ISMARA results: PATZ1

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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for PATZ1_KLF4

Z-value: 1.90

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Transcription factors associated with PATZ1_KLF4

Gene Symbol	Gene ID	Gene Info
PATZ1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000100105.13	POZ/BTB and AT hook containing zinc finger 1
KLF4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000136826.10	Kruppel like factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PATZ1	hg19_v2_chr22_-_31742218_31742350	-0.60	1.5e-03	Click!
KLF4	hg19_v2_chr9_-_110251836_110251927	0.29	1.5e-01	Click!

Activity profile of PATZ1_KLF4 motif

Sorted Z-values of PATZ1_KLF4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_72353451 Show fit	13.20	ENST00000376450.3	PDE2A Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphodiesterase 2A, cGMP-stimulated
chr6_-_29595779 Show fit	13.13	ENST00000355973.3 ENST00000377012.4	GABBR1 Ensembl NCBI GeneCards UniProt NextProt Show fit	gamma-aminobutyric acid (GABA) B receptor, 1
chr19_+_45504688 Show fit	12.79	ENST00000221452.8 ENST00000540120.1 ENST00000505236.1	RELB Ensembl NCBI GeneCards UniProt NextProt Show fit	v-rel avian reticuloendotheliosis viral oncogene homolog B
chr3_-_127541679 Show fit	12.19	ENST00000265052.5	MGLL Ensembl NCBI GeneCards UniProt NextProt Show fit	monoglyceride lipase
chr16_+_66638685 Show fit	11.12	ENST00000565003.1	CMTM3 Ensembl NCBI GeneCards UniProt NextProt Show fit	CKLF-like MARVEL transmembrane domain containing 3
chr2_-_220252603 Show fit	10.95	ENST00000322176.7 ENST00000273075.4	DNPEP Ensembl NCBI GeneCards UniProt NextProt Show fit	aspartyl aminopeptidase
chr10_-_49812997 Show fit	10.61	ENST00000417912.2	ARHGAP22 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho GTPase activating protein 22
chr1_-_41328018 Show fit	9.85	ENST00000372638.2	CITED4 Ensembl NCBI GeneCards UniProt NextProt Show fit	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr6_+_37137939 Show fit	9.83	ENST00000373509.5	PIM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	pim-1 oncogene
chr6_+_14117872 Show fit	9.83	ENST00000379153.3	CD83 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD83 molecule

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of PATZ1_KLF4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	41.5	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.4	35.0	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
5.5	27.5	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.6	26.7	GO:0032456	endocytic recycling(GO:0032456)
0.1	25.3	GO:0008380	RNA splicing(GO:0008380)
3.6	25.2	GO:2000124	regulation of endocannabinoid signaling pathway(GO:2000124)
2.7	21.8	GO:0031444	slow-twitch skeletal muscle fiber contraction(GO:0031444)
2.6	21.0	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.8	20.6	GO:0043011	myeloid dendritic cell differentiation(GO:0043011)
0.7	20.6	GO:0006972	hyperosmotic response(GO:0006972)

Showing 1 to 10 of 1,331 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	49.7	GO:0005759	mitochondrial matrix(GO:0005759)
0.2	44.7	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	42.6	GO:0044431	Golgi apparatus part(GO:0044431)
0.2	29.5	GO:0019898	extrinsic component of membrane(GO:0019898)
0.0	28.4	GO:0009986	cell surface(GO:0009986)
0.4	27.9	GO:0055038	recycling endosome membrane(GO:0055038)
0.3	26.2	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.9	21.2	GO:0005861	troponin complex(GO:0005861)
0.2	20.4	GO:0005581	collagen trimer(GO:0005581)
0.1	19.1	GO:0005769	early endosome(GO:0005769)

Showing 1 to 10 of 452 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	66.2	GO:0003924	GTPase activity(GO:0003924)
0.2	64.5	GO:0005096	GTPase activator activity(GO:0005096)
0.7	38.5	GO:0031593	polyubiquitin binding(GO:0031593)
0.2	32.8	GO:0005125	cytokine activity(GO:0005125)
0.2	32.6	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4	30.7	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
3.1	27.5	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2	26.2	GO:0004222	metalloendopeptidase activity(GO:0004222)
1.5	26.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
1.0	25.1	GO:0031005	filamin binding(GO:0031005)

Showing 1 to 10 of 744 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	42.7	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.5	39.9	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.9	36.8	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.1	35.3	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	34.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	31.3	PID LKB1 PATHWAY	LKB1 signaling events
0.4	29.0	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.2	27.2	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.7	25.5	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.6	25.2	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.

Showing 1 to 10 of 129 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	56.9	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
1.0	45.2	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.5	38.0	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.7	37.5	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.8	35.5	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.2	31.3	REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	Genes involved in Processing of Capped Intron-Containing Pre-mRNA
0.9	29.8	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.4	27.7	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	22.4	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.3	22.0	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling

Showing 1 to 10 of 202 entries

Results for PATZ1_KLF4

Z-value: 1.90

Motif logo

Transcription factors associated with PATZ1_KLF4

Activity-expression correlation:

Activity profile of PATZ1_KLF4 motif

Sorted Z-values of PATZ1_KLF4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of PATZ1_KLF4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: