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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NKX6-2

Z-value: 0.74

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Transcription factors associated with NKX6-2

Gene Symbol Gene ID Gene Info
NKX6-2
ENSG00000148826.6 NK6 homeobox 2

Activity profile of NKX6-2 motif

Sorted Z-values of NKX6-2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_79816965 5.18 ENST00000464233.1
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr5_-_58295712 2.02 ENST00000317118.8
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_-_22233442 1.72 ENST00000401957.2
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr1_-_150738261 1.71 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr6_+_114178512 1.34 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr2_-_208030647 1.22 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr14_+_52164820 1.15 ENST00000554167.1
FRMD6
FERM domain containing 6
chr4_+_169013666 1.13 ENST00000359299.3
ANXA10
annexin A10
chr4_+_100495864 1.13 ENST00000265517.5
ENST00000422897.2
MTTP
microsomal triglyceride transfer protein
chr6_+_26402465 1.09 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr2_-_175712270 1.03 ENST00000295497.7
ENST00000444394.1
CHN1
chimerin 1
chr3_-_71294304 1.03 ENST00000498215.1
FOXP1
forkhead box P1
chr2_+_108994466 0.98 ENST00000272452.2
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr5_-_13944652 0.95 ENST00000265104.4
DNAH5
dynein, axonemal, heavy chain 5
chr7_-_107880508 0.95 ENST00000425651.2
NRCAM
neuronal cell adhesion molecule
chr2_+_108994633 0.92 ENST00000409309.3
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr14_-_101295407 0.91 ENST00000596284.1
AL117190.2
AL117190.2
chr2_-_136678123 0.91 ENST00000422708.1
DARS
aspartyl-tRNA synthetase
chr1_+_244515930 0.89 ENST00000366537.1
ENST00000308105.4
C1orf100
chromosome 1 open reading frame 100
chr5_-_16916624 0.87 ENST00000513882.1
MYO10
myosin X
chr4_-_23891693 0.84 ENST00000264867.2
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr14_-_51027838 0.83 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr13_+_27844464 0.82 ENST00000241463.4
RASL11A
RAS-like, family 11, member A
chr2_-_217559517 0.77 ENST00000449583.1
IGFBP5
insulin-like growth factor binding protein 5
chr3_+_39509070 0.74 ENST00000354668.4
ENST00000428261.1
ENST00000420739.1
ENST00000415443.1
ENST00000447324.1
ENST00000383754.3
MOBP
myelin-associated oligodendrocyte basic protein
chr4_+_55095264 0.70 ENST00000257290.5
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr3_+_39509163 0.70 ENST00000436143.2
ENST00000441980.2
ENST00000311042.6
MOBP
myelin-associated oligodendrocyte basic protein
chr1_-_49242553 0.69 ENST00000371833.3
BEND5
BEN domain containing 5
chr6_+_12007897 0.69 ENST00000437559.1
RP11-456H18.2
RP11-456H18.2
chr8_-_103876965 0.68 ENST00000337198.5
AZIN1
antizyme inhibitor 1
chr4_+_169418195 0.65 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr12_+_105380073 0.64 ENST00000552951.1
ENST00000280749.5
C12orf45
chromosome 12 open reading frame 45
chr21_-_36421535 0.63 ENST00000416754.1
ENST00000437180.1
ENST00000455571.1
RUNX1
runt-related transcription factor 1
chr2_+_11864458 0.61 ENST00000396098.1
ENST00000396099.1
ENST00000425416.2
LPIN1
lipin 1
chr21_-_36421626 0.61 ENST00000300305.3
RUNX1
runt-related transcription factor 1
chr6_+_41021027 0.61 ENST00000244669.2
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr6_-_9933500 0.59 ENST00000492169.1
OFCC1
orofacial cleft 1 candidate 1
chr11_+_94277017 0.58 ENST00000358752.2
FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr10_+_6625605 0.58 ENST00000414894.1
ENST00000449648.1
PRKCQ-AS1
PRKCQ antisense RNA 1
chr13_+_97928395 0.56 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr1_+_209878182 0.54 ENST00000367027.3
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr17_-_60885700 0.53 ENST00000583600.1
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr4_+_88896819 0.52 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
SPP1
secreted phosphoprotein 1
chr14_-_64804814 0.52 ENST00000554572.1
ENST00000358599.5
ESR2
estrogen receptor 2 (ER beta)
chr6_+_31582961 0.51 ENST00000376059.3
ENST00000337917.7
AIF1
allograft inflammatory factor 1
chr20_-_7921090 0.51 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr17_-_60885659 0.50 ENST00000311269.5
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr18_+_76829441 0.50 ENST00000458297.2
ATP9B
ATPase, class II, type 9B
chr18_-_3219847 0.49 ENST00000261606.7
MYOM1
myomesin 1
chr15_+_64680003 0.49 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr6_-_87804815 0.49 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chrX_+_36254051 0.49 ENST00000378657.4
CXorf30
chromosome X open reading frame 30
chr6_+_26402517 0.48 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr5_+_67586465 0.47 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr16_+_25228242 0.46 ENST00000219660.5
AQP8
aquaporin 8
chr14_-_24658053 0.46 ENST00000354464.6
IPO4
importin 4
chr18_-_19994830 0.46 ENST00000525417.1
CTAGE1
cutaneous T-cell lymphoma-associated antigen 1
chr3_+_137490748 0.46 ENST00000478772.1
RP11-2A4.3
RP11-2A4.3
chrX_-_48901012 0.45 ENST00000315869.7
TFE3
transcription factor binding to IGHM enhancer 3
chr17_-_39306054 0.44 ENST00000343246.4
KRTAP4-5
keratin associated protein 4-5
chrX_-_103087136 0.43 ENST00000243298.2
RAB9B
RAB9B, member RAS oncogene family
chr3_+_52245458 0.43 ENST00000459884.1
ALAS1
aminolevulinate, delta-, synthase 1
chr17_-_40828969 0.43 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr11_-_62521614 0.43 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chr7_+_150065278 0.42 ENST00000519397.1
ENST00000479668.1
ENST00000540729.1
REPIN1
replication initiator 1
chr1_+_79115503 0.42 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr17_+_73663402 0.40 ENST00000355423.3
SAP30BP
SAP30 binding protein
chr3_+_130650738 0.39 ENST00000504612.1
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr4_+_55095428 0.39 ENST00000508170.1
ENST00000512143.1
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr15_+_69857515 0.39 ENST00000559477.1
RP11-279F6.1
RP11-279F6.1
chr4_-_23891658 0.37 ENST00000507380.1
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chrX_+_82763265 0.36 ENST00000373200.2
POU3F4
POU class 3 homeobox 4
chr2_+_169757750 0.36 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
G6PC2
glucose-6-phosphatase, catalytic, 2
chr16_+_84801852 0.36 ENST00000569925.1
ENST00000567526.1
USP10
ubiquitin specific peptidase 10
chr10_-_100995603 0.35 ENST00000370552.3
ENST00000370549.1
HPSE2
heparanase 2
chr6_+_12007963 0.35 ENST00000607445.1
RP11-456H18.2
RP11-456H18.2
chr7_-_20256965 0.35 ENST00000400331.5
ENST00000332878.4
MACC1
metastasis associated in colon cancer 1
chr1_+_85527987 0.34 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
WDR63
WD repeat domain 63
chr5_+_145316120 0.34 ENST00000359120.4
SH3RF2
SH3 domain containing ring finger 2
chr5_-_159546396 0.33 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chr3_-_45838011 0.33 ENST00000358525.4
ENST00000413781.1
SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr10_-_73848531 0.33 ENST00000373109.2
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr20_-_18477862 0.33 ENST00000337227.4
RBBP9
retinoblastoma binding protein 9
chr18_+_61575200 0.32 ENST00000238508.3
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr12_+_9980069 0.32 ENST00000354855.3
ENST00000324214.4
ENST00000279544.3
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr7_-_92855762 0.32 ENST00000453812.2
ENST00000394468.2
HEPACAM2
HEPACAM family member 2
chr3_-_45837959 0.32 ENST00000353278.4
ENST00000456124.2
SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr1_-_89357179 0.31 ENST00000448623.1
ENST00000418217.1
ENST00000370500.5
GTF2B
general transcription factor IIB
chr6_+_15401075 0.31 ENST00000541660.1
JARID2
jumonji, AT rich interactive domain 2
chr19_+_45394477 0.30 ENST00000252487.5
ENST00000405636.2
ENST00000592434.1
ENST00000426677.2
ENST00000589649.1
TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr14_+_77582905 0.30 ENST00000557408.1
TMEM63C
transmembrane protein 63C
chr8_-_109799793 0.30 ENST00000297459.3
TMEM74
transmembrane protein 74
chr10_-_73848086 0.30 ENST00000536168.1
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr9_+_88556036 0.29 ENST00000361671.5
ENST00000416045.1
NAA35
N(alpha)-acetyltransferase 35, NatC auxiliary subunit
chr1_-_243326612 0.29 ENST00000492145.1
ENST00000490813.1
ENST00000464936.1
CEP170
centrosomal protein 170kDa
chr1_+_174933899 0.28 ENST00000367688.3
RABGAP1L
RAB GTPase activating protein 1-like
chr1_+_156095951 0.28 ENST00000448611.2
ENST00000368297.1
LMNA
lamin A/C
chr2_+_68961905 0.28 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr22_+_46476192 0.28 ENST00000443490.1
FLJ27365
hsa-mir-4763
chr14_-_27066636 0.27 ENST00000267422.7
ENST00000344429.5
ENST00000574031.1
ENST00000465357.2
ENST00000547619.1
NOVA1
neuro-oncological ventral antigen 1
chr2_+_68961934 0.27 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr16_+_31271274 0.27 ENST00000287497.8
ENST00000544665.3
ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr7_-_102283238 0.27 ENST00000340457.8
UPK3BL
uroplakin 3B-like
chr4_+_41258786 0.27 ENST00000503431.1
ENST00000284440.4
ENST00000508768.1
ENST00000512788.1
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr7_-_102184083 0.27 ENST00000379357.5
POLR2J3
polymerase (RNA) II (DNA directed) polypeptide J3
chr6_-_37665751 0.26 ENST00000297153.7
ENST00000434837.3
MDGA1
MAM domain containing glycosylphosphatidylinositol anchor 1
chr3_+_178276488 0.26 ENST00000432997.1
ENST00000455865.1
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr5_+_31193847 0.26 ENST00000514738.1
ENST00000265071.2
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr14_-_99737565 0.26 ENST00000357195.3
BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr5_-_20575959 0.25 ENST00000507958.1
CDH18
cadherin 18, type 2
chr5_-_146258205 0.24 ENST00000394413.3
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr12_-_53045948 0.24 ENST00000309680.3
KRT2
keratin 2
chr1_-_32384693 0.24 ENST00000602683.1
ENST00000470404.1
PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr5_-_78365437 0.24 ENST00000380311.4
ENST00000540686.1
ENST00000255189.3
DMGDH
dimethylglycine dehydrogenase
chr2_+_68962014 0.24 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr15_+_93443419 0.24 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr1_+_100810575 0.24 ENST00000542213.1
CDC14A
cell division cycle 14A
chr22_-_39268308 0.24 ENST00000407418.3
CBX6
chromobox homolog 6
chr19_-_49220084 0.23 ENST00000595591.1
ENST00000356751.4
ENST00000594582.1
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr10_-_115904361 0.23 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr7_-_140482926 0.23 ENST00000496384.2
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr3_+_68053359 0.23 ENST00000478136.1
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr15_-_89764929 0.23 ENST00000268125.5
RLBP1
retinaldehyde binding protein 1
chr1_-_200379180 0.23 ENST00000294740.3
ZNF281
zinc finger protein 281
chr22_-_40929812 0.22 ENST00000422851.1
MKL1
megakaryoblastic leukemia (translocation) 1
chr17_-_41836153 0.22 ENST00000301691.2
SOST
sclerostin
chr10_-_48055018 0.21 ENST00000426610.2
ASAH2C
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2C
chr8_+_104831472 0.21 ENST00000262231.10
ENST00000507740.1
RIMS2
regulating synaptic membrane exocytosis 2
chr14_-_27066960 0.21 ENST00000539517.2
NOVA1
neuro-oncological ventral antigen 1
chr6_+_26199737 0.21 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chr18_+_32290218 0.21 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
DTNA
dystrobrevin, alpha
chr2_-_74570520 0.20 ENST00000394019.2
ENST00000346834.4
ENST00000359484.4
ENST00000423644.1
ENST00000377634.4
ENST00000436454.1
SLC4A5
solute carrier family 4 (sodium bicarbonate cotransporter), member 5
chr22_+_17956618 0.20 ENST00000262608.8
CECR2
cat eye syndrome chromosome region, candidate 2
chr2_-_207023918 0.18 ENST00000455934.2
ENST00000449699.1
ENST00000454195.1
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr8_-_15095832 0.18 ENST00000382080.1
SGCZ
sarcoglycan, zeta
chr6_-_46703430 0.18 ENST00000537365.1
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr16_+_19422035 0.18 ENST00000381414.4
ENST00000396229.2
TMC5
transmembrane channel-like 5
chr2_-_80531399 0.18 ENST00000409148.1
ENST00000415098.1
ENST00000452811.1
LRRTM1
leucine rich repeat transmembrane neuronal 1
chr14_+_72399833 0.17 ENST00000553530.1
ENST00000556437.1
RGS6
regulator of G-protein signaling 6
chr1_-_226926864 0.17 ENST00000429204.1
ENST00000366784.1
ITPKB
inositol-trisphosphate 3-kinase B
chr9_-_23825956 0.17 ENST00000397312.2
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr15_+_49715293 0.17 ENST00000267843.4
ENST00000560270.1
FGF7
fibroblast growth factor 7
chr2_+_233527443 0.17 ENST00000410095.1
EFHD1
EF-hand domain family, member D1
chr5_+_155753745 0.17 ENST00000435422.3
ENST00000337851.4
ENST00000447401.1
SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr6_-_26199471 0.16 ENST00000341023.1
HIST1H2AD
histone cluster 1, H2ad
chr2_-_207024134 0.16 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr11_-_13517565 0.16 ENST00000282091.1
ENST00000529816.1
PTH
parathyroid hormone
chr14_-_98444386 0.16 ENST00000556462.1
ENST00000556138.1
C14orf64
chromosome 14 open reading frame 64
chr4_+_113568207 0.15 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr21_-_27462351 0.15 ENST00000448850.1
APP
amyloid beta (A4) precursor protein
chr3_-_147124547 0.14 ENST00000491672.1
ENST00000383075.3
ZIC4
Zic family member 4
chr18_-_3220106 0.14 ENST00000356443.4
ENST00000400569.3
MYOM1
myomesin 1
chrX_+_105937068 0.14 ENST00000324342.3
RNF128
ring finger protein 128, E3 ubiquitin protein ligase
chr1_-_17766198 0.14 ENST00000375436.4
RCC2
regulator of chromosome condensation 2
chr8_-_82395461 0.14 ENST00000256104.4
FABP4
fatty acid binding protein 4, adipocyte
chr4_+_74269956 0.14 ENST00000295897.4
ENST00000415165.2
ENST00000503124.1
ENST00000509063.1
ENST00000401494.3
ALB
albumin
chr17_+_73663470 0.13 ENST00000583536.1
SAP30BP
SAP30 binding protein
chr1_+_32379174 0.13 ENST00000391369.1
AL136115.1
HCG2032337; PRO1848; Uncharacterized protein
chr1_-_114696472 0.13 ENST00000393296.1
ENST00000369547.1
ENST00000610222.1
SYT6
synaptotagmin VI
chr1_-_116383322 0.13 ENST00000429731.1
NHLH2
nescient helix loop helix 2
chr1_-_150849174 0.13 ENST00000515192.1
ARNT
aryl hydrocarbon receptor nuclear translocator
chr4_-_185139062 0.13 ENST00000296741.2
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr15_-_49103235 0.12 ENST00000380950.2
CEP152
centrosomal protein 152kDa
chr2_-_228244013 0.12 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chr9_-_93405352 0.12 ENST00000375765.3
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr11_+_100558384 0.12 ENST00000524892.2
ENST00000298815.8
ARHGAP42
Rho GTPase activating protein 42
chr9_-_23826298 0.12 ENST00000380117.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr7_-_111032971 0.12 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr5_+_68513622 0.11 ENST00000512880.1
ENST00000602380.1
MRPS36
mitochondrial ribosomal protein S36
chr17_-_56494713 0.11 ENST00000407977.2
RNF43
ring finger protein 43
chr2_-_217560248 0.11 ENST00000233813.4
IGFBP5
insulin-like growth factor binding protein 5
chr5_+_161495038 0.11 ENST00000393933.4
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr18_+_76829385 0.11 ENST00000426216.2
ENST00000307671.7
ENST00000586672.1
ENST00000586722.1
ATP9B
ATPase, class II, type 9B
chr12_+_40787194 0.10 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr4_+_169418255 0.10 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr3_+_159943362 0.10 ENST00000326474.3
C3orf80
chromosome 3 open reading frame 80
chr4_-_87374283 0.10 ENST00000361569.2
MAPK10
mitogen-activated protein kinase 10
chr10_+_26505179 0.10 ENST00000376261.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr19_+_54641444 0.10 ENST00000221232.5
ENST00000358389.3
CNOT3
CCR4-NOT transcription complex, subunit 3
chr10_-_100995540 0.10 ENST00000370546.1
ENST00000404542.1
HPSE2
heparanase 2
chr6_-_131277510 0.09 ENST00000525193.1
ENST00000527659.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr18_-_10701979 0.09 ENST00000538948.1
ENST00000285141.4
PIEZO2
piezo-type mechanosensitive ion channel component 2
chr3_-_193272874 0.09 ENST00000342695.4
ATP13A4
ATPase type 13A4
chr17_-_56494882 0.09 ENST00000584437.1
RNF43
ring finger protein 43
chr5_+_68513557 0.09 ENST00000256441.4
MRPS36
mitochondrial ribosomal protein S36
chr14_+_73706308 0.09 ENST00000554301.1
ENST00000555445.1
PAPLN
papilin, proteoglycan-like sulfated glycoprotein
chr6_-_33864684 0.09 ENST00000506222.2
ENST00000533304.1
LINC01016
long intergenic non-protein coding RNA 1016
chr9_+_116263778 0.09 ENST00000394646.3
RGS3
regulator of G-protein signaling 3
chr7_+_16828866 0.09 ENST00000597084.1
AC073333.1
Uncharacterized protein
chr6_-_26199499 0.09 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chr1_-_200379129 0.09 ENST00000367353.1
ZNF281
zinc finger protein 281
chr1_+_115397424 0.08 ENST00000369522.3
ENST00000455987.1
SYCP1
synaptonemal complex protein 1
chrX_+_68835911 0.08 ENST00000525810.1
ENST00000527388.1
ENST00000374553.2
ENST00000374552.4
ENST00000338901.3
ENST00000524573.1
EDA
ectodysplasin A
chr7_-_137028498 0.08 ENST00000393083.2
PTN
pleiotrophin
chr1_-_186430222 0.08 ENST00000391997.2
PDC
phosducin
chr12_+_54422142 0.08 ENST00000243108.4
HOXC6
homeobox C6
chr1_-_110155671 0.07 ENST00000351050.3
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr4_+_54927213 0.07 ENST00000595906.1
AC110792.1
HCG2027126; Uncharacterized protein
chrX_+_135388147 0.07 ENST00000394141.1
GPR112
G protein-coupled receptor 112
chr18_-_12656715 0.07 ENST00000462226.1
ENST00000497844.2
ENST00000309836.5
ENST00000453447.2
SPIRE1
spire-type actin nucleation factor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.4 1.2 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.3 0.9 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.3 0.9 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.3 1.1 GO:0072276 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.2 2.0 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.2 1.0 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.2 0.5 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.2 0.7 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.2 1.1 GO:0003383 apical constriction(GO:0003383)
0.1 0.5 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
0.1 1.4 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.1 1.1 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.3 GO:0007412 axon target recognition(GO:0007412)
0.1 0.6 GO:0006642 triglyceride mobilization(GO:0006642)
0.1 0.6 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 1.0 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.1 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 1.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.2 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.1 2.4 GO:0034310 primary alcohol catabolic process(GO:0034310)
0.1 0.6 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 0.2 GO:2000053 regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.1 0.2 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.1 1.7 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.4 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 0.3 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.1 1.6 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.6 GO:0015824 proline transport(GO:0015824)
0.1 0.3 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.1 1.3 GO:0051764 actin crosslink formation(GO:0051764)
0.1 1.3 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.2 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.2 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 0.2 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 1.0 GO:0021670 lateral ventricle development(GO:0021670)
0.0 0.1 GO:0019836 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.0 0.6 GO:0042355 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.1 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.0 0.1 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.2 GO:0060437 lung growth(GO:0060437)
0.0 0.2 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.4 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0 0.1 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 0.2 GO:0071873 response to norepinephrine(GO:0071873)
0.0 0.2 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.0 0.8 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.8 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 0.5 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.4 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.0 0.5 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.5 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 1.0 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.2 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.3 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.1 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.0 0.2 GO:0035726 regulation of neutrophil apoptotic process(GO:0033029) common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.1 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.0 0.5 GO:1900115 extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.6 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.3 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.2 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.1 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.0 0.3 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.1 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.5 GO:0006833 water transport(GO:0006833)
0.0 0.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.3 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.0 0.9 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.1 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.3 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.2 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.3 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.5 GO:0016486 peptide hormone processing(GO:0016486)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0042585 germinal vesicle(GO:0042585)
0.2 1.7 GO:0036021 endolysosome lumen(GO:0036021)
0.2 0.6 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.1 0.5 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 0.9 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 1.0 GO:0036157 outer dynein arm(GO:0036157)
0.1 0.4 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.1 0.3 GO:0031417 NatC complex(GO:0031417)
0.0 1.5 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.9 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.9 GO:0032433 filopodium tip(GO:0032433)
0.0 0.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.3 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 0.2 GO:0098536 deuterosome(GO:0098536)
0.0 0.3 GO:0005638 lamin filament(GO:0005638)
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.2 GO:1990812 growth cone filopodium(GO:1990812)
0.0 0.5 GO:0043194 axon initial segment(GO:0043194)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 0.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.8 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0031010 ISWI-type complex(GO:0031010)
0.0 1.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.1 GO:0005902 microvillus(GO:0005902)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.3 1.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.2 0.9 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.2 0.5 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.2 0.5 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.2 0.6 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.4 GO:0016749 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.1 1.7 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.4 GO:0030305 heparanase activity(GO:0030305)
0.1 2.0 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 0.7 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.1 0.9 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.4 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 1.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.6 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 1.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 0.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.9 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 0.3 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.1 0.5 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.2 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.1 0.2 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.1 0.6 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 1.7 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.4 GO:0043559 insulin binding(GO:0043559)
0.1 1.0 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 1.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 1.0 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.2 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.3 GO:0015288 porin activity(GO:0015288)
0.0 0.5 GO:0015250 water channel activity(GO:0015250)
0.0 0.3 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.6 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 1.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.7 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 0.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.3 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.3 GO:0001851 complement component C3b binding(GO:0001851)
0.0 0.3 GO:0045503 dynein light chain binding(GO:0045503)
0.0 0.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.2 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 1.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 1.0 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.1 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.3 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 0.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.6 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0042731 PH domain binding(GO:0042731)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.6 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 1.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.5 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 1.3 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.8 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.6 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 1.7 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.9 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.2 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.5 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 2.0 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.6 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.5 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.2 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 1.6 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF