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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NR2C1

Z-value: 0.82

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Transcription factors associated with NR2C1

Gene Symbol Gene ID Gene Info
ENSG00000120798.12 nuclear receptor subfamily 2 group C member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR2C1hg19_v2_chr12_-_95467267_954673500.563.4e-03Click!

Activity profile of NR2C1 motif

Sorted Z-values of NR2C1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_160148356 5.90 ENST00000401980.3
ENST00000545162.1
superoxide dismutase 2, mitochondrial
chr6_-_160147925 5.88 ENST00000535561.1
superoxide dismutase 2, mitochondrial
chr6_+_160148593 2.57 ENST00000337387.4
Wilms tumor 1 associated protein
chr2_+_219433588 2.32 ENST00000295701.5
RCD1 required for cell differentiation1 homolog (S. pombe)
chr19_+_10197463 2.26 ENST00000590378.1
ENST00000397881.3
chromosome 19 open reading frame 66
chr2_+_74757050 1.60 ENST00000352222.3
ENST00000437202.1
HtrA serine peptidase 2
chr1_+_165796753 1.40 ENST00000367879.4
uridine-cytidine kinase 2
chr19_+_10196981 1.34 ENST00000591813.1
chromosome 19 open reading frame 66
chr13_-_33760216 1.33 ENST00000255486.4
StAR-related lipid transfer (START) domain containing 13
chr8_-_80680078 1.26 ENST00000337919.5
ENST00000354724.3
hes-related family bHLH transcription factor with YRPW motif 1
chr2_+_219433281 1.25 ENST00000273064.6
ENST00000509807.2
ENST00000542068.1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr19_+_676385 1.20 ENST00000166139.4
follistatin-like 3 (secreted glycoprotein)
chr19_+_48828788 1.20 ENST00000594198.1
ENST00000597279.1
ENST00000593437.1
epithelial membrane protein 3
chr19_+_48828582 1.19 ENST00000270221.6
ENST00000596315.1
epithelial membrane protein 3
chr10_+_104005272 1.13 ENST00000369983.3
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr20_+_44486246 1.08 ENST00000255152.2
ENST00000454862.2
zinc finger, SWIM-type containing 3
chr3_-_58613323 1.03 ENST00000474531.1
ENST00000465970.1
family with sequence similarity 107, member A
chr11_-_65430554 1.01 ENST00000308639.9
ENST00000406246.3
v-rel avian reticuloendotheliosis viral oncogene homolog A
chr3_-_116163830 0.99 ENST00000333617.4
limbic system-associated membrane protein
chr2_-_219134822 0.91 ENST00000444053.1
ENST00000248450.4
angio-associated, migratory cell protein
chr1_+_25071848 0.84 ENST00000374379.4
chloride intracellular channel 4
chr10_+_26986582 0.81 ENST00000376215.5
ENST00000376203.5
prenyl (decaprenyl) diphosphate synthase, subunit 1
chr19_+_39616410 0.81 ENST00000602004.1
ENST00000599470.1
ENST00000321944.4
ENST00000593480.1
ENST00000358301.3
ENST00000593690.1
ENST00000599386.1
p21 protein (Cdc42/Rac)-activated kinase 4
chr10_+_24755416 0.79 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
chr3_+_37284824 0.77 ENST00000431105.1
golgin A4
chr7_+_100770328 0.76 ENST00000223095.4
ENST00000445463.2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr19_-_49371711 0.71 ENST00000355496.5
ENST00000263265.6
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
chr11_-_67275542 0.70 ENST00000531506.1
cyclin-dependent kinase 2 associated protein 2
chr5_-_1801408 0.69 ENST00000505818.1
mitochondrial ribosomal protein L36
chr15_-_82555000 0.66 ENST00000557844.1
ENST00000359445.3
ENST00000268206.7
elongation factor Tu GTP binding domain containing 1
chr11_-_45939565 0.65 ENST00000525192.1
ENST00000378750.5
peroxisomal biogenesis factor 16
chr6_+_43737939 0.65 ENST00000372067.3
vascular endothelial growth factor A
chr3_+_101546827 0.64 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr18_+_8609402 0.63 ENST00000329286.6
RAB12, member RAS oncogene family
chr3_-_113465065 0.61 ENST00000497255.1
ENST00000478020.1
ENST00000240922.3
ENST00000493900.1
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr2_+_210636697 0.61 ENST00000439458.1
ENST00000272845.6
unc-80 homolog (C. elegans)
chr16_+_30710462 0.59 ENST00000262518.4
ENST00000395059.2
ENST00000344771.4
Snf2-related CREBBP activator protein
chr1_-_229569834 0.58 ENST00000366684.3
ENST00000366683.2
actin, alpha 1, skeletal muscle
chr12_-_42631529 0.56 ENST00000548917.1
YY1 associated factor 2
chr12_+_132413798 0.56 ENST00000440818.2
ENST00000542167.2
ENST00000538037.1
ENST00000456665.2
pseudouridylate synthase 1
chr3_-_116164306 0.55 ENST00000490035.2
limbic system-associated membrane protein
chr11_-_45939374 0.55 ENST00000533151.1
ENST00000241041.3
peroxisomal biogenesis factor 16
chr17_+_4853442 0.53 ENST00000522301.1
enolase 3 (beta, muscle)
chr6_+_149068464 0.53 ENST00000367463.4
uronyl-2-sulfotransferase
chr3_-_126236605 0.52 ENST00000290868.2
urocanate hydratase 1
chr20_+_18794370 0.52 ENST00000377428.2
SCP2 sterol-binding domain containing 1
chr12_+_132413739 0.52 ENST00000443358.2
pseudouridylate synthase 1
chr19_+_16771936 0.50 ENST00000187762.2
ENST00000599479.1
transmembrane protein 38A
chr6_+_31515337 0.48 ENST00000376148.4
ENST00000376145.4
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr12_-_48499591 0.47 ENST00000551330.1
ENST00000004980.5
ENST00000339976.6
ENST00000448372.1
SUMO1/sentrin specific peptidase 1
chr16_-_70729496 0.46 ENST00000567648.1
Vac14 homolog (S. cerevisiae)
chr9_-_139839064 0.45 ENST00000325285.3
ENST00000428398.1
F-box and WD repeat domain containing 5
chr3_+_183903811 0.44 ENST00000429586.2
ENST00000292808.5
ATP-binding cassette, sub-family F (GCN20), member 3
chr2_+_120124497 0.44 ENST00000355857.3
ENST00000535617.1
ENST00000535757.1
ENST00000409094.1
ENST00000311521.4
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr11_-_64013288 0.43 ENST00000542235.1
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr4_-_111544254 0.43 ENST00000306732.3
paired-like homeodomain 2
chr2_-_25194476 0.42 ENST00000534855.1
DnaJ (Hsp40) homolog, subfamily C, member 27
chr3_-_150264272 0.41 ENST00000491660.1
ENST00000487153.1
ENST00000239944.2
stress-associated endoplasmic reticulum protein 1
chr16_+_2255841 0.41 ENST00000301725.7
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr3_-_50605077 0.40 ENST00000426034.1
ENST00000441239.1
chromosome 3 open reading frame 18
chr2_-_219134343 0.40 ENST00000447885.1
ENST00000420660.1
angio-associated, migratory cell protein
chr12_-_42632016 0.40 ENST00000442791.3
ENST00000327791.4
ENST00000534854.2
ENST00000380788.3
ENST00000380790.4
YY1 associated factor 2
chr11_+_131781290 0.39 ENST00000425719.2
ENST00000374784.1
neurotrimin
chr11_-_64013663 0.37 ENST00000392210.2
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr2_+_120125245 0.37 ENST00000393103.2
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr21_-_32931290 0.37 ENST00000286827.3
T-cell lymphoma invasion and metastasis 1
chr2_-_88427568 0.37 ENST00000393750.3
ENST00000295834.3
fatty acid binding protein 1, liver
chr16_+_2255710 0.37 ENST00000397124.1
ENST00000565250.1
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr2_-_42721110 0.36 ENST00000394973.4
ENST00000306078.1
potassium voltage-gated channel, subfamily G, member 3
chr2_-_202316260 0.36 ENST00000332624.3
trafficking protein, kinesin binding 2
chr9_-_139137648 0.35 ENST00000358701.5
quiescin Q6 sulfhydryl oxidase 2
chr2_-_163099885 0.35 ENST00000443424.1
fibroblast activation protein, alpha
chr17_-_1928621 0.34 ENST00000331238.6
reticulon 4 receptor-like 1
chr22_-_31536480 0.33 ENST00000215885.3
phospholipase A2, group III
chr2_-_96701722 0.33 ENST00000434632.1
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr14_+_74035763 0.33 ENST00000238651.5
acyl-CoA thioesterase 2
chr3_+_37284668 0.32 ENST00000361924.2
ENST00000444882.1
ENST00000356847.4
ENST00000450863.2
ENST00000429018.1
golgin A4
chr12_-_48500085 0.32 ENST00000549518.1
SUMO1/sentrin specific peptidase 1
chr4_-_76598296 0.32 ENST00000395719.3
GTPase activating protein (SH3 domain) binding protein 2
chr10_-_118502070 0.32 ENST00000369209.3
heat shock 70kDa protein 12A
chrX_+_38420623 0.31 ENST00000378482.2
tetraspanin 7
chr2_-_163100045 0.31 ENST00000188790.4
fibroblast activation protein, alpha
chr14_+_74003818 0.31 ENST00000311148.4
acyl-CoA thioesterase 1
chr1_-_31381528 0.31 ENST00000339394.6
syndecan 3
chr3_-_113464906 0.30 ENST00000477813.1
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr8_-_30706608 0.30 ENST00000256246.2
testis expressed 15
chr16_-_88752889 0.30 ENST00000332281.5
snail family zinc finger 3
chr11_-_116663127 0.29 ENST00000433069.1
ENST00000542499.1
apolipoprotein A-V
chr21_-_15918618 0.29 ENST00000400564.1
ENST00000400566.1
SAM domain, SH3 domain and nuclear localization signals 1
chr11_+_67798363 0.29 ENST00000525628.1
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr20_+_37590942 0.29 ENST00000373325.2
ENST00000252011.3
ENST00000373323.4
DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr3_+_113465866 0.29 ENST00000273398.3
ENST00000538620.1
ENST00000496747.1
ENST00000475322.1
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr1_-_166944561 0.28 ENST00000271417.3
immunoglobulin-like domain containing receptor 2
chr12_-_22487618 0.28 ENST00000404299.3
ENST00000396037.4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr14_+_42076765 0.27 ENST00000298119.4
leucine rich repeat and fibronectin type III domain containing 5
chr8_-_80942467 0.27 ENST00000518271.1
ENST00000276585.4
ENST00000521605.1
mitochondrial ribosomal protein S28
chr12_-_53729525 0.26 ENST00000303846.3
Sp7 transcription factor
chr19_+_6464243 0.25 ENST00000600229.1
ENST00000356762.3
crumbs homolog 3 (Drosophila)
chr5_+_78908233 0.24 ENST00000453514.1
ENST00000423041.2
ENST00000504233.1
ENST00000428308.2
PAP associated domain containing 4
chr15_+_45422178 0.24 ENST00000389037.3
ENST00000558322.1
dual oxidase 1
chr11_+_67798090 0.24 ENST00000313468.5
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr15_+_82555125 0.23 ENST00000566205.1
ENST00000339465.5
ENST00000569120.1
ENST00000566861.1
family with sequence similarity 154, member B
chr11_+_94501497 0.23 ENST00000317829.8
ENST00000317837.9
ENST00000433060.2
angiomotin like 1
chr2_-_25194963 0.23 ENST00000264711.2
DnaJ (Hsp40) homolog, subfamily C, member 27
chr6_+_33172407 0.22 ENST00000374662.3
hydroxysteroid (17-beta) dehydrogenase 8
chr8_+_77318769 0.22 ENST00000518732.1
long intergenic non-protein coding RNA 1111
chr9_+_33795533 0.22 ENST00000379405.3
protease, serine, 3
chr15_+_45422131 0.22 ENST00000321429.4
dual oxidase 1
chr11_+_65383227 0.22 ENST00000355703.3
pecanex-like 3 (Drosophila)
chr15_+_90728145 0.22 ENST00000561085.1
ENST00000379122.3
ENST00000332496.6
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr11_+_67798114 0.22 ENST00000453471.2
ENST00000528492.1
ENST00000526339.1
ENST00000525419.1
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr1_-_226374373 0.21 ENST00000366812.5
acyl-CoA binding domain containing 3
chr2_-_74757066 0.21 ENST00000377526.3
ancient ubiquitous protein 1
chr10_+_127661942 0.21 ENST00000417114.1
ENST00000445510.1
ENST00000368691.1
fibronectin type III and ankyrin repeat domains 1
chr5_+_179125907 0.21 ENST00000247461.4
ENST00000452673.2
ENST00000502498.1
ENST00000507307.1
ENST00000513246.1
ENST00000502673.1
ENST00000506654.1
ENST00000512607.2
ENST00000510810.1
calnexin
chr7_+_121513143 0.20 ENST00000393386.2
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr3_-_50605150 0.20 ENST00000357203.3
chromosome 3 open reading frame 18
chr12_+_96252706 0.20 ENST00000266735.5
ENST00000553192.1
ENST00000552085.1
small nuclear ribonucleoprotein polypeptide F
chr1_+_160097462 0.19 ENST00000447527.1
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr17_+_13972807 0.19 ENST00000429152.2
ENST00000261643.3
ENST00000536205.1
ENST00000537334.1
cytochrome c oxidase assembly homolog 10 (yeast)
chr19_-_10679697 0.19 ENST00000335766.2
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr15_-_65715401 0.18 ENST00000352385.2
immunoglobulin superfamily, DCC subclass, member 4
chr3_+_150264458 0.17 ENST00000487799.1
ENST00000460851.1
eukaryotic translation initiation factor 2A, 65kDa
chr1_+_45140360 0.17 ENST00000418644.1
ENST00000458657.2
ENST00000441519.1
ENST00000535358.1
ENST00000445071.1
chromosome 1 open reading frame 228
chr14_+_22236722 0.17 ENST00000390428.3
T cell receptor alpha variable 6
chr11_-_123756334 0.17 ENST00000528595.1
ENST00000375026.2
transmembrane protein 225
chr4_-_76598326 0.17 ENST00000503660.1
GTPase activating protein (SH3 domain) binding protein 2
chr4_+_26321284 0.16 ENST00000506956.1
ENST00000512671.1
ENST00000345843.3
ENST00000342295.1
recombination signal binding protein for immunoglobulin kappa J region
chr10_+_64564469 0.16 ENST00000373783.1
2-aminoethanethiol (cysteamine) dioxygenase
chrX_-_40036520 0.16 ENST00000406200.2
ENST00000378455.4
ENST00000342274.4
BCL6 corepressor
chr9_-_140513231 0.16 ENST00000371417.3
chromosome 9 open reading frame 37
chr12_-_95467267 0.15 ENST00000330677.7
nuclear receptor subfamily 2, group C, member 1
chr11_-_63684316 0.15 ENST00000301459.4
REST corepressor 2
chr2_-_154335300 0.15 ENST00000325926.3
reprimo, TP53 dependent G2 arrest mediator candidate
chr2_-_219433014 0.15 ENST00000418019.1
ENST00000454775.1
ENST00000338465.5
ENST00000415516.1
ENST00000258399.3
ubiquitin specific peptidase 37
chr3_+_42897512 0.14 ENST00000493193.1
atypical chemokine receptor 2
chr5_-_87564620 0.12 ENST00000506536.1
ENST00000512429.1
ENST00000514135.1
ENST00000296595.6
ENST00000509387.1
transmembrane protein 161B
chr3_+_150264555 0.12 ENST00000406576.3
ENST00000482093.1
ENST00000273435.5
eukaryotic translation initiation factor 2A, 65kDa
chr1_+_40713573 0.12 ENST00000372766.3
transmembrane and coiled-coil domains 2
chr19_+_44100544 0.12 ENST00000391965.2
ENST00000525771.1
zinc finger protein 576
chr14_+_42077552 0.12 ENST00000554120.1
leucine rich repeat and fibronectin type III domain containing 5
chr1_-_917466 0.11 ENST00000341290.2
chromosome 1 open reading frame 170
chr17_-_49021974 0.11 ENST00000501718.2
RP11-700H6.1
chr3_+_184055240 0.11 ENST00000383847.2
family with sequence similarity 131, member A
chr2_-_38303218 0.11 ENST00000407341.1
ENST00000260630.3
cytochrome P450, family 1, subfamily B, polypeptide 1
chr1_-_205419053 0.10 ENST00000367154.1
LEM domain containing 1
chr5_+_78908388 0.10 ENST00000296783.3
PAP associated domain containing 4
chrX_-_132095419 0.09 ENST00000370836.2
ENST00000521489.1
heparan sulfate 6-O-sulfotransferase 2
chrX_+_38420783 0.09 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
tetraspanin 7
chr13_+_21714913 0.09 ENST00000450573.1
ENST00000467636.1
Sin3A-associated protein, 18kDa
chr19_-_4066890 0.09 ENST00000322357.4
zinc finger and BTB domain containing 7A
chr6_+_10585979 0.09 ENST00000265012.4
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr11_-_66206260 0.08 ENST00000329819.4
ENST00000310999.7
ENST00000430466.2
mitochondrial ribosomal protein L11
chr1_+_212797789 0.08 ENST00000294829.3
family with sequence similarity 71, member A
chr1_+_110577229 0.08 ENST00000369795.3
ENST00000369794.2
striatin interacting protein 1
chr20_+_30946106 0.08 ENST00000375687.4
ENST00000542461.1
additional sex combs like 1 (Drosophila)
chr9_+_135037334 0.08 ENST00000393229.3
ENST00000360670.3
ENST00000393228.4
ENST00000372179.3
netrin G2
chr1_-_120439112 0.06 ENST00000369400.1
ADAM metallopeptidase domain 30
chr11_-_26743546 0.06 ENST00000280467.6
ENST00000396005.3
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr14_-_65289812 0.06 ENST00000389720.3
ENST00000389721.5
ENST00000389722.3
spectrin, beta, erythrocytic
chr18_+_54318616 0.06 ENST00000254442.3
WD repeat domain 7
chr20_-_30458432 0.06 ENST00000375966.4
ENST00000278979.3
dual specificity phosphatase 15
chr9_-_35685452 0.05 ENST00000607559.1
tropomyosin 2 (beta)
chr9_-_34397800 0.05 ENST00000297623.2
chromosome 9 open reading frame 24
chr6_+_54172653 0.05 ENST00000370869.3
tubulointerstitial nephritis antigen
chr12_+_109577202 0.04 ENST00000377848.3
ENST00000377854.5
acetyl-CoA carboxylase beta
chr22_+_41777927 0.03 ENST00000266304.4
thyrotrophic embryonic factor
chr6_-_109703663 0.02 ENST00000368961.5
CD164 molecule, sialomucin
chr2_+_202316392 0.02 ENST00000194530.3
ENST00000392249.2
STE20-related kinase adaptor beta
chr15_-_83474806 0.01 ENST00000541889.1
ENST00000334574.8
ENST00000561368.1
fibronectin type III and SPRY domain containing 2
chr16_+_83932684 0.01 ENST00000262430.4
malonyl-CoA decarboxylase
chr19_+_51293672 0.00 ENST00000270593.1
ENST00000270594.3
acid phosphatase, testicular
chr20_-_44485835 0.00 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
acyl-CoA thioesterase 8

Network of associatons between targets according to the STRING database.

First level regulatory network of NR2C1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 11.8 GO:0001315 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.5 1.6 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.4 1.2 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.4 2.6 GO:0080009 mRNA methylation(GO:0080009)
0.4 1.1 GO:0070902 mitochondrial tRNA pseudouridine synthesis(GO:0070902)
0.3 1.4 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.3 1.3 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.3 1.1 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.3 0.8 GO:0001300 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.3 1.0 GO:0014040 positive regulation of Schwann cell differentiation(GO:0014040)
0.2 1.3 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.2 0.7 GO:1903572 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.2 0.7 GO:0097325 melanocyte proliferation(GO:0097325)
0.1 0.4 GO:0060578 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.1 0.6 GO:0045204 MAPK export from nucleus(GO:0045204)
0.1 1.2 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.1 0.4 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.1 0.5 GO:0019556 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.1 0.7 GO:2000035 regulation of stem cell division(GO:2000035)
0.1 0.6 GO:0090131 mesenchyme migration(GO:0090131)
0.1 2.4 GO:0032060 bleb assembly(GO:0032060)
0.1 0.8 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 0.3 GO:0071484 cellular response to light intensity(GO:0071484)
0.1 0.1 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.1 1.5 GO:0035641 locomotory exploration behavior(GO:0035641)
0.1 0.5 GO:0042335 cuticle development(GO:0042335)
0.1 0.9 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.1 0.8 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 0.3 GO:1990928 response to amino acid starvation(GO:1990928)
0.1 0.3 GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
0.1 0.2 GO:1901297 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.1 0.4 GO:1904338 NMDA selective glutamate receptor signaling pathway(GO:0098989) positive regulation of glial cell migration(GO:1903977) regulation of dopaminergic neuron differentiation(GO:1904338)
0.1 0.5 GO:0006477 protein sulfation(GO:0006477)
0.1 0.2 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.3 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.4 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.2 GO:0051946 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.0 1.1 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.8 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.3 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 0.5 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.5 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.0 0.1 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.0 0.2 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 0.8 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.4 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.0 0.3 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 0.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.8 GO:0038202 TORC1 signaling(GO:0038202)
0.0 0.2 GO:0048102 autophagic cell death(GO:0048102)
0.0 0.6 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 0.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 1.4 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.3 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 0.2 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.5 GO:0061621 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.6 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.3 1.0 GO:0071159 NF-kappaB complex(GO:0071159)
0.1 0.9 GO:0031415 NatA complex(GO:0031415)
0.1 0.3 GO:0031379 RNA-directed RNA polymerase complex(GO:0031379)
0.1 1.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 0.8 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.2 GO:0072534 perineuronal net(GO:0072534)
0.1 0.5 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 0.7 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.3 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 1.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 1.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.2 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.4 GO:0045179 apical cortex(GO:0045179)
0.0 0.2 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 2.5 GO:0005811 lipid particle(GO:0005811)
0.0 13.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.4 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.3 GO:0042627 chylomicron(GO:0042627)
0.0 1.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 2.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 11.8 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.4 1.1 GO:0004730 pseudouridylate synthase activity(GO:0004730)
0.3 1.3 GO:0035939 microsatellite binding(GO:0035939)
0.1 0.8 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 1.4 GO:0004849 uridine kinase activity(GO:0004849)
0.1 1.0 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.3 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1 0.7 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.8 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 0.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.2 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.1 0.6 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 0.3 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 1.2 GO:0048185 activin binding(GO:0048185)
0.1 0.9 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 0.4 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.3 GO:0060230 lipase binding(GO:0035473) lipoprotein lipase activator activity(GO:0060230)
0.0 1.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.3 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.5 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.3 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.3 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.7 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 3.1 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.6 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.3 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:1990239 steroid hormone binding(GO:1990239)
0.0 0.5 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.5 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.2 GO:0000150 recombinase activity(GO:0000150)
0.0 0.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.2 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.6 GO:0043531 ADP binding(GO:0043531)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 11.8 PID FOXO PATHWAY FoxO family signaling
0.0 1.1 PID ARF 3PATHWAY Arf1 pathway
0.0 0.7 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.0 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.8 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 1.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.9 ST GAQ PATHWAY G alpha q Pathway
0.0 0.4 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 3.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 0.8 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 1.0 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 1.4 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.8 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.7 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.4 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.8 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.3 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis