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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 0.52

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Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Gene Symbol Gene ID Gene Info
OTP
ENSG00000171540.6 orthopedia homeobox
PHOX2B
ENSG00000109132.5 paired like homeobox 2B
LHX1
ENSG00000132130.7 LIM homeobox 1
LMX1A
ENSG00000162761.10 LIM homeobox transcription factor 1 alpha
LHX5
ENSG00000089116.3 LIM homeobox 5
HOXC4
ENSG00000198353.6 homeobox C4
HOXC4
ENSG00000273266.1 homeobox C4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXC4hg19_v2_chr12_+_54447637_544476610.452.5e-02Click!
OTPhg19_v2_chr5_-_76935513_769355130.349.3e-02Click!
LHX5hg19_v2_chr12_-_113909877_113909877-0.321.2e-01Click!
LMX1Ahg19_v2_chr1_-_165325939_165325958,
hg19_v2_chr1_-_165325449_165325478		-0.262.0e-01Click!
LHX1hg19_v2_chr17_+_35294075_352941020.164.4e-01Click!
PHOX2Bhg19_v2_chr4_-_41750922_41750987-0.058.2e-01Click!

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_141747950 1.72 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr12_+_26348582 1.43 ENST00000535504.1
SSPN
sarcospan
chr1_+_117544366 1.08 ENST00000256652.4
ENST00000369470.1
CD101
CD101 molecule
chr11_-_121986923 1.01 ENST00000560104.1
BLID
BH3-like motif containing, cell death inducer
chr17_+_1674982 0.79 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr3_-_141719195 0.74 ENST00000397991.4
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr1_-_160924589 0.70 ENST00000368029.3
ITLN2
intelectin 2
chr14_+_31046959 0.69 ENST00000547532.1
ENST00000555429.1
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr20_-_33735070 0.68 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr16_-_30122717 0.59 ENST00000566613.1
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr10_-_118928543 0.57 ENST00000419373.2
RP11-501J20.2
RP11-501J20.2
chr19_+_50016411 0.51 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr2_-_241497374 0.50 ENST00000373318.2
ENST00000406958.1
ENST00000391987.1
ENST00000373320.4
ANKMY1
ankyrin repeat and MYND domain containing 1
chr11_-_63376013 0.49 ENST00000540943.1
PLA2G16
phospholipase A2, group XVI
chr19_+_50016610 0.44 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr1_+_225600404 0.44 ENST00000366845.2
AC092811.1
AC092811.1
chr1_-_92371839 0.42 ENST00000370399.2
TGFBR3
transforming growth factor, beta receptor III
chr4_+_169418255 0.42 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr15_-_20193370 0.41 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr3_-_149293990 0.39 ENST00000472417.1
WWTR1
WW domain containing transcription regulator 1
chr5_+_66300446 0.38 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr1_-_201140673 0.37 ENST00000367333.2
TMEM9
transmembrane protein 9
chr20_+_15177480 0.35 ENST00000402914.1
MACROD2
MACRO domain containing 2
chrX_-_18690210 0.35 ENST00000379984.3
RS1
retinoschisin 1
chr11_-_5323226 0.35 ENST00000380224.1
OR51B4
olfactory receptor, family 51, subfamily B, member 4
chr7_+_133812052 0.35 ENST00000285928.2
LRGUK
leucine-rich repeats and guanylate kinase domain containing
chr1_-_190446759 0.34 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr4_+_169418195 0.34 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr12_+_8309630 0.33 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr2_+_90211643 0.32 ENST00000390277.2
IGKV3D-11
immunoglobulin kappa variable 3D-11
chr2_+_234826016 0.31 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr11_-_128894053 0.31 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr3_-_64211112 0.31 ENST00000295902.6
PRICKLE2
prickle homolog 2 (Drosophila)
chr6_+_130339710 0.29 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr12_-_10022735 0.28 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr11_+_114168085 0.27 ENST00000541754.1
NNMT
nicotinamide N-methyltransferase
chr4_+_76481258 0.26 ENST00000311623.4
ENST00000435974.2
C4orf26
chromosome 4 open reading frame 26
chr6_-_32157947 0.25 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr2_+_90077680 0.24 ENST00000390270.2
IGKV3D-20
immunoglobulin kappa variable 3D-20
chr12_-_46121554 0.24 ENST00000609803.1
LINC00938
long intergenic non-protein coding RNA 938
chr13_+_24144796 0.24 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr15_+_58702742 0.23 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr1_+_15668240 0.23 ENST00000444385.1
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr2_-_89327228 0.23 ENST00000483158.1
IGKV3-11
immunoglobulin kappa variable 3-11
chr12_-_9913489 0.22 ENST00000228434.3
ENST00000536709.1
CD69
CD69 molecule
chr16_+_15489603 0.22 ENST00000568766.1
ENST00000287594.7
RP11-1021N1.1
MPV17L
Uncharacterized protein
MPV17 mitochondrial membrane protein-like
chr3_-_20053741 0.21 ENST00000389050.4
PP2D1
protein phosphatase 2C-like domain containing 1
chr15_-_75748115 0.21 ENST00000360439.4
SIN3A
SIN3 transcription regulator family member A
chr8_-_86253888 0.21 ENST00000522389.1
ENST00000432364.2
ENST00000517618.1
CA1
carbonic anhydrase I
chr19_-_51920952 0.20 ENST00000356298.5
ENST00000339313.5
ENST00000529627.1
ENST00000439889.2
ENST00000353836.5
ENST00000432469.2
SIGLEC10
sialic acid binding Ig-like lectin 10
chr7_-_37024665 0.20 ENST00000396040.2
ELMO1
engulfment and cell motility 1
chr19_+_49199209 0.20 ENST00000522966.1
ENST00000425340.2
ENST00000391876.4
FUT2
fucosyltransferase 2 (secretor status included)
chr3_+_186353756 0.20 ENST00000431018.1
ENST00000450521.1
ENST00000539949.1
FETUB
fetuin B
chr9_+_95997205 0.20 ENST00000411624.1
WNK2
WNK lysine deficient protein kinase 2
chr17_+_48823896 0.19 ENST00000511974.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr2_-_74618964 0.18 ENST00000417090.1
ENST00000409868.1
DCTN1
dynactin 1
chr7_+_129932974 0.18 ENST00000445470.2
ENST00000222482.4
ENST00000492072.1
ENST00000473956.1
ENST00000493259.1
ENST00000486598.1
CPA4
carboxypeptidase A4
chr12_-_52779433 0.18 ENST00000257951.3
KRT84
keratin 84
chr2_-_43266680 0.18 ENST00000425212.1
ENST00000422351.1
ENST00000449766.1
AC016735.2
AC016735.2
chr7_-_143599207 0.17 ENST00000355951.2
ENST00000479870.1
ENST00000478172.1
FAM115A
family with sequence similarity 115, member A
chr5_+_140762268 0.17 ENST00000518325.1
PCDHGA7
protocadherin gamma subfamily A, 7
chr12_-_54653313 0.17 ENST00000550411.1
ENST00000439541.2
CBX5
chromobox homolog 5
chr12_-_22063787 0.17 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr9_+_71986182 0.17 ENST00000303068.7
FAM189A2
family with sequence similarity 189, member A2
chr7_+_115862858 0.17 ENST00000393481.2
TES
testis derived transcript (3 LIM domains)
chr1_-_92952433 0.17 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor
chr2_+_90273679 0.15 ENST00000423080.2
IGKV3D-7
immunoglobulin kappa variable 3D-7
chr11_-_327537 0.15 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr2_-_89385283 0.14 ENST00000390252.2
IGKV3-15
immunoglobulin kappa variable 3-15
chr7_+_102553430 0.14 ENST00000339431.4
ENST00000249377.4
LRRC17
leucine rich repeat containing 17
chr5_+_95066823 0.14 ENST00000506817.1
ENST00000379982.3
RHOBTB3
Rho-related BTB domain containing 3
chr20_-_18477862 0.14 ENST00000337227.4
RBBP9
retinoblastoma binding protein 9
chr11_-_102576537 0.14 ENST00000260229.4
MMP27
matrix metallopeptidase 27
chr6_+_47624172 0.13 ENST00000507065.1
ENST00000296862.1
GPR111
G protein-coupled receptor 111
chr19_-_14945933 0.13 ENST00000322301.3
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chrX_-_21676442 0.13 ENST00000379499.2
KLHL34
kelch-like family member 34
chr6_+_47749718 0.13 ENST00000489301.2
ENST00000371211.2
ENST00000393699.2
OPN5
opsin 5
chr7_+_73868120 0.13 ENST00000265755.3
GTF2IRD1
GTF2I repeat domain containing 1
chr9_-_99540328 0.12 ENST00000223428.4
ENST00000375231.1
ENST00000374641.3
ZNF510
zinc finger protein 510
chr2_-_74619152 0.12 ENST00000440727.1
ENST00000409240.1
DCTN1
dynactin 1
chr16_-_66584059 0.12 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
TK2
thymidine kinase 2, mitochondrial
chr2_-_241497390 0.12 ENST00000272972.3
ENST00000401804.1
ENST00000361678.4
ENST00000405523.3
ANKMY1
ankyrin repeat and MYND domain containing 1
chr2_-_191115229 0.12 ENST00000409820.2
ENST00000410045.1
HIBCH
3-hydroxyisobutyryl-CoA hydrolase
chr7_+_73868439 0.12 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr9_+_125133315 0.12 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr2_-_231860596 0.12 ENST00000441063.1
ENST00000434094.1
ENST00000418330.1
ENST00000457803.1
ENST00000414876.1
ENST00000446741.1
ENST00000426904.1
AC105344.2
SPATA3 antisense RNA 1 (head to head)
chr12_+_20963632 0.12 ENST00000540853.1
ENST00000261196.2
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chrX_-_100872911 0.12 ENST00000361910.4
ENST00000539247.1
ENST00000538627.1
ARMCX6
armadillo repeat containing, X-linked 6
chr12_-_25348007 0.11 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
CASC1
cancer susceptibility candidate 1
chr14_+_22670455 0.11 ENST00000390460.1
TRAV26-2
T cell receptor alpha variable 26-2
chr21_+_17909594 0.11 ENST00000441820.1
ENST00000602280.1
LINC00478
long intergenic non-protein coding RNA 478
chr20_-_50419055 0.11 ENST00000217086.4
SALL4
spalt-like transcription factor 4
chr4_+_155484155 0.11 ENST00000509493.1
FGB
fibrinogen beta chain
chr2_-_40680578 0.10 ENST00000455476.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr10_+_101542462 0.10 ENST00000370449.4
ENST00000370434.1
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr12_+_59989918 0.10 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr17_+_20978854 0.10 ENST00000456235.1
AC087393.1
AC087393.1
chr9_+_34652164 0.10 ENST00000441545.2
ENST00000553620.1
IL11RA
interleukin 11 receptor, alpha
chr12_-_10282742 0.10 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chrX_+_77166172 0.10 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr7_-_111032971 0.10 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr16_+_31271274 0.10 ENST00000287497.8
ENST00000544665.3
ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr20_-_56265680 0.10 ENST00000414037.1
PMEPA1
prostate transmembrane protein, androgen induced 1
chr12_-_10282836 0.10 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr3_+_44840679 0.10 ENST00000425755.1
KIF15
kinesin family member 15
chr1_+_180601139 0.10 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr7_+_150020329 0.10 ENST00000323078.7
LRRC61
leucine rich repeat containing 61
chr14_+_102276192 0.09 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr4_+_108745711 0.09 ENST00000394684.4
SGMS2
sphingomyelin synthase 2
chr15_-_37393406 0.09 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr12_+_104337515 0.09 ENST00000550595.1
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr18_-_52989217 0.08 ENST00000570287.2
TCF4
transcription factor 4
chr10_-_95241951 0.08 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
MYOF
myoferlin
chr17_-_46688334 0.08 ENST00000239165.7
HOXB7
homeobox B7
chr4_+_155484103 0.08 ENST00000302068.4
FGB
fibrinogen beta chain
chr17_-_38821373 0.08 ENST00000394052.3
KRT222
keratin 222
chr19_-_44388116 0.08 ENST00000587539.1
ZNF404
zinc finger protein 404
chr10_-_28571015 0.08 ENST00000375719.3
ENST00000375732.1
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chrX_+_55744228 0.08 ENST00000262850.7
RRAGB
Ras-related GTP binding B
chr1_+_205682497 0.08 ENST00000598338.1
AC119673.1
AC119673.1
chr10_-_95242044 0.08 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
MYOF
myoferlin
chr16_-_28937027 0.08 ENST00000358201.4
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr17_+_74463650 0.08 ENST00000392492.3
AANAT
aralkylamine N-acetyltransferase
chr5_+_175288631 0.08 ENST00000509837.1
CPLX2
complexin 2
chrX_+_55744166 0.08 ENST00000374941.4
ENST00000414239.1
RRAGB
Ras-related GTP binding B
chr9_+_90112767 0.08 ENST00000408954.3
DAPK1
death-associated protein kinase 1
chr18_-_53177984 0.08 ENST00000543082.1
TCF4
transcription factor 4
chr2_+_202047596 0.08 ENST00000286186.6
ENST00000360132.3
CASP10
caspase 10, apoptosis-related cysteine peptidase
chrX_+_153533275 0.08 ENST00000426989.1
ENST00000426203.1
ENST00000369912.2
TKTL1
transketolase-like 1
chr6_-_116833500 0.07 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr11_+_118398178 0.07 ENST00000302783.4
ENST00000539546.1
TTC36
tetratricopeptide repeat domain 36
chr7_+_150020363 0.07 ENST00000359623.4
ENST00000493307.1
LRRC61
leucine rich repeat containing 61
chr2_-_163008903 0.07 ENST00000418842.2
ENST00000375497.3
GCG
glucagon
chr3_-_164796269 0.07 ENST00000264382.3
SI
sucrase-isomaltase (alpha-glucosidase)
chr9_+_90112590 0.07 ENST00000472284.1
DAPK1
death-associated protein kinase 1
chr19_-_58326267 0.07 ENST00000391701.1
ZNF552
zinc finger protein 552
chr21_-_27423339 0.07 ENST00000415997.1
APP
amyloid beta (A4) precursor protein
chr14_-_45252031 0.07 ENST00000556405.1
RP11-398E10.1
RP11-398E10.1
chr2_+_109237717 0.07 ENST00000409441.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr6_-_155776966 0.07 ENST00000159060.2
NOX3
NADPH oxidase 3
chr17_-_9694614 0.07 ENST00000330255.5
ENST00000571134.1
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr6_+_3259148 0.07 ENST00000419065.2
ENST00000473000.2
ENST00000451246.2
ENST00000454610.2
PSMG4
proteasome (prosome, macropain) assembly chaperone 4
chr2_+_105050794 0.07 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
AC013402.2
long intergenic non-protein coding RNA 1102
chr15_+_84115868 0.07 ENST00000427482.2
SH3GL3
SH3-domain GRB2-like 3
chr7_+_73868220 0.07 ENST00000455841.2
GTF2IRD1
GTF2I repeat domain containing 1
chrX_+_1710484 0.07 ENST00000313871.3
ENST00000381261.3
AKAP17A
A kinase (PRKA) anchor protein 17A
chr4_-_185275104 0.07 ENST00000317596.3
RP11-290F5.2
RP11-290F5.2
chrX_+_134975753 0.06 ENST00000535938.1
SAGE1
sarcoma antigen 1
chr12_-_10151773 0.06 ENST00000298527.6
ENST00000348658.4
CLEC1B
C-type lectin domain family 1, member B
chrX_+_134975858 0.06 ENST00000537770.1
SAGE1
sarcoma antigen 1
chr14_+_50234309 0.06 ENST00000298307.5
KLHDC2
kelch domain containing 2
chr17_+_67498538 0.06 ENST00000589647.1
MAP2K6
mitogen-activated protein kinase kinase 6
chr6_-_144385698 0.06 ENST00000444202.1
ENST00000437412.1
PLAGL1
pleiomorphic adenoma gene-like 1
chr6_+_26087509 0.06 ENST00000397022.3
ENST00000353147.5
ENST00000352392.4
ENST00000349999.4
ENST00000317896.7
ENST00000357618.5
ENST00000470149.1
ENST00000336625.8
ENST00000461397.1
ENST00000488199.1
HFE
hemochromatosis
chr5_-_176889381 0.06 ENST00000393563.4
ENST00000512501.1
DBN1
drebrin 1
chr12_+_26348246 0.06 ENST00000422622.2
SSPN
sarcospan
chr20_-_50418947 0.06 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr1_-_211307404 0.06 ENST00000367007.4
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr17_+_66511540 0.06 ENST00000588188.2
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr12_-_74686314 0.06 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
RP11-81H3.2
chr6_-_10415470 0.06 ENST00000379604.2
ENST00000379613.3
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chrX_+_36254051 0.06 ENST00000378657.4
CXorf30
chromosome X open reading frame 30
chr7_-_102283238 0.06 ENST00000340457.8
UPK3BL
uroplakin 3B-like
chr3_+_141457105 0.06 ENST00000480908.1
ENST00000393000.3
RNF7
ring finger protein 7
chr20_-_50418972 0.05 ENST00000395997.3
SALL4
spalt-like transcription factor 4
chr10_-_75415825 0.05 ENST00000394810.2
SYNPO2L
synaptopodin 2-like
chr12_-_7655329 0.05 ENST00000541972.1
CD163
CD163 molecule
chr18_+_61254534 0.05 ENST00000269489.5
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr12_+_26348429 0.05 ENST00000242729.2
SSPN
sarcospan
chr17_-_42992856 0.05 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
GFAP
glial fibrillary acidic protein
chr3_+_141457030 0.05 ENST00000273480.3
RNF7
ring finger protein 7
chr7_-_140482926 0.05 ENST00000496384.2
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr10_+_94451574 0.05 ENST00000492654.2
HHEX
hematopoietically expressed homeobox
chr3_-_114477787 0.05 ENST00000464560.1
ZBTB20
zinc finger and BTB domain containing 20
chr5_+_140593509 0.05 ENST00000341948.4
PCDHB13
protocadherin beta 13
chr4_+_158493642 0.05 ENST00000507108.1
ENST00000455598.1
ENST00000509450.1
RP11-364P22.1
RP11-364P22.1
chr5_-_125930929 0.05 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chr2_-_27886460 0.05 ENST00000404798.2
ENST00000405491.1
ENST00000464789.2
ENST00000406540.1
SUPT7L
suppressor of Ty 7 (S. cerevisiae)-like
chr9_-_116065551 0.05 ENST00000297894.5
RNF183
ring finger protein 183
chr9_-_21202204 0.05 ENST00000239347.3
IFNA7
interferon, alpha 7
chr2_-_8977714 0.05 ENST00000319688.5
ENST00000489024.1
ENST00000256707.3
ENST00000427284.1
ENST00000418530.1
ENST00000473731.1
KIDINS220
kinase D-interacting substrate, 220kDa
chrX_+_36053908 0.05 ENST00000378660.2
CHDC2
calponin homology domain containing 2
chr22_+_40297105 0.05 ENST00000540310.1
GRAP2
GRB2-related adaptor protein 2
chr12_-_10282681 0.05 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr2_+_166095898 0.05 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr19_+_29456034 0.05 ENST00000589921.1
LINC00906
long intergenic non-protein coding RNA 906
chr6_+_125304502 0.05 ENST00000519799.1
ENST00000368414.2
ENST00000359704.2
RNF217
ring finger protein 217
chr3_-_114477962 0.05 ENST00000471418.1
ZBTB20
zinc finger and BTB domain containing 20
chr3_+_20081515 0.05 ENST00000263754.4
KAT2B
K(lysine) acetyltransferase 2B
chr15_+_54901540 0.04 ENST00000539562.2
UNC13C
unc-13 homolog C (C. elegans)
chr20_+_22034809 0.04 ENST00000449427.1
RP11-125P18.1
RP11-125P18.1
chr13_-_36050819 0.04 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr18_-_52989525 0.04 ENST00000457482.3
TCF4
transcription factor 4
chr10_-_50396425 0.04 ENST00000374148.1
C10orf128
chromosome 10 open reading frame 128
chr4_-_177116772 0.04 ENST00000280191.2
SPATA4
spermatogenesis associated 4
chr7_-_87342564 0.04 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr3_+_138340049 0.04 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chr13_-_70682590 0.04 ENST00000377844.4
KLHL1
kelch-like family member 1
chr3_-_149095652 0.04 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr5_+_140220769 0.04 ENST00000531613.1
ENST00000378123.3
PCDHA8
protocadherin alpha 8

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0036509 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.2 0.9 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.1 1.0 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.1 0.4 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 0.3 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 0.3 GO:0050955 thermoception(GO:0050955)
0.1 2.6 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 0.2 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.1 0.2 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 0.4 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.5 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.3 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 0.1 GO:0046125 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.0 0.1 GO:0016999 antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787)
0.0 0.1 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.8 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.1 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.1 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.4 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.0 0.1 GO:0034761 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) regulation of T cell antigen processing and presentation(GO:0002625) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)
0.0 0.1 GO:0030187 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:0072709 cellular response to sorbitol(GO:0072709)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:0006574 valine catabolic process(GO:0006574)
0.0 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.2 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.1 GO:0071461 cellular response to redox state(GO:0071461)
0.0 0.1 GO:0061010 negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010)
0.0 0.4 GO:0009642 response to light intensity(GO:0009642)
0.0 0.0 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.2 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0003409 optic cup structural organization(GO:0003409)
0.0 0.1 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.0 0.1 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 1.1 GO:0002763 positive regulation of myeloid leukocyte differentiation(GO:0002763)
0.0 0.1 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.0 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.2 GO:0035878 nail development(GO:0035878)
0.0 0.2 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.1 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 0.8 GO:0043203 axon hillock(GO:0043203)
0.0 0.3 GO:0002177 manchette(GO:0002177)
0.0 1.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.2 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.3 GO:0005869 dynactin complex(GO:0005869)
0.0 0.1 GO:1990357 terminal web(GO:1990357)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.7 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.0 GO:0000125 PCAF complex(GO:0000125)
0.0 0.1 GO:0030914 STAGA complex(GO:0030914)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 2.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.1 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.8 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0019770 IgG receptor activity(GO:0019770)
0.2 1.1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 0.5 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 0.3 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.1 0.7 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0004797 thymidine kinase activity(GO:0004797)
0.0 0.2 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.4 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.1 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.2 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.1 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.4 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.1 GO:0004802 transketolase activity(GO:0004802)
0.0 0.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.1 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.2 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.7 PID E2F PATHWAY E2F transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.5 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo