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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for OTX2_CRX

Z-value: 0.46

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Transcription factors associated with OTX2_CRX

Gene Symbol Gene ID Gene Info
OTX2
ENSG00000165588.12 orthodenticle homeobox 2
CRX
ENSG00000105392.11 cone-rod homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
OTX2hg19_v2_chr14_-_57272366_57272391-0.341.0e-01Click!
CRXhg19_v2_chr19_+_48325097_483252110.341.0e-01Click!

Activity profile of OTX2_CRX motif

Sorted Z-values of OTX2_CRX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_6949964 1.63 ENST00000541978.1
ENST00000435982.2
GNB3
guanine nucleotide binding protein (G protein), beta polypeptide 3
chr6_+_130339710 0.76 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr14_-_95236551 0.61 ENST00000238558.3
GSC
goosecoid homeobox
chr1_-_165414414 0.42 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr11_-_62752162 0.40 ENST00000458333.2
ENST00000421062.2
SLC22A6
solute carrier family 22 (organic anion transporter), member 6
chr19_+_46001697 0.39 ENST00000451287.2
ENST00000324688.4
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr12_+_15125954 0.36 ENST00000266395.2
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr11_+_61248583 0.35 ENST00000432063.2
ENST00000338608.2
PPP1R32
protein phosphatase 1, regulatory subunit 32
chr19_+_2476116 0.35 ENST00000215631.4
ENST00000587345.1
GADD45B
growth arrest and DNA-damage-inducible, beta
chr12_+_85673868 0.34 ENST00000316824.3
ALX1
ALX homeobox 1
chr6_-_42690312 0.34 ENST00000230381.5
PRPH2
peripherin 2 (retinal degeneration, slow)
chr10_+_103986085 0.29 ENST00000370005.3
ELOVL3
ELOVL fatty acid elongase 3
chr14_-_22005018 0.28 ENST00000546363.1
SALL2
spalt-like transcription factor 2
chr19_+_48325097 0.28 ENST00000221996.7
ENST00000539067.1
CRX
cone-rod homeobox
chr22_-_38380543 0.26 ENST00000396884.2
SOX10
SRY (sex determining region Y)-box 10
chr8_+_54764346 0.25 ENST00000297313.3
ENST00000344277.6
RGS20
regulator of G-protein signaling 20
chr13_-_33780133 0.25 ENST00000399365.3
STARD13
StAR-related lipid transfer (START) domain containing 13
chr11_+_67222818 0.24 ENST00000325656.5
CABP4
calcium binding protein 4
chr14_-_22005062 0.23 ENST00000317492.5
SALL2
spalt-like transcription factor 2
chr5_-_88179302 0.23 ENST00000504921.2
MEF2C
myocyte enhancer factor 2C
chr4_+_129730947 0.22 ENST00000452328.2
ENST00000504089.1
PHF17
jade family PHD finger 1
chr8_-_133123406 0.22 ENST00000434736.2
HHLA1
HERV-H LTR-associating 1
chr17_-_40264692 0.22 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr2_+_66662510 0.22 ENST00000272369.9
ENST00000407092.2
MEIS1
Meis homeobox 1
chr20_-_18774614 0.21 ENST00000412553.1
LINC00652
long intergenic non-protein coding RNA 652
chr3_-_54962100 0.21 ENST00000273286.5
LRTM1
leucine-rich repeats and transmembrane domains 1
chr2_+_66662690 0.21 ENST00000488550.1
MEIS1
Meis homeobox 1
chr4_+_129730779 0.21 ENST00000226319.6
PHF17
jade family PHD finger 1
chr1_+_144989309 0.21 ENST00000596396.1
AL590452.1
Uncharacterized protein
chr1_+_162351503 0.20 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr6_+_35310312 0.20 ENST00000448077.2
ENST00000360694.3
ENST00000418635.2
ENST00000444397.1
PPARD
peroxisome proliferator-activated receptor delta
chr1_+_244214577 0.19 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr3_-_112218205 0.18 ENST00000383680.4
BTLA
B and T lymphocyte associated
chr3_-_50649192 0.18 ENST00000443053.2
ENST00000348721.3
CISH
cytokine inducible SH2-containing protein
chr3_+_63953415 0.18 ENST00000484332.1
ATXN7
ataxin 7
chr6_-_29399744 0.17 ENST00000377154.1
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr2_-_89459813 0.17 ENST00000390256.2
IGKV6-21
immunoglobulin kappa variable 6-21 (non-functional)
chrX_-_21676442 0.17 ENST00000379499.2
KLHL34
kelch-like family member 34
chr11_-_118436606 0.17 ENST00000530872.1
IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chr7_-_100171270 0.17 ENST00000538735.1
SAP25
Sin3A-associated protein, 25kDa
chr15_+_41221536 0.17 ENST00000249749.5
DLL4
delta-like 4 (Drosophila)
chrX_+_15767971 0.16 ENST00000479740.1
ENST00000454127.2
CA5B
carbonic anhydrase VB, mitochondrial
chr7_+_73868220 0.16 ENST00000455841.2
GTF2IRD1
GTF2I repeat domain containing 1
chr14_-_22005343 0.16 ENST00000327430.3
SALL2
spalt-like transcription factor 2
chr10_-_126716459 0.16 ENST00000309035.6
CTBP2
C-terminal binding protein 2
chr13_-_95131923 0.16 ENST00000377028.5
ENST00000446125.1
DCT
dopachrome tautomerase
chr18_+_32290218 0.16 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
DTNA
dystrobrevin, alpha
chr12_+_81101277 0.16 ENST00000228641.3
MYF6
myogenic factor 6 (herculin)
chrX_+_129473859 0.15 ENST00000424447.1
SLC25A14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr6_+_34433844 0.15 ENST00000244458.2
ENST00000374043.2
PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr3_-_190580404 0.15 ENST00000442080.1
GMNC
geminin coiled-coil domain containing
chr17_-_46690839 0.15 ENST00000498634.2
HOXB8
homeobox B8
chr11_-_118436707 0.15 ENST00000264020.2
ENST00000264021.3
IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chrX_-_124097620 0.14 ENST00000371130.3
ENST00000422452.2
TENM1
teneurin transmembrane protein 1
chr11_-_128712362 0.14 ENST00000392664.2
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr1_-_117664317 0.14 ENST00000256649.4
ENST00000369464.3
ENST00000485032.1
TRIM45
tripartite motif containing 45
chr17_+_68100989 0.14 ENST00000585558.1
ENST00000392670.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr15_+_96869165 0.14 ENST00000421109.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chrX_+_17653413 0.14 ENST00000398097.3
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr16_-_31076273 0.13 ENST00000426488.2
ZNF668
zinc finger protein 668
chr5_+_5140436 0.13 ENST00000511368.1
ENST00000274181.7
ADAMTS16
ADAM metallopeptidase with thrombospondin type 1 motif, 16
chr14_+_88471468 0.13 ENST00000267549.3
GPR65
G protein-coupled receptor 65
chr3_-_112218378 0.13 ENST00000334529.5
BTLA
B and T lymphocyte associated
chr4_-_153601136 0.13 ENST00000504064.1
ENST00000304385.3
TMEM154
transmembrane protein 154
chr2_+_170366203 0.13 ENST00000284669.1
KLHL41
kelch-like family member 41
chr11_-_130184555 0.13 ENST00000525842.1
ZBTB44
zinc finger and BTB domain containing 44
chr2_-_121223697 0.13 ENST00000593290.1
FLJ14816
long intergenic non-protein coding RNA 1101
chr6_-_170599561 0.12 ENST00000366756.3
DLL1
delta-like 1 (Drosophila)
chr3_-_49058479 0.12 ENST00000440857.1
DALRD3
DALR anticodon binding domain containing 3
chr18_-_64271363 0.12 ENST00000262150.2
CDH19
cadherin 19, type 2
chr2_+_33661382 0.12 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr16_-_31076332 0.12 ENST00000539836.3
ENST00000535577.1
ENST00000442862.2
ZNF668
zinc finger protein 668
chr12_+_53693466 0.12 ENST00000267103.5
ENST00000548632.1
C12orf10
chromosome 12 open reading frame 10
chr13_-_52027134 0.12 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chr5_+_161494770 0.12 ENST00000414552.2
ENST00000361925.4
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr9_-_39288092 0.12 ENST00000323947.7
ENST00000297668.6
ENST00000377656.2
ENST00000377659.1
CNTNAP3
contactin associated protein-like 3
chr1_+_207277590 0.12 ENST00000367070.3
C4BPA
complement component 4 binding protein, alpha
chr17_+_7905912 0.12 ENST00000254854.4
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr5_-_524445 0.12 ENST00000514375.1
ENST00000264938.3
SLC9A3
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
chr20_+_59654146 0.12 ENST00000441660.1
RP5-827L5.1
RP5-827L5.1
chr12_+_53693812 0.11 ENST00000549488.1
C12orf10
chromosome 12 open reading frame 10
chrX_-_10588459 0.11 ENST00000380782.2
MID1
midline 1 (Opitz/BBB syndrome)
chr5_+_63461642 0.11 ENST00000296615.6
ENST00000381081.2
ENST00000389100.4
RNF180
ring finger protein 180
chr5_-_88179017 0.11 ENST00000514028.1
ENST00000514015.1
ENST00000503075.1
ENST00000437473.2
MEF2C
myocyte enhancer factor 2C
chr2_+_201170703 0.11 ENST00000358677.5
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr2_-_188312971 0.11 ENST00000410068.1
ENST00000447403.1
ENST00000410102.1
CALCRL
calcitonin receptor-like
chr17_-_38859996 0.11 ENST00000264651.2
KRT24
keratin 24
chr5_-_88178964 0.11 ENST00000513252.1
ENST00000508569.1
ENST00000510942.1
ENST00000506554.1
MEF2C
myocyte enhancer factor 2C
chr6_+_35310391 0.11 ENST00000337400.2
ENST00000311565.4
ENST00000540939.1
PPARD
peroxisome proliferator-activated receptor delta
chrX_-_10588595 0.10 ENST00000423614.1
ENST00000317552.4
MID1
midline 1 (Opitz/BBB syndrome)
chr12_-_53189892 0.10 ENST00000309505.3
ENST00000417996.2
KRT3
keratin 3
chr17_+_4643337 0.10 ENST00000592813.1
ZMYND15
zinc finger, MYND-type containing 15
chr2_-_70780572 0.10 ENST00000450929.1
TGFA
transforming growth factor, alpha
chr7_+_90338712 0.10 ENST00000265741.3
ENST00000406263.1
CDK14
cyclin-dependent kinase 14
chr1_+_55505184 0.10 ENST00000302118.5
PCSK9
proprotein convertase subtilisin/kexin type 9
chr17_+_4643300 0.10 ENST00000433935.1
ZMYND15
zinc finger, MYND-type containing 15
chr9_-_130966497 0.10 ENST00000393608.1
ENST00000372948.3
CIZ1
CDKN1A interacting zinc finger protein 1
chr5_+_161494521 0.10 ENST00000356592.3
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr5_-_149669192 0.10 ENST00000398376.3
CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr17_-_9808887 0.10 ENST00000226193.5
RCVRN
recoverin
chr1_+_11751748 0.09 ENST00000294485.5
DRAXIN
dorsal inhibitory axon guidance protein
chr6_-_111804905 0.09 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr2_-_14541060 0.09 ENST00000418420.1
ENST00000417751.1
LINC00276
long intergenic non-protein coding RNA 276
chr15_+_58430368 0.09 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr3_-_137851220 0.09 ENST00000236709.3
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr10_+_18240834 0.09 ENST00000377371.3
ENST00000539911.1
SLC39A12
solute carrier family 39 (zinc transporter), member 12
chr4_+_154125565 0.09 ENST00000338700.5
TRIM2
tripartite motif containing 2
chr19_-_48547294 0.09 ENST00000293255.2
CABP5
calcium binding protein 5
chr9_-_139361503 0.09 ENST00000453963.1
SEC16A
SEC16 homolog A (S. cerevisiae)
chr14_-_36789865 0.09 ENST00000416007.4
MBIP
MAP3K12 binding inhibitory protein 1
chr3_+_4535025 0.09 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr14_-_36789783 0.09 ENST00000605579.1
ENST00000604336.1
ENST00000359527.7
ENST00000603139.1
ENST00000318473.7
MBIP
MAP3K12 binding inhibitory protein 1
chr4_-_100484825 0.09 ENST00000273962.3
ENST00000514547.1
ENST00000455368.2
TRMT10A
tRNA methyltransferase 10 homolog A (S. cerevisiae)
chr15_+_58430567 0.08 ENST00000536493.1
AQP9
aquaporin 9
chr14_-_67981870 0.08 ENST00000555994.1
TMEM229B
transmembrane protein 229B
chrM_+_9207 0.08 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr4_-_100485143 0.08 ENST00000394877.3
TRMT10A
tRNA methyltransferase 10 homolog A (S. cerevisiae)
chr2_-_175499294 0.08 ENST00000392547.2
WIPF1
WAS/WASL interacting protein family, member 1
chr15_-_74495188 0.08 ENST00000563965.1
ENST00000395105.4
STRA6
stimulated by retinoic acid 6
chr16_-_21663919 0.08 ENST00000569602.1
IGSF6
immunoglobulin superfamily, member 6
chr7_-_97881429 0.08 ENST00000420697.1
ENST00000379795.3
ENST00000415086.1
ENST00000542604.1
ENST00000447648.2
TECPR1
tectonin beta-propeller repeat containing 1
chr15_-_65407524 0.08 ENST00000559089.1
UBAP1L
ubiquitin associated protein 1-like
chr12_-_53171128 0.08 ENST00000332411.2
KRT76
keratin 76
chr18_+_616711 0.08 ENST00000579494.1
CLUL1
clusterin-like 1 (retinal)
chr5_-_36301984 0.08 ENST00000502994.1
ENST00000515759.1
ENST00000296604.3
RANBP3L
RAN binding protein 3-like
chr11_-_130184470 0.07 ENST00000357899.4
ENST00000397753.1
ZBTB44
zinc finger and BTB domain containing 44
chr12_-_118628350 0.07 ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chrX_+_28605516 0.07 ENST00000378993.1
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr10_-_94003003 0.07 ENST00000412050.4
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr12_-_21487829 0.07 ENST00000445053.1
ENST00000452078.1
ENST00000458504.1
ENST00000422327.1
ENST00000421294.1
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr1_+_66999268 0.07 ENST00000371039.1
ENST00000424320.1
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr19_+_11457175 0.07 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
CCDC159
coiled-coil domain containing 159
chrX_-_119077695 0.07 ENST00000371410.3
NKAP
NFKB activating protein
chr7_+_73868439 0.07 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr1_-_102312517 0.07 ENST00000338858.5
OLFM3
olfactomedin 3
chr12_-_54779511 0.07 ENST00000551109.1
ENST00000546970.1
ZNF385A
zinc finger protein 385A
chr5_+_173316341 0.07 ENST00000520867.1
ENST00000334035.5
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr11_-_67290867 0.07 ENST00000353903.5
ENST00000294288.4
CABP2
calcium binding protein 2
chr8_+_70378852 0.07 ENST00000525061.1
ENST00000458141.2
ENST00000260128.4
SULF1
sulfatase 1
chr9_-_20622478 0.07 ENST00000355930.6
ENST00000380338.4
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr10_+_18240753 0.07 ENST00000377369.2
SLC39A12
solute carrier family 39 (zinc transporter), member 12
chr3_-_47950745 0.07 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr12_-_90049878 0.07 ENST00000359142.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr2_+_192141611 0.06 ENST00000392316.1
MYO1B
myosin IB
chr18_-_64271316 0.06 ENST00000540086.1
ENST00000580157.1
CDH19
cadherin 19, type 2
chr9_+_18474098 0.06 ENST00000327883.7
ENST00000431052.2
ENST00000380570.4
ADAMTSL1
ADAMTS-like 1
chr18_+_616672 0.06 ENST00000338387.7
CLUL1
clusterin-like 1 (retinal)
chr17_-_39661849 0.06 ENST00000246635.3
ENST00000336861.3
ENST00000587544.1
ENST00000587435.1
KRT13
keratin 13
chr11_+_124735282 0.06 ENST00000397801.1
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr2_+_120770686 0.06 ENST00000331393.4
ENST00000443124.1
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr10_-_105845674 0.06 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr17_-_48207157 0.06 ENST00000330175.4
ENST00000503131.1
SAMD14
sterile alpha motif domain containing 14
chr12_+_133757995 0.06 ENST00000536435.2
ENST00000228289.5
ENST00000541211.2
ENST00000500625.3
ENST00000539248.2
ENST00000542711.2
ENST00000536899.2
ENST00000542986.2
ENST00000537565.1
ENST00000541975.2
ZNF268
zinc finger protein 268
chr12_-_90049828 0.06 ENST00000261173.2
ENST00000348959.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr1_+_202431859 0.06 ENST00000391959.3
ENST00000367270.4
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr2_+_183943464 0.06 ENST00000354221.4
DUSP19
dual specificity phosphatase 19
chr2_-_61765315 0.06 ENST00000406957.1
ENST00000401558.2
XPO1
exportin 1 (CRM1 homolog, yeast)
chr10_-_89577910 0.06 ENST00000308448.7
ENST00000541004.1
ATAD1
ATPase family, AAA domain containing 1
chr2_+_201170596 0.06 ENST00000439084.1
ENST00000409718.1
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr7_-_104909435 0.05 ENST00000357311.3
SRPK2
SRSF protein kinase 2
chr12_-_56848426 0.05 ENST00000257979.4
MIP
major intrinsic protein of lens fiber
chr10_+_18240814 0.05 ENST00000377374.4
SLC39A12
solute carrier family 39 (zinc transporter), member 12
chrX_+_41306575 0.05 ENST00000342595.2
ENST00000378220.1
NYX
nyctalopin
chr11_-_128894053 0.05 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr10_+_134150835 0.05 ENST00000432555.2
LRRC27
leucine rich repeat containing 27
chr17_-_14683517 0.05 ENST00000379640.1
AC005863.1
AC005863.1
chr11_+_36589547 0.05 ENST00000299440.5
RAG1
recombination activating gene 1
chr5_-_150138061 0.05 ENST00000521533.1
ENST00000424236.1
DCTN4
dynactin 4 (p62)
chr3_-_186262166 0.05 ENST00000307944.5
CRYGS
crystallin, gamma S
chr2_-_55237484 0.05 ENST00000394609.2
RTN4
reticulon 4
chr15_+_33603147 0.05 ENST00000415757.3
ENST00000389232.4
RYR3
ryanodine receptor 3
chr16_+_81272287 0.05 ENST00000425577.2
ENST00000564552.1
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr1_+_81771806 0.05 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
LPHN2
latrophilin 2
chr3_+_129247479 0.05 ENST00000296271.3
RHO
rhodopsin
chr2_+_219472637 0.05 ENST00000417849.1
PLCD4
phospholipase C, delta 4
chr1_+_159141397 0.05 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr16_-_68269971 0.05 ENST00000565858.1
ESRP2
epithelial splicing regulatory protein 2
chr19_+_18208603 0.05 ENST00000262811.6
MAST3
microtubule associated serine/threonine kinase 3
chr1_+_167298281 0.05 ENST00000367862.5
POU2F1
POU class 2 homeobox 1
chr12_-_55375622 0.05 ENST00000316577.8
TESPA1
thymocyte expressed, positive selection associated 1
chr2_+_120770581 0.05 ENST00000263713.5
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr12_+_7941989 0.05 ENST00000229307.4
NANOG
Nanog homeobox
chr19_-_42931567 0.05 ENST00000244289.4
LIPE
lipase, hormone-sensitive
chrX_-_153363188 0.05 ENST00000303391.6
MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr7_+_73868120 0.05 ENST00000265755.3
GTF2IRD1
GTF2I repeat domain containing 1
chr11_-_30608413 0.05 ENST00000528686.1
MPPED2
metallophosphoesterase domain containing 2
chr19_+_39989580 0.05 ENST00000596614.1
ENST00000205143.4
DLL3
delta-like 3 (Drosophila)
chr7_+_80231466 0.05 ENST00000309881.7
ENST00000534394.1
CD36
CD36 molecule (thrombospondin receptor)
chr3_-_50605150 0.04 ENST00000357203.3
C3orf18
chromosome 3 open reading frame 18
chr9_+_17134980 0.04 ENST00000380647.3
CNTLN
centlein, centrosomal protein
chrX_-_110655306 0.04 ENST00000371993.2
DCX
doublecortin
chr19_+_39989535 0.04 ENST00000356433.5
DLL3
delta-like 3 (Drosophila)
chr12_+_104697504 0.04 ENST00000527879.1
EID3
EP300 interacting inhibitor of differentiation 3
chr17_-_43209862 0.04 ENST00000322765.5
PLCD3
phospholipase C, delta 3
chr14_-_58894332 0.04 ENST00000395159.2
TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr14_+_96722152 0.04 ENST00000216629.6
BDKRB1
bradykinin receptor B1
chr9_-_95244781 0.04 ENST00000375544.3
ENST00000375543.1
ENST00000395538.3
ENST00000450139.2
ASPN
asporin
chr10_-_62761188 0.04 ENST00000357917.4
RHOBTB1
Rho-related BTB domain containing 1
chr2_-_225362533 0.04 ENST00000451538.1
CUL3
cullin 3
chrM_+_8527 0.04 ENST00000361899.2
MT-ATP6
mitochondrially encoded ATP synthase 6

Network of associatons between targets according to the STRING database.

First level regulatory network of OTX2_CRX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.1 0.4 GO:0097254 renal tubular secretion(GO:0097254)
0.1 0.1 GO:0060844 arterial endothelial cell fate commitment(GO:0060844)
0.1 0.4 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.1 0.3 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.1 0.3 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1 0.8 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 0.3 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.2 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.0 0.2 GO:0072554 blood vessel lumenization(GO:0072554)
0.0 0.2 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.2 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.2 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.0 0.3 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.0 0.1 GO:0009956 radial pattern formation(GO:0009956)
0.0 0.1 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.0 0.3 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 1.6 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.3 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.0 0.1 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.2 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 0.4 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.0 0.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.1 GO:0061143 alveolar primary septum development(GO:0061143)
0.0 0.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0071386 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.1 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.0 0.3 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.1 GO:0030450 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
0.0 0.2 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.0 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.0 0.2 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.3 GO:0001502 cartilage condensation(GO:0001502)
0.0 0.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.2 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 0.0 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.0 0.4 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.1 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.1 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.1 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.1 GO:1903365 regulation of fear response(GO:1903365) regulation of behavioral fear response(GO:2000822)
0.0 0.0 GO:0015766 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1990667 PCSK9-LDLR complex(GO:1990666) PCSK9-AnxA2 complex(GO:1990667)
0.0 0.7 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.2 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.2 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.0 0.2 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.2 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 0.1 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.0 0.3 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 1.6 GO:0030507 spectrin binding(GO:0030507)
0.0 0.4 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.2 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.2 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.2 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.0 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.0 GO:0004947 bradykinin receptor activity(GO:0004947)
0.0 0.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 0.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.3 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.0 0.0 GO:0008506 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.3 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.4 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide