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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for PAX1_PAX9

Z-value: 0.49

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Transcription factors associated with PAX1_PAX9

Gene Symbol Gene ID Gene Info
PAX1
ENSG00000125813.9 paired box 1
PAX9
ENSG00000198807.8 paired box 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX9hg19_v2_chr14_+_37126765_37126799-0.145.0e-01Click!
PAX1hg19_v2_chr20_+_21686290_21686311-0.067.9e-01Click!

Activity profile of PAX1_PAX9 motif

Sorted Z-values of PAX1_PAX9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_84824920 2.65 ENST00000523678.1
RP11-120I21.2
RP11-120I21.2
chr4_+_123747834 2.02 ENST00000264498.3
FGF2
fibroblast growth factor 2 (basic)
chr8_-_125384927 1.89 ENST00000297632.6
TMEM65
transmembrane protein 65
chr4_+_123747979 1.77 ENST00000608478.1
FGF2
fibroblast growth factor 2 (basic)
chr6_+_34857019 1.46 ENST00000360359.3
ENST00000535627.1
ANKS1A
ankyrin repeat and sterile alpha motif domain containing 1A
chr9_-_124991124 1.43 ENST00000394319.4
ENST00000340587.3
LHX6
LIM homeobox 6
chr19_-_18995029 1.22 ENST00000596048.1
CERS1
ceramide synthase 1
chr5_-_133747589 1.07 ENST00000458198.2
CDKN2AIPNL
CDKN2A interacting protein N-terminal like
chr13_+_21141270 0.72 ENST00000319980.6
ENST00000537103.1
ENST00000389373.3
IFT88
intraflagellar transport 88 homolog (Chlamydomonas)
chr13_+_21141208 0.65 ENST00000351808.5
IFT88
intraflagellar transport 88 homolog (Chlamydomonas)
chr17_-_39968406 0.43 ENST00000393928.1
LEPREL4
leprecan-like 4
chr6_+_132891461 0.41 ENST00000275198.1
TAAR6
trace amine associated receptor 6
chr17_-_39968855 0.39 ENST00000355468.3
ENST00000590496.1
LEPREL4
leprecan-like 4
chr15_+_63569785 0.38 ENST00000380343.4
ENST00000560353.1
APH1B
APH1B gamma secretase subunit
chr17_+_76374714 0.38 ENST00000262764.6
ENST00000589689.1
ENST00000329897.7
ENST00000592043.1
ENST00000587356.1
PGS1
phosphatidylglycerophosphate synthase 1
chr15_+_63569731 0.31 ENST00000261879.5
APH1B
APH1B gamma secretase subunit
chr4_-_163085141 0.28 ENST00000427802.2
ENST00000306100.5
FSTL5
follistatin-like 5
chr2_+_119699864 0.26 ENST00000541757.1
ENST00000412481.1
MARCO
macrophage receptor with collagenous structure
chrX_-_153707545 0.24 ENST00000357360.4
LAGE3
L antigen family, member 3
chr1_-_204165610 0.23 ENST00000367194.4
KISS1
KiSS-1 metastasis-suppressor
chr18_-_47017956 0.21 ENST00000584895.1
ENST00000332968.6
ENST00000580210.1
ENST00000579408.1
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr2_-_207629997 0.21 ENST00000454776.2
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr1_-_162838551 0.21 ENST00000367910.1
ENST00000367912.2
ENST00000367911.2
C1orf110
chromosome 1 open reading frame 110
chr3_+_15247686 0.20 ENST00000253693.2
CAPN7
calpain 7
chr11_+_6947720 0.19 ENST00000414517.2
ZNF215
zinc finger protein 215
chr17_+_15848231 0.19 ENST00000304222.2
ADORA2B
adenosine A2b receptor
chr7_-_112758665 0.18 ENST00000397764.3
LINC00998
long intergenic non-protein coding RNA 998
chr7_-_112758589 0.18 ENST00000413744.1
ENST00000439551.1
ENST00000441359.1
LINC00998
long intergenic non-protein coding RNA 998
chr9_-_104249400 0.17 ENST00000374848.3
TMEM246
transmembrane protein 246
chr6_-_137494775 0.17 ENST00000349184.4
ENST00000296980.2
ENST00000339602.3
IL22RA2
interleukin 22 receptor, alpha 2
chrX_-_148669116 0.16 ENST00000243314.5
MAGEA9B
melanoma antigen family A, 9B
chrX_-_153707246 0.15 ENST00000407062.1
LAGE3
L antigen family, member 3
chr17_-_3461092 0.15 ENST00000301365.4
ENST00000572519.1
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr19_+_14184370 0.15 ENST00000590772.1
hsa-mir-1199
hsa-mir-1199
chr1_-_213031418 0.15 ENST00000356684.3
ENST00000426161.1
ENST00000424044.1
FLVCR1-AS1
FLVCR1 antisense RNA 1 (head to head)
chr2_-_162931052 0.14 ENST00000360534.3
DPP4
dipeptidyl-peptidase 4
chr3_-_57113314 0.13 ENST00000338458.4
ENST00000468727.1
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr3_+_195447738 0.12 ENST00000447234.2
ENST00000320736.6
ENST00000436408.1
MUC20
mucin 20, cell surface associated
chr4_+_619386 0.12 ENST00000496514.1
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr11_+_6947647 0.11 ENST00000278319.5
ZNF215
zinc finger protein 215
chr17_+_39969183 0.10 ENST00000321562.4
FKBP10
FK506 binding protein 10, 65 kDa
chr3_-_25824872 0.08 ENST00000308710.5
NGLY1
N-glycanase 1
chr9_-_21142144 0.07 ENST00000380229.2
IFNW1
interferon, omega 1
chr3_+_31574189 0.07 ENST00000295770.2
STT3B
STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
chr1_+_160121356 0.07 ENST00000368081.4
ATP1A4
ATPase, Na+/K+ transporting, alpha 4 polypeptide
chr11_+_61522844 0.06 ENST00000265460.5
MYRF
myelin regulatory factor
chr3_-_25824925 0.06 ENST00000396649.3
ENST00000428257.1
ENST00000280700.5
NGLY1
N-glycanase 1
chr4_+_619347 0.06 ENST00000255622.6
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr22_+_39745930 0.05 ENST00000318801.4
ENST00000216155.7
ENST00000406293.3
ENST00000328933.5
SYNGR1
synaptogyrin 1
chr4_-_77997126 0.05 ENST00000537948.1
ENST00000507788.1
ENST00000237654.4
CCNI
cyclin I
chr10_-_99393242 0.05 ENST00000370635.3
ENST00000478953.1
ENST00000335628.3
MORN4
MORN repeat containing 4
chr6_-_170893742 0.05 ENST00000443345.2
ENST00000541970.1
PDCD2
programmed cell death 2
chr14_+_24540046 0.04 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
CPNE6
copine VI (neuronal)
chr17_-_7137582 0.04 ENST00000575756.1
ENST00000575458.1
DVL2
dishevelled segment polarity protein 2
chr19_-_52148798 0.04 ENST00000534261.2
SIGLEC5
sialic acid binding Ig-like lectin 5
chr19_-_5838768 0.03 ENST00000527106.1
ENST00000531199.1
ENST00000529165.1
FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr8_-_121824374 0.02 ENST00000517992.1
SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr7_+_142457315 0.02 ENST00000486171.1
ENST00000311737.7
PRSS1
protease, serine, 1 (trypsin 1)
chr22_-_41940404 0.01 ENST00000355209.4
ENST00000337566.5
ENST00000396504.2
ENST00000407461.1
POLR3H
polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)
chr9_-_131418944 0.01 ENST00000419989.1
ENST00000451652.1
ENST00000372715.2
WDR34
WD repeat domain 34
chr6_+_3118926 0.00 ENST00000380379.5
BPHL
biphenyl hydrolase-like (serine hydrolase)
chr18_-_47018769 0.00 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
RPL17
ribosomal protein L17
chr17_+_37356555 0.00 ENST00000579374.1
RPL19
ribosomal protein L19
chr7_-_144533074 0.00 ENST00000360057.3
ENST00000378099.3
TPK1
thiamin pyrophosphokinase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX1_PAX9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.8 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.4 1.2 GO:0072720 cellular response to mycotoxin(GO:0036146) response to dithiothreitol(GO:0072720)
0.4 1.5 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.1 1.4 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.2 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.0 0.2 GO:0002880 chronic inflammatory response to non-antigenic stimulus(GO:0002545) regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002880)
0.0 0.4 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.1 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.0 0.7 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.1 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
0.0 1.4 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.2 GO:0042636 negative regulation of hair cycle(GO:0042636)
0.0 2.0 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.0 0.2 GO:0097264 self proteolysis(GO:0097264)
0.0 0.1 GO:0006108 malate metabolic process(GO:0006108)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 0.4 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 1.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 1.9 GO:0014704 intercalated disc(GO:0014704)
0.0 0.1 GO:0071438 invadopodium membrane(GO:0071438)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.4 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 0.2 GO:0090541 MIT domain binding(GO:0090541)
0.0 0.4 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.7 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.4 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.8 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.7 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR