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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for OTX1

Z-value: 0.60

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Transcription factors associated with OTX1

Gene Symbol Gene ID Gene Info
OTX1
ENSG00000115507.5 orthodenticle homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
OTX1hg19_v2_chr2_+_63277927_63277938-0.096.7e-01Click!

Activity profile of OTX1 motif

Sorted Z-values of OTX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_8717369 2.07 ENST00000359865.3
ENST00000400050.3
ENST00000306285.7
SOGA2
SOGA family member 2
chr1_-_92351769 1.78 ENST00000212355.4
TGFBR3
transforming growth factor, beta receptor III
chr2_-_106054952 1.51 ENST00000336660.5
ENST00000393352.3
ENST00000607522.1
FHL2
four and a half LIM domains 2
chr2_-_160654745 1.18 ENST00000259053.4
ENST00000429078.2
CD302
CD302 molecule
chr4_-_70626314 1.08 ENST00000510821.1
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr3_+_58223228 1.05 ENST00000478253.1
ENST00000295962.4
ABHD6
abhydrolase domain containing 6
chr5_-_39425222 1.04 ENST00000320816.6
DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr7_-_120498357 0.97 ENST00000415871.1
ENST00000222747.3
ENST00000430985.1
TSPAN12
tetraspanin 12
chr5_-_39425290 0.96 ENST00000545653.1
DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr1_-_204116078 0.95 ENST00000367198.2
ENST00000452983.1
ETNK2
ethanolamine kinase 2
chrX_+_53123314 0.94 ENST00000605526.1
ENST00000604062.1
ENST00000604369.1
ENST00000366185.2
ENST00000604849.1
RP11-258C19.5
long intergenic non-protein coding RNA 1155
chr19_-_47616992 0.83 ENST00000253048.5
ZC3H4
zinc finger CCCH-type containing 4
chr2_+_110656005 0.79 ENST00000437679.2
LIMS3
LIM and senescent cell antigen-like domains 3
chr2_-_111230393 0.76 ENST00000447537.2
ENST00000413601.2
LIMS3L
LIMS3L
LIM and senescent cell antigen-like-containing domain protein 3; Uncharacterized protein; cDNA FLJ59124, highly similar to Particularly interesting newCys-His protein; cDNA, FLJ79109, highly similar to Particularly interesting newCys-His protein
LIM and senescent cell antigen-like domains 3-like
chr16_-_66583701 0.74 ENST00000527800.1
ENST00000525974.1
ENST00000563369.2
TK2
thymidine kinase 2, mitochondrial
chr17_+_56769924 0.74 ENST00000461271.1
ENST00000583539.1
ENST00000337432.4
ENST00000421782.2
RAD51C
RAD51 paralog C
chr1_+_28764653 0.69 ENST00000373836.3
PHACTR4
phosphatase and actin regulator 4
chr1_+_24882560 0.69 ENST00000374392.2
NCMAP
noncompact myelin associated protein
chr6_+_96025341 0.69 ENST00000369293.1
ENST00000358812.4
MANEA
mannosidase, endo-alpha
chr6_+_35420091 0.68 ENST00000229769.2
FANCE
Fanconi anemia, complementation group E
chr9_-_113100088 0.66 ENST00000374510.4
ENST00000423740.2
ENST00000374511.3
ENST00000374507.4
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr3_-_141747950 0.61 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr5_-_111091948 0.59 ENST00000447165.2
NREP
neuronal regeneration related protein
chr14_-_65769392 0.59 ENST00000555736.1
CTD-2509G16.5
CTD-2509G16.5
chr19_+_41903709 0.52 ENST00000542943.1
ENST00000457836.2
BCKDHA
branched chain keto acid dehydrogenase E1, alpha polypeptide
chr2_+_201936458 0.51 ENST00000237889.4
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr19_+_17448348 0.51 ENST00000324894.8
ENST00000358792.7
ENST00000600625.1
GTPBP3
GTP binding protein 3 (mitochondrial)
chr3_-_69062764 0.49 ENST00000295571.5
EOGT
EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
chr1_+_243419306 0.49 ENST00000355875.4
ENST00000391846.1
ENST00000366541.3
ENST00000343783.6
SDCCAG8
serologically defined colon cancer antigen 8
chr1_-_154928562 0.46 ENST00000368463.3
ENST00000539880.1
ENST00000542459.1
ENST00000368460.3
ENST00000368465.1
PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr12_-_107380910 0.45 ENST00000392830.2
ENST00000240050.4
MTERFD3
MTERF domain containing 3
chr14_+_21458127 0.45 ENST00000382985.4
ENST00000556670.2
ENST00000553564.1
ENST00000554751.1
ENST00000554283.1
ENST00000555670.1
METTL17
methyltransferase like 17
chr12_-_107380846 0.44 ENST00000548101.1
ENST00000550496.1
ENST00000552029.1
MTERFD3
MTERF domain containing 3
chr1_+_81771806 0.44 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
LPHN2
latrophilin 2
chr1_+_196621002 0.43 ENST00000367429.4
ENST00000439155.2
CFH
complement factor H
chr19_-_36001113 0.43 ENST00000434389.1
DMKN
dermokine
chr14_+_50234309 0.43 ENST00000298307.5
KLHDC2
kelch domain containing 2
chr22_-_36903101 0.41 ENST00000397224.4
FOXRED2
FAD-dependent oxidoreductase domain containing 2
chr11_-_78052923 0.38 ENST00000340149.2
GAB2
GRB2-associated binding protein 2
chr9_+_128509624 0.37 ENST00000342287.5
ENST00000373487.4
PBX3
pre-B-cell leukemia homeobox 3
chrX_-_109561294 0.37 ENST00000372059.2
ENST00000262844.5
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr14_-_106539557 0.36 ENST00000390599.2
IGHV1-8
immunoglobulin heavy variable 1-8
chr19_-_41903161 0.35 ENST00000602129.1
ENST00000593771.1
ENST00000596905.1
ENST00000221233.4
EXOSC5
exosome component 5
chr17_+_41476327 0.33 ENST00000320033.4
ARL4D
ADP-ribosylation factor-like 4D
chr12_+_100594557 0.33 ENST00000546902.1
ENST00000552376.1
ENST00000551617.1
ACTR6
ARP6 actin-related protein 6 homolog (yeast)
chr14_-_106471723 0.33 ENST00000390595.2
IGHV1-3
immunoglobulin heavy variable 1-3
chr21_+_18811205 0.33 ENST00000440664.1
C21orf37
chromosome 21 open reading frame 37
chr1_-_9811600 0.32 ENST00000435891.1
CLSTN1
calsyntenin 1
chr16_-_29874462 0.31 ENST00000566113.1
ENST00000569956.1
ENST00000570016.1
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr1_+_117910047 0.31 ENST00000356554.3
MAN1A2
mannosidase, alpha, class 1A, member 2
chr15_-_55657428 0.31 ENST00000568543.1
CCPG1
cell cycle progression 1
chr12_+_20963632 0.31 ENST00000540853.1
ENST00000261196.2
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr3_-_69129501 0.30 ENST00000540295.1
ENST00000415609.2
ENST00000361055.4
ENST00000349511.4
UBA3
ubiquitin-like modifier activating enzyme 3
chr1_+_63989004 0.30 ENST00000371088.4
EFCAB7
EF-hand calcium binding domain 7
chr10_-_35104185 0.30 ENST00000374789.3
ENST00000374788.3
ENST00000346874.4
ENST00000374794.3
ENST00000350537.4
ENST00000374790.3
ENST00000374776.1
ENST00000374773.1
ENST00000545693.1
ENST00000545260.1
ENST00000340077.5
PARD3
par-3 family cell polarity regulator
chr12_+_20963647 0.30 ENST00000381545.3
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr19_-_36001286 0.30 ENST00000602679.1
ENST00000492341.2
ENST00000472252.2
ENST00000602781.1
ENST00000402589.2
ENST00000458071.1
ENST00000436012.1
ENST00000443640.1
ENST00000450261.1
ENST00000467637.1
ENST00000480502.1
ENST00000474928.1
ENST00000414866.2
ENST00000392206.2
ENST00000488892.1
DMKN
dermokine
chr13_+_57741718 0.30 ENST00000445351.1
PRR20E
proline rich 20E
chr16_-_29875057 0.29 ENST00000219789.6
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr22_+_39052632 0.28 ENST00000411557.1
ENST00000396811.2
ENST00000216029.3
ENST00000416285.1
CBY1
chibby homolog 1 (Drosophila)
chr11_-_67210930 0.28 ENST00000453768.2
ENST00000545016.1
ENST00000341356.5
CORO1B
coronin, actin binding protein, 1B
chr16_-_29874211 0.27 ENST00000563415.1
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr16_-_8962200 0.27 ENST00000562843.1
ENST00000561530.1
ENST00000396593.2
CARHSP1
calcium regulated heat stable protein 1, 24kDa
chr2_-_112642267 0.26 ENST00000341068.3
ANAPC1
anaphase promoting complex subunit 1
chr6_+_42018614 0.26 ENST00000465926.1
ENST00000482432.1
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr8_-_56986768 0.25 ENST00000523936.1
RPS20
ribosomal protein S20
chr22_+_30163340 0.25 ENST00000330029.6
ENST00000401406.3
UQCR10
ubiquinol-cytochrome c reductase, complex III subunit X
chr14_-_89878369 0.24 ENST00000553840.1
ENST00000556916.1
FOXN3
forkhead box N3
chr12_-_54071181 0.24 ENST00000338662.5
ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr13_-_31736478 0.23 ENST00000445273.2
HSPH1
heat shock 105kDa/110kDa protein 1
chr17_-_26876350 0.23 ENST00000470125.1
UNC119
unc-119 homolog (C. elegans)
chr14_+_21236586 0.23 ENST00000326783.3
EDDM3B
epididymal protein 3B
chr3_-_138763734 0.23 ENST00000413199.1
ENST00000502927.2
PRR23C
proline rich 23C
chr15_+_58702742 0.23 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr12_-_11214893 0.23 ENST00000533467.1
TAS2R46
taste receptor, type 2, member 46
chr16_-_21436459 0.23 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
NPIPB3
nuclear pore complex interacting protein family, member B3
chr9_-_35563896 0.22 ENST00000399742.2
FAM166B
family with sequence similarity 166, member B
chr5_-_54603368 0.22 ENST00000508346.1
ENST00000251636.5
DHX29
DEAH (Asp-Glu-Ala-His) box polypeptide 29
chrX_-_148571884 0.22 ENST00000537071.1
IDS
iduronate 2-sulfatase
chr2_+_16080659 0.22 ENST00000281043.3
MYCN
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
chr4_-_54424366 0.22 ENST00000306888.2
LNX1
ligand of numb-protein X 1, E3 ubiquitin protein ligase
chr2_+_1418154 0.21 ENST00000423320.1
ENST00000382198.1
TPO
thyroid peroxidase
chr3_-_156878540 0.21 ENST00000461804.1
CCNL1
cyclin L1
chr7_+_23338819 0.21 ENST00000466681.1
MALSU1
mitochondrial assembly of ribosomal large subunit 1
chr1_+_229440129 0.21 ENST00000366688.3
SPHAR
S-phase response (cyclin related)
chr1_-_247335269 0.21 ENST00000543802.2
ENST00000491356.1
ENST00000472531.1
ENST00000340684.6
ZNF124
zinc finger protein 124
chr3_-_27410847 0.20 ENST00000429845.2
ENST00000341435.5
ENST00000435750.1
NEK10
NIMA-related kinase 10
chr6_-_32731243 0.19 ENST00000427449.1
ENST00000411527.1
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr16_-_21868978 0.19 ENST00000357370.5
ENST00000451409.1
ENST00000341400.7
ENST00000518761.4
NPIPB4
nuclear pore complex interacting protein family, member B4
chr1_-_160924589 0.19 ENST00000368029.3
ITLN2
intelectin 2
chr6_+_26251835 0.19 ENST00000356350.2
HIST1H2BH
histone cluster 1, H2bh
chr3_+_145782358 0.18 ENST00000422482.1
AC107021.1
HCG1786590; PRO2533; Uncharacterized protein
chr4_+_83956312 0.18 ENST00000509317.1
ENST00000503682.1
ENST00000511653.1
COPS4
COP9 signalosome subunit 4
chr4_+_83956237 0.18 ENST00000264389.2
COPS4
COP9 signalosome subunit 4
chr3_+_142315225 0.18 ENST00000457734.2
ENST00000483373.1
ENST00000475296.1
ENST00000495744.1
ENST00000476044.1
ENST00000461644.1
PLS1
plastin 1
chr1_-_186430222 0.17 ENST00000391997.2
PDC
phosducin
chr12_-_117537240 0.17 ENST00000392545.4
ENST00000541210.1
ENST00000335209.7
TESC
tescalcin
chr4_+_159727272 0.17 ENST00000379346.3
FNIP2
folliculin interacting protein 2
chr2_-_74618964 0.17 ENST00000417090.1
ENST00000409868.1
DCTN1
dynactin 1
chr2_-_14541060 0.16 ENST00000418420.1
ENST00000417751.1
LINC00276
long intergenic non-protein coding RNA 276
chr8_-_133637624 0.16 ENST00000522789.1
LRRC6
leucine rich repeat containing 6
chr2_-_74619152 0.16 ENST00000440727.1
ENST00000409240.1
DCTN1
dynactin 1
chr2_+_109403193 0.16 ENST00000412964.2
ENST00000295124.4
CCDC138
coiled-coil domain containing 138
chr3_+_136649311 0.16 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chrX_+_1734051 0.16 ENST00000381229.4
ENST00000381233.3
ASMT
acetylserotonin O-methyltransferase
chrX_-_43832711 0.16 ENST00000378062.5
NDP
Norrie disease (pseudoglioma)
chr15_-_61521495 0.16 ENST00000335670.6
RORA
RAR-related orphan receptor A
chr22_-_30162924 0.16 ENST00000344318.3
ENST00000397781.3
ZMAT5
zinc finger, matrin-type 5
chr16_-_69448 0.15 ENST00000326592.9
WASH4P
WAS protein family homolog 4 pseudogene
chr9_+_125132803 0.15 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr16_-_29415350 0.15 ENST00000524087.1
NPIPB11
nuclear pore complex interacting protein family, member B11
chr18_+_44812072 0.14 ENST00000598649.1
ENST00000586905.2
CTD-2130O13.1
CTD-2130O13.1
chr17_-_34329084 0.14 ENST00000354059.4
ENST00000536149.1
CCL15
CCL14
chemokine (C-C motif) ligand 15
chemokine (C-C motif) ligand 14
chr6_+_26158343 0.14 ENST00000377777.4
ENST00000289316.2
HIST1H2BD
histone cluster 1, H2bd
chr5_+_134303591 0.14 ENST00000282611.6
CATSPER3
cation channel, sperm associated 3
chr12_-_71533055 0.13 ENST00000552128.1
TSPAN8
tetraspanin 8
chr6_-_105307711 0.13 ENST00000519645.1
ENST00000262903.4
ENST00000369125.2
HACE1
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
chr11_-_124767693 0.13 ENST00000533054.1
ROBO4
roundabout, axon guidance receptor, homolog 4 (Drosophila)
chrX_+_76709648 0.13 ENST00000439435.1
FGF16
fibroblast growth factor 16
chr1_+_17531614 0.13 ENST00000375471.4
PADI1
peptidyl arginine deiminase, type I
chr1_-_161039753 0.13 ENST00000368015.1
ARHGAP30
Rho GTPase activating protein 30
chr20_-_33539655 0.12 ENST00000451957.2
GSS
glutathione synthetase
chr5_-_9712312 0.12 ENST00000506620.1
ENST00000514078.1
ENST00000606744.1
TAS2R1
CTD-2143L24.1
taste receptor, type 2, member 1
CTD-2143L24.1
chr6_+_140175987 0.12 ENST00000414038.1
ENST00000431609.1
RP5-899B16.1
RP5-899B16.1
chr3_+_195447738 0.12 ENST00000447234.2
ENST00000320736.6
ENST00000436408.1
MUC20
mucin 20, cell surface associated
chrX_+_1733876 0.12 ENST00000381241.3
ASMT
acetylserotonin O-methyltransferase
chr16_+_14802801 0.12 ENST00000526520.1
ENST00000531598.2
NPIPA3
nuclear pore complex interacting protein family, member A3
chrX_+_133507283 0.12 ENST00000370803.3
PHF6
PHD finger protein 6
chr1_+_241695424 0.11 ENST00000366558.3
ENST00000366559.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr6_+_38690622 0.11 ENST00000327475.6
DNAH8
dynein, axonemal, heavy chain 8
chr8_+_22132847 0.11 ENST00000521356.1
PIWIL2
piwi-like RNA-mediated gene silencing 2
chr1_+_3668962 0.11 ENST00000294600.2
CCDC27
coiled-coil domain containing 27
chr3_+_11314099 0.11 ENST00000446450.2
ENST00000354956.5
ENST00000354449.3
ENST00000419112.1
ATG7
autophagy related 7
chrX_+_79675965 0.11 ENST00000308293.5
FAM46D
family with sequence similarity 46, member D
chr2_+_234580525 0.11 ENST00000609637.1
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr1_+_174844645 0.10 ENST00000486220.1
RABGAP1L
RAB GTPase activating protein 1-like
chr9_-_95298314 0.10 ENST00000344604.5
ENST00000375540.1
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr5_+_135496675 0.10 ENST00000507637.1
SMAD5
SMAD family member 5
chr19_-_42916499 0.10 ENST00000601189.1
ENST00000599211.1
LIPE
lipase, hormone-sensitive
chr2_+_201936707 0.10 ENST00000433898.1
ENST00000454214.1
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr4_+_88754113 0.09 ENST00000560249.1
ENST00000540395.1
ENST00000511670.1
ENST00000361056.3
MEPE
matrix extracellular phosphoglycoprotein
chr19_+_35940486 0.09 ENST00000246549.2
FFAR2
free fatty acid receptor 2
chr15_-_34629922 0.09 ENST00000559484.1
ENST00000354181.3
ENST00000558589.1
ENST00000458406.2
SLC12A6
solute carrier family 12 (potassium/chloride transporter), member 6
chr2_+_234580499 0.09 ENST00000354728.4
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr12_+_49740700 0.09 ENST00000549441.2
ENST00000395069.3
DNAJC22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr1_-_26372602 0.08 ENST00000374278.3
ENST00000374276.3
SLC30A2
solute carrier family 30 (zinc transporter), member 2
chr1_+_160709076 0.08 ENST00000359331.4
ENST00000495334.1
SLAMF7
SLAM family member 7
chr17_-_34592032 0.08 ENST00000457979.3
TBC1D3C
TBC1 domain family, member 3C
chr4_-_122744998 0.08 ENST00000274026.5
CCNA2
cyclin A2
chr8_+_101162812 0.08 ENST00000353107.3
ENST00000522439.1
POLR2K
polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
chr8_-_110988070 0.08 ENST00000524391.1
KCNV1
potassium channel, subfamily V, member 1
chr7_+_55980331 0.07 ENST00000429591.2
ZNF713
zinc finger protein 713
chr6_-_133055815 0.07 ENST00000509351.1
ENST00000417437.2
ENST00000414302.2
ENST00000423615.2
ENST00000427187.2
ENST00000275223.3
ENST00000519686.2
VNN3
vanin 3
chr2_-_234475380 0.07 ENST00000443711.2
ENST00000251722.6
USP40
ubiquitin specific peptidase 40
chr11_-_111957451 0.07 ENST00000504148.2
ENST00000541231.1
TIMM8B
translocase of inner mitochondrial membrane 8 homolog B (yeast)
chr9_+_116172958 0.07 ENST00000374165.1
C9orf43
chromosome 9 open reading frame 43
chr1_+_241695670 0.07 ENST00000366557.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr16_-_15950868 0.07 ENST00000396324.3
ENST00000452625.2
ENST00000576790.2
ENST00000300036.5
MYH11
myosin, heavy chain 11, smooth muscle
chr4_+_189060573 0.06 ENST00000332517.3
TRIML1
tripartite motif family-like 1
chr19_-_12941469 0.06 ENST00000586969.1
ENST00000589681.1
ENST00000585384.1
ENST00000589808.1
RTBDN
retbindin
chr2_+_122513109 0.06 ENST00000389682.3
ENST00000536142.1
TSN
translin
chr14_-_106967788 0.06 ENST00000390622.2
IGHV1-46
immunoglobulin heavy variable 1-46
chr16_-_69373396 0.05 ENST00000562595.1
ENST00000562081.1
ENST00000306875.4
COG8
component of oligomeric golgi complex 8
chr2_-_201936302 0.05 ENST00000453765.1
ENST00000452799.1
ENST00000446678.1
ENST00000418596.3
FAM126B
family with sequence similarity 126, member B
chr10_+_52724028 0.05 ENST00000561565.1
RP11-96B5.4
RP11-96B5.4
chr11_-_130786333 0.05 ENST00000533214.1
ENST00000528555.1
ENST00000530356.1
ENST00000539184.1
SNX19
sorting nexin 19
chr6_+_150070857 0.05 ENST00000544496.1
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr1_-_205719295 0.05 ENST00000367142.4
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr20_+_3052264 0.05 ENST00000217386.2
OXT
oxytocin/neurophysin I prepropeptide
chr19_-_12941215 0.05 ENST00000458671.2
RTBDN
retbindin
chr6_-_34393825 0.04 ENST00000605528.1
ENST00000326199.8
RPS10-NUDT3
RPS10
RPS10-NUDT3 readthrough
ribosomal protein S10
chr1_-_36930012 0.04 ENST00000373116.5
MRPS15
mitochondrial ribosomal protein S15
chr5_+_80256453 0.04 ENST00000265080.4
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2
chr7_+_128379449 0.04 ENST00000479257.1
CALU
calumenin
chr1_-_160832642 0.04 ENST00000368034.4
CD244
CD244 molecule, natural killer cell receptor 2B4
chr7_+_128379346 0.04 ENST00000535011.2
ENST00000542996.2
ENST00000535623.1
ENST00000538546.1
ENST00000249364.4
ENST00000449187.2
CALU
calumenin
chr1_+_40840320 0.03 ENST00000372708.1
SMAP2
small ArfGAP2
chr6_-_144416737 0.03 ENST00000367569.2
SF3B5
splicing factor 3b, subunit 5, 10kDa
chr17_-_4689649 0.03 ENST00000441199.2
ENST00000416307.2
VMO1
vitelline membrane outer layer 1 homolog (chicken)
chr1_-_16539094 0.03 ENST00000270747.3
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr14_-_102706934 0.02 ENST00000523231.1
ENST00000524370.1
ENST00000517966.1
MOK
MOK protein kinase
chr3_-_193272741 0.02 ENST00000392443.3
ATP13A4
ATPase type 13A4
chrX_+_100645812 0.02 ENST00000427805.2
ENST00000553110.3
ENST00000392994.3
ENST00000409338.1
ENST00000409170.3
RPL36A
RPL36A-HNRNPH2
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chr5_-_147286065 0.02 ENST00000318315.4
ENST00000515291.1
C5orf46
chromosome 5 open reading frame 46
chr11_+_130029457 0.02 ENST00000278742.5
ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr7_+_120702819 0.02 ENST00000423795.1
CPED1
cadherin-like and PC-esterase domain containing 1
chr1_+_178310581 0.02 ENST00000462775.1
RASAL2
RAS protein activator like 2
chr11_+_8704748 0.02 ENST00000526562.1
ENST00000525981.1
RPL27A
ribosomal protein L27a
chr15_+_43425672 0.02 ENST00000260403.2
TMEM62
transmembrane protein 62
chr15_+_75550940 0.02 ENST00000300576.5
GOLGA6C
golgin A6 family, member C
chr1_+_184020830 0.01 ENST00000533373.1
ENST00000423085.2
TSEN15
TSEN15 tRNA splicing endonuclease subunit
chr11_-_8959758 0.01 ENST00000531618.1
ASCL3
achaete-scute family bHLH transcription factor 3
chr8_-_145652336 0.01 ENST00000529182.1
ENST00000526054.1
VPS28
vacuolar protein sorting 28 homolog (S. cerevisiae)
chr14_-_107131560 0.01 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr18_-_59274139 0.01 ENST00000586949.1
RP11-879F14.2
RP11-879F14.2
chr10_-_28571015 0.00 ENST00000375719.3
ENST00000375732.1
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr6_+_26204825 0.00 ENST00000360441.4
HIST1H4E
histone cluster 1, H4e
chr5_-_154230130 0.00 ENST00000519501.1
ENST00000518651.1
ENST00000517938.1
ENST00000520461.1
FAXDC2
fatty acid hydroxylase domain containing 2
chr10_-_10836919 0.00 ENST00000602763.1
ENST00000415590.2
ENST00000434919.2
SFTA1P
surfactant associated 1, pseudogene
chr19_+_55084438 0.00 ENST00000439534.1
LILRA2
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of OTX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0035026 leading edge cell differentiation(GO:0035026)
0.4 1.8 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.3 1.5 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.2 0.7 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.2 0.7 GO:0032290 peripheral nervous system myelin formation(GO:0032290)
0.2 0.7 GO:0046104 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.2 1.1 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.7 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.3 GO:0007113 endomitotic cell cycle(GO:0007113)
0.1 0.3 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.1 0.7 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
0.1 0.3 GO:1902463 protein localization to cell leading edge(GO:1902463)
0.1 0.4 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.1 0.3 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 0.2 GO:2001287 negative regulation of clathrin-mediated endocytosis(GO:1900186) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.1 0.4 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.2 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.1 0.2 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.1 0.3 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.1 0.7 GO:0001675 acrosome assembly(GO:0001675)
0.0 1.3 GO:0009812 flavonoid metabolic process(GO:0009812)
0.0 0.3 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 0.9 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.1 GO:1902534 single-organism membrane invagination(GO:1902534)
0.0 0.2 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.9 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.2 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.2 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.0 0.2 GO:1903751 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.0 0.1 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.0 1.0 GO:0010842 retina layer formation(GO:0010842)
0.0 0.2 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.1 GO:0071314 cellular response to cocaine(GO:0071314)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.2 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.1 GO:0070346 positive regulation of fat cell proliferation(GO:0070346)
0.0 0.4 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.2 GO:0032417 positive regulation of sodium:proton antiporter activity(GO:0032417)
0.0 0.4 GO:0043306 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.0 0.1 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.1 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0 0.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.1 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.0 GO:0045925 maternal aggressive behavior(GO:0002125) positive regulation of female receptivity(GO:0045925)
0.0 0.5 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.2 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.2 GO:0034638 very-low-density lipoprotein particle remodeling(GO:0034372) phosphatidylcholine catabolic process(GO:0034638)
0.0 0.3 GO:0008356 asymmetric cell division(GO:0008356)
0.0 0.0 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0 0.1 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.6 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.1 GO:1990502 dense core granule maturation(GO:1990502)
0.0 0.6 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.0 GO:0019046 release from viral latency(GO:0019046)
0.0 0.2 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.2 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.2 2.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2 0.7 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 0.5 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1 0.7 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.3 GO:0033269 internode region of axon(GO:0033269)
0.0 0.1 GO:1990923 PET complex(GO:1990923)
0.0 0.6 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.7 GO:0043220 paranode region of axon(GO:0033270) Schmidt-Lanterman incisure(GO:0043220)
0.0 0.2 GO:1990357 terminal web(GO:1990357)
0.0 0.1 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.0 1.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.5 GO:0031430 M band(GO:0031430)
0.0 0.3 GO:0005869 dynactin complex(GO:0005869)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0036128 CatSper complex(GO:0036128)
0.0 0.2 GO:0071203 WASH complex(GO:0071203)
0.0 0.1 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.5 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.3 GO:0005902 microvillus(GO:0005902)
0.0 0.1 GO:0036157 outer dynein arm(GO:0036157)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
0.2 0.7 GO:0004797 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.2 0.5 GO:0003826 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
0.2 1.8 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.1 0.5 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 0.7 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 0.9 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.1 2.0 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 0.7 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 1.0 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.1 1.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.7 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 1.1 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.7 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 1.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.2 GO:0004447 iodide peroxidase activity(GO:0004447)
0.0 0.2 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.4 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.2 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.4 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.3 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.2 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.6 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:1902444 riboflavin binding(GO:1902444)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 1.5 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.2 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 3.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.7 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.9 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.6 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.1 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.4 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.7 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.7 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.5 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.8 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.8 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression