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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for PAX6

Z-value: 0.70

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Transcription factors associated with PAX6

Gene Symbol Gene ID Gene Info
PAX6
ENSG00000007372.16 paired box 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX6hg19_v2_chr11_-_31832862_31832884,
hg19_v2_chr11_-_31832581_31832601,
hg19_v2_chr11_-_31832785_31832823,
hg19_v2_chr11_-_31832207_31832226		-0.096.5e-01Click!

Activity profile of PAX6 motif

Sorted Z-values of PAX6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_13372253 1.04 ENST00000316609.5
DLC1
deleted in liver cancer 1
chr9_-_5185629 1.02 ENST00000381641.3
INSL6
insulin-like 6
chr12_-_47473425 0.87 ENST00000550413.1
AMIGO2
adhesion molecule with Ig-like domain 2
chr1_+_79115503 0.83 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr1_-_36906474 0.83 ENST00000433045.2
OSCP1
organic solute carrier partner 1
chr14_+_29241910 0.82 ENST00000399387.4
ENST00000552957.1
ENST00000548213.1
C14orf23
chromosome 14 open reading frame 23
chr12_+_113354341 0.78 ENST00000553152.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr12_-_47473707 0.73 ENST00000429635.1
AMIGO2
adhesion molecule with Ig-like domain 2
chr12_+_6949964 0.72 ENST00000541978.1
ENST00000435982.2
GNB3
guanine nucleotide binding protein (G protein), beta polypeptide 3
chr16_+_618837 0.72 ENST00000409439.2
PIGQ
phosphatidylinositol glycan anchor biosynthesis, class Q
chr18_+_18822185 0.71 ENST00000424526.1
ENST00000400483.4
ENST00000431264.1
GREB1L
growth regulation by estrogen in breast cancer-like
chr1_+_104068562 0.70 ENST00000423855.2
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr2_-_86116093 0.68 ENST00000377332.3
ST3GAL5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr6_+_147527103 0.62 ENST00000179882.6
STXBP5
syntaxin binding protein 5 (tomosyn)
chr6_-_85474219 0.61 ENST00000369663.5
TBX18
T-box 18
chr4_-_88141755 0.58 ENST00000273963.5
KLHL8
kelch-like family member 8
chr20_-_44144249 0.56 ENST00000217428.6
SPINT3
serine peptidase inhibitor, Kunitz type, 3
chr4_-_88141615 0.55 ENST00000545252.1
ENST00000425278.2
ENST00000498875.2
KLHL8
kelch-like family member 8
chr8_-_95487331 0.54 ENST00000336148.5
RAD54B
RAD54 homolog B (S. cerevisiae)
chr18_+_18822216 0.51 ENST00000269218.6
GREB1L
growth regulation by estrogen in breast cancer-like
chr11_-_28129656 0.50 ENST00000263181.6
KIF18A
kinesin family member 18A
chr12_-_10151773 0.47 ENST00000298527.6
ENST00000348658.4
CLEC1B
C-type lectin domain family 1, member B
chr16_-_80926457 0.45 ENST00000563626.1
ENST00000562231.1
RP11-314O13.1
RP11-314O13.1
chr2_+_109204909 0.44 ENST00000393310.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr3_-_122512619 0.44 ENST00000383659.1
ENST00000306103.2
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr7_-_97501706 0.39 ENST00000455086.1
ENST00000453600.1
ASNS
asparagine synthetase (glutamine-hydrolyzing)
chr7_-_138348969 0.38 ENST00000436657.1
SVOPL
SVOP-like
chr12_+_83080659 0.38 ENST00000321196.3
TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr6_-_31846744 0.38 ENST00000414427.1
ENST00000229729.6
ENST00000375562.4
SLC44A4
solute carrier family 44, member 4
chr9_-_113100088 0.37 ENST00000374510.4
ENST00000423740.2
ENST00000374511.3
ENST00000374507.4
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr1_-_144932014 0.35 ENST00000529945.1
PDE4DIP
phosphodiesterase 4D interacting protein
chr9_+_42704004 0.35 ENST00000457288.1
CBWD7
COBW domain containing 7
chr10_+_12110963 0.34 ENST00000263035.4
ENST00000437298.1
DHTKD1
dehydrogenase E1 and transketolase domain containing 1
chr4_+_77356248 0.34 ENST00000296043.6
SHROOM3
shroom family member 3
chr20_-_1472029 0.34 ENST00000359801.3
SIRPB2
signal-regulatory protein beta 2
chr12_-_10007448 0.33 ENST00000538152.1
CLEC2B
C-type lectin domain family 2, member B
chr19_-_54327542 0.33 ENST00000391775.3
ENST00000324134.6
ENST00000535162.1
ENST00000351894.4
ENST00000354278.3
ENST00000391773.1
ENST00000345770.5
ENST00000391772.1
NLRP12
NLR family, pyrin domain containing 12
chr3_+_151531810 0.33 ENST00000232892.7
AADAC
arylacetamide deacetylase
chr2_-_165812028 0.33 ENST00000303735.4
SLC38A11
solute carrier family 38, member 11
chr5_-_159546396 0.32 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chr11_-_58343319 0.32 ENST00000395074.2
LPXN
leupaxin
chr5_-_160279207 0.31 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr19_-_37701386 0.31 ENST00000527838.1
ENST00000591492.1
ENST00000532828.2
ZNF585B
zinc finger protein 585B
chr7_+_76109827 0.31 ENST00000446820.2
DTX2
deltex homolog 2 (Drosophila)
chr7_-_97501733 0.31 ENST00000444334.1
ENST00000422745.1
ENST00000394308.3
ENST00000451771.1
ENST00000175506.4
ASNS
asparagine synthetase (glutamine-hydrolyzing)
chr11_+_28129795 0.31 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
METTL15
methyltransferase like 15
chr16_-_67450325 0.30 ENST00000348579.2
ZDHHC1
zinc finger, DHHC-type containing 1
chr4_-_69215467 0.28 ENST00000579690.1
YTHDC1
YTH domain containing 1
chr20_+_62887081 0.28 ENST00000369758.4
ENST00000299468.7
ENST00000609372.1
ENST00000610196.1
ENST00000308824.6
PCMTD2
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
chr4_+_187148556 0.28 ENST00000264690.6
ENST00000446598.2
ENST00000414291.1
ENST00000513864.1
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr1_-_43282906 0.27 ENST00000372521.4
CCDC23
coiled-coil domain containing 23
chr13_+_53602894 0.27 ENST00000219022.2
OLFM4
olfactomedin 4
chr1_-_43282945 0.27 ENST00000537227.1
CCDC23
coiled-coil domain containing 23
chr1_+_2005425 0.27 ENST00000461106.2
PRKCZ
protein kinase C, zeta
chr16_+_77822427 0.26 ENST00000302536.2
VAT1L
vesicle amine transport 1-like
chr19_-_57347415 0.26 ENST00000601070.1
ZIM2
zinc finger, imprinted 2
chr4_+_70916119 0.26 ENST00000246896.3
ENST00000511674.1
HTN1
histatin 1
chr19_-_10047219 0.26 ENST00000264833.4
OLFM2
olfactomedin 2
chr8_+_16884740 0.25 ENST00000318063.5
MICU3
mitochondrial calcium uptake family, member 3
chr7_-_150864635 0.25 ENST00000297537.4
GBX1
gastrulation brain homeobox 1
chr2_+_114195268 0.25 ENST00000259199.4
ENST00000416503.2
ENST00000433343.2
CBWD2
COBW domain containing 2
chr4_+_87928140 0.25 ENST00000307808.6
AFF1
AF4/FMR2 family, member 1
chr2_-_29093132 0.25 ENST00000306108.5
TRMT61B
tRNA methyltransferase 61 homolog B (S. cerevisiae)
chr10_-_118765081 0.25 ENST00000392903.2
ENST00000355371.4
KIAA1598
KIAA1598
chr4_+_76995855 0.24 ENST00000355810.4
ENST00000349321.3
ART3
ADP-ribosyltransferase 3
chr9_-_14180778 0.24 ENST00000380924.1
ENST00000543693.1
NFIB
nuclear factor I/B
chr3_-_119379719 0.24 ENST00000493094.1
POPDC2
popeye domain containing 2
chr6_+_125475335 0.23 ENST00000532429.1
ENST00000534199.1
TPD52L1
tumor protein D52-like 1
chr3_-_101232019 0.23 ENST00000394095.2
ENST00000394091.1
ENST00000394094.2
ENST00000358203.3
ENST00000348610.3
ENST00000314261.7
SENP7
SUMO1/sentrin specific peptidase 7
chr2_+_202098166 0.23 ENST00000392263.2
ENST00000264274.9
ENST00000392259.2
ENST00000392266.3
ENST00000432109.2
ENST00000264275.5
CASP8
caspase 8, apoptosis-related cysteine peptidase
chr6_+_88299833 0.22 ENST00000392844.3
ENST00000257789.4
ENST00000546266.1
ENST00000417380.2
ORC3
origin recognition complex, subunit 3
chr4_-_68749745 0.22 ENST00000283916.6
TMPRSS11D
transmembrane protease, serine 11D
chr4_+_115519577 0.22 ENST00000310836.6
UGT8
UDP glycosyltransferase 8
chrX_-_124097620 0.22 ENST00000371130.3
ENST00000422452.2
TENM1
teneurin transmembrane protein 1
chr4_-_68749699 0.22 ENST00000545541.1
TMPRSS11D
transmembrane protease, serine 11D
chr16_-_3767551 0.21 ENST00000246957.5
TRAP1
TNF receptor-associated protein 1
chr10_-_118764862 0.21 ENST00000260777.10
KIAA1598
KIAA1598
chr7_-_152373216 0.20 ENST00000359321.1
XRCC2
X-ray repair complementing defective repair in Chinese hamster cells 2
chr1_+_163291732 0.20 ENST00000271452.3
NUF2
NUF2, NDC80 kinetochore complex component
chr11_-_117747434 0.20 ENST00000529335.2
ENST00000530956.1
ENST00000260282.4
FXYD6
FXYD domain containing ion transport regulator 6
chr11_-_117748138 0.20 ENST00000527717.1
FXYD6
FXYD domain containing ion transport regulator 6
chr10_-_27389320 0.19 ENST00000436985.2
ANKRD26
ankyrin repeat domain 26
chr17_-_77023723 0.19 ENST00000577521.1
C1QTNF1-AS1
C1QTNF1 antisense RNA 1
chr21_+_39628852 0.19 ENST00000398938.2
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_-_86174065 0.19 ENST00000370574.3
ENST00000431532.2
ZNHIT6
zinc finger, HIT-type containing 6
chr10_+_114135952 0.19 ENST00000356116.1
ENST00000433418.1
ENST00000354273.4
ACSL5
acyl-CoA synthetase long-chain family member 5
chr16_+_77233294 0.19 ENST00000378644.4
SYCE1L
synaptonemal complex central element protein 1-like
chr12_-_3982511 0.18 ENST00000427057.2
ENST00000228820.4
PARP11
poly (ADP-ribose) polymerase family, member 11
chr16_-_3767506 0.18 ENST00000538171.1
TRAP1
TNF receptor-associated protein 1
chr3_-_142297668 0.18 ENST00000350721.4
ENST00000383101.3
ATR
ataxia telangiectasia and Rad3 related
chr5_+_79615790 0.18 ENST00000296739.4
SPZ1
spermatogenic leucine zipper 1
chr11_-_117747607 0.18 ENST00000540359.1
ENST00000539526.1
FXYD6
FXYD domain containing ion transport regulator 6
chr10_-_27389392 0.17 ENST00000376087.4
ANKRD26
ankyrin repeat domain 26
chr11_+_4788500 0.17 ENST00000380390.1
MMP26
matrix metallopeptidase 26
chr6_-_134373732 0.17 ENST00000275230.5
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr7_+_90012986 0.17 ENST00000416322.1
CLDN12
claudin 12
chr20_+_48807351 0.17 ENST00000303004.3
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr14_+_88471468 0.17 ENST00000267549.3
GPR65
G protein-coupled receptor 65
chr18_+_32173276 0.17 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
DTNA
dystrobrevin, alpha
chr2_-_40680578 0.17 ENST00000455476.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr5_+_93954039 0.17 ENST00000265140.5
ANKRD32
ankyrin repeat domain 32
chr19_+_15852203 0.17 ENST00000305892.1
OR10H3
olfactory receptor, family 10, subfamily H, member 3
chr2_-_85625857 0.16 ENST00000453973.1
CAPG
capping protein (actin filament), gelsolin-like
chr9_+_131549610 0.16 ENST00000223865.8
TBC1D13
TBC1 domain family, member 13
chr7_+_90338712 0.16 ENST00000265741.3
ENST00000406263.1
CDK14
cyclin-dependent kinase 14
chr9_+_131549483 0.16 ENST00000372648.5
ENST00000539497.1
TBC1D13
TBC1 domain family, member 13
chr1_-_247697141 0.16 ENST00000366487.3
OR2C3
olfactory receptor, family 2, subfamily C, member 3
chr4_+_129349188 0.16 ENST00000511497.1
RP11-420A23.1
RP11-420A23.1
chr6_+_125474939 0.16 ENST00000527711.1
TPD52L1
tumor protein D52-like 1
chr21_-_35014027 0.16 ENST00000399442.1
ENST00000413017.2
ENST00000445393.1
ENST00000417979.1
ENST00000426935.1
ENST00000381540.3
ENST00000361534.2
ENST00000381554.3
CRYZL1
crystallin, zeta (quinone reductase)-like 1
chr18_-_21242774 0.16 ENST00000322980.9
ANKRD29
ankyrin repeat domain 29
chr6_+_170151708 0.16 ENST00000592367.1
ENST00000590711.1
ENST00000366772.2
ENST00000592745.1
ENST00000392095.4
ENST00000366773.3
ENST00000586341.1
ENST00000418781.3
ENST00000588437.1
ERMARD
ER membrane-associated RNA degradation
chr12_-_5352315 0.16 ENST00000536518.1
RP11-319E16.1
RP11-319E16.1
chr15_+_52043758 0.16 ENST00000249700.4
ENST00000539962.2
TMOD2
tropomodulin 2 (neuronal)
chr5_+_42756903 0.15 ENST00000361970.5
ENST00000388827.4
CCDC152
coiled-coil domain containing 152
chr6_+_125474992 0.15 ENST00000528193.1
TPD52L1
tumor protein D52-like 1
chr6_-_2634820 0.14 ENST00000296847.3
C6orf195
chromosome 6 open reading frame 195
chr12_-_3982548 0.14 ENST00000397096.2
ENST00000447133.3
ENST00000450737.2
PARP11
poly (ADP-ribose) polymerase family, member 11
chr8_-_121457608 0.14 ENST00000306185.3
MRPL13
mitochondrial ribosomal protein L13
chr7_-_14029283 0.13 ENST00000433547.1
ENST00000405192.2
ETV1
ets variant 1
chr3_-_15563229 0.13 ENST00000383786.5
ENST00000383787.2
ENST00000383785.2
ENST00000383788.5
ENST00000603808.1
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr9_-_116861337 0.13 ENST00000374118.3
KIF12
kinesin family member 12
chr19_-_51920835 0.13 ENST00000442846.3
ENST00000530476.1
SIGLEC10
sialic acid binding Ig-like lectin 10
chrX_+_37545012 0.13 ENST00000378616.3
XK
X-linked Kx blood group (McLeod syndrome)
chr4_-_16077741 0.13 ENST00000447510.2
ENST00000540805.1
ENST00000539194.1
PROM1
prominin 1
chr2_+_220363579 0.13 ENST00000313597.5
ENST00000373917.3
ENST00000358215.3
ENST00000373908.1
ENST00000455657.1
ENST00000435316.1
ENST00000341142.3
GMPPA
GDP-mannose pyrophosphorylase A
chr2_+_179184955 0.13 ENST00000315022.2
OSBPL6
oxysterol binding protein-like 6
chr2_-_677369 0.13 ENST00000281017.3
TMEM18
transmembrane protein 18
chr17_+_43224684 0.13 ENST00000332499.2
HEXIM1
hexamethylene bis-acetamide inducible 1
chr3_-_58652523 0.13 ENST00000489857.1
ENST00000358781.2
FAM3D
family with sequence similarity 3, member D
chr15_-_56757329 0.12 ENST00000260453.3
MNS1
meiosis-specific nuclear structural 1
chr1_+_87380299 0.12 ENST00000370551.4
ENST00000370550.5
HS2ST1
heparan sulfate 2-O-sulfotransferase 1
chr4_+_123747834 0.12 ENST00000264498.3
FGF2
fibroblast growth factor 2 (basic)
chr7_+_138943265 0.12 ENST00000483726.1
UBN2
ubinuclein 2
chr5_+_140254884 0.12 ENST00000398631.2
PCDHA12
protocadherin alpha 12
chr16_+_4897912 0.12 ENST00000545171.1
UBN1
ubinuclein 1
chr6_+_1080164 0.11 ENST00000314040.1
AL033381.1
Uncharacterized protein; cDNA FLJ34594 fis, clone KIDNE2009109
chr2_-_136743169 0.11 ENST00000264161.4
DARS
aspartyl-tRNA synthetase
chr5_+_94982558 0.11 ENST00000311364.4
ENST00000458310.1
RFESD
Rieske (Fe-S) domain containing
chr3_-_15540055 0.11 ENST00000605797.1
ENST00000435459.2
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr1_+_167298281 0.11 ENST00000367862.5
POU2F1
POU class 2 homeobox 1
chr18_+_61445007 0.11 ENST00000447428.1
ENST00000546027.1
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr1_-_85725316 0.10 ENST00000344356.5
ENST00000471115.1
C1orf52
chromosome 1 open reading frame 52
chr22_-_17702729 0.10 ENST00000449907.2
ENST00000441548.1
ENST00000399839.1
CECR1
cat eye syndrome chromosome region, candidate 1
chr17_-_39041479 0.10 ENST00000167588.3
KRT20
keratin 20
chr10_+_90354503 0.10 ENST00000531458.1
LIPJ
lipase, family member J
chr7_-_91808845 0.10 ENST00000343318.5
LRRD1
leucine-rich repeats and death domain containing 1
chr2_+_196521845 0.10 ENST00000359634.5
ENST00000412905.1
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr16_-_18911366 0.09 ENST00000565224.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chrX_-_64196351 0.09 ENST00000374839.3
ZC4H2
zinc finger, C4H2 domain containing
chr1_-_23504176 0.09 ENST00000302291.4
LUZP1
leucine zipper protein 1
chrX_-_130423386 0.09 ENST00000370903.3
IGSF1
immunoglobulin superfamily, member 1
chr6_-_88299678 0.09 ENST00000369536.5
RARS2
arginyl-tRNA synthetase 2, mitochondrial
chr12_-_121476959 0.09 ENST00000339275.5
OASL
2'-5'-oligoadenylate synthetase-like
chr19_-_14911023 0.09 ENST00000248073.2
OR7C1
olfactory receptor, family 7, subfamily C, member 1
chr10_-_104597286 0.09 ENST00000369887.3
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr19_-_51920873 0.09 ENST00000441969.3
ENST00000525998.1
ENST00000436984.2
SIGLEC10
sialic acid binding Ig-like lectin 10
chr8_-_33370607 0.09 ENST00000360742.5
ENST00000523305.1
TTI2
TELO2 interacting protein 2
chr4_+_113970772 0.09 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ANK2
ankyrin 2, neuronal
chr12_-_2986107 0.09 ENST00000359843.3
ENST00000342628.2
ENST00000361953.3
FOXM1
forkhead box M1
chr16_-_15982440 0.09 ENST00000575938.1
ENST00000573396.1
ENST00000573968.1
ENST00000575744.1
ENST00000573429.1
ENST00000255759.6
ENST00000575073.1
FOPNL
FGFR1OP N-terminal like
chr11_+_118175132 0.09 ENST00000361763.4
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr8_-_21771182 0.09 ENST00000523932.1
ENST00000544659.1
DOK2
docking protein 2, 56kDa
chr7_+_39773160 0.09 ENST00000340510.4
LINC00265
long intergenic non-protein coding RNA 265
chrX_-_64196376 0.09 ENST00000447788.2
ZC4H2
zinc finger, C4H2 domain containing
chr8_+_49984894 0.09 ENST00000522267.1
ENST00000399653.4
ENST00000303202.8
C8orf22
chromosome 8 open reading frame 22
chr9_+_134065506 0.09 ENST00000483497.2
NUP214
nucleoporin 214kDa
chr10_-_13523073 0.09 ENST00000440282.1
BEND7
BEN domain containing 7
chr17_-_79633590 0.08 ENST00000374741.3
ENST00000571503.1
OXLD1
oxidoreductase-like domain containing 1
chr9_-_95166884 0.08 ENST00000375561.5
OGN
osteoglycin
chr17_-_77023683 0.08 ENST00000581579.1
C1QTNF1-AS1
C1QTNF1 antisense RNA 1
chr2_-_161056762 0.08 ENST00000428609.2
ENST00000409967.2
ITGB6
integrin, beta 6
chr8_-_95487272 0.08 ENST00000297592.5
RAD54B
RAD54 homolog B (S. cerevisiae)
chr13_-_24007815 0.08 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr8_-_21771214 0.08 ENST00000276420.4
DOK2
docking protein 2, 56kDa
chrX_-_64196307 0.08 ENST00000545618.1
ZC4H2
zinc finger, C4H2 domain containing
chr6_-_117923520 0.08 ENST00000368498.2
GOPC
golgi-associated PDZ and coiled-coil motif containing
chr2_+_191334212 0.08 ENST00000444317.1
ENST00000535751.1
MFSD6
major facilitator superfamily domain containing 6
chr14_+_57671888 0.08 ENST00000391612.1
AL391152.1
AL391152.1
chr5_+_3596168 0.08 ENST00000302006.3
IRX1
iroquois homeobox 1
chr6_-_52705641 0.07 ENST00000370989.2
GSTA5
glutathione S-transferase alpha 5
chr1_-_87380002 0.07 ENST00000331835.5
SEP15
Homo sapiens 15 kDa selenoprotein (SEP15), transcript variant 2, mRNA.
chr5_-_169725231 0.07 ENST00000046794.5
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr17_+_72270429 0.07 ENST00000311014.6
DNAI2
dynein, axonemal, intermediate chain 2
chr16_+_89228757 0.07 ENST00000565008.1
LINC00304
long intergenic non-protein coding RNA 304
chr12_+_122516626 0.07 ENST00000319080.7
MLXIP
MLX interacting protein
chr11_-_102576537 0.07 ENST00000260229.4
MMP27
matrix metallopeptidase 27
chr10_+_102222798 0.07 ENST00000343737.5
WNT8B
wingless-type MMTV integration site family, member 8B
chrX_-_130423200 0.07 ENST00000361420.3
IGSF1
immunoglobulin superfamily, member 1
chrX_-_13835147 0.07 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr6_+_125474795 0.07 ENST00000304877.13
ENST00000534000.1
ENST00000368402.5
ENST00000368388.2
TPD52L1
tumor protein D52-like 1
chr2_-_162931052 0.07 ENST00000360534.3
DPP4
dipeptidyl-peptidase 4
chr11_+_134094508 0.07 ENST00000281187.5
ENST00000525095.2
VPS26B
vacuolar protein sorting 26 homolog B (S. pombe)
chr2_+_196521458 0.07 ENST00000409086.3
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr11_-_117747327 0.07 ENST00000584230.1
ENST00000527429.1
ENST00000584394.1
ENST00000532984.1
FXYD6
FXYD6-FXYD2
FXYD domain containing ion transport regulator 6
FXYD6-FXYD2 readthrough
chr2_+_98986400 0.07 ENST00000272602.2
CNGA3
cyclic nucleotide gated channel alpha 3
chr15_-_23034322 0.07 ENST00000539711.2
ENST00000560039.1
ENST00000398013.3
ENST00000337451.3
ENST00000359727.4
ENST00000398014.2
NIPA2
non imprinted in Prader-Willi/Angelman syndrome 2
chr19_-_41903161 0.07 ENST00000602129.1
ENST00000593771.1
ENST00000596905.1
ENST00000221233.4
EXOSC5
exosome component 5
chr19_+_35939154 0.07 ENST00000599180.2
FFAR2
free fatty acid receptor 2
chr12_-_70093065 0.06 ENST00000553096.1
BEST3
bestrophin 3

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823)
0.2 0.7 GO:0070982 L-asparagine biosynthetic process(GO:0070981) L-asparagine metabolic process(GO:0070982)
0.1 0.4 GO:0009386 translational attenuation(GO:0009386)
0.1 0.3 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.1 0.6 GO:0008291 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.1 0.2 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.3 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588) regulation of interleukin-18 production(GO:0032661)
0.1 1.0 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.1 0.2 GO:1904868 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 0.3 GO:0019230 proprioception(GO:0019230)
0.0 0.7 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0031133 regulation of axon diameter(GO:0031133)
0.0 0.3 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.3 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.0 0.2 GO:0039513 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.2 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.5 GO:0072520 seminiferous tubule development(GO:0072520)
0.0 0.3 GO:2000664 positive regulation of interleukin-5 secretion(GO:2000664)
0.0 0.1 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.0 0.1 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.0 0.4 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.1 GO:0021503 neural fold bending(GO:0021503)
0.0 0.7 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.1 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.3 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.0 0.1 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.2 GO:0048254 snoRNA localization(GO:0048254)
0.0 0.2 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 1.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.4 GO:0045176 apical protein localization(GO:0045176)
0.0 0.1 GO:0010716 negative regulation of extracellular matrix disassembly(GO:0010716)
0.0 0.2 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.1 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.0 0.6 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.2 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.1 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.0 0.1 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.5 GO:0030220 platelet formation(GO:0030220)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.3 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.3 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.1 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.1 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.0 GO:2000910 regulation of very-low-density lipoprotein particle remodeling(GO:0010901) negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.0 0.1 GO:1900063 regulation of peroxisome organization(GO:1900063)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.7 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.0 0.5 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.2 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.2 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.3 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.0 0.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.8 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.3 GO:0045179 axon hillock(GO:0043203) apical cortex(GO:0045179)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.1 GO:0036398 TCR signalosome(GO:0036398)
0.0 0.8 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.0 GO:1990716 axonemal central apparatus(GO:1990716)
0.0 0.0 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0030626 U12 snRNA binding(GO:0030626)
0.2 0.6 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.7 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
0.1 0.9 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.4 GO:0045118 azole transporter activity(GO:0045118)
0.1 0.2 GO:0016426 tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.1 0.7 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.3 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 0.3 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.7 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.3 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.2 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.4 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.2 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 0.2 GO:0034711 inhibin binding(GO:0034711)
0.0 0.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.2 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.2 GO:0000150 recombinase activity(GO:0000150)
0.0 1.0 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.2 GO:0032407 MutSalpha complex binding(GO:0032407)
0.0 0.0 GO:0046848 hydroxyapatite binding(GO:0046848)
0.0 0.1 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.3 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.3 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.2 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 0.2 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.1 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.1 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056)
0.0 0.0 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.0 0.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.2 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.1 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.7 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.7 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.2 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.2 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.3 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.5 REACTOME KINESINS Genes involved in Kinesins
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters