ISMARA results: OTP_PHOX2B_LHX1_LMX1A_LHX5

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 0.52

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Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Gene Symbol	Gene ID	Gene Info
OTP Ensembl NCBI GeneCards UniProt NextProt	ENSG00000171540.6	orthopedia homeobox
PHOX2B Ensembl NCBI GeneCards UniProt NextProt	ENSG00000109132.5	paired like homeobox 2B
LHX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000132130.7	LIM homeobox 1
LMX1A Ensembl NCBI GeneCards UniProt NextProt	ENSG00000162761.10	LIM homeobox transcription factor 1 alpha
LHX5 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000089116.3	LIM homeobox 5
HOXC4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000198353.6	homeobox C4
HOXC4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000273266.1	homeobox C4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXC4	hg19_v2_chr12_+_54447637_54447661	0.45	2.5e-02	Click!
OTP	hg19_v2_chr5_-_76935513_76935513	0.34	9.3e-02	Click!
LHX5	hg19_v2_chr12_-_113909877_113909877	-0.32	1.2e-01	Click!
LMX1A	hg19_v2_chr1_-_165325939_165325958, hg19_v2_chr1_-_165325449_165325478	-0.26	2.0e-01	Click!
LHX1	hg19_v2_chr17_+_35294075_35294102	0.16	4.4e-01	Click!
PHOX2B	hg19_v2_chr4_-_41750922_41750987	-0.05	8.2e-01	Click!

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_141747950 Show fit	1.72	ENST00000497579.1	TFDP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription factor Dp-2 (E2F dimerization partner 2)
chr12_+_26348582 Show fit	1.43	ENST00000535504.1	SSPN Ensembl NCBI GeneCards UniProt NextProt Show fit	sarcospan
chr1_+_117544366 Show fit	1.08	ENST00000256652.4 ENST00000369470.1	CD101 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD101 molecule
chr11_-_121986923 Show fit	1.01	ENST00000560104.1	BLID Ensembl NCBI GeneCards UniProt NextProt Show fit	BH3-like motif containing, cell death inducer
chr17_+_1674982 Show fit	0.79	ENST00000572048.1 ENST00000573763.1	SERPINF1 Ensembl NCBI GeneCards UniProt NextProt Show fit	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr3_-_141719195 Show fit	0.74	ENST00000397991.4	TFDP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription factor Dp-2 (E2F dimerization partner 2)
chr1_-_160924589 Show fit	0.70	ENST00000368029.3	ITLN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	intelectin 2
chr14_+_31046959 Show fit	0.69	ENST00000547532.1 ENST00000555429.1	G2E3 Ensembl NCBI GeneCards UniProt NextProt Show fit	G2/M-phase specific E3 ubiquitin protein ligase
chr20_-_33735070 Show fit	0.68	ENST00000374491.3 ENST00000542871.1 ENST00000374492.3	EDEM2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ER degradation enhancer, mannosidase alpha-like 2
chr16_-_30122717 Show fit	0.59	ENST00000566613.1	GDPD3 Ensembl NCBI GeneCards UniProt NextProt Show fit	glycerophosphodiester phosphodiesterase domain containing 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.6	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0	1.1	GO:0002763	positive regulation of myeloid leukocyte differentiation(GO:0002763)
0.1	1.0	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.2	0.9	GO:0071279	cellular response to cobalt ion(GO:0071279)
0.0	0.8	GO:0003334	keratinocyte development(GO:0003334)
0.2	0.7	GO:0036509	trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0	0.5	GO:0046485	ether lipid metabolic process(GO:0046485)
0.1	0.4	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.1	0.4	GO:0051725	protein de-ADP-ribosylation(GO:0051725)
0.0	0.4	GO:0072257	metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)

Showing 1 to 10 of 45 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.3	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.0	1.5	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1	0.8	GO:0043203	axon hillock(GO:0043203)
0.0	0.8	GO:0002102	podosome(GO:0002102)
0.0	0.7	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.1	0.4	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.3	GO:0002177	manchette(GO:0002177)
0.0	0.3	GO:0005869	dynactin complex(GO:0005869)
0.0	0.2	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.2	GO:1990131	Gtr1-Gtr2 GTPase complex(GO:1990131)

Showing 1 to 10 of 23 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.1	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.2	1.0	GO:0019770	IgG receptor activity(GO:0019770)
0.1	0.7	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.6	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.5	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0	0.4	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.4	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1	0.3	GO:0008112	nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0	0.2	GO:0008281	sulfonylurea receptor activity(GO:0008281)
0.0	0.2	GO:0004064	arylesterase activity(GO:0004064)

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	PID E2F PATHWAY	E2F transcription factor network

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Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.7	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.5	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.4	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.2	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway

Showing 1 to 5 of 5 entries

Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 0.52

Motif logo

Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Activity-expression correlation:

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: