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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NR2C1

Z-value: 0.82

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Transcription factors associated with NR2C1

Gene Symbol Gene ID Gene Info
NR2C1
ENSG00000120798.12 nuclear receptor subfamily 2 group C member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR2C1hg19_v2_chr12_-_95467267_954673500.563.4e-03Click!

Activity profile of NR2C1 motif

Sorted Z-values of NR2C1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_160148356 5.90 ENST00000401980.3
ENST00000545162.1
SOD2
superoxide dismutase 2, mitochondrial
chr6_-_160147925 5.88 ENST00000535561.1
SOD2
superoxide dismutase 2, mitochondrial
chr6_+_160148593 2.57 ENST00000337387.4
WTAP
Wilms tumor 1 associated protein
chr2_+_219433588 2.32 ENST00000295701.5
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr19_+_10197463 2.26 ENST00000590378.1
ENST00000397881.3
C19orf66
chromosome 19 open reading frame 66
chr2_+_74757050 1.60 ENST00000352222.3
ENST00000437202.1
HTRA2
HtrA serine peptidase 2
chr1_+_165796753 1.40 ENST00000367879.4
UCK2
uridine-cytidine kinase 2
chr19_+_10196981 1.34 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr13_-_33760216 1.33 ENST00000255486.4
STARD13
StAR-related lipid transfer (START) domain containing 13
chr8_-_80680078 1.26 ENST00000337919.5
ENST00000354724.3
HEY1
hes-related family bHLH transcription factor with YRPW motif 1
chr2_+_219433281 1.25 ENST00000273064.6
ENST00000509807.2
ENST00000542068.1
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr19_+_676385 1.20 ENST00000166139.4
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr19_+_48828788 1.20 ENST00000594198.1
ENST00000597279.1
ENST00000593437.1
EMP3
epithelial membrane protein 3
chr19_+_48828582 1.19 ENST00000270221.6
ENST00000596315.1
EMP3
epithelial membrane protein 3
chr10_+_104005272 1.13 ENST00000369983.3
GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr20_+_44486246 1.08 ENST00000255152.2
ENST00000454862.2
ZSWIM3
zinc finger, SWIM-type containing 3
chr3_-_58613323 1.03 ENST00000474531.1
ENST00000465970.1
FAM107A
family with sequence similarity 107, member A
chr11_-_65430554 1.01 ENST00000308639.9
ENST00000406246.3
RELA
v-rel avian reticuloendotheliosis viral oncogene homolog A
chr3_-_116163830 0.99 ENST00000333617.4
LSAMP
limbic system-associated membrane protein
chr2_-_219134822 0.91 ENST00000444053.1
ENST00000248450.4
AAMP
angio-associated, migratory cell protein
chr1_+_25071848 0.84 ENST00000374379.4
CLIC4
chloride intracellular channel 4
chr10_+_26986582 0.81 ENST00000376215.5
ENST00000376203.5
PDSS1
prenyl (decaprenyl) diphosphate synthase, subunit 1
chr19_+_39616410 0.81 ENST00000602004.1
ENST00000599470.1
ENST00000321944.4
ENST00000593480.1
ENST00000358301.3
ENST00000593690.1
ENST00000599386.1
PAK4
p21 protein (Cdc42/Rac)-activated kinase 4
chr10_+_24755416 0.79 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr3_+_37284824 0.77 ENST00000431105.1
GOLGA4
golgin A4
chr7_+_100770328 0.76 ENST00000223095.4
ENST00000445463.2
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr19_-_49371711 0.71 ENST00000355496.5
ENST00000263265.6
PLEKHA4
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
chr11_-_67275542 0.70 ENST00000531506.1
CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr5_-_1801408 0.69 ENST00000505818.1
MRPL36
mitochondrial ribosomal protein L36
chr15_-_82555000 0.66 ENST00000557844.1
ENST00000359445.3
ENST00000268206.7
EFTUD1
elongation factor Tu GTP binding domain containing 1
chr11_-_45939565 0.65 ENST00000525192.1
ENST00000378750.5
PEX16
peroxisomal biogenesis factor 16
chr6_+_43737939 0.65 ENST00000372067.3
VEGFA
vascular endothelial growth factor A
chr3_+_101546827 0.64 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr18_+_8609402 0.63 ENST00000329286.6
RAB12
RAB12, member RAS oncogene family
chr3_-_113465065 0.61 ENST00000497255.1
ENST00000478020.1
ENST00000240922.3
ENST00000493900.1
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr2_+_210636697 0.61 ENST00000439458.1
ENST00000272845.6
UNC80
unc-80 homolog (C. elegans)
chr16_+_30710462 0.59 ENST00000262518.4
ENST00000395059.2
ENST00000344771.4
SRCAP
Snf2-related CREBBP activator protein
chr1_-_229569834 0.58 ENST00000366684.3
ENST00000366683.2
ACTA1
actin, alpha 1, skeletal muscle
chr12_-_42631529 0.56 ENST00000548917.1
YAF2
YY1 associated factor 2
chr12_+_132413798 0.56 ENST00000440818.2
ENST00000542167.2
ENST00000538037.1
ENST00000456665.2
PUS1
pseudouridylate synthase 1
chr3_-_116164306 0.55 ENST00000490035.2
LSAMP
limbic system-associated membrane protein
chr11_-_45939374 0.55 ENST00000533151.1
ENST00000241041.3
PEX16
peroxisomal biogenesis factor 16
chr17_+_4853442 0.53 ENST00000522301.1
ENO3
enolase 3 (beta, muscle)
chr6_+_149068464 0.53 ENST00000367463.4
UST
uronyl-2-sulfotransferase
chr3_-_126236605 0.52 ENST00000290868.2
UROC1
urocanate hydratase 1
chr20_+_18794370 0.52 ENST00000377428.2
SCP2D1
SCP2 sterol-binding domain containing 1
chr12_+_132413739 0.52 ENST00000443358.2
PUS1
pseudouridylate synthase 1
chr19_+_16771936 0.50 ENST00000187762.2
ENST00000599479.1
TMEM38A
transmembrane protein 38A
chr6_+_31515337 0.48 ENST00000376148.4
ENST00000376145.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr12_-_48499591 0.47 ENST00000551330.1
ENST00000004980.5
ENST00000339976.6
ENST00000448372.1
SENP1
SUMO1/sentrin specific peptidase 1
chr16_-_70729496 0.46 ENST00000567648.1
VAC14
Vac14 homolog (S. cerevisiae)
chr9_-_139839064 0.45 ENST00000325285.3
ENST00000428398.1
FBXW5
F-box and WD repeat domain containing 5
chr3_+_183903811 0.44 ENST00000429586.2
ENST00000292808.5
ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chr2_+_120124497 0.44 ENST00000355857.3
ENST00000535617.1
ENST00000535757.1
ENST00000409094.1
ENST00000311521.4
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr11_-_64013288 0.43 ENST00000542235.1
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr4_-_111544254 0.43 ENST00000306732.3
PITX2
paired-like homeodomain 2
chr2_-_25194476 0.42 ENST00000534855.1
DNAJC27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr3_-_150264272 0.41 ENST00000491660.1
ENST00000487153.1
ENST00000239944.2
SERP1
stress-associated endoplasmic reticulum protein 1
chr16_+_2255841 0.41 ENST00000301725.7
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr3_-_50605077 0.40 ENST00000426034.1
ENST00000441239.1
C3orf18
chromosome 3 open reading frame 18
chr2_-_219134343 0.40 ENST00000447885.1
ENST00000420660.1
AAMP
angio-associated, migratory cell protein
chr12_-_42632016 0.40 ENST00000442791.3
ENST00000327791.4
ENST00000534854.2
ENST00000380788.3
ENST00000380790.4
YAF2
YY1 associated factor 2
chr11_+_131781290 0.39 ENST00000425719.2
ENST00000374784.1
NTM
neurotrimin
chr11_-_64013663 0.37 ENST00000392210.2
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr2_+_120125245 0.37 ENST00000393103.2
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr21_-_32931290 0.37 ENST00000286827.3
TIAM1
T-cell lymphoma invasion and metastasis 1
chr2_-_88427568 0.37 ENST00000393750.3
ENST00000295834.3
FABP1
fatty acid binding protein 1, liver
chr16_+_2255710 0.37 ENST00000397124.1
ENST00000565250.1
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr2_-_42721110 0.36 ENST00000394973.4
ENST00000306078.1
KCNG3
potassium voltage-gated channel, subfamily G, member 3
chr2_-_202316260 0.36 ENST00000332624.3
TRAK2
trafficking protein, kinesin binding 2
chr9_-_139137648 0.35 ENST00000358701.5
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr2_-_163099885 0.35 ENST00000443424.1
FAP
fibroblast activation protein, alpha
chr17_-_1928621 0.34 ENST00000331238.6
RTN4RL1
reticulon 4 receptor-like 1
chr22_-_31536480 0.33 ENST00000215885.3
PLA2G3
phospholipase A2, group III
chr2_-_96701722 0.33 ENST00000434632.1
GPAT2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr14_+_74035763 0.33 ENST00000238651.5
ACOT2
acyl-CoA thioesterase 2
chr3_+_37284668 0.32 ENST00000361924.2
ENST00000444882.1
ENST00000356847.4
ENST00000450863.2
ENST00000429018.1
GOLGA4
golgin A4
chr12_-_48500085 0.32 ENST00000549518.1
SENP1
SUMO1/sentrin specific peptidase 1
chr4_-_76598296 0.32 ENST00000395719.3
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr10_-_118502070 0.32 ENST00000369209.3
HSPA12A
heat shock 70kDa protein 12A
chrX_+_38420623 0.31 ENST00000378482.2
TSPAN7
tetraspanin 7
chr2_-_163100045 0.31 ENST00000188790.4
FAP
fibroblast activation protein, alpha
chr14_+_74003818 0.31 ENST00000311148.4
ACOT1
acyl-CoA thioesterase 1
chr1_-_31381528 0.31 ENST00000339394.6
SDC3
syndecan 3
chr3_-_113464906 0.30 ENST00000477813.1
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr8_-_30706608 0.30 ENST00000256246.2
TEX15
testis expressed 15
chr16_-_88752889 0.30 ENST00000332281.5
SNAI3
snail family zinc finger 3
chr11_-_116663127 0.29 ENST00000433069.1
ENST00000542499.1
APOA5
apolipoprotein A-V
chr21_-_15918618 0.29 ENST00000400564.1
ENST00000400566.1
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr11_+_67798363 0.29 ENST00000525628.1
NDUFS8
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr20_+_37590942 0.29 ENST00000373325.2
ENST00000252011.3
ENST00000373323.4
DHX35
DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr3_+_113465866 0.29 ENST00000273398.3
ENST00000538620.1
ENST00000496747.1
ENST00000475322.1
ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr1_-_166944561 0.28 ENST00000271417.3
ILDR2
immunoglobulin-like domain containing receptor 2
chr12_-_22487618 0.28 ENST00000404299.3
ENST00000396037.4
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr14_+_42076765 0.27 ENST00000298119.4
LRFN5
leucine rich repeat and fibronectin type III domain containing 5
chr8_-_80942467 0.27 ENST00000518271.1
ENST00000276585.4
ENST00000521605.1
MRPS28
mitochondrial ribosomal protein S28
chr12_-_53729525 0.26 ENST00000303846.3
SP7
Sp7 transcription factor
chr19_+_6464243 0.25 ENST00000600229.1
ENST00000356762.3
CRB3
crumbs homolog 3 (Drosophila)
chr5_+_78908233 0.24 ENST00000453514.1
ENST00000423041.2
ENST00000504233.1
ENST00000428308.2
PAPD4
PAP associated domain containing 4
chr15_+_45422178 0.24 ENST00000389037.3
ENST00000558322.1
DUOX1
dual oxidase 1
chr11_+_67798090 0.24 ENST00000313468.5
NDUFS8
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr15_+_82555125 0.23 ENST00000566205.1
ENST00000339465.5
ENST00000569120.1
ENST00000566861.1
FAM154B
family with sequence similarity 154, member B
chr11_+_94501497 0.23 ENST00000317829.8
ENST00000317837.9
ENST00000433060.2
AMOTL1
angiomotin like 1
chr2_-_25194963 0.23 ENST00000264711.2
DNAJC27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr6_+_33172407 0.22 ENST00000374662.3
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr8_+_77318769 0.22 ENST00000518732.1
RP11-706J10.1
long intergenic non-protein coding RNA 1111
chr9_+_33795533 0.22 ENST00000379405.3
PRSS3
protease, serine, 3
chr15_+_45422131 0.22 ENST00000321429.4
DUOX1
dual oxidase 1
chr11_+_65383227 0.22 ENST00000355703.3
PCNXL3
pecanex-like 3 (Drosophila)
chr15_+_90728145 0.22 ENST00000561085.1
ENST00000379122.3
ENST00000332496.6
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr11_+_67798114 0.22 ENST00000453471.2
ENST00000528492.1
ENST00000526339.1
ENST00000525419.1
NDUFS8
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr1_-_226374373 0.21 ENST00000366812.5
ACBD3
acyl-CoA binding domain containing 3
chr2_-_74757066 0.21 ENST00000377526.3
AUP1
ancient ubiquitous protein 1
chr10_+_127661942 0.21 ENST00000417114.1
ENST00000445510.1
ENST00000368691.1
FANK1
fibronectin type III and ankyrin repeat domains 1
chr5_+_179125907 0.21 ENST00000247461.4
ENST00000452673.2
ENST00000502498.1
ENST00000507307.1
ENST00000513246.1
ENST00000502673.1
ENST00000506654.1
ENST00000512607.2
ENST00000510810.1
CANX
calnexin
chr7_+_121513143 0.20 ENST00000393386.2
PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr3_-_50605150 0.20 ENST00000357203.3
C3orf18
chromosome 3 open reading frame 18
chr12_+_96252706 0.20 ENST00000266735.5
ENST00000553192.1
ENST00000552085.1
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr1_+_160097462 0.19 ENST00000447527.1
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr17_+_13972807 0.19 ENST00000429152.2
ENST00000261643.3
ENST00000536205.1
ENST00000537334.1
COX10
cytochrome c oxidase assembly homolog 10 (yeast)
chr19_-_10679697 0.19 ENST00000335766.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr15_-_65715401 0.18 ENST00000352385.2
IGDCC4
immunoglobulin superfamily, DCC subclass, member 4
chr3_+_150264458 0.17 ENST00000487799.1
ENST00000460851.1
EIF2A
eukaryotic translation initiation factor 2A, 65kDa
chr1_+_45140360 0.17 ENST00000418644.1
ENST00000458657.2
ENST00000441519.1
ENST00000535358.1
ENST00000445071.1
C1orf228
chromosome 1 open reading frame 228
chr14_+_22236722 0.17 ENST00000390428.3
TRAV6
T cell receptor alpha variable 6
chr11_-_123756334 0.17 ENST00000528595.1
ENST00000375026.2
TMEM225
transmembrane protein 225
chr4_-_76598326 0.17 ENST00000503660.1
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr4_+_26321284 0.16 ENST00000506956.1
ENST00000512671.1
ENST00000345843.3
ENST00000342295.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr10_+_64564469 0.16 ENST00000373783.1
ADO
2-aminoethanethiol (cysteamine) dioxygenase
chrX_-_40036520 0.16 ENST00000406200.2
ENST00000378455.4
ENST00000342274.4
BCOR
BCL6 corepressor
chr9_-_140513231 0.16 ENST00000371417.3
C9orf37
chromosome 9 open reading frame 37
chr12_-_95467267 0.15 ENST00000330677.7
NR2C1
nuclear receptor subfamily 2, group C, member 1
chr11_-_63684316 0.15 ENST00000301459.4
RCOR2
REST corepressor 2
chr2_-_154335300 0.15 ENST00000325926.3
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr2_-_219433014 0.15 ENST00000418019.1
ENST00000454775.1
ENST00000338465.5
ENST00000415516.1
ENST00000258399.3
USP37
ubiquitin specific peptidase 37
chr3_+_42897512 0.14 ENST00000493193.1
ACKR2
atypical chemokine receptor 2
chr5_-_87564620 0.12 ENST00000506536.1
ENST00000512429.1
ENST00000514135.1
ENST00000296595.6
ENST00000509387.1
TMEM161B
transmembrane protein 161B
chr3_+_150264555 0.12 ENST00000406576.3
ENST00000482093.1
ENST00000273435.5
EIF2A
eukaryotic translation initiation factor 2A, 65kDa
chr1_+_40713573 0.12 ENST00000372766.3
TMCO2
transmembrane and coiled-coil domains 2
chr19_+_44100544 0.12 ENST00000391965.2
ENST00000525771.1
ZNF576
zinc finger protein 576
chr14_+_42077552 0.12 ENST00000554120.1
LRFN5
leucine rich repeat and fibronectin type III domain containing 5
chr1_-_917466 0.11 ENST00000341290.2
C1orf170
chromosome 1 open reading frame 170
chr17_-_49021974 0.11 ENST00000501718.2
RP11-700H6.1
RP11-700H6.1
chr3_+_184055240 0.11 ENST00000383847.2
FAM131A
family with sequence similarity 131, member A
chr2_-_38303218 0.11 ENST00000407341.1
ENST00000260630.3
CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
chr1_-_205419053 0.10 ENST00000367154.1
LEMD1
LEM domain containing 1
chr5_+_78908388 0.10 ENST00000296783.3
PAPD4
PAP associated domain containing 4
chrX_-_132095419 0.09 ENST00000370836.2
ENST00000521489.1
HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chrX_+_38420783 0.09 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
TSPAN7
tetraspanin 7
chr13_+_21714913 0.09 ENST00000450573.1
ENST00000467636.1
SAP18
Sin3A-associated protein, 18kDa
chr19_-_4066890 0.09 ENST00000322357.4
ZBTB7A
zinc finger and BTB domain containing 7A
chr6_+_10585979 0.09 ENST00000265012.4
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr11_-_66206260 0.08 ENST00000329819.4
ENST00000310999.7
ENST00000430466.2
MRPL11
mitochondrial ribosomal protein L11
chr1_+_212797789 0.08 ENST00000294829.3
FAM71A
family with sequence similarity 71, member A
chr1_+_110577229 0.08 ENST00000369795.3
ENST00000369794.2
STRIP1
striatin interacting protein 1
chr20_+_30946106 0.08 ENST00000375687.4
ENST00000542461.1
ASXL1
additional sex combs like 1 (Drosophila)
chr9_+_135037334 0.08 ENST00000393229.3
ENST00000360670.3
ENST00000393228.4
ENST00000372179.3
NTNG2
netrin G2
chr1_-_120439112 0.06 ENST00000369400.1
ADAM30
ADAM metallopeptidase domain 30
chr11_-_26743546 0.06 ENST00000280467.6
ENST00000396005.3
SLC5A12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr14_-_65289812 0.06 ENST00000389720.3
ENST00000389721.5
ENST00000389722.3
SPTB
spectrin, beta, erythrocytic
chr18_+_54318616 0.06 ENST00000254442.3
WDR7
WD repeat domain 7
chr20_-_30458432 0.06 ENST00000375966.4
ENST00000278979.3
DUSP15
dual specificity phosphatase 15
chr9_-_35685452 0.05 ENST00000607559.1
TPM2
tropomyosin 2 (beta)
chr9_-_34397800 0.05 ENST00000297623.2
C9orf24
chromosome 9 open reading frame 24
chr6_+_54172653 0.05 ENST00000370869.3
TINAG
tubulointerstitial nephritis antigen
chr12_+_109577202 0.04 ENST00000377848.3
ENST00000377854.5
ACACB
acetyl-CoA carboxylase beta
chr22_+_41777927 0.03 ENST00000266304.4
TEF
thyrotrophic embryonic factor
chr6_-_109703663 0.02 ENST00000368961.5
CD164
CD164 molecule, sialomucin
chr2_+_202316392 0.02 ENST00000194530.3
ENST00000392249.2
STRADB
STE20-related kinase adaptor beta
chr15_-_83474806 0.01 ENST00000541889.1
ENST00000334574.8
ENST00000561368.1
FSD2
fibronectin type III and SPRY domain containing 2
chr16_+_83932684 0.01 ENST00000262430.4
MLYCD
malonyl-CoA decarboxylase
chr19_+_51293672 0.00 ENST00000270593.1
ENST00000270594.3
ACPT
acid phosphatase, testicular
chr20_-_44485835 0.00 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
ACOT8
acyl-CoA thioesterase 8

Network of associatons between targets according to the STRING database.

First level regulatory network of NR2C1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 11.8 GO:0001315 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.5 1.6 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.4 1.2 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.4 2.6 GO:0080009 mRNA methylation(GO:0080009)
0.4 1.1 GO:0070902 mitochondrial tRNA pseudouridine synthesis(GO:0070902)
0.3 1.4 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.3 1.3 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.3 1.1 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.3 0.8 GO:0001300 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.3 1.0 GO:0014040 positive regulation of Schwann cell differentiation(GO:0014040)
0.2 1.3 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.2 0.7 GO:1903572 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.2 0.7 GO:0097325 melanocyte proliferation(GO:0097325)
0.1 0.4 GO:0060578 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.1 0.6 GO:0045204 MAPK export from nucleus(GO:0045204)
0.1 1.2 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.1 0.4 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.1 0.5 GO:0019556 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.1 0.7 GO:2000035 regulation of stem cell division(GO:2000035)
0.1 0.6 GO:0090131 mesenchyme migration(GO:0090131)
0.1 2.4 GO:0032060 bleb assembly(GO:0032060)
0.1 0.8 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 0.3 GO:0071484 cellular response to light intensity(GO:0071484)
0.1 0.1 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.1 1.5 GO:0035641 locomotory exploration behavior(GO:0035641)
0.1 0.5 GO:0042335 cuticle development(GO:0042335)
0.1 0.9 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.1 0.8 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 0.3 GO:1990928 response to amino acid starvation(GO:1990928)
0.1 0.3 GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
0.1 0.2 GO:1901297 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.1 0.4 GO:1904338 NMDA selective glutamate receptor signaling pathway(GO:0098989) positive regulation of glial cell migration(GO:1903977) regulation of dopaminergic neuron differentiation(GO:1904338)
0.1 0.5 GO:0006477 protein sulfation(GO:0006477)
0.1 0.2 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.3 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.4 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.2 GO:0051946 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.0 1.1 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.8 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.3 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 0.5 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.5 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.0 0.1 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.0 0.2 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 0.8 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.4 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.0 0.3 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 0.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.8 GO:0038202 TORC1 signaling(GO:0038202)
0.0 0.2 GO:0048102 autophagic cell death(GO:0048102)
0.0 0.6 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 0.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 1.4 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.3 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 0.2 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.5 GO:0061621 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.6 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.3 1.0 GO:0071159 NF-kappaB complex(GO:0071159)
0.1 0.9 GO:0031415 NatA complex(GO:0031415)
0.1 0.3 GO:0031379 RNA-directed RNA polymerase complex(GO:0031379)
0.1 1.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 0.8 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.2 GO:0072534 perineuronal net(GO:0072534)
0.1 0.5 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 0.7 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.3 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 1.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 1.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.2 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.4 GO:0045179 apical cortex(GO:0045179)
0.0 0.2 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 2.5 GO:0005811 lipid particle(GO:0005811)
0.0 13.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.4 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.3 GO:0042627 chylomicron(GO:0042627)
0.0 1.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 2.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 11.8 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.4 1.1 GO:0004730 pseudouridylate synthase activity(GO:0004730)
0.3 1.3 GO:0035939 microsatellite binding(GO:0035939)
0.1 0.8 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 1.4 GO:0004849 uridine kinase activity(GO:0004849)
0.1 1.0 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.3 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1 0.7 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.8 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 0.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.2 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.1 0.6 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 0.3 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 1.2 GO:0048185 activin binding(GO:0048185)
0.1 0.9 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 0.4 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.3 GO:0060230 lipase binding(GO:0035473) lipoprotein lipase activator activity(GO:0060230)
0.0 1.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.3 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.5 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.3 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.3 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.7 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 3.1 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.6 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.3 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:1990239 steroid hormone binding(GO:1990239)
0.0 0.5 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.5 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.2 GO:0000150 recombinase activity(GO:0000150)
0.0 0.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.2 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.6 GO:0043531 ADP binding(GO:0043531)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 11.8 PID FOXO PATHWAY FoxO family signaling
0.0 1.1 PID ARF 3PATHWAY Arf1 pathway
0.0 0.7 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.0 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.8 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 1.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.9 ST GAQ PATHWAY G alpha q Pathway
0.0 0.4 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 3.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 0.8 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 1.0 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 1.4 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.8 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.7 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.4 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.8 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.3 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis