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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for PAX4

Z-value: 0.50

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Transcription factors associated with PAX4

Gene Symbol Gene ID Gene Info
PAX4
ENSG00000106331.10 paired box 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX4hg19_v2_chr7_-_127255982_1272559820.164.5e-01Click!

Activity profile of PAX4 motif

Sorted Z-values of PAX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_102972363 1.43 ENST00000409599.1
IL18R1
interleukin 18 receptor 1
chr12_+_121570631 0.97 ENST00000546057.1
ENST00000377162.2
ENST00000328963.5
ENST00000535250.1
ENST00000541446.1
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7
chr9_-_123676827 0.90 ENST00000546084.1
TRAF1
TNF receptor-associated factor 1
chr7_-_22259845 0.75 ENST00000420196.1
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr7_-_139763521 0.72 ENST00000263549.3
PARP12
poly (ADP-ribose) polymerase family, member 12
chr6_-_32806506 0.68 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr3_+_111805182 0.66 ENST00000430855.1
ENST00000431717.2
ENST00000264848.5
C3orf52
chromosome 3 open reading frame 52
chr16_-_28621353 0.65 ENST00000567512.1
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr3_-_79816965 0.62 ENST00000464233.1
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr6_+_31553901 0.57 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
LST1
leukocyte specific transcript 1
chr21_+_26934165 0.55 ENST00000456917.1
MIR155HG
MIR155 host gene (non-protein coding)
chr6_+_31553978 0.55 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
LST1
leukocyte specific transcript 1
chr16_+_50730910 0.44 ENST00000300589.2
NOD2
nucleotide-binding oligomerization domain containing 2
chr3_-_123339418 0.44 ENST00000583087.1
MYLK
myosin light chain kinase
chr3_-_123339343 0.43 ENST00000578202.1
MYLK
myosin light chain kinase
chr6_+_31554636 0.42 ENST00000433492.1
LST1
leukocyte specific transcript 1
chr1_+_152881014 0.42 ENST00000368764.3
ENST00000392667.2
IVL
involucrin
chr4_-_169931231 0.39 ENST00000504561.1
CBR4
carbonyl reductase 4
chr5_-_13944652 0.34 ENST00000265104.4
DNAH5
dynein, axonemal, heavy chain 5
chr20_-_18810797 0.34 ENST00000278779.4
C20orf78
chromosome 20 open reading frame 78
chr6_+_31554456 0.33 ENST00000339530.4
LST1
leukocyte specific transcript 1
chr8_-_623547 0.33 ENST00000522893.1
ERICH1
glutamate-rich 1
chr1_+_15480197 0.32 ENST00000400796.3
ENST00000434578.2
ENST00000376008.2
TMEM51
transmembrane protein 51
chr17_+_47448102 0.32 ENST00000576461.1
RP11-81K2.1
Uncharacterized protein
chr6_-_90062543 0.32 ENST00000435041.2
UBE2J1
ubiquitin-conjugating enzyme E2, J1
chr10_-_25012115 0.30 ENST00000446003.1
ARHGAP21
Rho GTPase activating protein 21
chrX_+_110187513 0.30 ENST00000446737.1
ENST00000425146.1
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr5_-_133304473 0.30 ENST00000231512.3
C5orf15
chromosome 5 open reading frame 15
chr3_-_4793274 0.30 ENST00000414938.1
EGOT
eosinophil granule ontogeny transcript (non-protein coding)
chr8_+_17434689 0.29 ENST00000398074.3
PDGFRL
platelet-derived growth factor receptor-like
chr1_-_228594490 0.29 ENST00000366699.3
ENST00000284551.6
TRIM11
tripartite motif containing 11
chr7_+_26191809 0.28 ENST00000056233.3
NFE2L3
nuclear factor, erythroid 2-like 3
chr3_-_71632894 0.28 ENST00000493089.1
FOXP1
forkhead box P1
chr11_-_114466471 0.28 ENST00000424261.2
NXPE4
neurexophilin and PC-esterase domain family, member 4
chr2_-_217559517 0.28 ENST00000449583.1
IGFBP5
insulin-like growth factor binding protein 5
chr1_+_168756151 0.28 ENST00000420691.1
LINC00626
long intergenic non-protein coding RNA 626
chr12_+_122181529 0.28 ENST00000541467.1
TMEM120B
transmembrane protein 120B
chr11_-_35440579 0.28 ENST00000606205.1
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr18_-_5396271 0.26 ENST00000579951.1
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr17_-_77005860 0.26 ENST00000591773.1
ENST00000588611.1
ENST00000586916.2
ENST00000592033.1
ENST00000588075.1
ENST00000302345.2
ENST00000591811.1
CANT1
calcium activated nucleotidase 1
chr12_-_13248598 0.26 ENST00000337630.6
ENST00000545699.1
GSG1
germ cell associated 1
chr6_+_31515337 0.26 ENST00000376148.4
ENST00000376145.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr21_+_43933946 0.26 ENST00000352133.2
SLC37A1
solute carrier family 37 (glucose-6-phosphate transporter), member 1
chr7_-_23053719 0.25 ENST00000432176.2
ENST00000440481.1
FAM126A
family with sequence similarity 126, member A
chr12_+_123717458 0.25 ENST00000253233.1
C12orf65
chromosome 12 open reading frame 65
chr17_-_77005801 0.25 ENST00000392446.5
CANT1
calcium activated nucleotidase 1
chr16_-_28608364 0.25 ENST00000533150.1
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr6_+_31554612 0.25 ENST00000211921.7
LST1
leukocyte specific transcript 1
chr5_+_143584814 0.25 ENST00000507359.3
KCTD16
potassium channel tetramerization domain containing 16
chr1_+_244816371 0.24 ENST00000263831.7
DESI2
desumoylating isopeptidase 2
chr7_-_137686791 0.24 ENST00000452463.1
ENST00000330387.6
ENST00000456390.1
CREB3L2
cAMP responsive element binding protein 3-like 2
chr15_-_82641706 0.23 ENST00000439287.4
GOLGA6L10
golgin A6 family-like 10
chr10_-_70092635 0.23 ENST00000309049.4
PBLD
phenazine biosynthesis-like protein domain containing
chr16_-_28621298 0.23 ENST00000566189.1
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr22_-_31688381 0.23 ENST00000487265.2
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr19_-_10420459 0.23 ENST00000403352.1
ENST00000403903.3
ZGLP1
zinc finger, GATA-like protein 1
chr11_+_61891445 0.23 ENST00000394818.3
ENST00000533896.1
ENST00000278849.4
INCENP
inner centromere protein antigens 135/155kDa
chr7_-_16872932 0.22 ENST00000419572.2
ENST00000412973.1
AGR2
anterior gradient 2
chrX_-_47004878 0.22 ENST00000377811.3
NDUFB11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
chr5_-_142782862 0.22 ENST00000415690.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chrX_+_47004639 0.22 ENST00000345781.6
RBM10
RNA binding motif protein 10
chr7_+_100482595 0.21 ENST00000448764.1
SRRT
serrate RNA effector molecule homolog (Arabidopsis)
chr19_+_14544099 0.21 ENST00000242783.6
ENST00000586557.1
ENST00000590097.1
PKN1
protein kinase N1
chr7_+_72848092 0.21 ENST00000344575.3
FZD9
frizzled family receptor 9
chr6_+_55039050 0.20 ENST00000370862.3
HCRTR2
hypocretin (orexin) receptor 2
chr7_-_96654133 0.20 ENST00000486603.2
ENST00000222598.4
DLX5
distal-less homeobox 5
chr5_-_142783175 0.20 ENST00000231509.3
ENST00000394464.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr6_+_10694900 0.20 ENST00000379568.3
PAK1IP1
PAK1 interacting protein 1
chr12_-_109221160 0.20 ENST00000326470.5
SSH1
slingshot protein phosphatase 1
chr11_+_72975578 0.19 ENST00000393592.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chrX_+_47004599 0.19 ENST00000329236.7
RBM10
RNA binding motif protein 10
chr11_+_72975559 0.19 ENST00000349767.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr11_+_72975524 0.19 ENST00000540342.1
ENST00000542092.1
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr3_-_142166904 0.19 ENST00000264951.4
XRN1
5'-3' exoribonuclease 1
chr10_+_6186847 0.19 ENST00000536985.1
ENST00000379789.4
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr5_-_58882219 0.19 ENST00000505453.1
ENST00000360047.5
PDE4D
phosphodiesterase 4D, cAMP-specific
chr16_-_28621312 0.18 ENST00000314752.7
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr12_-_13248562 0.18 ENST00000457134.2
ENST00000537302.1
GSG1
germ cell associated 1
chr3_+_130569429 0.18 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr15_+_63340553 0.17 ENST00000334895.5
TPM1
tropomyosin 1 (alpha)
chr17_+_1674982 0.17 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr7_+_116139424 0.17 ENST00000222693.4
CAV2
caveolin 2
chr13_+_28712614 0.17 ENST00000380958.3
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr5_+_147258266 0.17 ENST00000296694.4
SCGB3A2
secretoglobin, family 3A, member 2
chr5_+_146614579 0.16 ENST00000541094.1
ENST00000398521.3
STK32A
serine/threonine kinase 32A
chr10_+_33271469 0.16 ENST00000414157.1
RP11-462L8.1
RP11-462L8.1
chr12_-_13248705 0.16 ENST00000396310.2
GSG1
germ cell associated 1
chr19_-_51336443 0.16 ENST00000598673.1
KLK15
kallikrein-related peptidase 15
chr12_-_13248732 0.16 ENST00000396302.3
GSG1
germ cell associated 1
chr13_+_37247934 0.16 ENST00000315190.3
SERTM1
serine-rich and transmembrane domain containing 1
chr5_-_172662303 0.16 ENST00000517440.1
ENST00000329198.4
NKX2-5
NK2 homeobox 5
chr2_+_202937972 0.16 ENST00000541917.1
ENST00000295844.3
AC079354.1
uncharacterized protein KIAA2012
chr2_-_122042770 0.16 ENST00000263707.5
TFCP2L1
transcription factor CP2-like 1
chr4_-_113207048 0.16 ENST00000361717.3
TIFA
TRAF-interacting protein with forkhead-associated domain
chr8_+_145215928 0.15 ENST00000528919.1
MROH1
maestro heat-like repeat family member 1
chr8_+_143781513 0.15 ENST00000292430.6
ENST00000561179.1
ENST00000518841.1
ENST00000519387.1
LY6K
lymphocyte antigen 6 complex, locus K
chr2_+_185463093 0.15 ENST00000302277.6
ZNF804A
zinc finger protein 804A
chrX_-_75005054 0.15 ENST00000373359.2
MAGEE2
melanoma antigen family E, 2
chr19_+_49622646 0.15 ENST00000334186.4
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr11_+_114168085 0.15 ENST00000541754.1
NNMT
nicotinamide N-methyltransferase
chr3_+_119298523 0.14 ENST00000357003.3
ADPRH
ADP-ribosylarginine hydrolase
chr15_-_40401062 0.14 ENST00000354670.4
ENST00000559701.1
ENST00000557870.1
ENST00000558774.1
BMF
Bcl2 modifying factor
chr8_+_143781883 0.14 ENST00000522591.1
LY6K
lymphocyte antigen 6 complex, locus K
chr12_-_45269430 0.14 ENST00000395487.2
NELL2
NEL-like 2 (chicken)
chr7_+_133812052 0.14 ENST00000285928.2
LRGUK
leucine-rich repeats and guanylate kinase domain containing
chr4_+_165675269 0.14 ENST00000507311.1
RP11-294O2.2
RP11-294O2.2
chr16_-_67224002 0.13 ENST00000563889.1
ENST00000564418.1
ENST00000545725.2
ENST00000314586.6
EXOC3L1
exocyst complex component 3-like 1
chr9_-_100000957 0.13 ENST00000366109.2
ENST00000607322.1
RP11-498P14.5
RP11-498P14.5
chr19_-_6333614 0.13 ENST00000301452.4
ACER1
alkaline ceramidase 1
chr16_-_84273304 0.13 ENST00000308251.4
ENST00000568181.1
KCNG4
potassium voltage-gated channel, subfamily G, member 4
chr8_-_134309335 0.13 ENST00000522890.1
ENST00000323851.7
ENST00000518176.1
ENST00000354944.5
ENST00000537882.1
ENST00000522476.1
ENST00000518066.1
ENST00000521544.1
ENST00000518480.1
ENST00000523892.1
NDRG1
N-myc downstream regulated 1
chr1_-_72748417 0.12 ENST00000357731.5
NEGR1
neuronal growth regulator 1
chr1_+_33439268 0.12 ENST00000594612.1
FKSG48
FKSG48
chr6_-_31697977 0.12 ENST00000375787.2
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr11_-_65374430 0.12 ENST00000532507.1
MAP3K11
mitogen-activated protein kinase kinase kinase 11
chr19_-_35085490 0.12 ENST00000379204.2
SCGB2B2
secretoglobin, family 2B, member 2
chr17_+_16284104 0.12 ENST00000577958.1
ENST00000302182.3
ENST00000577640.1
UBB
ubiquitin B
chr18_-_3874271 0.12 ENST00000400149.3
ENST00000400155.1
ENST00000400150.3
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr19_-_49622348 0.11 ENST00000408991.2
C19orf73
chromosome 19 open reading frame 73
chr8_-_38853990 0.11 ENST00000456845.2
ENST00000397070.2
ENST00000517872.1
ENST00000412303.1
ENST00000456397.2
TM2D2
TM2 domain containing 2
chr6_-_32083106 0.11 ENST00000442721.1
TNXB
tenascin XB
chr17_-_41116454 0.11 ENST00000427569.2
ENST00000430739.1
AARSD1
alanyl-tRNA synthetase domain containing 1
chr1_+_15802594 0.11 ENST00000375910.3
CELA2B
chymotrypsin-like elastase family, member 2B
chr17_-_17480779 0.11 ENST00000395782.1
PEMT
phosphatidylethanolamine N-methyltransferase
chr4_-_171011323 0.11 ENST00000509167.1
ENST00000353187.2
ENST00000507375.1
ENST00000515480.1
AADAT
aminoadipate aminotransferase
chr1_-_109618566 0.11 ENST00000338366.5
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr11_+_120107344 0.11 ENST00000260264.4
POU2F3
POU class 2 homeobox 3
chrX_-_102943022 0.10 ENST00000433176.2
MORF4L2
mortality factor 4 like 2
chr12_-_121477039 0.10 ENST00000257570.5
OASL
2'-5'-oligoadenylate synthetase-like
chr19_-_52551814 0.10 ENST00000594154.1
ENST00000598745.1
ENST00000597273.1
ZNF432
zinc finger protein 432
chrX_-_153523462 0.10 ENST00000361930.3
ENST00000369926.1
TEX28
testis expressed 28
chr8_-_145653885 0.10 ENST00000531032.1
ENST00000292510.4
ENST00000377348.2
ENST00000530790.1
ENST00000533806.1
VPS28
vacuolar protein sorting 28 homolog (S. cerevisiae)
chr17_-_74049720 0.10 ENST00000602720.1
SRP68
signal recognition particle 68kDa
chr4_+_3465027 0.10 ENST00000389653.2
ENST00000507039.1
ENST00000340083.5
DOK7
docking protein 7
chr16_-_28608424 0.10 ENST00000335715.4
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr8_+_104892639 0.10 ENST00000436393.2
RIMS2
regulating synaptic membrane exocytosis 2
chr10_+_114135004 0.10 ENST00000393081.1
ACSL5
acyl-CoA synthetase long-chain family member 5
chr17_+_72270380 0.10 ENST00000582036.1
ENST00000307504.5
DNAI2
dynein, axonemal, intermediate chain 2
chr11_-_62368696 0.10 ENST00000527204.1
MTA2
metastasis associated 1 family, member 2
chr6_-_116989916 0.10 ENST00000368576.3
ENST00000368573.1
ZUFSP
zinc finger with UFM1-specific peptidase domain
chr15_+_63340647 0.10 ENST00000404484.4
TPM1
tropomyosin 1 (alpha)
chr4_-_140544386 0.10 ENST00000561977.1
RP11-308D13.3
RP11-308D13.3
chr8_+_41347915 0.10 ENST00000518270.1
ENST00000520817.1
GOLGA7
golgin A7
chr5_+_167913450 0.09 ENST00000231572.3
ENST00000538719.1
RARS
arginyl-tRNA synthetase
chr19_+_49891475 0.09 ENST00000447857.3
CCDC155
coiled-coil domain containing 155
chr19_-_49955050 0.09 ENST00000262265.5
PIH1D1
PIH1 domain containing 1
chrX_-_48827976 0.09 ENST00000218176.3
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr17_+_16284399 0.09 ENST00000535788.1
UBB
ubiquitin B
chr9_+_130565487 0.09 ENST00000373225.3
ENST00000431857.1
FPGS
folylpolyglutamate synthase
chrM_+_5824 0.09 ENST00000361624.2
MT-CO1
mitochondrially encoded cytochrome c oxidase I
chr7_-_130080818 0.09 ENST00000343969.5
ENST00000541543.1
ENST00000489512.1
CEP41
centrosomal protein 41kDa
chr11_-_124622134 0.08 ENST00000326621.5
VSIG2
V-set and immunoglobulin domain containing 2
chr5_-_32444828 0.08 ENST00000265069.8
ZFR
zinc finger RNA binding protein
chr2_-_87088995 0.08 ENST00000393759.2
ENST00000349455.3
ENST00000331469.2
ENST00000431506.2
ENST00000393761.2
ENST00000390655.6
CD8B
CD8b molecule
chr12_-_113574028 0.08 ENST00000546530.1
ENST00000261729.5
RASAL1
RAS protein activator like 1 (GAP1 like)
chr1_+_162039558 0.08 ENST00000530878.1
ENST00000361897.5
NOS1AP
nitric oxide synthase 1 (neuronal) adaptor protein
chr18_-_3874247 0.08 ENST00000581699.1
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr2_-_170550877 0.08 ENST00000447353.1
CCDC173
coiled-coil domain containing 173
chr17_+_43299241 0.08 ENST00000328118.3
FMNL1
formin-like 1
chrX_-_102942961 0.08 ENST00000434230.1
ENST00000418819.1
ENST00000360458.1
MORF4L2
mortality factor 4 like 2
chr3_+_35682913 0.08 ENST00000449196.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr8_+_41348072 0.08 ENST00000405786.2
GOLGA7
golgin A7
chr19_+_38779778 0.08 ENST00000590738.1
ENST00000587519.2
ENST00000591889.1
SPINT2
CTB-102L5.4
serine peptidase inhibitor, Kunitz type, 2
CTB-102L5.4
chr7_+_66386204 0.08 ENST00000341567.4
ENST00000607045.1
TMEM248
transmembrane protein 248
chr3_-_142166846 0.08 ENST00000463916.1
ENST00000544157.1
XRN1
5'-3' exoribonuclease 1
chr2_-_217560248 0.08 ENST00000233813.4
IGFBP5
insulin-like growth factor binding protein 5
chr3_-_9921934 0.08 ENST00000423850.1
CIDEC
cell death-inducing DFFA-like effector c
chr20_-_54580523 0.08 ENST00000064571.2
CBLN4
cerebellin 4 precursor
chr12_+_110906169 0.08 ENST00000377673.5
FAM216A
family with sequence similarity 216, member A
chr11_-_93276582 0.07 ENST00000298966.2
SMCO4
single-pass membrane protein with coiled-coil domains 4
chr17_-_33390667 0.07 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr14_+_78227105 0.07 ENST00000439131.2
ENST00000355883.3
ENST00000557011.1
ENST00000556047.1
C14orf178
chromosome 14 open reading frame 178
chr11_-_35440796 0.07 ENST00000278379.3
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr1_-_151319283 0.07 ENST00000392746.3
RFX5
regulatory factor X, 5 (influences HLA class II expression)
chr4_-_176733897 0.07 ENST00000393658.2
GPM6A
glycoprotein M6A
chrX_+_7810303 0.07 ENST00000381059.3
ENST00000341408.4
VCX
variable charge, X-linked
chr19_-_37064145 0.07 ENST00000591340.1
ENST00000334116.7
ZNF529
zinc finger protein 529
chr2_+_203879568 0.07 ENST00000449802.1
NBEAL1
neurobeachin-like 1
chr22_-_31688431 0.07 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr9_+_19049372 0.07 ENST00000380527.1
RRAGA
Ras-related GTP binding A
chr4_+_14113592 0.06 ENST00000502759.1
ENST00000511200.1
ENST00000512754.1
ENST00000506739.1
LINC01085
long intergenic non-protein coding RNA 1085
chr19_-_6767431 0.06 ENST00000437152.3
ENST00000597687.1
SH2D3A
SH2 domain containing 3A
chr14_+_104394770 0.06 ENST00000409874.4
ENST00000339063.5
TDRD9
tudor domain containing 9
chr17_+_72322346 0.06 ENST00000551294.1
ENST00000389916.4
KIF19
kinesin family member 19
chr1_-_155145721 0.06 ENST00000295682.4
KRTCAP2
keratinocyte associated protein 2
chr10_+_74653330 0.06 ENST00000334011.5
OIT3
oncoprotein induced transcript 3
chr1_-_25291475 0.06 ENST00000338888.3
ENST00000399916.1
RUNX3
runt-related transcription factor 3
chr18_-_60986613 0.06 ENST00000444484.1
BCL2
B-cell CLL/lymphoma 2
chr6_+_32407619 0.05 ENST00000395388.2
ENST00000374982.5
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr11_-_58980342 0.05 ENST00000361050.3
MPEG1
macrophage expressed 1
chr10_-_71332994 0.05 ENST00000242462.4
NEUROG3
neurogenin 3
chr9_+_92219919 0.05 ENST00000252506.6
ENST00000375769.1
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr1_-_240775447 0.05 ENST00000318160.4
GREM2
gremlin 2, DAN family BMP antagonist
chr19_-_4457776 0.05 ENST00000301281.6
UBXN6
UBX domain protein 6
chr8_-_7673238 0.05 ENST00000335021.2
DEFB107A
defensin, beta 107A
chr1_+_26644441 0.05 ENST00000374213.2
CD52
CD52 molecule
chr20_-_52210368 0.05 ENST00000371471.2
ZNF217
zinc finger protein 217
chr3_+_46283916 0.05 ENST00000395940.2
CCR3
chemokine (C-C motif) receptor 3
chr13_-_25496926 0.04 ENST00000545981.1
ENST00000381884.4
CENPJ
centromere protein J
chr6_+_32605134 0.04 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:1904170 NAD transport(GO:0043132) regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172)
0.2 0.6 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.1 0.4 GO:0032499 detection of peptidoglycan(GO:0032499) activation of MAPK activity involved in innate immune response(GO:0035419) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585) positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.1 0.4 GO:0018262 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.1 0.4 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.1 0.4 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.1 1.4 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655)
0.1 0.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.2 GO:1904397 negative regulation of neuromuscular junction development(GO:1904397)
0.1 0.2 GO:0060166 olfactory pit development(GO:0060166)
0.1 0.3 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.1 0.2 GO:1904717 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.1 0.3 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 0.3 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.3 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.3 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.1 0.4 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 1.4 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 0.2 GO:0003162 atrioventricular node development(GO:0003162) right ventricular cardiac muscle tissue morphogenesis(GO:0003221) septum secundum development(GO:0003285)
0.1 0.3 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.6 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.2 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.0 0.3 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.2 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 0.2 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.0 0.1 GO:2000395 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.0 0.3 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.0 0.2 GO:0042746 regulation of circadian sleep/wake cycle, wakefulness(GO:0010840) circadian sleep/wake cycle, wakefulness(GO:0042746)
0.0 0.3 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.2 GO:0060480 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0 0.3 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.1 GO:1903939 negative regulation of histone H3-K9 dimethylation(GO:1900110) regulation of TORC2 signaling(GO:1903939)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.0 0.2 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.1 GO:1903762 positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903762) positive regulation of ventricular cardiac muscle cell action potential(GO:1903947) positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential(GO:1905026) positive regulation of membrane repolarization during cardiac muscle cell action potential(GO:1905033)
0.0 0.3 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.0 0.1 GO:0010446 response to alkaline pH(GO:0010446)
0.0 0.2 GO:0044789 receptor-mediated endocytosis of virus by host cell(GO:0019065) modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) endocytosis involved in viral entry into host cell(GO:0075509)
0.0 0.3 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.0 0.3 GO:0044597 polyketide metabolic process(GO:0030638) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0 0.4 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.3 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway(GO:0035791)
0.0 0.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.2 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.0 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0 0.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.1 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.0 0.1 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.2 GO:0031053 primary miRNA processing(GO:0031053)
0.0 0.1 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.2 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.3 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 0.1 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.0 0.3 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 1.4 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.0 0.1 GO:0070050 neuron cellular homeostasis(GO:0070050)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:0032059 bleb(GO:0032059)
0.1 0.4 GO:0042825 TAP complex(GO:0042825)
0.0 0.2 GO:0031251 PAN complex(GO:0031251)
0.0 0.4 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.4 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.1 GO:1990742 microvesicle(GO:1990742)
0.0 0.2 GO:0000801 central element(GO:0000801)
0.0 0.1 GO:0002177 manchette(GO:0002177)
0.0 0.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.6 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0043203 axon hillock(GO:0043203)
0.0 1.3 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.1 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.1 GO:0070761 pre-snoRNP complex(GO:0070761)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.2 0.5 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.1 0.3 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 0.6 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.1 0.3 GO:0047025 NAD(P)H dehydrogenase (quinone) activity(GO:0003955) 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.1 1.4 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.1 1.0 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.9 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.4 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 0.4 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.1 0.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.3 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.9 GO:0031996 thioesterase binding(GO:0031996)
0.1 0.7 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.2 GO:0016499 orexin receptor activity(GO:0016499)
0.0 0.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.3 GO:0061513 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0 0.3 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.3 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.1 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.1 GO:0004608 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.0 0.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.1 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.0 0.1 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0004331 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.4 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.1 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.9 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 1.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.6 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 1.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC