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Inflammatory response time course, HUVEC (Wada et al., 2009)

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Results for PBX2

Z-value: 0.35

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Transcription factors associated with PBX2

Gene Symbol Gene ID Gene Info
PBX2
ENSG00000204304.7 PBX homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PBX2hg19_v2_chr6_-_32157947_321579920.528.3e-03Click!

Activity profile of PBX2 motif

Sorted Z-values of PBX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_12857015 1.36 ENST00000155926.4
TRIB2
tribbles pseudokinase 2
chr2_+_12857043 1.34 ENST00000381465.2
TRIB2
tribbles pseudokinase 2
chr8_-_6420930 0.87 ENST00000325203.5
ANGPT2
angiopoietin 2
chr10_-_45474237 0.74 ENST00000448778.1
ENST00000298295.3
C10orf10
chromosome 10 open reading frame 10
chr3_-_129158676 0.64 ENST00000393278.2
MBD4
methyl-CpG binding domain protein 4
chr3_-_129158850 0.59 ENST00000503197.1
ENST00000249910.1
ENST00000429544.2
ENST00000507208.1
MBD4
methyl-CpG binding domain protein 4
chr2_+_20646824 0.47 ENST00000272233.4
RHOB
ras homolog family member B
chr18_-_72920372 0.46 ENST00000581620.1
ENST00000582437.1
ZADH2
zinc binding alcohol dehydrogenase domain containing 2
chr17_+_7758374 0.42 ENST00000301599.6
ENST00000574668.1
TMEM88
transmembrane protein 88
chr11_-_2162162 0.36 ENST00000381389.1
IGF2
insulin-like growth factor 2 (somatomedin A)
chr11_-_104769141 0.33 ENST00000508062.1
ENST00000422698.2
CASP12
caspase 12 (gene/pseudogene)
chr3_+_129159039 0.27 ENST00000507564.1
ENST00000431818.2
ENST00000504021.1
ENST00000349441.2
ENST00000348417.2
ENST00000440957.2
IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr3_+_129158926 0.27 ENST00000347300.2
ENST00000296266.3
IFT122
intraflagellar transport 122 homolog (Chlamydomonas)
chr2_+_234104079 0.24 ENST00000417661.1
INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr7_-_33140498 0.23 ENST00000448915.1
RP9
retinitis pigmentosa 9 (autosomal dominant)
chr2_+_33661382 0.15 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr13_-_107220455 0.14 ENST00000400198.3
ARGLU1
arginine and glutamate rich 1
chr12_-_28124903 0.12 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr16_+_1128781 0.12 ENST00000293897.4
ENST00000562758.1
SSTR5
somatostatin receptor 5
chr14_-_23624511 0.11 ENST00000529705.2
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr16_-_11492366 0.08 ENST00000595360.1
CTD-3088G3.8
Protein LOC388210
chr10_+_124320156 0.07 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
DMBT1
deleted in malignant brain tumors 1
chr10_+_124320195 0.07 ENST00000359586.6
DMBT1
deleted in malignant brain tumors 1
chr3_+_159943362 0.06 ENST00000326474.3
C3orf80
chromosome 3 open reading frame 80
chr6_+_26045603 0.06 ENST00000540144.1
HIST1H3C
histone cluster 1, H3c
chrX_+_119737806 0.05 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr17_+_8191815 0.05 ENST00000226105.6
ENST00000407006.4
ENST00000580434.1
ENST00000439238.3
RANGRF
RAN guanine nucleotide release factor
chr1_+_207038699 0.05 ENST00000367098.1
IL20
interleukin 20
chr14_+_58765103 0.05 ENST00000355431.3
ENST00000348476.3
ENST00000395168.3
ARID4A
AT rich interactive domain 4A (RBP1-like)
chr12_-_39734783 0.04 ENST00000552961.1
KIF21A
kinesin family member 21A
chr6_+_160211481 0.04 ENST00000367034.4
MRPL18
mitochondrial ribosomal protein L18
chr3_+_188889737 0.04 ENST00000345063.3
TPRG1
tumor protein p63 regulated 1
chr1_+_101702417 0.04 ENST00000305352.6
S1PR1
sphingosine-1-phosphate receptor 1
chr3_-_52864680 0.03 ENST00000406595.1
ENST00000485816.1
ENST00000434759.3
ENST00000346281.5
ENST00000266041.4
ITIH4
inter-alpha-trypsin inhibitor heavy chain family, member 4
chr7_+_134528635 0.03 ENST00000445569.2
CALD1
caldesmon 1
chr3_+_120626919 0.02 ENST00000273666.6
ENST00000471454.1
ENST00000472879.1
ENST00000497029.1
ENST00000492541.1
STXBP5L
syntaxin binding protein 5-like
chr7_-_32529973 0.02 ENST00000410044.1
ENST00000409987.1
ENST00000409782.1
ENST00000450169.2
LSM5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr2_+_234602305 0.02 ENST00000406651.1
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr10_+_47894572 0.02 ENST00000355876.5
FAM21B
family with sequence similarity 21, member B
chr2_+_204732666 0.02 ENST00000295854.6
ENST00000472206.1
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr17_-_29151794 0.02 ENST00000324238.6
CRLF3
cytokine receptor-like factor 3
chr4_-_100065419 0.01 ENST00000504125.1
ENST00000505590.1
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
chr2_+_204732487 0.01 ENST00000302823.3
CTLA4
cytotoxic T-lymphocyte-associated protein 4

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.7 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.2 0.9 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.1 0.5 GO:0060830 intraciliary anterograde transport(GO:0035720) ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.1 0.2 GO:0045659 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.1 1.2 GO:0045008 depyrimidination(GO:0045008)
0.0 0.4 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 0.1 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.3 GO:0097264 self proteolysis(GO:0097264)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.1 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.0 0.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.5 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.0 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.0 0.0 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.3 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.2 GO:0005785 signal recognition particle receptor complex(GO:0005785)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.1 2.7 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 0.5 GO:0047522 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.2 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.0 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.0 0.4 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.9 GO:0030971 receptor tyrosine kinase binding(GO:0030971)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.9 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse