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Inflammatory response time course, HUVEC (Wada et al., 2009)
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Results for PBX2
Z-value: 0.35
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Transcription factors associated with PBX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PBX2 | hg19_v2_chr6_-_32157947_32157992 | 0.52 | 8.3e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_12857015 Show fit | 1.36 |
ENST00000155926.4
|
tribbles pseudokinase 2 |
|
| chr2_+_12857043 Show fit | 1.34 |
ENST00000381465.2
|
tribbles pseudokinase 2 |
|
| chr8_-_6420930 Show fit | 0.87 |
ENST00000325203.5
|
angiopoietin 2 |
|
| chr10_-_45474237 Show fit | 0.74 |
ENST00000448778.1
ENST00000298295.3 |
chromosome 10 open reading frame 10 |
|
| chr3_-_129158676 Show fit | 0.64 |
ENST00000393278.2
|
methyl-CpG binding domain protein 4 |
|
| chr3_-_129158850 Show fit | 0.59 |
ENST00000503197.1
ENST00000249910.1 ENST00000429544.2 ENST00000507208.1 |
methyl-CpG binding domain protein 4 |
|
| chr2_+_20646824 Show fit | 0.47 |
ENST00000272233.4
|
ras homolog family member B |
|
| chr18_-_72920372 Show fit | 0.46 |
ENST00000581620.1
ENST00000582437.1 |
zinc binding alcohol dehydrogenase domain containing 2 |
|
| chr17_+_7758374 Show fit | 0.42 |
ENST00000301599.6
ENST00000574668.1 |
transmembrane protein 88 |
|
| chr11_-_2162162 Show fit | 0.36 |
ENST00000381389.1
|
insulin-like growth factor 2 (somatomedin A) |
Network of associatons between targets according to the STRING database.
First level regulatory network of PBX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.7 | GO:0045074 | interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074) |
| 0.1 | 1.2 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.2 | 0.9 | GO:0050928 | negative regulation of positive chemotaxis(GO:0050928) |
| 0.1 | 0.5 | GO:0060830 | intraciliary anterograde transport(GO:0035720) ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) |
| 0.0 | 0.5 | GO:0061154 | endothelial tube morphogenesis(GO:0061154) |
| 0.0 | 0.4 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.0 | 0.3 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.1 | 0.2 | GO:0045659 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 0.0 | 0.1 | GO:0038170 | somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170) |
| 0.0 | 0.1 | GO:0002188 | translation reinitiation(GO:0002188) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.0 | 0.3 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 0.2 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.2 | 1.2 | GO:0008263 | pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263) |
| 0.0 | 0.9 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.1 | 0.5 | GO:0047522 | 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522) |
| 0.0 | 0.4 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 0.2 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.0 | 0.1 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.0 | 0.0 | GO:0045518 | interleukin-22 receptor binding(GO:0045518) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 0.9 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 0.5 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 0.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |