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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for OLIG1

Z-value: 0.62

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Transcription factors associated with OLIG1

Gene Symbol Gene ID Gene Info
ENSG00000184221.8 oligodendrocyte transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
OLIG1hg19_v2_chr21_+_34442439_344424550.252.2e-01Click!

Activity profile of OLIG1 motif

Sorted Z-values of OLIG1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_160147925 1.97 ENST00000535561.1
superoxide dismutase 2, mitochondrial
chr2_+_152214098 1.88 ENST00000243347.3
tumor necrosis factor, alpha-induced protein 6
chr1_-_8000872 1.86 ENST00000377507.3
tumor necrosis factor receptor superfamily, member 9
chr8_+_62747349 1.71 ENST00000517953.1
ENST00000520097.1
ENST00000519766.1
RP11-705O24.1
chr5_-_150460539 1.69 ENST00000520931.1
ENST00000520695.1
ENST00000521591.1
ENST00000518977.1
TNFAIP3 interacting protein 1
chr2_+_201994042 1.67 ENST00000417748.1
CASP8 and FADD-like apoptosis regulator
chr4_+_154622652 1.45 ENST00000260010.6
toll-like receptor 2
chr2_+_108994466 1.35 ENST00000272452.2
sulfotransferase family, cytosolic, 1C, member 4
chr2_+_108994633 1.28 ENST00000409309.3
sulfotransferase family, cytosolic, 1C, member 4
chr2_+_201994208 1.27 ENST00000440180.1
CASP8 and FADD-like apoptosis regulator
chr3_-_107777208 1.22 ENST00000398258.3
CD47 molecule
chr8_+_86121448 1.18 ENST00000520225.1
E2F transcription factor 5, p130-binding
chr4_-_113207048 1.18 ENST00000361717.3
TRAF-interacting protein with forkhead-associated domain
chr1_+_153750622 1.15 ENST00000532853.1
solute carrier family 27 (fatty acid transporter), member 3
chr3_+_111393659 1.01 ENST00000477665.1
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr12_+_26126681 1.00 ENST00000542865.1
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr21_+_42792442 0.98 ENST00000398600.2
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr2_+_201994569 0.94 ENST00000457277.1
CASP8 and FADD-like apoptosis regulator
chr12_+_117348742 0.92 ENST00000309909.5
ENST00000455858.2
F-box and WD repeat domain containing 8
chr6_+_69942298 0.92 ENST00000238918.8
brain-specific angiogenesis inhibitor 3
chr6_+_30539153 0.84 ENST00000326195.8
ENST00000376545.3
ENST00000396515.4
ENST00000441867.1
ENST00000468958.1
ATP-binding cassette, sub-family F (GCN20), member 1
chr1_+_169764163 0.80 ENST00000413811.2
ENST00000359326.4
ENST00000456684.1
chromosome 1 open reading frame 112
chr14_-_107283278 0.80 ENST00000390639.2
immunoglobulin heavy variable 7-81 (non-functional)
chr1_+_206808918 0.79 ENST00000367108.3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
chr16_-_69385681 0.78 ENST00000288025.3
transmembrane emp24 protein transport domain containing 6
chr17_-_73874654 0.77 ENST00000254816.2
tripartite motif containing 47
chr1_+_206808868 0.77 ENST00000367109.2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
chr1_+_50569575 0.72 ENST00000371827.1
ELAV like neuron-specific RNA binding protein 4
chr1_+_159409512 0.71 ENST00000423932.3
olfactory receptor, family 10, subfamily J, member 1
chr11_-_57194550 0.69 ENST00000528187.1
ENST00000524863.1
ENST00000533051.1
ENST00000529494.1
ENST00000395124.1
ENST00000533524.1
ENST00000533245.1
ENST00000530316.1
solute carrier family 43, member 3
chr6_+_135502501 0.65 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
v-myb avian myeloblastosis viral oncogene homolog
chr12_+_133657461 0.64 ENST00000412146.2
ENST00000544426.1
ENST00000440984.2
ENST00000319849.3
ENST00000440550.2
zinc finger protein 140
chr7_+_4721885 0.62 ENST00000328914.4
forkhead box K1
chr6_+_31553978 0.60 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
leukocyte specific transcript 1
chr7_-_101212244 0.58 ENST00000451953.1
ENST00000434537.1
ENST00000437900.1
long intergenic non-protein coding RNA 1007
chr3_-_195310802 0.58 ENST00000421243.1
ENST00000453131.1
apolipoprotein D
chr5_-_35938674 0.56 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
calcyphosine-like
chr2_+_89986318 0.55 ENST00000491977.1
immunoglobulin kappa variable 2D-29
chr6_+_31553901 0.54 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
leukocyte specific transcript 1
chr3_-_46068969 0.54 ENST00000542109.1
ENST00000395946.2
chemokine (C motif) receptor 1
chr1_+_180897269 0.52 ENST00000367587.1
KIAA1614
chr1_+_220863187 0.52 ENST00000294889.5
chromosome 1 open reading frame 115
chr18_-_44561988 0.51 ENST00000332567.4
transcription elongation factor B polypeptide 3B (elongin A2)
chr13_+_49551020 0.51 ENST00000541916.1
fibronectin type III domain containing 3A
chr5_-_171433579 0.50 ENST00000265094.5
ENST00000393802.2
F-box and WD repeat domain containing 11
chr1_+_100810575 0.50 ENST00000542213.1
cell division cycle 14A
chr5_+_68485433 0.50 ENST00000502689.1
centromere protein H
chr10_-_61513146 0.49 ENST00000430431.1
long intergenic non-protein coding RNA 948
chr1_+_196743943 0.49 ENST00000471440.2
ENST00000391985.3
complement factor H-related 3
chr11_+_60163918 0.49 ENST00000526375.1
ENST00000531783.1
ENST00000395001.1
membrane-spanning 4-domains, subfamily A, member 14
chr2_+_198318147 0.48 ENST00000263960.2
coenzyme Q10 homolog B (S. cerevisiae)
chrX_-_154563889 0.48 ENST00000369449.2
ENST00000321926.4
chloride intracellular channel 2
chr11_+_60163775 0.48 ENST00000300187.6
ENST00000395005.2
membrane-spanning 4-domains, subfamily A, member 14
chr15_-_58306295 0.47 ENST00000559517.1
aldehyde dehydrogenase 1 family, member A2
chr4_+_144354644 0.47 ENST00000512843.1
GRB2-associated binding protein 1
chr20_+_31805131 0.47 ENST00000375454.3
ENST00000375452.3
BPI fold containing family A, member 3
chr4_-_174451370 0.47 ENST00000359562.4
heart and neural crest derivatives expressed 2
chr9_-_132404374 0.44 ENST00000277459.4
ENST00000450050.2
ENST00000277458.4
ankyrin repeat and SOCS box containing 6
chr22_+_26138108 0.43 ENST00000536101.1
ENST00000335473.7
ENST00000407587.2
myosin XVIIIB
chr1_-_24306835 0.42 ENST00000484146.2
serine/arginine-rich splicing factor 10
chr19_-_1021113 0.39 ENST00000333175.5
ENST00000356663.3
transmembrane protein 259
chr12_-_95941987 0.39 ENST00000537435.2
ubiquitin specific peptidase 44
chr5_+_135496675 0.39 ENST00000507637.1
SMAD family member 5
chr16_+_31119615 0.38 ENST00000394950.3
ENST00000287507.3
ENST00000219794.6
ENST00000561755.1
branched chain ketoacid dehydrogenase kinase
chr5_-_171433819 0.37 ENST00000296933.6
F-box and WD repeat domain containing 11
chr4_-_76912070 0.37 ENST00000395711.4
ENST00000356260.5
SDA1 domain containing 1
chr4_+_2470664 0.37 ENST00000314289.8
ENST00000541204.1
ENST00000502316.1
ENST00000507247.1
ENST00000509258.1
ENST00000511859.1
ring finger protein 4
chr18_-_56296182 0.36 ENST00000361673.3
alpha-kinase 2
chr11_-_44972418 0.36 ENST00000525680.1
ENST00000528290.1
ENST00000530035.1
tumor protein p53 inducible protein 11
chr11_+_120107344 0.36 ENST00000260264.4
POU class 2 homeobox 3
chr15_-_98417780 0.35 ENST00000503874.3
long intergenic non-protein coding RNA 923
chr5_-_115872142 0.35 ENST00000510263.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr4_-_41216619 0.35 ENST00000508676.1
ENST00000506352.1
ENST00000295974.8
amyloid beta (A4) precursor protein-binding, family B, member 2
chr13_+_38923959 0.35 ENST00000379649.1
ENST00000239878.4
ENST00000437952.1
ENST00000379641.1
ubiquitin-fold modifier 1
chr19_+_15904761 0.34 ENST00000308940.8
olfactory receptor, family 10, subfamily H, member 5
chr1_-_52831796 0.33 ENST00000284376.3
ENST00000438831.1
ENST00000371586.2
coiled-coil and C2 domain containing 1B
chr7_+_107531580 0.33 ENST00000537148.1
ENST00000440410.1
ENST00000437604.2
dihydrolipoamide dehydrogenase
chr2_+_223162866 0.33 ENST00000295226.1
coiled-coil domain containing 140
chr2_+_186603355 0.32 ENST00000343098.5
fibrous sheath interacting protein 2
chr7_+_110731062 0.32 ENST00000308478.5
ENST00000451085.1
ENST00000422987.3
ENST00000421101.1
leucine rich repeat neuronal 3
chr8_-_145701718 0.31 ENST00000377317.4
forkhead box H1
chr1_+_15479021 0.31 ENST00000428417.1
transmembrane protein 51
chr1_+_15479054 0.31 ENST00000376014.3
ENST00000451326.2
transmembrane protein 51
chr5_+_101569696 0.31 ENST00000597120.1
AC008948.1
chr6_-_28891709 0.31 ENST00000377194.3
ENST00000377199.3
tripartite motif containing 27
chr2_+_90458201 0.31 ENST00000603238.1
Uncharacterized protein
chr4_-_153456153 0.31 ENST00000603548.1
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr18_-_29340827 0.31 ENST00000269205.5
solute carrier family 25, member 52
chr11_+_65405556 0.31 ENST00000534313.1
ENST00000533361.1
ENST00000526137.1
signal-induced proliferation-associated 1
chr3_-_121379739 0.31 ENST00000428394.2
ENST00000314583.3
hematopoietic cell-specific Lyn substrate 1
chr1_-_168464875 0.31 ENST00000422253.1
RP5-968D22.3
chr10_+_80027105 0.31 ENST00000461034.1
ENST00000476909.1
ENST00000459633.1
long intergenic non-protein coding RNA 595
chr16_+_21716284 0.30 ENST00000388957.3
otoancorin
chr5_+_140739537 0.30 ENST00000522605.1
protocadherin gamma subfamily B, 2
chr15_+_63354769 0.30 ENST00000558910.1
tropomyosin 1 (alpha)
chr10_+_133918175 0.30 ENST00000298622.4
Janus kinase and microtubule interacting protein 3
chr11_+_55650773 0.30 ENST00000449290.2
tripartite motif-containing 51
chr19_+_58095501 0.29 ENST00000536878.2
ENST00000597850.1
ENST00000597219.1
ENST00000598689.1
ENST00000599456.1
ENST00000307468.4
zinc finger protein interacting with K protein 1
chr3_+_185300391 0.29 ENST00000545472.1
SUMO1/sentrin/SMT3 specific peptidase 2
chr17_+_42923686 0.28 ENST00000591513.1
HIG1 hypoxia inducible domain family, member 1B
chr4_+_146402925 0.28 ENST00000302085.4
SMAD family member 1
chr18_-_50240 0.27 ENST00000573909.1
Tubulin beta-8 chain-like protein LOC260334
chr1_-_24306768 0.27 ENST00000374453.3
ENST00000453840.3
serine/arginine-rich splicing factor 10
chr4_-_100575781 0.27 ENST00000511828.1
Protein LOC285556
chr1_-_240906911 0.26 ENST00000431139.2
RP11-80B9.4
chr19_+_40476912 0.26 ENST00000157812.2
proteasome (prosome, macropain) 26S subunit, ATPase, 4
chr1_+_244515930 0.26 ENST00000366537.1
ENST00000308105.4
chromosome 1 open reading frame 100
chr12_+_117013656 0.25 ENST00000556529.1
microtubule-associated protein 1 light chain 3 beta 2
chr19_+_40477062 0.25 ENST00000455878.2
proteasome (prosome, macropain) 26S subunit, ATPase, 4
chr9_-_19786926 0.25 ENST00000341998.2
ENST00000286344.3
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr7_-_72972319 0.25 ENST00000223368.2
B-cell CLL/lymphoma 7B
chr5_-_133510456 0.25 ENST00000520417.1
S-phase kinase-associated protein 1
chr21_+_46654249 0.24 ENST00000584169.1
ENST00000328344.2
long intergenic non-protein coding RNA 334
chr12_-_16761007 0.24 ENST00000354662.1
ENST00000441439.2
LIM domain only 3 (rhombotin-like 2)
chr3_-_46069223 0.24 ENST00000309285.3
chemokine (C motif) receptor 1
chr4_-_171011084 0.24 ENST00000337664.4
aminoadipate aminotransferase
chr3_+_75713481 0.24 ENST00000308062.3
ENST00000464571.1
FSHD region gene 2 family, member C
chr14_+_38091270 0.24 ENST00000553443.1
tetratricopeptide repeat domain 6
chr19_+_46498704 0.24 ENST00000595358.1
ENST00000594672.1
ENST00000536603.1
coiled-coil domain containing 61
chr3_-_128185811 0.24 ENST00000469083.1
DnaJ (Hsp40) homolog, subfamily B, member 8
chr15_-_89755034 0.23 ENST00000563254.1
retinaldehyde binding protein 1
chr18_-_49557 0.23 ENST00000308911.6
Tubulin beta-8 chain-like protein LOC260334
chr1_-_198990166 0.23 ENST00000427439.1
RP11-16L9.3
chr1_+_152881014 0.23 ENST00000368764.3
ENST00000392667.2
involucrin
chr12_+_21284118 0.23 ENST00000256958.2
solute carrier organic anion transporter family, member 1B1
chr1_+_196743912 0.23 ENST00000367425.4
complement factor H-related 3
chr10_-_61495760 0.23 ENST00000395347.1
solute carrier family 16, member 9
chr3_-_49466686 0.23 ENST00000273598.3
ENST00000436744.2
nicolin 1
chr14_-_60632011 0.23 ENST00000554101.1
ENST00000557137.1
dehydrogenase/reductase (SDR family) member 7
chr11_-_71823266 0.22 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
anaphase promoting complex subunit 15
chr6_+_10528560 0.22 ENST00000379597.3
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr2_+_105471969 0.21 ENST00000361360.2
POU class 3 homeobox 3
chr11_+_55653396 0.21 ENST00000244891.3
tripartite motif-containing 51
chr14_+_69865401 0.21 ENST00000556605.1
ENST00000336643.5
ENST00000031146.4
solute carrier family 39, member 9
chr12_+_10124001 0.21 ENST00000396507.3
ENST00000304361.4
ENST00000434319.2
C-type lectin domain family 12, member A
chr2_+_219840955 0.20 ENST00000598002.1
ENST00000432733.1
long intergenic non-protein coding RNA 608
chr2_-_97760576 0.20 ENST00000414820.1
ENST00000272610.3
fumarylacetoacetate hydrolase domain containing 2B
chr5_+_180336564 0.20 ENST00000505126.1
ENST00000533815.2
butyrophilin-like 8
chr16_-_20364122 0.20 ENST00000396138.4
ENST00000577168.1
uromodulin
chr1_+_201159914 0.20 ENST00000335211.4
ENST00000451870.2
ENST00000295591.8
immunoglobulin-like and fibronectin type III domain containing 1
chr22_+_20105259 0.20 ENST00000416427.1
ENST00000421656.1
ENST00000423859.1
ENST00000418705.2
RAN binding protein 1
chr11_-_59612969 0.20 ENST00000541311.1
ENST00000257248.2
gastric intrinsic factor (vitamin B synthesis)
chr17_-_17485731 0.20 ENST00000395783.1
phosphatidylethanolamine N-methyltransferase
chr10_-_61513201 0.20 ENST00000414264.1
ENST00000594536.1
long intergenic non-protein coding RNA 948
chr19_+_39390320 0.19 ENST00000576510.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr16_-_71843047 0.19 ENST00000299980.4
ENST00000393512.3
adaptor-related protein complex 1, gamma 1 subunit
chr2_-_166930131 0.18 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
sodium channel, voltage-gated, type I, alpha subunit
chr5_+_157158205 0.18 ENST00000231198.7
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr3_-_53916202 0.18 ENST00000335754.3
ARP8 actin-related protein 8 homolog (yeast)
chr11_+_94501497 0.18 ENST00000317829.8
ENST00000317837.9
ENST00000433060.2
angiomotin like 1
chr12_+_26348429 0.18 ENST00000242729.2
sarcospan
chrX_+_120181457 0.17 ENST00000328078.1
glutamate dehydrogenase 2
chr14_-_60632162 0.17 ENST00000557185.1
dehydrogenase/reductase (SDR family) member 7
chr3_+_9839335 0.17 ENST00000453882.1
ARPC4-TTLL3 readthrough
chr1_+_6508100 0.17 ENST00000461727.1
espin
chr12_-_11002063 0.17 ENST00000544994.1
ENST00000228811.4
ENST00000540107.1
proline rich 4 (lacrimal)
chr19_+_44764031 0.17 ENST00000592581.1
ENST00000590668.1
ENST00000588489.1
ENST00000391958.2
zinc finger protein 233
chrX_+_55649833 0.16 ENST00000339140.3
forkhead box R2
chr16_+_2016821 0.16 ENST00000569210.2
ENST00000569714.1
ring finger protein 151
chr19_+_57874835 0.16 ENST00000543226.1
ENST00000596755.1
ENST00000282282.3
ENST00000597658.1
trafficking protein particle complex 2 pseudogene 1
zinc finger protein 547
Uncharacterized protein
chr4_-_147043058 0.16 ENST00000512063.1
ENST00000507726.1
long intergenic non-protein coding RNA 1095
chr16_-_52640834 0.16 ENST00000510238.3
cancer susceptibility candidate 16 (non-protein coding)
chr22_-_42526802 0.16 ENST00000359033.4
ENST00000389970.3
ENST00000360608.5
cytochrome P450, family 2, subfamily D, polypeptide 6
chr19_-_51472222 0.16 ENST00000376851.3
kallikrein-related peptidase 6
chr4_-_120243545 0.16 ENST00000274024.3
fatty acid binding protein 2, intestinal
chr1_+_196857144 0.16 ENST00000367416.2
ENST00000251424.4
ENST00000367418.2
complement factor H-related 4
chr2_+_96068436 0.16 ENST00000445649.1
ENST00000447036.1
ENST00000233379.4
ENST00000418606.1
fumarylacetoacetate hydrolase domain containing 2A
chr7_-_2854860 0.15 ENST00000447791.1
ENST00000407904.3
guanine nucleotide binding protein (G protein) alpha 12
chr19_-_51472823 0.15 ENST00000310157.2
kallikrein-related peptidase 6
chr16_-_71842941 0.15 ENST00000423132.2
ENST00000433195.2
ENST00000569748.1
ENST00000570017.1
adaptor-related protein complex 1, gamma 1 subunit
chr17_+_11924129 0.15 ENST00000353533.5
ENST00000415385.3
mitogen-activated protein kinase kinase 4
chr4_-_111563076 0.15 ENST00000354925.2
ENST00000511990.1
paired-like homeodomain 2
chrX_+_71996972 0.15 ENST00000334036.5
DMRT-like family C1B
chr5_-_11589131 0.15 ENST00000511377.1
catenin (cadherin-associated protein), delta 2
chr15_+_74466012 0.15 ENST00000249842.3
immunoglobulin superfamily containing leucine-rich repeat
chrX_+_2670066 0.15 ENST00000381174.5
ENST00000419513.2
ENST00000426774.1
Xg blood group
chr16_+_24550857 0.15 ENST00000568015.1
retinoblastoma binding protein 6
chr6_+_52051171 0.15 ENST00000340057.1
interleukin 17A
chr15_+_26360970 0.15 ENST00000556159.1
ENST00000557523.1
long intergenic non-protein coding RNA 929
chr2_-_163099885 0.15 ENST00000443424.1
fibroblast activation protein, alpha
chr14_+_21249200 0.15 ENST00000304677.2
ribonuclease, RNase A family, k6
chr10_+_26727125 0.14 ENST00000376236.4
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr1_-_24306798 0.14 ENST00000374452.5
ENST00000492112.2
ENST00000343255.5
ENST00000344989.6
serine/arginine-rich splicing factor 10
chr1_+_57320437 0.14 ENST00000361249.3
complement component 8, alpha polypeptide
chr16_-_4896205 0.14 ENST00000589389.1
glyoxylate reductase 1 homolog (Arabidopsis)
chr12_+_82347498 0.14 ENST00000550506.1
RP11-362A1.1
chr5_-_131132658 0.14 ENST00000514667.1
ENST00000511848.1
ENST00000510461.1
Folliculin-interacting protein 1
folliculin interacting protein 1
chr5_-_59481406 0.14 ENST00000546160.1
phosphodiesterase 4D, cAMP-specific
chr2_-_158345462 0.14 ENST00000439355.1
ENST00000540637.1
cytohesin 1 interacting protein
chr17_-_7017559 0.14 ENST00000446679.2
asialoglycoprotein receptor 2
chr20_+_48429233 0.14 ENST00000417961.1
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr16_-_30905584 0.14 ENST00000380317.4
B-cell CLL/lymphoma 7C
chr16_+_72142195 0.14 ENST00000563819.1
ENST00000567142.2
DEAH (Asp-Glu-Ala-His) box polypeptide 38
chr3_+_171758344 0.14 ENST00000336824.4
ENST00000423424.1
fibronectin type III domain containing 3B
chr5_-_137674000 0.14 ENST00000510119.1
ENST00000513970.1
cell division cycle 25C
chr11_-_117800080 0.14 ENST00000524993.1
ENST00000528626.1
ENST00000445164.2
ENST00000430170.2
ENST00000526090.1
transmembrane protease, serine 13
chrX_+_64887512 0.14 ENST00000360270.5
moesin
chr7_-_92855762 0.14 ENST00000453812.2
ENST00000394468.2
HEPACAM family member 2
chr1_+_17559776 0.13 ENST00000537499.1
ENST00000413717.2
ENST00000536552.1
peptidyl arginine deiminase, type I
chr4_+_70796784 0.13 ENST00000246891.4
ENST00000444405.3
casein alpha s1

Network of associatons between targets according to the STRING database.

First level regulatory network of OLIG1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0070340 central nervous system myelin formation(GO:0032289) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.4 1.7 GO:0085032 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.4 2.0 GO:0001315 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.4 3.9 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.3 1.6 GO:0035617 stress granule disassembly(GO:0035617)
0.3 1.9 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.2 0.6 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.2 1.0 GO:0034334 adherens junction maintenance(GO:0034334)
0.2 0.6 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.5 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.1 0.3 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.1 2.6 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 0.5 GO:0061032 cardiac right ventricle formation(GO:0003219) visceral serous pericardium development(GO:0061032)
0.1 0.4 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.1 1.0 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.1 0.3 GO:0043321 regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
0.1 0.3 GO:0009106 lipoate metabolic process(GO:0009106)
0.1 0.2 GO:0018262 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.1 0.3 GO:0097325 melanocyte proliferation(GO:0097325)
0.1 0.7 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.3 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.1 0.3 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.3 GO:0042631 cellular response to water deprivation(GO:0042631)
0.1 1.2 GO:0008228 opsonization(GO:0008228)
0.1 1.7 GO:0030728 ovulation(GO:0030728)
0.1 0.5 GO:0035799 ureter maturation(GO:0035799)
0.1 0.8 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 0.2 GO:0072709 cellular response to sorbitol(GO:0072709)
0.1 0.2 GO:0060127 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.0 0.3 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.6 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.2 GO:0097052 L-kynurenine metabolic process(GO:0097052)
0.0 0.4 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 0.2 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.2 GO:0090345 alkaloid catabolic process(GO:0009822) isoquinoline alkaloid metabolic process(GO:0033076) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346)
0.0 0.6 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.3 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.0 0.9 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.0 0.1 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
0.0 0.1 GO:0031990 mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) positive regulation of chromatin assembly or disassembly(GO:0045799) negative regulation of RNA export from nucleus(GO:0046832)
0.0 0.3 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.5 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 0.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.6 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.2 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.9 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.2 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.2 GO:0043622 cortical microtubule organization(GO:0043622) establishment of centrosome localization(GO:0051660) regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.1 GO:0035723 interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-15(GO:0071350)
0.0 0.2 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.2 GO:0010265 SCF complex assembly(GO:0010265)
0.0 0.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.5 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.2 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.5 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.2 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.2 GO:0050747 sphingomyelin biosynthetic process(GO:0006686) positive regulation of lipoprotein metabolic process(GO:0050747)
0.0 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.4 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.3 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.2 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.4 GO:1904294 positive regulation of ERAD pathway(GO:1904294)
0.0 0.1 GO:0070269 pyroptosis(GO:0070269)
0.0 0.2 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
0.0 0.2 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.2 GO:0006538 glutamate catabolic process(GO:0006538)
0.0 0.3 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.9 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.1 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.0 0.1 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.2 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.4 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.0 GO:2000360 negative regulation of binding of sperm to zona pellucida(GO:2000360)
0.0 0.1 GO:1902548 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) negative regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902548)
0.0 0.2 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.0 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0 0.0 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.0 1.1 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.2 3.9 GO:0097342 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.1 0.9 GO:1990393 3M complex(GO:1990393)
0.1 0.3 GO:0043159 acrosomal matrix(GO:0043159)
0.1 0.4 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1 0.3 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.5 GO:0060091 kinocilium(GO:0060091)
0.0 0.5 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.7 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.2 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.3 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.4 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 1.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.2 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862) bleb(GO:0032059)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.0 1.4 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0005610 laminin-5 complex(GO:0005610)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 1.4 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 1.2 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.1 0.8 GO:0050733 RS domain binding(GO:0050733)
0.1 3.9 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 2.6 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 0.6 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.4 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.2 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.1 1.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.2 GO:0004608 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.1 0.2 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.1 1.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.5 GO:0048039 ubiquinone binding(GO:0048039)
0.1 0.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.3 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.7 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 1.9 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.5 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 0.3 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.3 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.3 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 1.8 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.5 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.1 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.0 0.2 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.2 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.5 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.2 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 1.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.2 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.7 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.3 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.2 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.3 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.3 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.7 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.1 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 2.0 PID FOXO PATHWAY FoxO family signaling
0.0 1.2 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 1.0 PID ATR PATHWAY ATR signaling pathway
0.0 1.0 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.8 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.4 PID E2F PATHWAY E2F transcription factor network
0.0 0.2 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.4 PID MYC PATHWAY C-MYC pathway
0.0 0.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.9 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 2.6 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 1.1 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 1.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.9 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.5 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.5 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis