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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NR1I3

Z-value: 0.38

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Transcription factors associated with NR1I3

Gene Symbol Gene ID Gene Info
NR1I3
ENSG00000143257.7 nuclear receptor subfamily 1 group I member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1I3hg19_v2_chr1_-_161207875_161207901-0.232.7e-01Click!

Activity profile of NR1I3 motif

Sorted Z-values of NR1I3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_33336414 0.63 ENST00000373471.3
ENST00000609187.1
FNDC5
fibronectin type III domain containing 5
chr1_-_205290865 0.58 ENST00000367157.3
NUAK2
NUAK family, SNF1-like kinase, 2
chr12_+_53817633 0.52 ENST00000257863.4
ENST00000550311.1
ENST00000379791.3
AMHR2
anti-Mullerian hormone receptor, type II
chr17_+_32582293 0.49 ENST00000580907.1
ENST00000225831.4
CCL2
chemokine (C-C motif) ligand 2
chr19_-_7562334 0.38 ENST00000593942.1
PEX11G
peroxisomal biogenesis factor 11 gamma
chr19_+_676385 0.32 ENST00000166139.4
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr11_-_82611448 0.30 ENST00000393399.2
ENST00000313010.3
PRCP
prolylcarboxypeptidase (angiotensinase C)
chr2_-_69180083 0.30 ENST00000328895.4
GKN2
gastrokine 2
chr2_-_69180012 0.29 ENST00000481498.1
GKN2
gastrokine 2
chr20_-_62339190 0.29 ENST00000324228.2
ENST00000609142.1
ARFRP1
ADP-ribosylation factor related protein 1
chr17_-_8198636 0.26 ENST00000577745.1
ENST00000579192.1
ENST00000396278.1
SLC25A35
solute carrier family 25, member 35
chr4_+_70894130 0.26 ENST00000526767.1
ENST00000530128.1
ENST00000381057.3
HTN3
histatin 3
chr14_+_22977587 0.25 ENST00000390504.1
TRAJ33
T cell receptor alpha joining 33
chr20_-_62339315 0.24 ENST00000440854.1
ENST00000607873.1
ARFRP1
ADP-ribosylation factor related protein 1
chr17_-_53499310 0.23 ENST00000262065.3
MMD
monocyte to macrophage differentiation-associated
chr7_+_143079000 0.23 ENST00000392910.2
ZYX
zyxin
chr20_+_62339381 0.23 ENST00000355969.6
ENST00000357119.4
ENST00000431125.1
ENST00000369967.3
ENST00000328969.5
ZGPAT
zinc finger, CCCH-type with G patch domain
chr15_+_85523671 0.22 ENST00000310298.4
ENST00000557957.1
PDE8A
phosphodiesterase 8A
chr7_-_56160625 0.22 ENST00000446428.1
ENST00000432123.1
ENST00000452681.2
ENST00000537360.1
PHKG1
phosphorylase kinase, gamma 1 (muscle)
chr1_+_113217043 0.21 ENST00000413052.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr13_-_21635631 0.21 ENST00000382592.4
LATS2
large tumor suppressor kinase 2
chr11_-_57089671 0.21 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr10_-_50396425 0.20 ENST00000374148.1
C10orf128
chromosome 10 open reading frame 128
chr7_-_56160666 0.19 ENST00000297373.2
PHKG1
phosphorylase kinase, gamma 1 (muscle)
chr19_-_44306590 0.19 ENST00000377950.3
LYPD5
LY6/PLAUR domain containing 5
chr16_-_4465886 0.19 ENST00000539968.1
CORO7
coronin 7
chr6_-_43496605 0.19 ENST00000455285.2
XPO5
exportin 5
chr19_-_46296011 0.18 ENST00000377735.3
ENST00000270223.6
DMWD
dystrophia myotonica, WD repeat containing
chr9_-_91793675 0.18 ENST00000375835.4
ENST00000375830.1
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr3_-_50396978 0.18 ENST00000266025.3
TMEM115
transmembrane protein 115
chr20_+_57766075 0.18 ENST00000371030.2
ZNF831
zinc finger protein 831
chr7_+_100770328 0.17 ENST00000223095.4
ENST00000445463.2
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr11_+_62556596 0.17 ENST00000526546.1
TMEM179B
transmembrane protein 179B
chr2_-_69098566 0.16 ENST00000295379.1
BMP10
bone morphogenetic protein 10
chr12_-_75601778 0.16 ENST00000550433.1
ENST00000548513.1
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chrX_-_110655391 0.16 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr1_-_149900122 0.14 ENST00000271628.8
SF3B4
splicing factor 3b, subunit 4, 49kDa
chr5_-_135528822 0.14 ENST00000607574.1
AC009014.3
AC009014.3
chr7_-_31380502 0.14 ENST00000297142.3
NEUROD6
neuronal differentiation 6
chr12_-_54779511 0.13 ENST00000551109.1
ENST00000546970.1
ZNF385A
zinc finger protein 385A
chr14_+_21525981 0.13 ENST00000308227.2
RNASE8
ribonuclease, RNase A family, 8
chr16_+_67906919 0.13 ENST00000358933.5
EDC4
enhancer of mRNA decapping 4
chr16_+_30710462 0.13 ENST00000262518.4
ENST00000395059.2
ENST00000344771.4
SRCAP
Snf2-related CREBBP activator protein
chr4_-_82136114 0.13 ENST00000395578.1
ENST00000418486.2
PRKG2
protein kinase, cGMP-dependent, type II
chr20_+_5987890 0.12 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr7_-_99381884 0.12 ENST00000336411.2
CYP3A4
cytochrome P450, family 3, subfamily A, polypeptide 4
chr6_+_33422343 0.12 ENST00000395064.2
ZBTB9
zinc finger and BTB domain containing 9
chr2_-_228028829 0.12 ENST00000396625.3
ENST00000329662.7
COL4A4
collagen, type IV, alpha 4
chr19_-_46285646 0.11 ENST00000458663.2
DMPK
dystrophia myotonica-protein kinase
chr10_-_73848764 0.11 ENST00000317376.4
ENST00000412663.1
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr12_-_53729525 0.11 ENST00000303846.3
SP7
Sp7 transcription factor
chr9_+_34179003 0.10 ENST00000545103.1
ENST00000543944.1
ENST00000536252.1
ENST00000540348.1
ENST00000297661.4
ENST00000379186.4
UBAP1
ubiquitin associated protein 1
chr12_-_108991812 0.10 ENST00000392806.3
ENST00000547567.1
TMEM119
transmembrane protein 119
chr7_-_99381798 0.10 ENST00000415003.1
ENST00000354593.2
CYP3A4
cytochrome P450, family 3, subfamily A, polypeptide 4
chr8_-_52721975 0.10 ENST00000356297.4
ENST00000543296.1
PXDNL
peroxidasin homolog (Drosophila)-like
chr19_+_58919992 0.09 ENST00000306910.4
ENST00000598901.1
ENST00000593920.1
ENST00000596281.1
ZNF584
zinc finger protein 584
chr13_+_24883703 0.09 ENST00000332018.4
C1QTNF9
C1q and tumor necrosis factor related protein 9
chr15_+_43985084 0.09 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr15_+_43885252 0.09 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr6_+_108487245 0.09 ENST00000368986.4
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr16_+_577697 0.09 ENST00000562370.1
ENST00000568988.1
ENST00000219611.2
CAPN15
calpain 15
chr19_+_58920102 0.08 ENST00000599238.1
ENST00000322834.7
ZNF584
zinc finger protein 584
chr17_-_34270668 0.08 ENST00000293274.4
LYZL6
lysozyme-like 6
chr17_-_34270697 0.08 ENST00000585556.1
LYZL6
lysozyme-like 6
chr20_-_23549334 0.07 ENST00000376979.3
CST9L
cystatin 9-like
chr1_+_32930647 0.07 ENST00000609129.1
ZBTB8B
zinc finger and BTB domain containing 8B
chr11_-_104480019 0.07 ENST00000536529.1
ENST00000545630.1
ENST00000538641.1
RP11-886D15.1
RP11-886D15.1
chr8_+_11351876 0.07 ENST00000529894.1
BLK
B lymphoid tyrosine kinase
chr6_+_96969672 0.07 ENST00000369278.4
UFL1
UFM1-specific ligase 1
chr13_-_114107839 0.06 ENST00000375418.3
ADPRHL1
ADP-ribosylhydrolase like 1
chr17_-_33390667 0.06 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr8_-_109799793 0.06 ENST00000297459.3
TMEM74
transmembrane protein 74
chr1_+_43803475 0.06 ENST00000372470.3
ENST00000413998.2
MPL
myeloproliferative leukemia virus oncogene
chr4_-_170897045 0.06 ENST00000508313.1
RP11-205M3.3
RP11-205M3.3
chr14_+_22748980 0.06 ENST00000390465.2
TRAV38-2DV8
T cell receptor alpha variable 38-2/delta variable 8
chr3_-_116164306 0.05 ENST00000490035.2
LSAMP
limbic system-associated membrane protein
chr4_-_57524061 0.05 ENST00000508121.1
HOPX
HOP homeobox
chr5_-_39270725 0.05 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB
FYN binding protein
chr17_-_3301704 0.05 ENST00000322608.2
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr14_-_77787198 0.04 ENST00000261534.4
POMT2
protein-O-mannosyltransferase 2
chr19_+_12203069 0.04 ENST00000430298.2
ENST00000339302.4
ZNF788
ZNF788
zinc finger family member 788
Zinc finger protein 788
chr13_-_95131923 0.04 ENST00000377028.5
ENST00000446125.1
DCT
dopachrome tautomerase
chr3_-_116163830 0.04 ENST00000333617.4
LSAMP
limbic system-associated membrane protein
chr9_+_124048864 0.04 ENST00000545652.1
GSN
gelsolin
chr19_-_49140692 0.04 ENST00000222122.5
DBP
D site of albumin promoter (albumin D-box) binding protein
chrX_-_50386648 0.04 ENST00000460112.3
SHROOM4
shroom family member 4
chr2_-_241075706 0.04 ENST00000607357.1
ENST00000307266.3
MYEOV2
myeloma overexpressed 2
chr6_-_31509714 0.04 ENST00000456662.1
ENST00000431908.1
ENST00000456976.1
ENST00000428450.1
ENST00000453105.2
ENST00000418897.1
ENST00000415382.2
ENST00000449074.2
ENST00000419020.1
ENST00000428098.1
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr1_-_1690014 0.03 ENST00000400922.2
ENST00000342348.5
NADK
NAD kinase
chr10_+_88414338 0.03 ENST00000241891.5
ENST00000443292.1
OPN4
opsin 4
chr11_+_105480740 0.03 ENST00000393125.2
GRIA4
glutamate receptor, ionotropic, AMPA 4
chr6_-_34113856 0.03 ENST00000538487.2
GRM4
glutamate receptor, metabotropic 4
chr1_-_32210275 0.03 ENST00000440175.2
BAI2
brain-specific angiogenesis inhibitor 2
chr20_-_44007014 0.03 ENST00000372726.3
ENST00000537995.1
TP53TG5
TP53 target 5
chr2_-_128642434 0.03 ENST00000393001.1
AMMECR1L
AMMECR1-like
chr1_-_155159748 0.03 ENST00000473363.2
RP11-201K10.3
RP11-201K10.3
chrX_+_69674943 0.03 ENST00000542398.1
DLG3
discs, large homolog 3 (Drosophila)
chr18_-_33077556 0.02 ENST00000589273.1
ENST00000586489.1
INO80C
INO80 complex subunit C
chrX_-_15619076 0.02 ENST00000252519.3
ACE2
angiotensin I converting enzyme 2
chr18_-_23671139 0.02 ENST00000579061.1
ENST00000542420.2
SS18
synovial sarcoma translocation, chromosome 18
chr1_+_160097462 0.02 ENST00000447527.1
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr16_-_66968055 0.01 ENST00000568572.1
FAM96B
family with sequence similarity 96, member B
chr17_-_26695013 0.01 ENST00000555059.2
CTB-96E2.2
Homeobox protein SEBOX
chr1_+_57320437 0.01 ENST00000361249.3
C8A
complement component 8, alpha polypeptide
chr17_-_26694979 0.01 ENST00000438614.1
VTN
vitronectin
chr1_-_23886285 0.01 ENST00000374561.5
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr9_+_35605274 0.01 ENST00000336395.5
TESK1
testis-specific kinase 1
chr16_-_66968265 0.01 ENST00000567511.1
ENST00000422424.2
FAM96B
family with sequence similarity 96, member B
chr18_-_23670546 0.01 ENST00000542743.1
ENST00000545952.1
ENST00000539849.1
ENST00000415083.2
SS18
synovial sarcoma translocation, chromosome 18
chr18_-_19283649 0.00 ENST00000584464.1
ENST00000578270.1
ABHD3
abhydrolase domain containing 3
chr16_+_53133070 0.00 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr1_+_153330322 0.00 ENST00000368738.3
S100A9
S100 calcium binding protein A9
chr1_+_44401479 0.00 ENST00000438616.3
ARTN
artemin

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1I3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.1 0.5 GO:1990262 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.1 0.3 GO:0002353 regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.1 0.2 GO:0035281 pre-miRNA export from nucleus(GO:0035281)
0.1 0.2 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.2 GO:0009822 alkaloid catabolic process(GO:0009822) calcitriol biosynthetic process from calciol(GO:0036378)
0.1 0.6 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 0.2 GO:0001827 inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828)
0.0 0.1 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.0 0.3 GO:0044375 regulation of peroxisome size(GO:0044375)
0.0 0.3 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.1 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.0 0.1 GO:0061760 antifungal innate immune response(GO:0061760)
0.0 0.2 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.2 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 0.1 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.0 0.2 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 0.1 GO:0097068 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.2 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.5 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.0 0.4 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0042565 RNA nuclear export complex(GO:0042565)
0.0 0.4 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.1 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 0.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.2 GO:0090631 pre-miRNA transporter activity(GO:0090631)
0.1 0.2 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.4 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.1 GO:0043337 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.0 0.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.2 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.3 GO:0048185 activin binding(GO:0048185)
0.0 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID ALK2 PATHWAY ALK2 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.5 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.2 REACTOME XENOBIOTICS Genes involved in Xenobiotics