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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for NR2E3

Z-value: 1.19

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Transcription factors associated with NR2E3

Gene Symbol Gene ID Gene Info
ENSG00000031544.10 nuclear receptor subfamily 2 group E member 3

Activity profile of NR2E3 motif

Sorted Z-values of NR2E3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_61547894 7.62 ENST00000403491.3
nuclear factor I/A
chr1_+_61547405 6.40 ENST00000371189.4
nuclear factor I/A
chr1_+_61330931 4.88 ENST00000371191.1
nuclear factor I/A
chr9_+_72002837 4.36 ENST00000377216.3
family with sequence similarity 189, member A2
chr12_+_32655048 3.94 ENST00000427716.2
ENST00000266482.3
FYVE, RhoGEF and PH domain containing 4
chr17_+_68165657 3.67 ENST00000243457.3
potassium inwardly-rectifying channel, subfamily J, member 2
chr11_-_33913708 3.66 ENST00000257818.2
LIM domain only 2 (rhombotin-like 1)
chr7_+_94023873 3.44 ENST00000297268.6
collagen, type I, alpha 2
chr12_+_79258444 3.13 ENST00000261205.4
synaptotagmin I
chr6_-_76203345 3.04 ENST00000393004.2
filamin A interacting protein 1
chr3_-_64211112 2.98 ENST00000295902.6
prickle homolog 2 (Drosophila)
chr12_+_79258547 2.98 ENST00000457153.2
synaptotagmin I
chr18_+_8717369 2.87 ENST00000359865.3
ENST00000400050.3
ENST00000306285.7
SOGA family member 2
chr12_+_93963590 2.81 ENST00000340600.2
suppressor of cytokine signaling 2
chr4_-_186877806 2.80 ENST00000355634.5
sorbin and SH3 domain containing 2
chr6_-_76203454 2.69 ENST00000237172.7
filamin A interacting protein 1
chr1_+_84630053 2.53 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_164528866 2.48 ENST00000420696.2
pre-B-cell leukemia homeobox 1
chr18_+_42260861 2.48 ENST00000282030.5
SET binding protein 1
chr1_+_84630645 2.37 ENST00000394839.2
protein kinase, cAMP-dependent, catalytic, beta
chr12_+_53443963 2.30 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
tensin like C1 domain containing phosphatase (tensin 2)
chr13_-_45010939 2.29 ENST00000261489.2
TSC22 domain family, member 1
chr5_+_68788594 2.23 ENST00000396442.2
ENST00000380766.2
occludin
chr20_+_42574317 2.22 ENST00000358131.5
TOX high mobility group box family member 2
chr5_-_138210977 2.17 ENST00000274711.6
ENST00000521094.2
leucine rich repeat transmembrane neuronal 2
chr1_+_221051699 2.12 ENST00000366903.6
H2.0-like homeobox
chr9_+_71986182 2.10 ENST00000303068.7
family with sequence similarity 189, member A2
chr21_+_17792672 2.07 ENST00000602620.1
long intergenic non-protein coding RNA 478
chr3_+_193853927 2.03 ENST00000232424.3
hes family bHLH transcription factor 1
chr10_-_93392811 1.96 ENST00000238994.5
protein phosphatase 1, regulatory subunit 3C
chr19_-_14628645 1.95 ENST00000598235.1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr1_+_87797351 1.91 ENST00000370542.1
LIM domain only 4
chr9_-_14180778 1.90 ENST00000380924.1
ENST00000543693.1
nuclear factor I/B
chr9_+_139606983 1.87 ENST00000371692.4
family with sequence similarity 69, member B
chr18_-_53069419 1.78 ENST00000570177.2
transcription factor 4
chr3_-_169381183 1.78 ENST00000494292.1
MDS1 and EVI1 complex locus
chr12_+_56661461 1.76 ENST00000546544.1
ENST00000553234.1
coenzyme Q10 homolog A (S. cerevisiae)
chr1_+_66999799 1.75 ENST00000371035.3
ENST00000371036.3
ENST00000371037.4
SH3-domain GRB2-like (endophilin) interacting protein 1
chr2_+_110656005 1.74 ENST00000437679.2
LIM and senescent cell antigen-like domains 3
chr9_+_71939488 1.68 ENST00000455972.1
family with sequence similarity 189, member A2
chrX_-_117119243 1.66 ENST00000539496.1
ENST00000469946.1
kelch-like family member 13
chr9_+_71944241 1.66 ENST00000257515.8
family with sequence similarity 189, member A2
chr7_+_106809406 1.62 ENST00000468410.1
ENST00000478930.1
ENST00000464009.1
ENST00000222574.4
HMG-box transcription factor 1
chr7_+_102553430 1.62 ENST00000339431.4
ENST00000249377.4
leucine rich repeat containing 17
chr1_+_89829610 1.60 ENST00000370456.4
ENST00000535065.1
guanylate binding protein family, member 6
chr2_+_33359646 1.59 ENST00000390003.4
ENST00000418533.2
latent transforming growth factor beta binding protein 1
chr20_-_45981138 1.58 ENST00000446994.2
zinc finger, MYND-type containing 8
chr2_+_33359687 1.57 ENST00000402934.1
ENST00000404525.1
ENST00000407925.1
latent transforming growth factor beta binding protein 1
chr1_+_65775204 1.54 ENST00000371069.4
DnaJ (Hsp40) homolog, subfamily C, member 6
chr3_-_65583561 1.53 ENST00000460329.2
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr11_+_121447469 1.47 ENST00000532694.1
ENST00000534286.1
sortilin-related receptor, L(DLR class) A repeats containing
chr2_+_173600565 1.46 ENST00000397081.3
Rap guanine nucleotide exchange factor (GEF) 4
chr2_-_3584430 1.42 ENST00000438482.1
ENST00000422961.1
AC108488.4
chr12_+_56661033 1.35 ENST00000433805.2
coenzyme Q10 homolog A (S. cerevisiae)
chr15_-_52587945 1.33 ENST00000443683.2
ENST00000558479.1
ENST00000261839.7
myosin VC
chr19_-_14629224 1.31 ENST00000254322.2
DnaJ (Hsp40) homolog, subfamily B, member 1
chr5_-_90679145 1.31 ENST00000265138.3
arrestin domain containing 3
chr2_+_173600514 1.31 ENST00000264111.6
Rap guanine nucleotide exchange factor (GEF) 4
chr4_-_25865159 1.30 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
sel-1 suppressor of lin-12-like 3 (C. elegans)
chrX_-_70474910 1.24 ENST00000373988.1
ENST00000373998.1
zinc finger, MYM-type 3
chr15_+_65914260 1.24 ENST00000261892.6
ENST00000339868.6
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr11_+_92085707 1.24 ENST00000525166.1
FAT atypical cadherin 3
chr7_-_121784285 1.21 ENST00000417368.2
aminoadipate-semialdehyde synthase
chr6_+_74405501 1.21 ENST00000437994.2
ENST00000422508.2
CD109 molecule
chr1_-_153599426 1.20 ENST00000392622.1
S100 calcium binding protein A13
chr2_+_190722119 1.19 ENST00000452382.1
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
chr20_-_17539456 1.16 ENST00000544874.1
ENST00000377868.2
beaded filament structural protein 1, filensin
chrX_+_102883887 1.14 ENST00000372625.3
ENST00000372624.3
transcription elongation factor A (SII)-like 1
chr12_-_10541575 1.10 ENST00000540818.1
killer cell lectin-like receptor subfamily K, member 1
chr1_-_43282906 1.08 ENST00000372521.4
coiled-coil domain containing 23
chr2_+_173686303 1.08 ENST00000397087.3
Rap guanine nucleotide exchange factor (GEF) 4
chr2_-_158732340 1.06 ENST00000539637.1
ENST00000413751.1
ENST00000434821.1
ENST00000424669.1
activin A receptor, type I
chr3_-_129407535 1.05 ENST00000432054.2
transmembrane and coiled-coil domain family 1
chrX_-_102565858 1.04 ENST00000449185.1
ENST00000536889.1
brain expressed X-linked 2
chr3_-_165555200 1.04 ENST00000479451.1
ENST00000540653.1
ENST00000488954.1
ENST00000264381.3
butyrylcholinesterase
chr1_+_66999268 1.04 ENST00000371039.1
ENST00000424320.1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr4_+_174089904 1.02 ENST00000265000.4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr22_-_37915247 1.01 ENST00000251973.5
caspase recruitment domain family, member 10
chr6_-_42016385 1.01 ENST00000502771.1
ENST00000508143.1
ENST00000514588.1
ENST00000510503.1
ENST00000415497.2
ENST00000372988.4
cyclin D3
chr19_-_9546227 1.00 ENST00000361451.2
ENST00000361151.1
zinc finger protein 266
chr4_-_110723335 0.99 ENST00000394634.2
complement factor I
chr4_-_110723194 0.99 ENST00000394635.3
complement factor I
chr21_-_35016231 0.97 ENST00000438788.1
crystallin, zeta (quinone reductase)-like 1
chr12_+_48516357 0.97 ENST00000549022.1
ENST00000547587.1
ENST00000312352.7
phosphofructokinase, muscle
chr5_+_110559784 0.97 ENST00000282356.4
calcium/calmodulin-dependent protein kinase IV
chr9_+_134065506 0.97 ENST00000483497.2
nucleoporin 214kDa
chr5_+_140571902 0.97 ENST00000239446.4
protocadherin beta 10
chr13_+_76378357 0.96 ENST00000489941.2
ENST00000525373.1
LIM domain 7
chr11_-_82745238 0.96 ENST00000531021.1
RAB30, member RAS oncogene family
chr15_+_67841330 0.96 ENST00000354498.5
mitogen-activated protein kinase kinase 5
chr19_-_54693401 0.95 ENST00000338624.6
membrane bound O-acyltransferase domain containing 7
chr3_+_141105235 0.95 ENST00000503809.1
zinc finger and BTB domain containing 38
chr1_-_153599732 0.94 ENST00000392623.1
S100 calcium binding protein A13
chr17_-_39150385 0.94 ENST00000391586.1
keratin associated protein 3-3
chr4_+_170581213 0.94 ENST00000507875.1
chloride channel, voltage-sensitive 3
chr4_-_110723134 0.94 ENST00000510800.1
ENST00000512148.1
complement factor I
chr13_+_60971080 0.94 ENST00000377894.2
tudor domain containing 3
chr3_-_197300194 0.92 ENST00000358186.2
ENST00000431056.1
3-hydroxybutyrate dehydrogenase, type 1
chr2_-_45795145 0.92 ENST00000535761.1
S1 RNA binding domain 1
chr8_-_6836156 0.91 ENST00000382679.2
defensin, alpha 1
chr1_+_203595689 0.90 ENST00000357681.5
ATPase, Ca++ transporting, plasma membrane 4
chr17_-_46691990 0.90 ENST00000576562.1
homeobox B8
chr15_-_65067773 0.89 ENST00000300069.4
RNA binding protein with multiple splicing 2
chr11_+_92085262 0.87 ENST00000298047.6
ENST00000409404.2
ENST00000541502.1
FAT atypical cadherin 3
chr15_+_75639296 0.86 ENST00000564500.1
ENST00000355059.4
ENST00000566752.1
nei endonuclease VIII-like 1 (E. coli)
chr1_+_43291220 0.85 ENST00000372514.3
erythroblast membrane-associated protein (Scianna blood group)
chr17_-_64188177 0.84 ENST00000535342.2
centrosomal protein 112kDa
chr19_-_31840438 0.83 ENST00000240587.4
teashirt zinc finger homeobox 3
chr10_+_82168240 0.81 ENST00000372187.5
ENST00000372185.1
family with sequence similarity 213, member A
chr4_-_6711558 0.80 ENST00000320848.6
Morf4 family associated protein 1-like 1
chr12_+_96588279 0.80 ENST00000552142.1
ELK3, ETS-domain protein (SRF accessory protein 2)
chr8_+_74903580 0.80 ENST00000284818.2
ENST00000518893.1
lymphocyte antigen 96
chr2_-_216257849 0.79 ENST00000456923.1
fibronectin 1
chr1_+_46049706 0.79 ENST00000527470.1
ENST00000525515.1
ENST00000537798.1
ENST00000402363.3
ENST00000528238.1
ENST00000350030.3
ENST00000470768.1
ENST00000372052.4
ENST00000351223.3
nuclear autoantigenic sperm protein (histone-binding)
chr16_+_31404624 0.78 ENST00000389202.2
integrin, alpha D
chr2_+_24150180 0.77 ENST00000404924.1
UBX domain protein 2A
chr1_-_47131521 0.77 ENST00000542495.1
ENST00000532925.1
ATP synthase mitochondrial F1 complex assembly factor 1
chr19_+_17337473 0.77 ENST00000598068.1
occludin/ELL domain containing 1
chr6_+_130339710 0.76 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
l(3)mbt-like 3 (Drosophila)
chr1_+_84630367 0.76 ENST00000370680.1
protein kinase, cAMP-dependent, catalytic, beta
chr8_+_103563792 0.76 ENST00000285402.3
outer dense fiber of sperm tails 1
chrX_+_17755563 0.73 ENST00000380045.3
ENST00000380041.3
ENST00000380043.3
ENST00000398080.1
sex comb on midleg-like 1 (Drosophila)
chr20_-_56286479 0.73 ENST00000265626.4
prostate transmembrane protein, androgen induced 1
chr1_-_8483723 0.73 ENST00000476556.1
arginine-glutamic acid dipeptide (RE) repeats
chr4_+_71588372 0.73 ENST00000536664.1
RUN and FYVE domain containing 3
chr17_-_76870126 0.71 ENST00000586057.1
TIMP metallopeptidase inhibitor 2
chr2_-_65593784 0.71 ENST00000443619.2
sprouty-related, EVH1 domain containing 2
chrX_-_10588595 0.71 ENST00000423614.1
ENST00000317552.4
midline 1 (Opitz/BBB syndrome)
chr11_+_86013253 0.71 ENST00000533986.1
ENST00000278483.3
chromosome 11 open reading frame 73
chrX_+_37639264 0.70 ENST00000378588.4
cytochrome b-245, beta polypeptide
chrX_-_10588459 0.70 ENST00000380782.2
midline 1 (Opitz/BBB syndrome)
chr4_-_39367949 0.70 ENST00000503784.1
ENST00000349703.2
ENST00000381897.1
replication factor C (activator 1) 1, 145kDa
chr11_+_20385231 0.69 ENST00000530266.1
ENST00000421577.2
ENST00000443524.2
ENST00000419348.2
HIV-1 Tat interactive protein 2, 30kDa
chr18_+_7754957 0.69 ENST00000400053.4
protein tyrosine phosphatase, receptor type, M
chr4_+_76481258 0.69 ENST00000311623.4
ENST00000435974.2
chromosome 4 open reading frame 26
chr3_+_113616317 0.69 ENST00000440446.2
ENST00000488680.1
GRAM domain containing 1C
chr12_-_51664058 0.69 ENST00000605627.1
small cell adhesion glycoprotein
chr4_-_152147579 0.69 ENST00000304527.4
ENST00000455740.1
ENST00000424281.1
ENST00000409598.4
SH3 domain containing 19
chr18_-_52989217 0.68 ENST00000570287.2
transcription factor 4
chr1_-_17307173 0.68 ENST00000438542.1
ENST00000375535.3
microfibrillar-associated protein 2
chr14_+_101297740 0.67 ENST00000555928.1
maternally expressed 3 (non-protein coding)
chr14_+_24584508 0.67 ENST00000559354.1
ENST00000560459.1
ENST00000559593.1
ENST00000396941.4
ENST00000396936.1
DDB1 and CUL4 associated factor 11
chr6_-_79944336 0.67 ENST00000344726.5
ENST00000275036.7
high mobility group nucleosomal binding domain 3
chr8_-_82395461 0.67 ENST00000256104.4
fatty acid binding protein 4, adipocyte
chr16_+_29819372 0.65 ENST00000568544.1
ENST00000569978.1
MYC-associated zinc finger protein (purine-binding transcription factor)
chr4_+_71587669 0.65 ENST00000381006.3
ENST00000226328.4
RUN and FYVE domain containing 3
chr17_-_62208169 0.65 ENST00000606895.1
endoplasmic reticulum to nucleus signaling 1
chrX_-_24665208 0.64 ENST00000356768.4
phosphate cytidylyltransferase 1, choline, beta
chrX_+_107683096 0.63 ENST00000328300.6
ENST00000361603.2
collagen, type IV, alpha 5
chr3_-_125775629 0.63 ENST00000383598.2
solute carrier family 41, member 3
chr1_+_168250194 0.63 ENST00000367821.3
T-box 19
chr12_+_80603233 0.62 ENST00000547103.1
ENST00000458043.2
otogelin-like
chr17_-_40575535 0.62 ENST00000357037.5
polymerase I and transcript release factor
chr19_-_9546177 0.61 ENST00000592292.1
ENST00000588221.1
zinc finger protein 266
chr3_+_141043050 0.61 ENST00000509842.1
zinc finger and BTB domain containing 38
chr10_+_115939008 0.61 ENST00000369282.1
ENST00000251864.2
ENST00000369281.2
ENST00000422662.1
tudor domain containing 1
chr16_+_29819446 0.60 ENST00000568282.1
MYC-associated zinc finger protein (purine-binding transcription factor)
chr19_+_47421933 0.60 ENST00000404338.3
Rho GTPase activating protein 35
chr1_+_43282782 0.59 ENST00000372517.2
erythroblast membrane-associated protein (Scianna blood group)
chr10_-_50396407 0.59 ENST00000374153.2
ENST00000374151.3
chromosome 10 open reading frame 128
chrX_+_54835493 0.56 ENST00000396224.1
melanoma antigen family D, 2
chr19_-_37697976 0.56 ENST00000588873.1
Uncharacterized protein; Zinc finger protein 585B
chr21_-_27542972 0.56 ENST00000346798.3
ENST00000439274.2
ENST00000354192.3
ENST00000348990.5
ENST00000357903.3
ENST00000358918.3
ENST00000359726.3
amyloid beta (A4) precursor protein
chr1_+_22963158 0.55 ENST00000438241.1
complement component 1, q subcomponent, A chain
chr3_-_138312971 0.55 ENST00000485115.1
ENST00000484888.1
ENST00000468900.1
ENST00000542237.1
ENST00000481834.1
centrosomal protein 70kDa
chr12_+_53773944 0.54 ENST00000551969.1
ENST00000327443.4
Sp1 transcription factor
chr14_+_54976603 0.54 ENST00000557317.1
cell growth regulator with ring finger domain 1
chr7_-_130080977 0.53 ENST00000223208.5
centrosomal protein 41kDa
chr15_-_77197620 0.53 ENST00000565970.1
ENST00000563290.1
ENST00000565372.1
ENST00000564177.1
ENST00000568382.1
ENST00000563919.1
S-phase cyclin A-associated protein in the ER
chr14_+_22508822 0.53 ENST00000390448.3
T cell receptor alpha variable 20
chr11_+_63997750 0.53 ENST00000321685.3
DnaJ (Hsp40) homolog, subfamily C, member 4
chr3_+_69915385 0.53 ENST00000314589.5
microphthalmia-associated transcription factor
chr4_+_159727272 0.52 ENST00000379346.3
folliculin interacting protein 2
chr10_-_49459800 0.52 ENST00000305531.3
FERM and PDZ domain containing 2
chr3_+_52811596 0.51 ENST00000542827.1
ENST00000273283.2
inter-alpha-trypsin inhibitor heavy chain 1
chr6_-_28220002 0.51 ENST00000377294.2
zinc finger with KRAB and SCAN domains 4
chr12_-_8043736 0.51 ENST00000539924.1
solute carrier family 2 (facilitated glucose transporter), member 14
chr16_-_15149828 0.50 ENST00000566419.1
ENST00000568320.1
N-terminal asparagine amidase
chr10_-_45474237 0.50 ENST00000448778.1
ENST00000298295.3
chromosome 10 open reading frame 10
chr3_+_37035263 0.50 ENST00000458205.2
ENST00000539477.1
mutL homolog 1
chr11_-_5271122 0.50 ENST00000330597.3
hemoglobin, gamma A
chr5_+_41925325 0.49 ENST00000296812.2
ENST00000281623.3
ENST00000509134.1
F-box protein 4
chr3_-_196159268 0.49 ENST00000381887.3
ENST00000535858.1
ENST00000428095.1
ENST00000296328.4
UBX domain protein 7
chr11_+_20385327 0.49 ENST00000451739.2
ENST00000532505.1
HIV-1 Tat interactive protein 2, 30kDa
chr19_+_6373715 0.49 ENST00000599849.1
alkB, alkylation repair homolog 7 (E. coli)
chr1_+_203595903 0.49 ENST00000367218.3
ENST00000367219.3
ENST00000391954.2
ATPase, Ca++ transporting, plasma membrane 4
chr6_+_42896865 0.48 ENST00000372836.4
ENST00000394142.3
canopy FGF signaling regulator 3
chr17_+_45608430 0.48 ENST00000322157.4
aminopeptidase puromycin sensitive
chr3_+_148508845 0.48 ENST00000491148.1
carboxypeptidase B1 (tissue)
chr15_+_23255242 0.48 ENST00000450802.3
golgin A8 family, member I
chr15_+_75639951 0.48 ENST00000564784.1
ENST00000569035.1
nei endonuclease VIII-like 1 (E. coli)
chr2_-_201729393 0.46 ENST00000321356.4
CDC-like kinase 1
chr4_+_118955500 0.46 ENST00000296499.5
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr14_+_69658480 0.46 ENST00000409949.1
ENST00000409242.1
ENST00000312994.5
ENST00000413191.1
exonuclease 3'-5' domain containing 2
chr15_+_42696992 0.45 ENST00000561817.1
calpain 3, (p94)
chrX_-_135338503 0.45 ENST00000370663.5
MAP7 domain containing 3
chr1_+_24742264 0.45 ENST00000374399.4
ENST00000003912.3
ENST00000358028.4
ENST00000339255.2
NIPA-like domain containing 3
chr6_+_56911336 0.45 ENST00000370733.4
KIAA1586
chr1_-_8585945 0.44 ENST00000377464.1
arginine-glutamic acid dipeptide (RE) repeats
chr19_+_37808778 0.44 ENST00000544914.1
ENST00000589188.1
HKR1, GLI-Kruppel zinc finger family member

Network of associatons between targets according to the STRING database.

First level regulatory network of NR2E3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.9 3.7 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.8 5.7 GO:0097338 response to clozapine(GO:0097338)
0.7 2.1 GO:0045608 negative regulation of auditory receptor cell differentiation(GO:0045608)
0.6 16.8 GO:0072189 ureter development(GO:0072189)
0.5 1.5 GO:1902960 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.5 1.4 GO:0033241 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.4 1.3 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.4 1.1 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.4 1.1 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
0.3 1.0 GO:0014016 neuroblast differentiation(GO:0014016)
0.3 1.3 GO:0018032 protein amidation(GO:0018032)
0.3 1.0 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.3 3.2 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.3 1.2 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.3 0.9 GO:0035915 pore formation in membrane of other organism(GO:0035915)
0.3 1.2 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.3 2.8 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.3 1.9 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.3 2.1 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.3 1.6 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.3 0.8 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.2 1.0 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.2 3.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.2 1.6 GO:0048539 bone marrow development(GO:0048539)
0.2 3.4 GO:0043589 skin morphogenesis(GO:0043589)
0.2 0.8 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563)
0.2 1.2 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.2 0.6 GO:0060152 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.2 1.0 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.2 0.9 GO:0046952 ketone body catabolic process(GO:0046952)
0.2 1.3 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.2 0.5 GO:0036166 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.2 1.5 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.2 0.5 GO:0051257 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.2 0.9 GO:0048388 endosomal lumen acidification(GO:0048388)
0.2 0.6 GO:0046373 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.2 2.2 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.2 0.8 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.1 3.7 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1 0.7 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.1 0.4 GO:0035905 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1 1.9 GO:0021527 spinal cord association neuron differentiation(GO:0021527) regulation of cell fate specification(GO:0042659)
0.1 2.8 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.1 3.1 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 2.2 GO:0070673 response to interleukin-18(GO:0070673)
0.1 0.8 GO:0032497 detection of lipopolysaccharide(GO:0032497) negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
0.1 0.3 GO:0098759 response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
0.1 0.3 GO:0045925 female courtship behavior(GO:0008050) positive regulation of female receptivity(GO:0045925)
0.1 0.3 GO:0050760 negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
0.1 0.4 GO:0032053 ciliary basal body organization(GO:0032053) positive regulation of protein localization to cilium(GO:1903566)
0.1 1.4 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.5 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.1 0.7 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.1 0.9 GO:1901142 insulin metabolic process(GO:1901142)
0.1 0.9 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1 0.4 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 2.4 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.1 0.6 GO:0002371 dendritic cell cytokine production(GO:0002371)
0.1 0.6 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1 0.7 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.1 1.3 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.1 0.9 GO:0021516 dorsal spinal cord development(GO:0021516)
0.1 0.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.2 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 0.8 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 1.2 GO:0070307 lens fiber cell development(GO:0070307)
0.1 2.5 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.8 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.1 0.4 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.1 0.2 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.1 1.5 GO:0009642 response to light intensity(GO:0009642)
0.1 0.8 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 0.3 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.1 0.4 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 0.3 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.6 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.2 GO:1904604 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
0.1 0.8 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 0.1 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.1 0.1 GO:0071314 cellular response to cocaine(GO:0071314)
0.1 0.8 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.1 0.6 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.6 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.1 0.2 GO:1902723 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.1 0.4 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.1 1.7 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.1 0.4 GO:0018879 biphenyl metabolic process(GO:0018879)
0.0 0.5 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.7 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.4 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.5 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.1 GO:0050883 musculoskeletal movement, spinal reflex action(GO:0050883)
0.0 0.1 GO:1900275 negative regulation of phospholipase C activity(GO:1900275) regulation of proteinase activated receptor activity(GO:1900276) negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900737)
0.0 0.7 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 0.7 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 1.5 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.2 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0 0.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.1 GO:0010519 negative regulation of phospholipase activity(GO:0010519)
0.0 0.7 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.3 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.7 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 0.1 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.2 GO:0014050 negative regulation of glutamate secretion(GO:0014050) negative regulation of synaptic transmission, GABAergic(GO:0032229)
0.0 0.3 GO:0002860 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.2 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 1.0 GO:1901661 quinone metabolic process(GO:1901661)
0.0 2.4 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.5 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.2 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0 0.1 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.2 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 1.4 GO:1904031 positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0 0.1 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.3 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.0 0.3 GO:0048840 otolith development(GO:0048840)
0.0 0.6 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.6 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 4.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.1 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 2.5 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.9 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.2 GO:0006021 inositol biosynthetic process(GO:0006021)
0.0 0.3 GO:0055091 phospholipid homeostasis(GO:0055091)
0.0 1.2 GO:0006298 mismatch repair(GO:0006298)
0.0 0.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.2 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.3 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.1 GO:0046502 uroporphyrinogen III biosynthetic process(GO:0006780) uroporphyrinogen III metabolic process(GO:0046502)
0.0 0.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.7 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.7 GO:0010842 retina layer formation(GO:0010842)
0.0 0.4 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.2 GO:0030091 protein repair(GO:0030091)
0.0 0.4 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.2 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.1 GO:0060296 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0 0.1 GO:0003095 pressure natriuresis(GO:0003095)
0.0 0.3 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.3 GO:0015671 oxygen transport(GO:0015671)
0.0 1.0 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.1 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.0 0.1 GO:0070197 telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.1 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 2.3 GO:0090175 Wnt signaling pathway, planar cell polarity pathway(GO:0060071) regulation of establishment of planar polarity(GO:0090175)
0.0 0.2 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.3 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.1 GO:0006565 L-serine catabolic process(GO:0006565)
0.0 0.1 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.1 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.5 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.2 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.0 0.3 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.5 GO:0046785 microtubule polymerization(GO:0046785)
0.0 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.5 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 1.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.0 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.3 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 0.1 GO:1904382 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.0 2.9 GO:0050796 regulation of insulin secretion(GO:0050796)
0.0 0.7 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.2 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.2 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.0 0.1 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.1 GO:0015888 thiamine transport(GO:0015888)
0.0 0.1 GO:0042574 retinal metabolic process(GO:0042574)
0.0 0.2 GO:0030207 chondroitin sulfate catabolic process(GO:0030207)
0.0 0.9 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.7 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.5 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 6.1 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.4 1.1 GO:0048179 activin receptor complex(GO:0048179)
0.3 1.0 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.3 5.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 3.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 3.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 1.7 GO:0032389 MutLalpha complex(GO:0032389)
0.2 1.0 GO:0032449 CBM complex(GO:0032449)
0.2 0.8 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.2 1.0 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.2 3.8 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.1 0.7 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.6 GO:0005602 complement component C1 complex(GO:0005602)
0.1 2.8 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 1.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 0.7 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 0.7 GO:0005587 collagen type IV trimer(GO:0005587)
0.1 0.3 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 3.8 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 0.2 GO:0097059 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.1 0.4 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 0.8 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.6 GO:0071546 pi-body(GO:0071546)
0.1 1.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.3 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.3 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.1 0.8 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.4 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.1 0.4 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 1.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.8 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.3 GO:0031905 early endosome lumen(GO:0031905)
0.0 0.1 GO:0039713 viral factory(GO:0039713) cytoplasmic viral factory(GO:0039714) host cell viral assembly compartment(GO:0072517)
0.0 1.4 GO:0071437 invadopodium(GO:0071437)
0.0 0.8 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.4 GO:0035253 ciliary rootlet(GO:0035253)
0.0 1.5 GO:0042629 mast cell granule(GO:0042629)
0.0 0.4 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.4 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.7 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.5 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.2 GO:0070695 FHF complex(GO:0070695)
0.0 1.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.9 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.1 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 5.9 GO:0030018 Z disc(GO:0030018)
0.0 0.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.2 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.1 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
0.0 0.3 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 1.3 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.4 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.2 GO:0000812 Swr1 complex(GO:0000812)
0.0 1.0 GO:0098576 lumenal side of membrane(GO:0098576)
0.0 0.3 GO:0008091 spectrin(GO:0008091)
0.0 0.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.8 GO:0008305 integrin complex(GO:0008305)
0.0 0.7 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 1.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 1.8 GO:0030175 filopodium(GO:0030175)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0043196 varicosity(GO:0043196)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 2.9 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.9 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0031105 septin complex(GO:0031105)
0.0 0.7 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.7 GO:0031901 early endosome membrane(GO:0031901)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 6.1 GO:0030348 syntaxin-3 binding(GO:0030348)
0.6 3.2 GO:0050436 microfibril binding(GO:0050436)
0.5 2.8 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.5 1.4 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.4 1.2 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.4 1.2 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.3 3.1 GO:0048039 ubiquinone binding(GO:0048039)
0.3 1.3 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.3 5.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.3 0.9 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.3 1.0 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.2 0.7 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 3.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 1.3 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.2 1.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.2 3.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 2.5 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 0.5 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)
0.2 1.0 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.2 0.9 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.2 0.6 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.1 0.4 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 0.6 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 0.3 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 0.3 GO:0019959 interleukin-8 binding(GO:0019959)
0.1 1.0 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.1 1.3 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.1 2.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.4 GO:0003896 DNA primase activity(GO:0003896)
0.1 2.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 4.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.4 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 0.3 GO:0017129 triglyceride binding(GO:0017129)
0.1 0.5 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.8 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 0.5 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 0.3 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1 1.7 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 0.2 GO:0000035 acyl binding(GO:0000035)
0.1 1.5 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 0.8 GO:0051425 PTB domain binding(GO:0051425)
0.1 0.2 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 0.7 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 3.8 GO:0070888 E-box binding(GO:0070888)
0.1 0.5 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 1.0 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 1.3 GO:0031402 sodium ion binding(GO:0031402)
0.1 1.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 0.3 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.1 0.2 GO:1904599 advanced glycation end-product binding(GO:1904599)
0.1 1.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 0.3 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.4 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.1 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.1 0.5 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.2 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.0 0.2 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 1.9 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.7 GO:0004568 chitinase activity(GO:0004568)
0.0 1.2 GO:0002162 dystroglycan binding(GO:0002162)
0.0 19.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.1 GO:0004137 deoxycytidine kinase activity(GO:0004137)
0.0 0.3 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 1.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.2 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 1.2 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 3.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.7 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.1 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.0 GO:0031690 adrenergic receptor binding(GO:0031690)
0.0 0.3 GO:0042731 PH domain binding(GO:0042731)
0.0 0.1 GO:0004794 L-threonine ammonia-lyase activity(GO:0004794)
0.0 1.7 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 1.7 GO:0050699 WW domain binding(GO:0050699)
0.0 0.5 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.9 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 1.1 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.2 GO:0052833 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.2 GO:0001602 pancreatic polypeptide receptor activity(GO:0001602)
0.0 1.5 GO:0030552 cAMP binding(GO:0030552)
0.0 1.8 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.4 GO:0015643 toxic substance binding(GO:0015643)
0.0 3.0 GO:0051087 chaperone binding(GO:0051087)
0.0 3.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.5 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.6 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 2.1 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.5 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.5 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.3 GO:0048156 tau protein binding(GO:0048156)
0.0 4.2 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.8 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.3 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.4 GO:0008494 translation activator activity(GO:0008494)
0.0 0.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.1 GO:0043426 MRF binding(GO:0043426)
0.0 0.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 1.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.7 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.2 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0016279 protein-lysine N-methyltransferase activity(GO:0016279)
0.0 0.1 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.0 0.3 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.1 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.4 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.0 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.0 0.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 20.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 4.1 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.1 5.0 PID IL3 PATHWAY IL3-mediated signaling events
0.1 6.1 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.1 1.0 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 1.1 PID ALK2 PATHWAY ALK2 signaling events
0.1 2.4 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 2.8 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 1.5 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 2.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 2.6 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 1.2 ST GA12 PATHWAY G alpha 12 Pathway
0.0 2.1 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 2.0 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.6 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.2 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 2.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.2 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 1.5 PID AURORA B PATHWAY Aurora B signaling
0.0 1.9 PID E2F PATHWAY E2F transcription factor network
0.0 0.7 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.8 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.4 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.0 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.1 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.6 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.1 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.2 6.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 3.4 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 2.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 4.0 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 2.9 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 3.6 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.3 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.1 2.8 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.1 1.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.8 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 2.5 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 1.9 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.0 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 0.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 0.7 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 1.2 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 2.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 3.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.7 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.6 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.2 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.7 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.4 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.9 REACTOME DEFENSINS Genes involved in Defensins
0.0 1.0 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.6 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.0 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.3 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.3 REACTOME OPSINS Genes involved in Opsins
0.0 1.1 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.8 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.7 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.3 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport