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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for NRF1
Z-value: 1.74
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Transcription factors associated with NRF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NRF1 | hg19_v2_chr7_+_129251531_129251601 | -0.24 | 2.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NRF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 1.0 | 4.0 | GO:1903438 | regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490) |
| 0.7 | 3.5 | GO:0006203 | dGTP catabolic process(GO:0006203) |
| 0.2 | 3.5 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.1 | 3.3 | GO:0009226 | nucleotide-sugar biosynthetic process(GO:0009226) |
| 0.4 | 3.0 | GO:0045905 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.3 | 2.8 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) |
| 0.2 | 2.7 | GO:0098870 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.5 | 2.5 | GO:0060356 | leucine import(GO:0060356) |
| 0.8 | 2.4 | GO:1902214 | regulation of interleukin-4-mediated signaling pathway(GO:1902214) negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.0 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 4.0 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 3.5 | GO:0016605 | PML body(GO:0016605) |
| 0.3 | 3.4 | GO:0005655 | nucleolar ribonuclease P complex(GO:0005655) |
| 0.3 | 3.0 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.0 | 3.0 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.7 | 2.9 | GO:0016939 | kinesin II complex(GO:0016939) |
| 0.1 | 2.6 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.0 | 2.5 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.1 | 2.4 | GO:0043194 | axon initial segment(GO:0043194) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.4 | 3.5 | GO:0032554 | purine deoxyribonucleotide binding(GO:0032554) |
| 0.1 | 3.4 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.2 | 3.3 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 1.0 | 3.0 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
| 0.1 | 2.7 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.0 | 2.7 | GO:0008276 | protein methyltransferase activity(GO:0008276) |
| 0.1 | 2.6 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.1 | 2.5 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 2.4 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 3.9 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 2.7 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 2.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.9 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 1.9 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 1.9 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 1.7 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.7 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.7 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.1 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 5.6 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.1 | 3.2 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 2.9 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 2.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 2.5 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 2.5 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.0 | 2.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 2.4 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 2.1 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |