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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NR1D1

Z-value: 0.62

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Transcription factors associated with NR1D1

Gene Symbol Gene ID Gene Info
ENSG00000126368.5 nuclear receptor subfamily 1 group D member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1D1hg19_v2_chr17_-_38256973_382569900.019.8e-01Click!

Activity profile of NR1D1 motif

Sorted Z-values of NR1D1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_58223228 1.08 ENST00000478253.1
ENST00000295962.4
abhydrolase domain containing 6
chr17_+_39394250 1.06 ENST00000254072.6
keratin associated protein 9-8
chr7_+_114562172 0.83 ENST00000393486.1
ENST00000257724.3
MyoD family inhibitor domain containing
chr19_-_18995029 0.74 ENST00000596048.1
ceramide synthase 1
chrX_+_54947229 0.72 ENST00000442098.1
ENST00000430420.1
ENST00000453081.1
ENST00000173898.7
ENST00000319167.8
ENST00000375022.4
ENST00000399736.1
ENST00000440072.1
ENST00000420798.2
ENST00000431115.1
ENST00000440759.1
ENST00000375041.2
trophinin
chr5_-_111312622 0.70 ENST00000395634.3
neuronal regeneration related protein
chr19_-_42927251 0.69 ENST00000597001.1
lipase, hormone-sensitive
chr11_+_7534999 0.68 ENST00000528947.1
ENST00000299492.4
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr3_-_45957088 0.66 ENST00000539217.1
leucine zipper transcription factor-like 1
chr14_-_50999190 0.64 ENST00000557390.1
mitogen-activated protein kinase kinase kinase kinase 5
chr5_-_43313574 0.63 ENST00000325110.6
ENST00000433297.2
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr19_-_51220176 0.62 ENST00000359082.3
ENST00000293441.1
SH3 and multiple ankyrin repeat domains 1
chr22_+_27017921 0.54 ENST00000354760.3
crystallin, beta A4
chr22_-_37880543 0.54 ENST00000442496.1
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr17_+_39405939 0.52 ENST00000334109.2
keratin associated protein 9-4
chr1_-_147245484 0.45 ENST00000271348.2
gap junction protein, alpha 5, 40kDa
chr2_-_64371546 0.43 ENST00000358912.4
pellino E3 ubiquitin protein ligase 1
chr19_+_21203481 0.43 ENST00000595401.1
zinc finger protein 430
chr17_+_43922241 0.42 ENST00000329196.5
signal peptide peptidase like 2C
chr19_+_22235310 0.41 ENST00000600162.1
zinc finger protein 257
chr6_-_27440837 0.41 ENST00000211936.6
zinc finger protein 184
chr13_+_113622757 0.41 ENST00000375604.2
MCF.2 cell line derived transforming sequence-like
chr7_+_94139105 0.40 ENST00000297273.4
CAS1 domain containing 1
chr16_-_70712229 0.39 ENST00000562883.2
metastasis suppressor 1-like
chr14_+_24540731 0.38 ENST00000558859.1
ENST00000559197.1
ENST00000560828.1
ENST00000216775.2
ENST00000560884.1
copine VI (neuronal)
chr19_+_21324863 0.37 ENST00000598331.1
zinc finger protein 431
chr1_-_11866034 0.37 ENST00000376590.3
methylenetetrahydrofolate reductase (NAD(P)H)
chr4_+_1873100 0.37 ENST00000508803.1
Wolf-Hirschhorn syndrome candidate 1
chr1_+_203764742 0.36 ENST00000432282.1
ENST00000453771.1
ENST00000367214.1
ENST00000367212.3
ENST00000332127.4
zinc finger CCCH-type containing 11A
chr4_-_147043058 0.33 ENST00000512063.1
ENST00000507726.1
long intergenic non-protein coding RNA 1095
chr19_-_22605136 0.33 ENST00000357774.5
ENST00000601553.1
ENST00000593657.1
zinc finger protein 98
chr22_-_47882857 0.31 ENST00000405369.3
Novel protein; Uncharacterized protein
chrX_+_130192318 0.30 ENST00000370922.1
Rho GTPase activating protein 36
chr19_-_14629224 0.29 ENST00000254322.2
DnaJ (Hsp40) homolog, subfamily B, member 1
chr14_+_24540046 0.29 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
copine VI (neuronal)
chr19_+_21688366 0.28 ENST00000358491.4
ENST00000597078.1
zinc finger protein 429
chr4_+_88529681 0.27 ENST00000399271.1
dentin sialophosphoprotein
chr1_-_226374373 0.26 ENST00000366812.5
acyl-CoA binding domain containing 3
chr19_-_23433144 0.26 ENST00000418100.1
ENST00000597537.1
ENST00000597037.1
zinc finger protein 724, pseudogene
chr7_+_139025875 0.25 ENST00000297534.6
chromosome 7 open reading frame 55
chr2_-_63815860 0.24 ENST00000272321.7
ENST00000431065.1
WD repeat containing planar cell polarity effector
chr15_+_65903680 0.24 ENST00000537259.1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr12_-_123755639 0.24 ENST00000535979.1
cyclin-dependent kinase 2 associated protein 1
chr16_+_77225071 0.23 ENST00000439557.2
ENST00000545553.1
MON1 secretory trafficking family member B
chr17_-_76128488 0.23 ENST00000322914.3
transmembrane channel-like 6
chr19_+_21265028 0.23 ENST00000291770.7
zinc finger protein 714
chr7_-_44229022 0.23 ENST00000403799.3
glucokinase (hexokinase 4)
chr3_+_169755715 0.22 ENST00000355897.5
G protein-coupled receptor 160
chr12_-_110883346 0.22 ENST00000547365.1
actin related protein 2/3 complex, subunit 3, 21kDa
chr2_-_103353277 0.22 ENST00000258436.5
major facilitator superfamily domain containing 9
chr1_+_20915409 0.21 ENST00000375071.3
cytidine deaminase
chr1_+_159796534 0.21 ENST00000289707.5
SLAM family member 8
chr18_-_19284724 0.21 ENST00000580981.1
ENST00000289119.2
abhydrolase domain containing 3
chr16_+_71392616 0.19 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
calbindin 2
chr6_+_76458990 0.19 ENST00000369977.3
myosin VI
chr2_+_220306745 0.19 ENST00000431523.1
ENST00000396698.1
ENST00000396695.2
SPEG complex locus
chr14_+_100789669 0.18 ENST00000361529.3
ENST00000557052.1
solute carrier family 25, member 47
chr19_+_21264980 0.17 ENST00000596053.1
ENST00000597086.1
ENST00000596143.1
ENST00000596367.1
ENST00000601416.1
zinc finger protein 714
chr1_-_11007927 0.16 ENST00000468348.1
chromosome 1 open reading frame 127
chr22_+_37415776 0.16 ENST00000341116.3
ENST00000429360.2
ENST00000404393.1
mercaptopyruvate sulfurtransferase
chr1_-_26233423 0.15 ENST00000357865.2
stathmin 1
chr9_+_91150016 0.15 ENST00000375854.3
ENST00000375855.3
nucleoredoxin-like 2
chr19_-_43702231 0.15 ENST00000597374.1
ENST00000599371.1
pregnancy specific beta-1-glycoprotein 4
chr7_+_64126535 0.15 ENST00000344930.3
zinc finger protein 107
chr7_+_114562616 0.15 ENST00000448022.1
MyoD family inhibitor domain containing
chrX_+_24167828 0.15 ENST00000379188.3
ENST00000419690.1
ENST00000379177.1
ENST00000304543.5
zinc finger protein, X-linked
chr14_-_23770683 0.14 ENST00000561437.1
ENST00000559942.1
ENST00000560913.1
ENST00000559314.1
ENST00000558058.1
protein phosphatase 1, regulatory subunit 3E
chr13_+_100741269 0.14 ENST00000376286.4
ENST00000376279.3
ENST00000376285.1
propionyl CoA carboxylase, alpha polypeptide
chr22_+_37415700 0.13 ENST00000397129.1
mercaptopyruvate sulfurtransferase
chr17_-_38074842 0.13 ENST00000309481.7
gasdermin B
chr22_+_37415728 0.13 ENST00000404802.3
mercaptopyruvate sulfurtransferase
chr2_+_203776937 0.13 ENST00000402905.3
ENST00000414490.1
ENST00000431787.1
ENST00000444724.1
ENST00000414857.1
ENST00000430899.1
ENST00000445120.1
ENST00000441569.1
ENST00000432024.1
ENST00000443740.1
ENST00000414439.1
ENST00000428585.1
ENST00000545253.1
ENST00000545262.1
ENST00000447539.1
ENST00000456821.2
ENST00000434998.1
ENST00000320443.8
calcium responsive transcription factor
chr12_-_7125770 0.13 ENST00000261407.4
lysophosphatidylcholine acyltransferase 3
chr3_-_182703688 0.13 ENST00000466812.1
ENST00000487822.1
ENST00000460412.1
ENST00000469954.1
DCN1, defective in cullin neddylation 1, domain containing 1
chr4_+_169842707 0.13 ENST00000503290.1
palladin, cytoskeletal associated protein
chr19_-_58071201 0.12 ENST00000325134.5
ENST00000457177.1
zinc finger protein 550
chrX_+_24167746 0.12 ENST00000428571.1
ENST00000539115.1
zinc finger protein, X-linked
chr13_+_113622810 0.12 ENST00000397030.1
MCF.2 cell line derived transforming sequence-like
chr15_-_65903407 0.12 ENST00000395644.4
ENST00000567744.1
ENST00000568573.1
ENST00000562830.1
ENST00000569491.1
ENST00000561769.1
von Willebrand factor A domain containing 9
chr15_-_65903574 0.12 ENST00000420799.2
ENST00000313182.2
ENST00000431261.2
ENST00000442903.3
von Willebrand factor A domain containing 9
chr14_-_50999307 0.12 ENST00000013125.4
mitogen-activated protein kinase kinase kinase kinase 5
chr6_+_76458909 0.11 ENST00000369981.3
ENST00000369985.4
myosin VI
chr1_-_6557156 0.11 ENST00000537245.1
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr10_-_8095412 0.11 ENST00000458727.1
ENST00000355358.1
RP11-379F12.3
GATA3 antisense RNA 1
chr17_-_36347030 0.11 ENST00000518551.1
TBC1 domain family, member 3
chr1_+_165513231 0.11 ENST00000294818.1
leucine rich repeat containing 52
chr9_-_35112376 0.11 ENST00000488109.2
family with sequence similarity 214, member B
chr17_-_38074859 0.10 ENST00000520542.1
ENST00000418519.1
ENST00000394179.1
gasdermin B
chrX_-_49089771 0.10 ENST00000376251.1
ENST00000323022.5
ENST00000376265.2
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr8_+_105235572 0.09 ENST00000523362.1
regulating synaptic membrane exocytosis 2
chr19_-_19932501 0.09 ENST00000540806.2
ENST00000590766.1
ENST00000587452.1
ENST00000545006.1
ENST00000590319.1
ENST00000587461.1
ENST00000450683.2
ENST00000443905.2
ENST00000590274.1
zinc finger protein 506
CTC-559E9.4
chr2_+_103353367 0.08 ENST00000454536.1
ENST00000409528.1
ENST00000409173.1
transmembrane protein 182
chr19_+_21203426 0.08 ENST00000261560.5
ENST00000599548.1
ENST00000594110.1
zinc finger protein 430
chr7_+_64126503 0.07 ENST00000360117.3
zinc finger protein 107
chr4_-_21699380 0.07 ENST00000382148.3
Kv channel interacting protein 4
chr14_+_23352374 0.07 ENST00000267396.4
ENST00000536884.1
RAS (RAD and GEM)-like GTP binding 2
chr19_-_23578220 0.07 ENST00000595533.1
ENST00000397082.2
ENST00000599743.1
ENST00000300619.7
zinc finger protein 91
chr9_+_136243117 0.07 ENST00000426926.2
ENST00000371957.3
chromosome 9 open reading frame 96
chr8_+_11561660 0.07 ENST00000526716.1
ENST00000335135.4
ENST00000528027.1
GATA binding protein 4
chr19_-_38806390 0.07 ENST00000589247.1
ENST00000329420.8
ENST00000591784.1
Yip1 interacting factor homolog B (S. cerevisiae)
chr9_+_139221880 0.07 ENST00000392945.3
ENST00000440944.1
G-protein signaling modulator 1
chr10_+_90346519 0.06 ENST00000371939.3
lipase, family member J
chr8_+_101162812 0.06 ENST00000353107.3
ENST00000522439.1
polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
chr19_-_52035044 0.06 ENST00000359982.4
ENST00000436458.1
ENST00000425629.3
ENST00000391797.3
ENST00000343300.4
sialic acid binding Ig-like lectin 6
chr19_+_22235279 0.06 ENST00000594363.1
ENST00000597927.1
ENST00000594947.1
zinc finger protein 257
chr9_-_136242909 0.05 ENST00000371991.3
ENST00000545297.1
surfeit 4
chr9_+_136243264 0.04 ENST00000371955.1
chromosome 9 open reading frame 96
chr1_-_32403903 0.04 ENST00000344035.6
ENST00000356536.3
protein tyrosine phosphatase type IVA, member 2
chr6_+_63921351 0.04 ENST00000370659.1
FK506 binding protein 1C
chrX_+_16964985 0.04 ENST00000303843.7
RALBP1 associated Eps domain containing 2
chr2_-_73053126 0.04 ENST00000272427.6
ENST00000410104.1
exocyst complex component 6B
chr19_-_38806560 0.04 ENST00000591755.1
ENST00000337679.8
ENST00000339413.6
Yip1 interacting factor homolog B (S. cerevisiae)
chr10_+_23217006 0.04 ENST00000376528.4
ENST00000447081.1
armadillo repeat containing 3
chr1_+_168250194 0.03 ENST00000367821.3
T-box 19
chr19_-_38806540 0.03 ENST00000592694.1
Yip1 interacting factor homolog B (S. cerevisiae)
chr6_+_167525277 0.03 ENST00000400926.2
chemokine (C-C motif) receptor 6
chr10_+_23216944 0.03 ENST00000298032.5
ENST00000409983.3
ENST00000409049.3
armadillo repeat containing 3
chr1_-_11865982 0.03 ENST00000418034.1
methylenetetrahydrofolate reductase (NAD(P)H)
chr10_-_103880209 0.03 ENST00000425280.1
LIM domain binding 1
chr10_-_105156198 0.03 ENST00000369815.1
ENST00000309579.3
ENST00000337003.4
up-regulated during skeletal muscle growth 5 homolog (mouse)
chr7_+_62809239 0.03 ENST00000456890.1
AC006455.1
chr1_-_197169672 0.03 ENST00000367405.4
zinc finger and BTB domain containing 41
chr1_+_44398943 0.02 ENST00000372359.5
ENST00000414809.3
artemin
chr1_+_197382957 0.02 ENST00000367397.1
crumbs homolog 1 (Drosophila)
chr17_+_39411636 0.02 ENST00000394008.1
keratin associated protein 9-9
chr1_-_26232951 0.02 ENST00000426559.2
ENST00000455785.2
stathmin 1
chr11_-_327537 0.02 ENST00000602735.1
interferon induced transmembrane protein 3
chr9_+_126773880 0.02 ENST00000373615.4
LIM homeobox 2
chr21_-_28820892 0.02 ENST00000420186.2
AP001604.3
chr19_-_12833361 0.01 ENST00000592287.1
transportin 2
chrX_+_16964794 0.01 ENST00000357277.3
RALBP1 associated Eps domain containing 2
chr17_-_7145475 0.01 ENST00000571129.1
ENST00000571253.1
ENST00000573928.1
GABA(A) receptor-associated protein
chr1_-_11865351 0.01 ENST00000413656.1
ENST00000376585.1
ENST00000423400.1
ENST00000431243.1
methylenetetrahydrofolate reductase (NAD(P)H)

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1D1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0072720 cellular response to mycotoxin(GO:0036146) response to dithiothreitol(GO:0072720)
0.2 0.7 GO:1903565 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.2 0.6 GO:0050894 determination of affect(GO:0050894)
0.2 1.1 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.4 GO:0098905 pulmonary valve formation(GO:0003193) regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) foramen ovale closure(GO:0035922) regulation of bundle of His cell action potential(GO:0098905)
0.1 0.7 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.4 GO:0009440 cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
0.1 0.4 GO:0070829 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.1 0.2 GO:0019085 early viral transcription(GO:0019085)
0.1 0.4 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 0.2 GO:0019858 cytosine metabolic process(GO:0019858)
0.0 0.9 GO:0009642 response to light intensity(GO:0009642)
0.0 0.2 GO:0032185 regulation of embryonic cell shape(GO:0016476) septin cytoskeleton organization(GO:0032185) glomerular visceral epithelial cell migration(GO:0090521)
0.0 0.5 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 1.7 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.2 GO:0009730 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.1 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0 0.1 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.0 0.1 GO:0003285 septum secundum development(GO:0003285)
0.0 0.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.8 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.1 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.4 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.4 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.1 GO:0035865 cellular response to potassium ion(GO:0035865)
0.0 0.1 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.6 GO:0045095 keratin filament(GO:0045095)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)
0.0 0.4 GO:0000346 transcription export complex(GO:0000346)
0.0 1.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.2 GO:0005921 gap junction(GO:0005921)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.2 0.6 GO:0031877 somatostatin receptor binding(GO:0031877)
0.1 0.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.4 GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020)
0.1 0.4 GO:0016784 3-mercaptopyruvate sulfurtransferase activity(GO:0016784)
0.1 0.6 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.4 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.1 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.1 0.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 1.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 1.0 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.2 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.2 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.2 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.4 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0009374 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.0 0.0 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.5 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME GAP JUNCTION TRAFFICKING Genes involved in Gap junction trafficking