murine retrovirus integration site 1 homolog
chr16_+_67034466 0.05 ENST00000535696.1
CES4A
carboxylesterase 4A
chr14_+_58894103 0.05 ENST00000354386.6
ENST00000556134.1
KIAA0586
KIAA0586
chr11_-_104827425 0.05 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr16_-_3767506 0.05 ENST00000538171.1
TRAP1
TNF receptor-associated protein 1
chr16_+_23194033 0.05 ENST00000300061.2
SCNN1G
sodium channel, non-voltage-gated 1, gamma subunit
chr17_+_76210267 0.05 ENST00000301633.4
ENST00000350051.3
ENST00000374948.2
ENST00000590449.1
BIRC5
baculoviral IAP repeat containing 5
chr14_+_24540046 0.05 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
CPNE6
copine VI (neuronal)
chr14_+_58894706 0.05 ENST00000261244.5
KIAA0586
KIAA0586
chr15_+_40453204 0.05 ENST00000287598.6
ENST00000412359.3
BUB1B
BUB1 mitotic checkpoint serine/threonine kinase B
chr5_+_68665608 0.05 ENST00000509734.1
ENST00000354868.5
ENST00000521422.1
ENST00000354312.3
ENST00000345306.6
RAD17
RAD17 homolog (S. pombe)
chr8_-_145018905 0.05 ENST00000398774.2
PLEC
plectin
chr16_+_33020496 0.05 ENST00000565407.2
IGHV3OR16-8
immunoglobulin heavy variable 3/OR16-8 (non-functional)
chr16_-_3767551 0.05 ENST00000246957.5
TRAP1
TNF receptor-associated protein 1
chr11_-_19223523 0.05 ENST00000265968.3
CSRP3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr18_+_43304092 0.05 ENST00000321925.4
ENST00000587601.1
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr5_-_78808617 0.04 ENST00000282260.6
ENST00000508576.1
ENST00000535690.1
HOMER1
homer homolog 1 (Drosophila)
chr2_+_79252804 0.04 ENST00000393897.2
REG3G
regenerating islet-derived 3 gamma
chr20_+_47835884 0.04 ENST00000371764.4
DDX27
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
chr1_+_32671236 0.04 ENST00000537469.1
ENST00000291358.6
IQCC
IQ motif containing C
chr14_-_106622419 0.04 ENST00000390604.2
IGHV3-16
immunoglobulin heavy variable 3-16 (non-functional)
chr15_-_70387120 0.04 ENST00000539550.1
TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr3_-_53290016 0.04 ENST00000423525.2
ENST00000423516.1
ENST00000296289.6
ENST00000462138.1
TKT
transketolase
chr11_+_64808675 0.04 ENST00000529996.1
SAC3D1
SAC3 domain containing 1
chr9_+_131873659 0.04 ENST00000452489.2
ENST00000347048.4
ENST00000357197.4
ENST00000445241.1
ENST00000355007.3
ENST00000414331.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr4_+_71200681 0.04 ENST00000273936.5
CABS1
calcium-binding protein, spermatid-specific 1
chr16_+_8807419 0.04 ENST00000565016.1
ENST00000567812.1
ABAT
4-aminobutyrate aminotransferase
chr3_-_187455680 0.04 ENST00000438077.1
BCL6
B-cell CLL/lymphoma 6
chr7_+_100318423 0.04 ENST00000252723.2
EPO
erythropoietin
chr11_-_114466471 0.04 ENST00000424261.2
NXPE4
neurexophilin and PC-esterase domain family, member 4
chr7_-_95025661 0.04 ENST00000542556.1
ENST00000265627.5
ENST00000427422.1
ENST00000451904.1
PON1
PON3
paraoxonase 1
paraoxonase 3
chr12_-_371994 0.04 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
SLC6A13
solute carrier family 6 (neurotransmitter transporter), member 13
chr14_-_106845789 0.04 ENST00000390617.2
IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chr22_+_21213771 0.04 ENST00000439214.1
SNAP29
synaptosomal-associated protein, 29kDa
chr3_+_52813932 0.04 ENST00000537050.1
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr4_-_119274121 0.04 ENST00000296498.3
PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chrX_-_109590174 0.03 ENST00000372054.1
GNG5P2
guanine nucleotide binding protein (G protein), gamma 5 pseudogene 2
chrY_-_25345070 0.03 ENST00000382510.4
ENST00000426000.2
ENST00000540248.1
ENST00000405239.1
DAZ1
deleted in azoospermia 1
chr22_+_32754139 0.03 ENST00000382088.3
RFPL3
ret finger protein-like 3
chr11_+_27062272 0.03 ENST00000529202.1
ENST00000533566.1
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr4_-_46126093 0.03 ENST00000295452.4
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr11_-_114466477 0.03 ENST00000375478.3
NXPE4
neurexophilin and PC-esterase domain family, member 4
chr3_+_47021168 0.03 ENST00000450053.3
ENST00000292309.5
ENST00000383740.2
NBEAL2
neurobeachin-like 2
chr8_-_125551278 0.03 ENST00000519232.1
ENST00000523888.1
ENST00000522810.1
ENST00000519548.1
ENST00000517678.1
ENST00000605953.1
ENST00000276692.6
TATDN1
TatD DNase domain containing 1
chr2_+_204801471 0.03 ENST00000316386.6
ENST00000435193.1
ICOS
inducible T-cell co-stimulator
chr12_+_66218212 0.03 ENST00000393578.3
ENST00000425208.2
ENST00000536545.1
ENST00000354636.3
HMGA2
high mobility group AT-hook 2
chr3_-_114343039 0.03 ENST00000481632.1
ZBTB20
zinc finger and BTB domain containing 20
chr13_-_46425865 0.03 ENST00000400405.2
SIAH3
siah E3 ubiquitin protein ligase family member 3
chr6_-_160679905 0.03 ENST00000366953.3
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chrX_-_48858667 0.03 ENST00000376423.4
ENST00000376441.1
GRIPAP1
GRIP1 associated protein 1
chr2_-_55277436 0.03 ENST00000354474.6
RTN4
reticulon 4
chr12_+_51442101 0.03 ENST00000550929.1
ENST00000262055.4
ENST00000550442.1
ENST00000549340.1
ENST00000548209.1
ENST00000548251.1
ENST00000550814.1
ENST00000547660.1
ENST00000380123.2
ENST00000548401.1
ENST00000418425.2
ENST00000547008.1
ENST00000552739.1
LETMD1
LETM1 domain containing 1
chr17_+_76210367 0.02 ENST00000592734.1
ENST00000587746.1
BIRC5
baculoviral IAP repeat containing 5
chrX_-_15332665 0.02 ENST00000537676.1
ENST00000344384.4
ASB11
ankyrin repeat and SOCS box containing 11
chr2_-_55277512 0.02 ENST00000402434.2
RTN4
reticulon 4

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.1 0.6 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.1 0.2 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.1 0.2 GO:0003131 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.1 0.2 GO:0072268 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.0 0.1 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.0 0.1 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.0 0.1 GO:0044278 cell wall disruption in other organism(GO:0044278)
0.0 0.1 GO:0019242 methylglyoxal biosynthetic process(GO:0019242)
0.0 0.1 GO:0035565 regulation of pronephros size(GO:0035565) renal glucose absorption(GO:0035623)
0.0 0.1 GO:0099545 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.0 0.1 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.0 0.1 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0 0.1 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.0 0.1 GO:0009386 translational attenuation(GO:0009386)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.2 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.1 GO:0015960 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.0 0.0 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.0 0.1 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0 0.1 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.0 GO:0046166 glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.0 0.3 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 0.0 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764)
0.0 0.1 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.0 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.0 0.1 GO:0060423 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.0 0.2 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.2 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 0.1 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.0 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 0.1 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.2 GO:0014029 neural crest formation(GO:0014029)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.0 GO:1904450 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.0 0.5 GO:0008210 estrogen metabolic process(GO:0008210)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.0 0.3 GO:0061617 MICOS complex(GO:0061617)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.6 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.0 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0035501 MH1 domain binding(GO:0035501)
0.0 0.1 GO:0031780 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.0 0.1 GO:0004347 glucose-6-phosphate isomerase activity(GO:0004347)
0.0 0.3 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.2 GO:0071553 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0 0.1 GO:0042806 fucose binding(GO:0042806)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.0 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0 0.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.1 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.1 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.0 GO:0004802 transketolase activity(GO:0004802)
0.0 0.0 GO:0032145 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.0 0.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.5 REACTOME GLUCURONIDATION Genes involved in Glucuronidation