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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for PAX3
Z-value: 0.66
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Transcription factors associated with PAX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PAX3 | hg19_v2_chr2_-_223163465_223163730 | 0.03 | 8.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_101185290 Show fit | 3.91 |
ENST00000370119.4
ENST00000347652.2 ENST00000294728.2 ENST00000370115.1 |
vascular cell adhesion molecule 1 |
|
| chr2_+_152214098 Show fit | 3.50 |
ENST00000243347.3
|
tumor necrosis factor, alpha-induced protein 6 |
|
| chr10_+_91087651 Show fit | 2.27 |
ENST00000371818.4
|
interferon-induced protein with tetratricopeptide repeats 3 |
|
| chr15_-_80263506 Show fit | 2.07 |
ENST00000335661.6
|
BCL2-related protein A1 |
|
| chr6_+_14117872 Show fit | 1.51 |
ENST00000379153.3
|
CD83 molecule |
|
| chr10_-_24770632 Show fit | 1.15 |
ENST00000596413.1
|
AL353583.1 |
|
| chr12_-_89919965 Show fit | 1.04 |
ENST00000548729.1
|
POC1B-GALNT4 readthrough |
|
| chr11_-_615570 Show fit | 1.03 |
ENST00000525445.1
ENST00000348655.6 ENST00000397566.1 |
interferon regulatory factor 7 |
|
| chr4_+_8582287 Show fit | 0.99 |
ENST00000382487.4
|
G protein-coupled receptor 78 |
|
| chr5_-_35938674 Show fit | 0.95 |
ENST00000397366.1
ENST00000513623.1 ENST00000514524.1 ENST00000397367.2 |
calcyphosine-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of PAX3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.9 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 0.1 | 3.5 | GO:0030728 | ovulation(GO:0030728) |
| 0.2 | 2.3 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.1 | 2.1 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.4 | 1.8 | GO:2000110 | negative regulation of macrophage apoptotic process(GO:2000110) |
| 0.0 | 1.6 | GO:0045824 | negative regulation of innate immune response(GO:0045824) |
| 0.2 | 1.5 | GO:0032713 | negative regulation of interleukin-4 production(GO:0032713) |
| 0.1 | 0.9 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.0 | 0.9 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 0.8 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.9 | GO:0071065 | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
| 0.0 | 3.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 0.9 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.0 | 0.7 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.7 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.0 | 0.5 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.0 | 0.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.4 | GO:0072558 | NLRP1 inflammasome complex(GO:0072558) protease inhibitor complex(GO:0097179) |
| 0.0 | 0.3 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.0 | 0.3 | GO:0044666 | MLL3/4 complex(GO:0044666) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.6 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.1 | 3.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 2.1 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.0 | 1.5 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 0.9 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.9 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.0 | 0.8 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.0 | 0.8 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 0.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.8 | GO:0008175 | tRNA methyltransferase activity(GO:0008175) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.0 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.8 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.6 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 1.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.4 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.3 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 1.8 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.0 | 1.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.8 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 0.7 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 0.7 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.0 | 0.7 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 0.5 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 0.5 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.0 | 0.4 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |